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Items: 5

1.

Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity.

Saleme B, Gurtu V, Zhang Y, Kinnaird A, Boukouris AE, Gopal K, Ussher JR, Sutendra G.

Sci Transl Med. 2019 Feb 6;11(478). pii: eaau8866. doi: 10.1126/scitranslmed.aau8866.

PMID:
30728290
2.

Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients.

Michelakis ED, Gurtu V, Webster L, Barnes G, Watson G, Howard L, Cupitt J, Paterson I, Thompson RB, Chow K, O'Regan DP, Zhao L, Wharton J, Kiely DG, Kinnaird A, Boukouris AE, White C, Nagendran J, Freed DH, Wort SJ, Gibbs JSR, Wilkins MR.

Sci Transl Med. 2017 Oct 25;9(413). pii: eaao4583. doi: 10.1126/scitranslmed.aao4583.

3.

Metabolic Enzymes Moonlighting in the Nucleus: Metabolic Regulation of Gene Transcription.

Boukouris AE, Zervopoulos SD, Michelakis ED.

Trends Biochem Sci. 2016 Aug;41(8):712-730. doi: 10.1016/j.tibs.2016.05.013. Epub 2016 Jun 23. Review.

PMID:
27345518
4.

The degree of liver injury determines the role of p21 in liver regeneration and hepatocarcinogenesis in mice.

Buitrago-Molina LE, Marhenke S, Longerich T, Sharma AD, Boukouris AE, Geffers R, Guigas B, Manns MP, Vogel A.

Hepatology. 2013 Sep;58(3):1143-52. doi: 10.1002/hep.26412. Epub 2013 Aug 7.

PMID:
23526443
5.

Activity of the mTOR inhibitor RAD001, the dual mTOR and PI3-kinase inhibitor BEZ235 and the PI3-kinase inhibitor BKM120 in hepatocellular carcinoma.

Kirstein MM, Boukouris AE, Pothiraju D, Buitrago-Molina LE, Marhenke S, Schütt J, Orlik J, Kühnel F, Hegermann J, Manns MP, Vogel A.

Liver Int. 2013 May;33(5):780-93. doi: 10.1111/liv.12126. Epub 2013 Mar 15.

PMID:
23489999

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