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Pharmacology of the urotensin-II receptor antagonist palosuran (ACT-058362; 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea sulfate salt): first demonstration of a pathophysiological role of the urotensin System.

Clozel M, Binkert C, Birker-Robaczewska M, Boukhadra C, Ding SS, Fischli W, Hess P, Mathys B, Morrison K, Müller C, Müller C, Nayler O, Qiu C, Rey M, Scherz MW, Velker J, Weller T, Xi JF, Ziltener P.

J Pharmacol Exp Ther. 2004 Oct;311(1):204-12. Epub 2004 May 14.


The expression of urotensin II receptor (U2R) is up-regulated by interferon-gamma.

Birker-Robaczewska M, Boukhadra C, Studer R, Mueller C, Binkert C, Nayler O.

J Recept Signal Transduct Res. 2003;23(4):289-305.


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