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Items: 7


Lithocholic bile acid accumulated in yeast mitochondria orchestrates a development of an anti-aging cellular pattern by causing age-related changes in cellular proteome.

Beach A, Richard VR, Bourque S, Boukh-Viner T, Kyryakov P, Gomez-Perez A, Arlia-Ciommo A, Feldman R, Leonov A, Piano A, Svistkova V, Titorenko VI.

Cell Cycle. 2015;14(11):1643-56. doi: 10.1080/15384101.2015.1026493.


Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes.

Goldberg AA, Richard VR, Kyryakov P, Bourque SD, Beach A, Burstein MT, Glebov A, Koupaki O, Boukh-Viner T, Gregg C, Juneau M, English AM, Thomas DY, Titorenko VI.

Aging (Albany NY). 2010 Jul;2(7):393-414.


A novel function of lipid droplets in regulating longevity.

Goldberg AA, Bourque SD, Kyryakov P, Boukh-Viner T, Gregg C, Beach A, Burstein MT, Machkalyan G, Richard V, Rampersad S, Titorenko VI.

Biochem Soc Trans. 2009 Oct;37(Pt 5):1050-5. doi: 10.1042/BST0371050.


Effect of calorie restriction on the metabolic history of chronologically aging yeast.

Goldberg AA, Bourque SD, Kyryakov P, Gregg C, Boukh-Viner T, Beach A, Burstein MT, Machkalyan G, Richard V, Rampersad S, Cyr D, Milijevic S, Titorenko VI.

Exp Gerontol. 2009 Sep;44(9):555-71. doi: 10.1016/j.exger.2009.06.001. Epub 2009 Jun 17.


A signal from inside the peroxisome initiates its division by promoting the remodeling of the peroxisomal membrane.

Guo T, Gregg C, Boukh-Viner T, Kyryakov P, Goldberg A, Bourque S, Banu F, Haile S, Milijevic S, San KH, Solomon J, Wong V, Titorenko VI.

J Cell Biol. 2007 Apr 23;177(2):289-303. Epub 2007 Apr 16.


Lipids and lipid domains in the peroxisomal membrane of the yeast Yarrowia lipolytica.

Boukh-Viner T, Titorenko VI.

Biochim Biophys Acta. 2006 Dec;1763(12):1688-96. Epub 2006 Aug 23. Review.


Dynamic ergosterol- and ceramide-rich domains in the peroxisomal membrane serve as an organizing platform for peroxisome fusion.

Boukh-Viner T, Guo T, Alexandrian A, Cerracchio A, Gregg C, Haile S, Kyskan R, Milijevic S, Oren D, Solomon J, Wong V, Nicaud JM, Rachubinski RA, English AM, Titorenko VI.

J Cell Biol. 2005 Feb 28;168(5):761-73.

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