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Differentiation of Baboon (Papio anubis) Induced-Pluripotent Stem Cells into Enucleated Red Blood Cells.

Olivier EN, Wang K, Grossman J, Mahmud N, Bouhassira EE.

Cells. 2019 Oct 19;8(10). pii: E1282. doi: 10.3390/cells8101282.


PSC-RED and MNC-RED: Albumin-free and low-transferrin robust erythroid differentiation protocols to produce human enucleated red blood cells.

Olivier EN, Zhang S, Yan Z, Suzuka S, Roberts K, Wang K, Bouhassira EE.

Exp Hematol. 2019 Jul;75:31-52.e15. doi: 10.1016/j.exphem.2019.05.006. Epub 2019 Jun 6.


Ultra-High-Frequency Reprogramming of Individual Long-Term Hematopoietic Stem Cells Yields Low Somatic Variant Induced Pluripotent Stem Cells.

Wang K, Guzman AK, Yan Z, Zhang S, Hu MY, Hamaneh MB, Yu YK, Tolu S, Zhang J, Kanavy HE, Ye K, Bartholdy B, Bouhassira EE.

Cell Rep. 2019 Mar 5;26(10):2580-2592.e7. doi: 10.1016/j.celrep.2019.02.021.


Mechanisms of establishment and functional significance of DNA demethylation during erythroid differentiation.

Bartholdy B, Lajugie J, Yan Z, Zhang S, Mukhopadhyay R, Greally JM, Suzuki M, Bouhassira EE.

Blood Adv. 2018 Aug 14;2(15):1833-1852. doi: 10.1182/bloodadvances.2018015651.


The scientific legacy of Ronald L. Nagel (1936-2016), a true renaissance man.

Bouhassira EE, Billett HH, Fabry ME, Hirsch RE, Krishnamoorthy R.

Am J Hematol. 2016 Sep;91(9):865-6. doi: 10.1002/ajh.24444. Epub 2016 Jul 4. No abstract available.


Distinct epigenetic features of differentiation-regulated replication origins.

Smith OK, Kim R, Fu H, Martin MM, Lin CM, Utani K, Zhang Y, Marks AB, Lalande M, Chamberlain S, Libbrecht MW, Bouhassira EE, Ryan MC, Noble WS, Aladjem MI.

Epigenetics Chromatin. 2016 May 10;9:18. doi: 10.1186/s13072-016-0067-3. eCollection 2016.


Amelioration of Hyperbilirubinemia in Gunn Rats after Transplantation of Human Induced Pluripotent Stem Cell-Derived Hepatocytes.

Chen Y, Li Y, Wang X, Zhang W, Sauer V, Chang CJ, Han B, Tchaikovskaya T, Avsar Y, Tafaleng E, Madhusudana Girija S, Tar K, Polgar Z, Strom S, Bouhassira EE, Guha C, Fox IJ, Roy-Chowdhury J, Roy-Chowdhury N.

Stem Cell Reports. 2015 Jul 14;5(1):22-30. doi: 10.1016/j.stemcr.2015.04.017. Epub 2015 Jun 11.


Variation in Gamma-Globin Expression before and after Induction with Hydroxyurea Associated with BCL11A, KLF1 and TAL1.

Grieco AJ, Billett HH, Green NS, Driscoll MC, Bouhassira EE.

PLoS One. 2015 Jun 8;10(6):e0129431. doi: 10.1371/journal.pone.0129431. eCollection 2015.


Allele-specific analysis of DNA replication origins in mammalian cells.

Bartholdy B, Mukhopadhyay R, Lajugie J, Aladjem MI, Bouhassira EE.

Nat Commun. 2015 May 19;6:7051. doi: 10.1038/ncomms8051.


Histone h1.3 suppresses h19 noncoding RNA expression and cell growth of ovarian cancer cells.

Medrzycki M, Zhang Y, Zhang W, Cao K, Pan C, Lailler N, McDonald JF, Bouhassira EE, Fan Y.

Cancer Res. 2014 Nov 15;74(22):6463-73. doi: 10.1158/0008-5472.CAN-13-2922. Epub 2014 Sep 9.


GenPlay Multi-Genome, a tool to compare and analyze multiple human genomes in a graphical interface.

Lajugie J, Fourel N, Bouhassira EE.

Bioinformatics. 2015 Jan 1;31(1):109-11. doi: 10.1093/bioinformatics/btu588. Epub 2014 Aug 31.


The exosome complex establishes a barricade to erythroid maturation.

McIver SC, Kang YA, DeVilbiss AW, O'Driscoll CA, Ouellette JN, Pope NJ, Camprecios G, Chang CJ, Yang D, Bouhassira EE, Ghaffari S, Bresnick EH.

Blood. 2014 Oct 2;124(14):2285-97. doi: 10.1182/blood-2014-04-571083. Epub 2014 Aug 12.


Allele-specific genome-wide profiling in human primary erythroblasts reveal replication program organization.

Mukhopadhyay R, Lajugie J, Fourel N, Selzer A, Schizas M, Bartholdy B, Mar J, Lin CM, Martin MM, Ryan M, Aladjem MI, Bouhassira EE.

PLoS Genet. 2014 May 1;10(5):e1004319. doi: 10.1371/journal.pgen.1004319. eCollection 2014 May.


Erythropoiesis from human embryonic stem cells through erythropoietin-independent AKT signaling.

Kim WS, Zhu Y, Deng Q, Chin CJ, He CB, Grieco AJ, Dravid GG, Parekh C, Hollis RP, Lane TF, Bouhassira EE, Kohn DB, Crooks GM.

Stem Cells. 2014 Jun;32(6):1503-14. doi: 10.1002/stem.1677.


Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function.

Kim HS, Mukhopadhyay R, Rothbart SB, Silva AC, Vanoosthuyse V, Radovani E, Kislinger T, Roguev A, Ryan CJ, Xu J, Jahari H, Hardwick KG, Greenblatt JF, Krogan NJ, Fillingham JS, Strahl BD, Bouhassira EE, Edelmann W, Keogh MC.

Cell Rep. 2014 Mar 13;6(5):892-905. doi: 10.1016/j.celrep.2014.01.029. Epub 2014 Feb 22.


Complete genome phasing of family quartet by combination of genetic, physical and population-based phasing analysis.

Lajugie J, Mukhopadhyay R, Schizas M, Lailler N, Fourel N, Bouhassira EE.

PLoS One. 2013 May 31;8(5):e64571. doi: 10.1371/journal.pone.0064571. Print 2013.


High-resolution mapping of h1 linker histone variants in embryonic stem cells.

Cao K, Lailler N, Zhang Y, Kumar A, Uppal K, Liu Z, Lee EK, Wu H, Medrzycki M, Pan C, Ho PY, Cooper GP Jr, Dong X, Bock C, Bouhassira EE, Fan Y.

PLoS Genet. 2013;9(4):e1003417. doi: 10.1371/journal.pgen.1003417. Epub 2013 Apr 25.


Therapeutic potential of hematopoietic cells derived from pluripotent stem cells.

Bouhassira EE.

Expert Opin Biol Ther. 2013 Aug;13(8):1099-102. doi: 10.1517/14712598.2013.792803. Epub 2013 Apr 23.


Concise review: production of cultured red blood cells from stem cells.

Bouhassira EE.

Stem Cells Transl Med. 2012 Dec;1(12):927-33. doi: 10.5966/sctm.2012-0097. Epub 2012 Nov 26. Review.


Novel, high-yield red blood cell production methods from CD34-positive cells derived from human embryonic stem, yolk sac, fetal liver, cord blood, and peripheral blood.

Olivier E, Qiu C, Bouhassira EE.

Stem Cells Transl Med. 2012 Aug;1(8):604-14. doi: 10.5966/sctm.2012-0059. Epub 2012 Aug 2.


Zinc-finger nuclease-mediated correction of α-thalassemia in iPS cells.

Chang CJ, Bouhassira EE.

Blood. 2012 Nov 8;120(19):3906-14. doi: 10.1182/blood-2012-03-420703. Epub 2012 Sep 21.


A transgenic mouse model expressing exclusively human hemoglobin E: indications of a mild oxidative stress.

Chen Q, Fabry ME, Rybicki AC, Suzuka SM, Balazs TC, Etzion Z, de Jong K, Akoto EK, Canterino JE, Kaul DK, Kuypers FA, Lefer D, Bouhassira EE, Hirsch RE.

Blood Cells Mol Dis. 2012 Feb 15;48(2):91-101. doi: 10.1016/j.bcmd.2011.12.002. Epub 2012 Jan 18.


Autophagy driven by a master regulator of hematopoiesis.

Kang YA, Sanalkumar R, O'Geen H, Linnemann AK, Chang CJ, Bouhassira EE, Farnham PJ, Keles S, Bresnick EH.

Mol Cell Biol. 2012 Jan;32(1):226-39. doi: 10.1128/MCB.06166-11. Epub 2011 Oct 24.


Production of embryonic and fetal-like red blood cells from human induced pluripotent stem cells.

Chang CJ, Mitra K, Koya M, Velho M, Desprat R, Lenz J, Bouhassira EE.

PLoS One. 2011;6(10):e25761. doi: 10.1371/journal.pone.0025761. Epub 2011 Oct 13.


Systematic targeted integration to study Albumin gene control elements.

Bhattacharyya S, Tian J, Bouhassira EE, Locker J.

PLoS One. 2011;6(8):e23234. doi: 10.1371/journal.pone.0023234. Epub 2011 Aug 12.


GenPlay, a multipurpose genome analyzer and browser.

Lajugie J, Bouhassira EE.

Bioinformatics. 2011 Jul 15;27(14):1889-93. doi: 10.1093/bioinformatics/btr309. Epub 2011 May 19.


Reprogramming of embryonic human fibroblasts into fetal hematopoietic progenitors by fusion with human fetal liver CD34+ cells.

Sandler VM, Lailler N, Bouhassira EE.

PLoS One. 2011 Apr 14;6(4):e18265. doi: 10.1371/journal.pone.0018265.


Differentiation of human embryonic stem cells into mesenchymal stem cells by the "raclure" method.

Olivier EN, Bouhassira EE.

Methods Mol Biol. 2011;690:183-93. doi: 10.1007/978-1-60761-962-8_13.


Efficient generation of lens progenitor cells and lentoid bodies from human embryonic stem cells in chemically defined conditions.

Yang C, Yang Y, Brennan L, Bouhassira EE, Kantorow M, Cvekl A.

FASEB J. 2010 Sep;24(9):3274-83. doi: 10.1096/fj.10-157255. Epub 2010 Apr 21.


Transferrin therapy ameliorates disease in beta-thalassemic mice.

Li H, Rybicki AC, Suzuka SM, von Bonsdorff L, Breuer W, Hall CB, Cabantchik ZI, Bouhassira EE, Fabry ME, Ginzburg YZ.

Nat Med. 2010 Feb;16(2):177-82. doi: 10.1038/nm.2073. Epub 2010 Jan 24.


Decreased replication origin activity in temporal transition regions.

Guan Z, Hughes CM, Kosiyatrakul S, Norio P, Sen R, Fiering S, Allis CD, Bouhassira EE, Schildkraut CL.

J Cell Biol. 2009 Nov 30;187(5):623-35. doi: 10.1083/jcb.200905144.


Predictable dynamic program of timing of DNA replication in human cells.

Desprat R, Thierry-Mieg D, Lailler N, Lajugie J, Schildkraut C, Thierry-Mieg J, Bouhassira EE.

Genome Res. 2009 Dec;19(12):2288-99. doi: 10.1101/gr.094060.109. Epub 2009 Sep 18.


Gene specificity of suppression of transgene-mediated insertional transcriptional activation by the chicken HS4 insulator.

Desprat R, Bouhassira EE.

PLoS One. 2009 Jun 18;4(6):e5956. doi: 10.1371/journal.pone.0005956.


Complex developmental patterns of histone modifications associated with the human beta-globin switch in primary cells.

Hsu M, Richardson CA, Olivier E, Qiu C, Bouhassira EE, Lowrey CH, Fiering S.

Exp Hematol. 2009 Jul;37(7):799-806.e4. doi: 10.1016/j.exphem.2009.04.006. Epub 2009 May 19.


Developmentally regulated extended domains of DNA hypomethylation encompass highly transcribed genes of the human beta-globin locus.

Lathrop MJ, Hsu M, Richardson CA, Olivier EN, Qiu C, Bouhassira EE, Fiering S, Lowrey CH.

Exp Hematol. 2009 Jul;37(7):807-813.e2. doi: 10.1016/j.exphem.2009.04.005. Epub 2009 May 19.


High-resolution genome-wide cytosine methylation profiling with simultaneous copy number analysis and optimization for limited cell numbers.

Oda M, Glass JL, Thompson RF, Mo Y, Olivier EN, Figueroa ME, Selzer RR, Richmond TA, Zhang X, Dannenberg L, Green RD, Melnick A, Hatchwell E, Bouhassira EE, Verma A, Suzuki M, Greally JM.

Nucleic Acids Res. 2009 Jul;37(12):3829-39. doi: 10.1093/nar/gkp260. Epub 2009 Apr 22.


Exogenous iron increases hemoglobin in beta-thalassemic mice.

Ginzburg YZ, Rybicki AC, Suzuka SM, Hall CB, Breuer W, Cabantchik ZI, Bouhassira EE, Fabry ME, Nagel RL.

Exp Hematol. 2009 Feb;37(2):172-83. doi: 10.1016/j.exphem.2008.10.004. Epub 2008 Dec 6.


Toward the manufacture of red blood cells?

Bouhassira EE.

Blood. 2008 Dec 1;112(12):4362-3. doi: 10.1182/blood-2008-09-177212. No abstract available.


Human embryonic stem cells in culture possess primary cilia with hedgehog signaling machinery.

Kiprilov EN, Awan A, Desprat R, Velho M, Clement CA, Byskov AG, Andersen CY, Satir P, Bouhassira EE, Christensen ST, Hirsch RE.

J Cell Biol. 2008 Mar 10;180(5):897-904. doi: 10.1083/jcb.200706028.


Globin switches in yolk sac-like primitive and fetal-like definitive red blood cells produced from human embryonic stem cells.

Qiu C, Olivier EN, Velho M, Bouhassira EE.

Blood. 2008 Feb 15;111(4):2400-8. Epub 2007 Nov 16.


CG dinucleotide clustering is a species-specific property of the genome.

Glass JL, Thompson RF, Khulan B, Figueroa ME, Olivier EN, Oakley EJ, Van Zant G, Bouhassira EE, Melnick A, Golden A, Fazzari MJ, Greally JM.

Nucleic Acids Res. 2007;35(20):6798-807. Epub 2007 Oct 10.


Large-scale production of embryonic red blood cells from human embryonic stem cells.

Olivier EN, Qiu C, Velho M, Hirsch RE, Bouhassira EE.

Exp Hematol. 2006 Dec;34(12):1635-42.


Transcriptional interference among the murine beta-like globin genes.

Hu X, Eszterhas S, Pallazzi N, Bouhassira EE, Fields J, Tanabe O, Gerber SA, Bulger M, Engel JD, Groudine M, Fiering S.

Blood. 2007 Mar 1;109(5):2210-6. Epub 2006 Oct 31.


DNA methylation supports intrinsic epigenetic memory in mammalian cells.

Feng YQ, Desprat R, Fu H, Olivier E, Lin CM, Lobell A, Gowda SN, Aladjem MI, Bouhassira EE.

PLoS Genet. 2006 Apr;2(4):e65. Epub 2006 Apr 28.


Differentiation of human embryonic stem cells into bipotent mesenchymal stem cells.

Olivier EN, Rybicki AC, Bouhassira EE.

Stem Cells. 2006 Aug;24(8):1914-22. Epub 2006 Apr 27.


Preventing gene silencing with human replicators.

Fu H, Wang L, Lin CM, Singhania S, Bouhassira EE, Aladjem MI.

Nat Biotechnol. 2006 May;24(5):572-6. Epub 2006 Apr 9.


Histone H1 depletion in mammals alters global chromatin structure but causes specific changes in gene regulation.

Fan Y, Nikitina T, Zhao J, Fleury TJ, Bhattacharyya R, Bouhassira EE, Stein A, Woodcock CL, Skoultchi AI.

Cell. 2005 Dec 29;123(7):1199-212.


Enzymatically active ADAMTS13 variants are not inhibited by anti-ADAMTS13 autoantibodies: a novel therapeutic strategy?

Zhou W, Dong L, Ginsburg D, Bouhassira EE, Tsai HM.

J Biol Chem. 2005 Dec 2;280(48):39934-41. Epub 2005 Oct 3.

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