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Items: 27


Metal-captured inhibition of pre-mRNA processing activity by CPSF3 controls Cryptosporidium infection.

Swale C, Bougdour A, Gnahoui-David A, Tottey J, Georgeault S, Laurent F, Palencia A, Hakimi MA.

Sci Transl Med. 2019 Nov 6;11(517). pii: eaax7161. doi: 10.1126/scitranslmed.aax7161.


The Toxoplasma effector TEEGR promotes parasite persistence by modulating NF-κB signalling via EZH2.

Braun L, Brenier-Pinchart MP, Hammoudi PM, Cannella D, Kieffer-Jaquinod S, Vollaire J, Josserand V, Touquet B, Couté Y, Tardieux I, Bougdour A, Hakimi MA.

Nat Microbiol. 2019 Jul;4(7):1208-1220. doi: 10.1038/s41564-019-0431-8. Epub 2019 Apr 29.


Characterization of a Toxoplasma effector uncovers an alternative GSK3/β-catenin-regulatory pathway of inflammation.

He H, Brenier-Pinchart MP, Braun L, Kraut A, Touquet B, Couté Y, Tardieux I, Hakimi MA, Bougdour A.

Elife. 2018 Oct 15;7. pii: e39887. doi: 10.7554/eLife.39887.


Modifications at K31 on the lateral surface of histone H4 contribute to genome structure and expression in apicomplexan parasites.

Sindikubwabo F, Ding S, Hussain T, Ortet P, Barakat M, Baumgarten S, Cannella D, Palencia A, Bougdour A, Belmudes L, Couté Y, Tardieux I, Botté CY, Scherf A, Hakimi MA.

Elife. 2017 Nov 4;6. pii: e29391. doi: 10.7554/eLife.29391.


Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis.

Palencia A, Bougdour A, Brenier-Pinchart MP, Touquet B, Bertini RL, Sensi C, Gay G, Vollaire J, Josserand V, Easom E, Freund YR, Pelloux H, Rosenthal PJ, Cusack S, Hakimi MA.

EMBO Mol Med. 2017 Mar;9(3):385-394. doi: 10.15252/emmm.201607370.


Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist.

Pellegrini E, Palencia A, Braun L, Kapp U, Bougdour A, Belrhali H, Bowler MW, Hakimi MA.

Structure. 2017 Jan 3;25(1):16-26. doi: 10.1016/j.str.2016.10.011. Epub 2016 Nov 23.


Toxoplasma gondii TgIST co-opts host chromatin repressors dampening STAT1-dependent gene regulation and IFN-γ-mediated host defenses.

Gay G, Braun L, Brenier-Pinchart MP, Vollaire J, Josserand V, Bertini RL, Varesano A, Touquet B, De Bock PJ, Coute Y, Tardieux I, Bougdour A, Hakimi MA.

J Exp Med. 2016 Aug 22;213(9):1779-98. doi: 10.1084/jem.20160340. Epub 2016 Aug 8.


Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.

Palencia A, Liu RJ, Lukarska M, Gut J, Bougdour A, Touquet B, Wang ED, Li X, Alley MR, Freund YR, Rosenthal PJ, Hakimi MA, Cusack S.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):5817-27. doi: 10.1128/AAC.00873-16. Print 2016 Oct.


The aspartyl protease TgASP5 mediates the export of the Toxoplasma GRA16 and GRA24 effectors into host cells.

Curt-Varesano A, Braun L, Ranquet C, Hakimi MA, Bougdour A.

Cell Microbiol. 2016 Feb;18(2):151-67. doi: 10.1111/cmi.12498. Epub 2015 Sep 6.


The Toxoplasma Dense Granule Proteins GRA17 and GRA23 Mediate the Movement of Small Molecules between the Host and the Parasitophorous Vacuole.

Gold DA, Kaplan AD, Lis A, Bett GC, Rosowski EE, Cirelli KM, Bougdour A, Sidik SM, Beck JR, Lourido S, Egea PF, Bradley PJ, Hakimi MA, Rasmusson RL, Saeij JP.

Cell Host Microbe. 2015 May 13;17(5):642-52. doi: 10.1016/j.chom.2015.04.003.


Toxoplasma's ways of manipulating the host transcriptome via secreted effectors.

Hakimi MA, Bougdour A.

Curr Opin Microbiol. 2015 Aug;26:24-31. doi: 10.1016/j.mib.2015.04.003. Epub 2015 Apr 24. Review.


miR-146a and miR-155 delineate a MicroRNA fingerprint associated with Toxoplasma persistence in the host brain.

Cannella D, Brenier-Pinchart MP, Braun L, van Rooyen JM, Bougdour A, Bastien O, Behnke MS, Curt RL, Curt A, Saeij JP, Sibley LD, Pelloux H, Hakimi MA.

Cell Rep. 2014 Mar 13;6(5):928-37. doi: 10.1016/j.celrep.2014.02.002. Epub 2014 Feb 27.


Toxoplasma exports dense granule proteins beyond the vacuole to the host cell nucleus and rewires the host genome expression.

Bougdour A, Tardieux I, Hakimi MA.

Cell Microbiol. 2014 Mar;16(3):334-43. doi: 10.1111/cmi.12255. Epub 2014 Jan 20. Review.


Anti-adaptors provide multiple modes for regulation of the RssB adaptor protein.

Battesti A, Hoskins JR, Tong S, Milanesio P, Mann JM, Kravats A, Tsegaye YM, Bougdour A, Wickner S, Gottesman S.

Genes Dev. 2013 Dec 15;27(24):2722-35. doi: 10.1101/gad.229617.113.


A Toxoplasma dense granule protein, GRA24, modulates the early immune response to infection by promoting a direct and sustained host p38 MAPK activation.

Braun L, Brenier-Pinchart MP, Yogavel M, Curt-Varesano A, Curt-Bertini RL, Hussain T, Kieffer-Jaquinod S, Coute Y, Pelloux H, Tardieux I, Sharma A, Belrhali H, Bougdour A, Hakimi MA.

J Exp Med. 2013 Sep 23;210(10):2071-86. doi: 10.1084/jem.20130103. Epub 2013 Sep 16.


Host cell subversion by Toxoplasma GRA16, an exported dense granule protein that targets the host cell nucleus and alters gene expression.

Bougdour A, Durandau E, Brenier-Pinchart MP, Ortet P, Barakat M, Kieffer S, Curt-Varesano A, Curt-Bertini RL, Bastien O, Coute Y, Pelloux H, Hakimi MA.

Cell Host Microbe. 2013 Apr 17;13(4):489-500. doi: 10.1016/j.chom.2013.03.002.


Flexible synthesis and evaluation of diverse anti-Apicomplexa cyclic peptides.

Traoré M, Mietton F, Maubon D, Peuchmaur M, Hilário FF, Pereira de Freitas R, Bougdour A, Curt A, Maynadier M, Vial H, Pelloux H, Hakimi MA, Wong YS.

J Org Chem. 2013 Apr 19;78(8):3655-75. doi: 10.1021/jo4001492. Epub 2013 Apr 4.


Activity of the histone deacetylase inhibitor FR235222 on Toxoplasma gondii: inhibition of stage conversion of the parasite cyst form and study of new derivative compounds.

Maubon D, Bougdour A, Wong YS, Brenier-Pinchart MP, Curt A, Hakimi MA, Pelloux H.

Antimicrob Agents Chemother. 2010 Nov;54(11):4843-50. doi: 10.1128/AAC.00462-10. Epub 2010 Aug 16.


Chromatin modifications: implications in the regulation of gene expression in Toxoplasma gondii.

Bougdour A, Braun L, Cannella D, Hakimi MA.

Cell Microbiol. 2010 Apr 1;12(4):413-23. doi: 10.1111/j.1462-5822.2010.01446.x. Epub 2010 Jan 26. Review.


Drug inhibition of HDAC3 and epigenetic control of differentiation in Apicomplexa parasites.

Bougdour A, Maubon D, Baldacci P, Ortet P, Bastien O, Bouillon A, Barale JC, Pelloux H, Ménard R, Hakimi MA.

J Exp Med. 2009 Apr 13;206(4):953-66. doi: 10.1084/jem.20082826. Epub 2009 Apr 6.


A DNA damage response in Escherichia coli involving the alternative sigma factor, RpoS.

Merrikh H, Ferrazzoli AE, Bougdour A, Olivier-Mason A, Lovett ST.

Proc Natl Acad Sci U S A. 2009 Jan 13;106(2):611-6. doi: 10.1073/pnas.0803665106. Epub 2009 Jan 5.


Toxoplasma gondii gene expression is under the control of regulatory pathways acting through chromatin structure.

Bougdour A, Sautel CF, Cannella D, Braun L, Hakimi MA.

Parasite. 2008 Sep;15(3):206-10. Review.


Multiple pathways for regulation of sigmaS (RpoS) stability in Escherichia coli via the action of multiple anti-adaptors.

Bougdour A, Cunning C, Baptiste PJ, Elliott T, Gottesman S.

Mol Microbiol. 2008 Apr;68(2):298-313.


ppGpp regulation of RpoS degradation via anti-adaptor protein IraP.

Bougdour A, Gottesman S.

Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12896-901. Epub 2007 Jul 19.


The PhoP/PhoQ two-component system stabilizes the alternative sigma factor RpoS in Salmonella enterica.

Tu X, Latifi T, Bougdour A, Gottesman S, Groisman EA.

Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13503-8. Epub 2006 Aug 28.


Modulating RssB activity: IraP, a novel regulator of sigma(S) stability in Escherichia coli.

Bougdour A, Wickner S, Gottesman S.

Genes Dev. 2006 Apr 1;20(7):884-97.


Crl, a low temperature-induced protein in Escherichia coli that binds directly to the stationary phase sigma subunit of RNA polymerase.

Bougdour A, Lelong C, Geiselmann J.

J Biol Chem. 2004 May 7;279(19):19540-50. Epub 2004 Feb 21.

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