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Items: 1 to 50 of 51

1.

Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity.

Heden TD, Johnson JM, Ferrara PJ, Eshima H, Verkerke ARP, Wentzler EJ, Siripoksup P, Narowski TM, Coleman CB, Lin CT, Ryan TE, Reidy PT, de Castro Brás LE, Karner CM, Burant CF, Maschek JA, Cox JE, Mashek DG, Kardon G, Boudina S, Zeczycki TN, Rutter J, Shaikh SR, Vance JE, Drummond MJ, Neufer PD, Funai K.

Sci Adv. 2019 Sep 11;5(9):eaax8352. doi: 10.1126/sciadv.aax8352. eCollection 2019 Sep.

PMID:
31535029
2.

T cell-mediated regulation of the microbiota protects against obesity.

Petersen C, Bell R, Klag KA, Lee SH, Soto R, Ghazaryan A, Buhrke K, Ekiz HA, Ost KS, Boudina S, O'Connell RM, Cox JE, Villanueva CJ, Stephens WZ, Round JL.

Science. 2019 Jul 26;365(6451). pii: eaat9351. doi: 10.1126/science.aat9351.

PMID:
31346040
3.

Suppression of Cardiac Autophagy by Hyperinsulinemia in Insulin Receptor-Deficient Hearts Is Mediated by Insulin-Like Growth Factor Receptor Signaling.

Pires KM, Torres NS, Buffolo M, Gunville R, Schaaf C, Davis K, Selzman CH, Gottlieb RA, Boudina S.

Antioxid Redox Signal. 2019 Aug 20;31(6):444-457. doi: 10.1089/ars.2018.7640. Epub 2019 Jun 20.

PMID:
31088290
4.

Neuromedin B receptor disruption impairs adipogenesis in mice and 3T3-L1 cells.

Paula GS, Wilieman M, Silva KR, Baptista L, Boudina S, Souza LL, Bento-Bernardes T, Asensi K, Goldenberg RCDS, Pazos-Moura CC.

J Mol Endocrinol. 2019 May 1. pii: JME-19-0032.R1. doi: 10.1530/JME-19-0032. [Epub ahead of print]

PMID:
31067509
5.

Anti-inflammatory microRNA-146a protects mice from diet-induced metabolic disease.

Runtsch MC, Nelson MC, Lee SH, Voth W, Alexander M, Hu R, Wallace J, Petersen C, Panic V, Villanueva CJ, Evason KJ, Bauer KM, Mosbruger T, Boudina S, Bronner M, Round JL, Drummond MJ, O'Connell RM.

PLoS Genet. 2019 Feb 15;15(2):e1007970. doi: 10.1371/journal.pgen.1007970. eCollection 2019 Feb.

6.

Elevated arterial shear rate increases indexes of endothelial cell autophagy and nitric oxide synthase activation in humans.

Park SK, La Salle DT, Cerbie J, Cho JM, Bledsoe A, Nelson A, Morgan DE, Richardson RS, Shiu YT, Boudina S, Trinity JD, Symons JD.

Am J Physiol Heart Circ Physiol. 2019 Jan 1;316(1):H106-H112. doi: 10.1152/ajpheart.00561.2018. Epub 2018 Nov 9.

PMID:
30556766
7.

Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk.

Cai J, Pires KM, Ferhat M, Chaurasia B, Buffolo MA, Smalling R, Sargsyan A, Atkinson DL, Summers SA, Graham TE, Boudina S.

Cell Rep. 2018 Nov 13;25(7):1708-1717.e5. doi: 10.1016/j.celrep.2018.10.040.

8.

Elevated arterial shear rate increases indexes of endothelial cell autophagy and nitric oxide synthase activation in humans.

Park SK, La Salle DT, Cerbie J, Cho JM, Bledsoe A, Nelson A, Morgan DE, Richardson RS, Shiu YT, Boudina S, Trinity JD, Symons JD.

Am J Physiol Heart Circ Physiol. 2019 Jan 1;316(1):H106-H112. doi: 10.1152/ajpheart.00561.2018. Epub 2018 Nov 9.

PMID:
30412436
9.

Autophagy in Adipose Tissue Physiology and Pathophysiology.

Ferhat M, Funai K, Boudina S.

Antioxid Redox Signal. 2019 Aug 20;31(6):487-501. doi: 10.1089/ars.2018.7626. Epub 2018 Nov 1.

PMID:
30234364
10.

Histone methyltransferase Smyd1 regulates mitochondrial energetics in the heart.

Warren JS, Tracy CM, Miller MR, Makaju A, Szulik MW, Oka SI, Yuzyuk TN, Cox JE, Kumar A, Lozier BK, Wang L, Llana JG, Sabry AD, Cawley KM, Barton DW, Han YH, Boudina S, Fiehn O, Tucker HO, Zaitsev AV, Franklin S.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7871-E7880. doi: 10.1073/pnas.1800680115. Epub 2018 Jul 30.

11.

Activation of IGF-1 receptors and Akt signaling by systemic hyperinsulinemia contributes to cardiac hypertrophy but does not regulate cardiac autophagy in obese diabetic mice.

Pires KM, Buffolo M, Schaaf C, David Symons J, Cox J, Abel ED, Selzman CH, Boudina S.

J Mol Cell Cardiol. 2017 Dec;113:39-50. doi: 10.1016/j.yjmcc.2017.10.001. Epub 2017 Oct 5.

12.

Endothelial Cell Autophagy Maintains Shear Stress-Induced Nitric Oxide Generation via Glycolysis-Dependent Purinergic Signaling to Endothelial Nitric Oxide Synthase.

Bharath LP, Cho JM, Park SK, Ruan T, Li Y, Mueller R, Bean T, Reese V, Richardson RS, Cai J, Sargsyan A, Pires K, Anandh Babu PV, Boudina S, Graham TE, Symons JD.

Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1646-1656. doi: 10.1161/ATVBAHA.117.309510. Epub 2017 Jul 6.

13.

Stress turns on the heat: Regulation of mitochondrial biogenesis and UCP1 by ROS in adipocytes.

Ortega SP, Chouchani ET, Boudina S.

Adipocyte. 2017 Jan 2;6(1):56-61. doi: 10.1080/21623945.2016.1273298. Epub 2016 Dec 16. Review.

14.

Adipocyte-Specific Deletion of Manganese Superoxide Dismutase Protects From Diet-Induced Obesity Through Increased Mitochondrial Uncoupling and Biogenesis.

Han YH, Buffolo M, Pires KM, Pei S, Scherer PE, Boudina S.

Diabetes. 2016 Sep;65(9):2639-51. doi: 10.2337/db16-0283. Epub 2016 Jun 9.

15.

Combinatorial gene construct and non-viral delivery for anti-obesity in diet-induced obese mice.

Park H, Cho S, Han YH, Janat-Amsbury MM, Boudina S, Bae YH.

J Control Release. 2015 Jun 10;207:154-62. doi: 10.1016/j.jconrel.2015.03.016. Epub 2015 Mar 25.

PMID:
25817008
16.

Mitochondrial function/dysfunction in white adipose tissue.

Boudina S, Graham TE.

Exp Physiol. 2014 Sep;99(9):1168-78. doi: 10.1113/expphysiol.2014.081414. Epub 2014 Aug 15. Review.

17.

Metabolically active human brown adipose tissue derived stem cells.

Silva FJ, Holt DJ, Vargas V, Yockman J, Boudina S, Atkinson D, Grainger DW, Revelo MP, Sherman W, Bull DA, Patel AN.

Stem Cells. 2014 Feb;32(2):572-81. doi: 10.1002/stem.1595.

18.

Insulin suppresses ischemic preconditioning-mediated cardioprotection through Akt-dependent mechanisms.

Fullmer TM, Pei S, Zhu Y, Sloan C, Manzanares R, Henrie B, Pires KM, Cox JE, Abel ED, Boudina S.

J Mol Cell Cardiol. 2013 Nov;64:20-9. doi: 10.1016/j.yjmcc.2013.08.005. Epub 2013 Aug 30.

19.

A long journey to effective obesity treatments: is there light at the end of the tunnel?

Dodson MV, Boudina S, Albrecht E, Bucci L, Culver MF, Wei S, Bergen WG, Amaral AJ, Moustaid-Moussa N, Poulos S, Hausman GJ.

Exp Biol Med (Maywood). 2013 May;238(5):491-501. doi: 10.1177/1535370213477603. Review.

PMID:
23856900
20.

Treatment with a SOD mimetic reduces visceral adiposity, adipocyte death, and adipose tissue inflammation in high fat-fed mice.

Pires KM, Ilkun O, Valente M, Boudina S.

Obesity (Silver Spring). 2014 Jan;22(1):178-87. doi: 10.1002/oby.20465. Epub 2013 Jun 13.

22.
23.

UCP3 regulates cardiac efficiency and mitochondrial coupling in high fat-fed mice but not in leptin-deficient mice.

Boudina S, Han YH, Pei S, Tidwell TJ, Henrie B, Tuinei J, Olsen C, Sena S, Abel ED.

Diabetes. 2012 Dec;61(12):3260-9. doi: 10.2337/db12-0063. Epub 2012 Aug 21.

24.

HSPB2 is dispensable for the cardiac hypertrophic response but reduces mitochondrial energetics following pressure overload in mice.

Ishiwata T, Orosz A, Wang X, Mustafi SB, Pratt GW, Christians ES, Boudina S, Abel ED, Benjamin IJ.

PLoS One. 2012;7(8):e42118. doi: 10.1371/journal.pone.0042118. Epub 2012 Aug 1.

25.

A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.

Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N, Redin C, Boudina S, Gygi SP, Brivet M, Thummel CS, Rutter J.

Science. 2012 Jul 6;337(6090):96-100. doi: 10.1126/science.1218099. Epub 2012 May 24.

26.

Early mitochondrial adaptations in skeletal muscle to diet-induced obesity are strain dependent and determine oxidative stress and energy expenditure but not insulin sensitivity.

Boudina S, Sena S, Sloan C, Tebbi A, Han YH, O'Neill BT, Cooksey RC, Jones D, Holland WL, McClain DA, Abel ED.

Endocrinology. 2012 Jun;153(6):2677-88. doi: 10.1210/en.2011-2147. Epub 2012 Apr 17.

27.

Genetic loss of insulin receptors worsens cardiac efficiency in diabetes.

Bugger H, Riehle C, Jaishy B, Wende AR, Tuinei J, Chen D, Soto J, Pires KM, Boudina S, Theobald HA, Luptak I, Wayment B, Wang X, Litwin SE, Weimer BC, Abel ED.

J Mol Cell Cardiol. 2012 May;52(5):1019-26. doi: 10.1016/j.yjmcc.2012.02.001. Epub 2012 Feb 9.

28.

Cytosolic, but not mitochondrial, oxidative stress is a likely contributor to cardiac hypertrophy resulting from cardiac specific GLUT4 deletion in mice.

Li Y, Wende AR, Nunthakungwan O, Huang Y, Hu E, Jin H, Boudina S, Abel ED, Jalili T.

FEBS J. 2012 Feb;279(4):599-611. doi: 10.1111/j.1742-4658.2011.08450.x. Epub 2012 Jan 9.

29.

Diabetic cardiomyopathy, causes and effects.

Boudina S, Abel ED.

Rev Endocr Metab Disord. 2010 Mar;11(1):31-9. doi: 10.1007/s11154-010-9131-7. Review.

30.

Role of Endothelial Cells in Myocardial Ischemia-Reperfusion Injury.

Singhal AK, Symons JD, Boudina S, Jaishy B, Shiu YT.

Vasc Dis Prev. 2010;7:1-14.

31.

Contribution of impaired myocardial insulin signaling to mitochondrial dysfunction and oxidative stress in the heart.

Boudina S, Bugger H, Sena S, O'Neill BT, Zaha VG, Ilkun O, Wright JJ, Mazumder PK, Palfreyman E, Tidwell TJ, Theobald H, Khalimonchuk O, Wayment B, Sheng X, Rodnick KJ, Centini R, Chen D, Litwin SE, Weimer BE, Abel ED.

Circulation. 2009 Mar 10;119(9):1272-83. doi: 10.1161/CIRCULATIONAHA.108.792101. Epub 2009 Feb 23.

32.

Mechanisms for increased myocardial fatty acid utilization following short-term high-fat feeding.

Wright JJ, Kim J, Buchanan J, Boudina S, Sena S, Bakirtzi K, Ilkun O, Theobald HA, Cooksey RC, Kandror KV, Abel ED.

Cardiovasc Res. 2009 May 1;82(2):351-60. doi: 10.1093/cvr/cvp017. Epub 2009 Jan 15.

33.

Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3.

Bugger H, Boudina S, Hu XX, Tuinei J, Zaha VG, Theobald HA, Yun UJ, McQueen AP, Wayment B, Litwin SE, Abel ED.

Diabetes. 2008 Nov;57(11):2924-32. doi: 10.2337/db08-0079. Epub 2008 Aug 4.

34.

The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis.

Lehman JJ, Boudina S, Banke NH, Sambandam N, Han X, Young DM, Leone TC, Gross RW, Lewandowski ED, Abel ED, Kelly DP.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H185-96. doi: 10.1152/ajpheart.00081.2008. Epub 2008 May 16.

35.

Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis.

Jouihan HA, Cobine PA, Cooksey RC, Hoagland EA, Boudina S, Abel ED, Winge DR, McClain DA.

Mol Med. 2008 Mar-Apr;14(3-4):98-108. doi: 10.2119/2007-00114.Jouihan.

36.

A conserved role for phosphatidylinositol 3-kinase but not Akt signaling in mitochondrial adaptations that accompany physiological cardiac hypertrophy.

O'Neill BT, Kim J, Wende AR, Theobald HA, Tuinei J, Buchanan J, Guo A, Zaha VG, Davis DK, Schell JC, Boudina S, Wayment B, Litwin SE, Shioi T, Izumo S, Birnbaum MJ, Abel ED.

Cell Metab. 2007 Oct;6(4):294-306.

37.

PAS kinase is required for normal cellular energy balance.

Hao HX, Cardon CM, Swiatek W, Cooksey RC, Smith TL, Wilde J, Boudina S, Abel ED, McClain DA, Rutter J.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15466-71. Epub 2007 Sep 18.

38.

CRYAB and HSPB2 deficiency alters cardiac metabolism and paradoxically confers protection against myocardial ischemia in aging mice.

Benjamin IJ, Guo Y, Srinivasan S, Boudina S, Taylor RP, Rajasekaran NS, Gottlieb R, Wawrousek EF, Abel ED, Bolli R.

Am J Physiol Heart Circ Physiol. 2007 Nov;293(5):H3201-9. Epub 2007 Sep 14.

39.

Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins.

Boudina S, Sena S, Theobald H, Sheng X, Wright JJ, Hu XX, Aziz S, Johnson JI, Bugger H, Zaha VG, Abel ED.

Diabetes. 2007 Oct;56(10):2457-66. Epub 2007 Jul 10.

40.

Diabetic cardiomyopathy revisited.

Boudina S, Abel ED.

Circulation. 2007 Jun 26;115(25):3213-23. Review.

PMID:
17592090
41.

Ménage-à-trois 1 is critical for the transcriptional function of PPARgamma coactivator 1.

Sano M, Izumi Y, Helenius K, Asakura M, Rossi DJ, Xie M, Taffet G, Hu L, Pautler RG, Wilson CR, Boudina S, Abel ED, Taegtmeyer H, Scaglia F, Graham BH, Kralli A, Shimizu N, Tanaka H, Mäkelä TP, Schneider MD.

Cell Metab. 2007 Feb;5(2):129-42.

42.

Ablation of PGC-1beta results in defective mitochondrial activity, thermogenesis, hepatic function, and cardiac performance.

Lelliott CJ, Medina-Gomez G, Petrovic N, Kis A, Feldmann HM, Bjursell M, Parker N, Curtis K, Campbell M, Hu P, Zhang D, Litwin SE, Zaha VG, Fountain KT, Boudina S, Jimenez-Linan M, Blount M, Lopez M, Meirhaeghe A, Bohlooly-Y M, Storlien L, Strömstedt M, Snaith M, Oresic M, Abel ED, Cannon B, Vidal-Puig A.

PLoS Biol. 2006 Nov;4(11):e369.

43.

Mitochondrial uncoupling: a key contributor to reduced cardiac efficiency in diabetes.

Boudina S, Abel ED.

Physiology (Bethesda). 2006 Aug;21:250-8. Review.

44.

Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity.

Boudina S, Sena S, O'Neill BT, Tathireddy P, Young ME, Abel ED.

Circulation. 2005 Oct 25;112(17):2686-95.

PMID:
16246967
45.

PGC-1alpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis.

Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, Courtois M, Wozniak DF, Sambandam N, Bernal-Mizrachi C, Chen Z, Holloszy JO, Medeiros DM, Schmidt RE, Saffitz JE, Abel ED, Semenkovich CF, Kelly DP.

PLoS Biol. 2005 Apr;3(4):e101. Epub 2005 Mar 15.

46.

Impaired cardiac efficiency and increased fatty acid oxidation in insulin-resistant ob/ob mouse hearts.

Mazumder PK, O'Neill BT, Roberts MW, Buchanan J, Yun UJ, Cooksey RC, Boudina S, Abel ED.

Diabetes. 2004 Sep;53(9):2366-74.

47.

Alterations of the bioenergetics systems of the cell in acute and chronic myocardial ischemia.

Dos Santos P, Laclau MN, Boudina S, Garlid KD.

Mol Cell Biochem. 2004 Jan-Feb;256-257(1-2):157-66.

PMID:
14977178
48.

Mechanisms by which opening the mitochondrial ATP- sensitive K(+) channel protects the ischemic heart.

Dos Santos P, Kowaltowski AJ, Laclau MN, Seetharaman S, Paucek P, Boudina S, Thambo JB, Tariosse L, Garlid KD.

Am J Physiol Heart Circ Physiol. 2002 Jul;283(1):H284-95.

49.

Effects of prolactin on intracellular calcium concentration and cell proliferation in human glioma cells.

Ducret T, Boudina S, Sorin B, Vacher AM, Gourdou I, Liguoro D, Guerin J, Bresson-Bepoldin L, Vacher P.

Glia. 2002 May;38(3):200-14.

PMID:
11968058
50.

Alteration of mitochondrial function in a model of chronic ischemia in vivo in rat heart.

Boudina S, Laclau MN, Tariosse L, Daret D, Gouverneur G, Bonoron-Adèle S, Saks VA, Dos Santos P.

Am J Physiol Heart Circ Physiol. 2002 Mar;282(3):H821-31.

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