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Items: 20


Verteporfin-induced lysosomal compartment dysregulation potentiates the effect of sorafenib in hepatocellular carcinoma.

Gavini J, Dommann N, Jakob MO, Keogh A, Bouchez LC, Karkampouna S, Julio MK, Medova M, Zimmer Y, Schläfli AM, Tschan MP, Candinas D, Stroka D, Banz V.

Cell Death Dis. 2019 Oct 3;10(10):749. doi: 10.1038/s41419-019-1989-z.


Design and Synthesis of Metabolically Stable tRNA Synthetase Inhibitors Derived from Cladosporin.

Rusch M, Thevenon A, Hoepfner D, Aust T, Studer C, Patoor M, Rollin P, Livendahl M, Ranieri B, Schmitt E, Spanka C, Gademann K, Bouchez LC.

Chembiochem. 2019 Mar 1;20(5):644-649. doi: 10.1002/cbic.201800587. Epub 2019 Feb 4.


Hypoxia-Activated, Small-Molecule-Induced Gene Expression.

Collins SL, Saha J, Bouchez LC, Hammond EM, Conway SJ.

ACS Chem Biol. 2018 Dec 21;13(12):3354-3360. doi: 10.1021/acschembio.8b00858. Epub 2018 Dec 7.


Screening of Intestinal Crypt Organoids: A Simple Readout for Complex Biology.

Ley S, Galuba O, Salathe A, Melin N, Aebi A, Pikiolek M, Knehr J, Carbone W, Beibel M, Nigsch F, Roma G, d'Ario G, Kirkland S, Bouchez LC, Gubser Keller C, Bouwmeester T, Parker CN, Ruffner H.

SLAS Discov. 2017 Jun;22(5):571-582. doi: 10.1177/2472555216683651. Epub 2017 Jan 6.


Identification of Small Molecules Which Induce Skeletal Muscle Differentiation in Embryonic Stem Cells via Activation of the Wnt and Inhibition of Smad2/3 and Sonic Hedgehog Pathways.

Lee H, Haller C, Manneville C, Doll T, Fruh I, Keller CG, Richards SM, Ibig-Rehm Y, Patoor M, Goette M, Bouchez LC, Mueller M.

Stem Cells. 2016 Feb;34(2):299-310. doi: 10.1002/stem.2228. Epub 2015 Nov 17.


CXCR4 as biomarker for radioresistant cancer stem cells.

Trautmann F, Cojoc M, Kurth I, Melin N, Bouchez LC, Dubrovska A, Peitzsch C.

Int J Radiat Biol. 2014 Aug;90(8):687-99. doi: 10.3109/09553002.2014.906766.


R-Spondin potentiates Wnt/β-catenin signaling through orphan receptors LGR4 and LGR5.

Ruffner H, Sprunger J, Charlat O, Leighton-Davies J, Grosshans B, Salathe A, Zietzling S, Beck V, Therier M, Isken A, Xie Y, Zhang Y, Hao H, Shi X, Liu D, Song Q, Clay I, Hintzen G, Tchorz J, Bouchez LC, Michaud G, Finan P, Myer VE, Bouwmeester T, Porter J, Hild M, Bassilana F, Parker CN, Cong F.

PLoS One. 2012;7(7):e40976. doi: 10.1371/journal.pone.0040976. Epub 2012 Jul 16.


CXCR4 activation maintains a stem cell population in tamoxifen-resistant breast cancer cells through AhR signalling.

Dubrovska A, Hartung A, Bouchez LC, Walker JR, Reddy VA, Cho CY, Schultz PG.

Br J Cancer. 2012 Jun 26;107(1):43-52. doi: 10.1038/bjc.2012.105. Epub 2012 May 29.


A stem cell-based approach to cartilage repair.

Johnson K, Zhu S, Tremblay MS, Payette JN, Wang J, Bouchez LC, Meeusen S, Althage A, Cho CY, Wu X, Schultz PG.

Science. 2012 May 11;336(6082):717-21. doi: 10.1126/science.1215157. Epub 2012 Apr 5.


CXCR4 expression in prostate cancer progenitor cells.

Dubrovska A, Elliott J, Salamone RJ, Telegeev GD, Stakhovsky AE, Schepotin IB, Yan F, Wang Y, Bouchez LC, Kularatne SA, Watson J, Trussell C, Reddy VA, Cho CY, Schultz PG.

PLoS One. 2012;7(2):e31226. doi: 10.1371/journal.pone.0031226. Epub 2012 Feb 16.


Pan-Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells.

Staerk J, Lyssiotis CA, Medeiro LA, Bollong M, Foreman RK, Zhu S, Garcia M, Gao Q, Bouchez LC, Lairson LL, Charette BD, Supekova L, Janes J, Brinker A, Cho CY, Jaenisch R, Schultz PG.

Angew Chem Int Ed Engl. 2011 Jun 14;50(25):5734-6. doi: 10.1002/anie.201101042. Epub 2011 May 5. No abstract available.


Small-molecule regulators of human stem cell self-renewal.

Bouchez LC, Boitano AE, de Lichtervelde L, Romeo R, Cooke MP, Schultz PG.

Chembiochem. 2011 Apr 11;12(6):854-7. doi: 10.1002/cbic.201000734. Epub 2011 Mar 4. No abstract available.


Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells.

Boitano AE, Wang J, Romeo R, Bouchez LC, Parker AE, Sutton SE, Walker JR, Flaveny CA, Perdew GH, Denison MS, Schultz PG, Cooke MP.

Science. 2010 Sep 10;329(5997):1345-8. doi: 10.1126/science.1191536. Epub 2010 Aug 5. Erratum in: Science. 2011 May 6;332(6030):664.


Reprogramming of murine fibroblasts to induced pluripotent stem cells with chemical complementation of Klf4.

Lyssiotis CA, Foreman RK, Staerk J, Garcia M, Mathur D, Markoulaki S, Hanna J, Lairson LL, Charette BD, Bouchez LC, Bollong M, Kunick C, Brinker A, Cho CY, Schultz PG, Jaenisch R.

Proc Natl Acad Sci U S A. 2009 Jun 2;106(22):8912-7. doi: 10.1073/pnas.0903860106. Epub 2009 May 15.


Total syntheses of amphidinolides B1, B4, G1, H1 and structure revision of amphidinolide H2.

Fürstner A, Bouchez LC, Morency L, Funel JA, Liepins V, Porée FH, Gilmour R, Laurich D, Beaufils F, Tamiya M.

Chemistry. 2009;15(16):3983-4010. doi: 10.1002/chem.200802067.


A versatile protocol for Stille-Migita cross coupling reactions.

Fürstner A, Funel JA, Tremblay M, Bouchez LC, Nevado C, Waser M, Ackerstaff J, Stimson CC.

Chem Commun (Camb). 2008 Jul 7;(25):2873-5. doi: 10.1039/b805299a. Epub 2008 Jun 2.


Total syntheses of amphidinolide H and G.

Fürstner A, Bouchez LC, Funel JA, Liepins V, Porée FH, Gilmour R, Beaufils F, Laurich D, Tamiya M.

Angew Chem Int Ed Engl. 2007;46(48):9265-70. No abstract available.


Synthesis of the C(1)-C(11) polyene fragment of apoptolidin with a new sulfur dioxide-based organic chemistry.

Bouchez LC, Vogel P.

Chemistry. 2005 Aug 5;11(16):4609-20. Erratum in: Chemistry. 2005 Dec 23;12(2):349.


Sulfur dioxide-mediated syntheses of polyfunctional alkenes and (E,Z)- and (E,E)-2,4-dien-1-ones.

Bouchez LC, Craita C, Vogel P.

Org Lett. 2005 Mar 3;7(5):897-900.


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