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Items: 1 to 50 of 440

1.

IL-1β dominates the promucin secretory cytokine profile in cystic fibrosis.

Chen G, Sun L, Kato T, Okuda K, Martino MB, Abzhanova A, Lin JM, Gilmore RC, Batson BD, O'Neal YK, Volmer AS, Dang H, Deng Y, Randell SH, Button B, Livraghi-Butrico A, Kesimer M, Ribeiro CM, O'Neal WK, Boucher RC.

J Clin Invest. 2019 Oct 1;129(10):4433-4450. doi: 10.1172/JCI125669.

2.

Muco-Obstructive Lung Diseases. Reply.

Boucher RC.

N Engl J Med. 2019 Sep 5;381(10):e20. doi: 10.1056/NEJMc1907962. No abstract available.

PMID:
31483986
3.

Endotracheal tube mucus as a source of airway mucus for rheological study.

Markovetz MR, Subramani DB, Kissner WJ, Morrison CB, Garbarine IC, Ghio A, Ramsey KA, Arora H, Kumar P, Nix DB, Kumagai T, Krunkosky TM, Krause DC, Radicioni G, Alexis NE, Kesimer M, Tiemeyer M, Boucher RC, Ehre C, Hill DB.

Am J Physiol Lung Cell Mol Physiol. 2019 Oct 1;317(4):L498-L509. doi: 10.1152/ajplung.00238.2019. Epub 2019 Aug 7.

PMID:
31389736
4.

Muco-Obstructive Lung Diseases.

Boucher RC.

N Engl J Med. 2019 May 16;380(20):1941-1953. doi: 10.1056/NEJMra1813799. Review. No abstract available.

PMID:
31091375
5.

XBP1S Regulates MUC5B in a Promoter Variant-Dependent Pathway in Idiopathic Pulmonary Fibrosis Airway Epithelia.

Chen G, Ribeiro CMP, Sun L, Okuda K, Kato T, Gilmore RC, Martino MB, Dang H, Abzhanova A, Lin JM, Hull-Ryde EA, Volmer AS, Randell SH, Livraghi-Butrico A, Deng Y, Scherer PE, Stripp BR, O'Neal WK, Boucher RC.

Am J Respir Crit Care Med. 2019 Jul 15;200(2):220-234. doi: 10.1164/rccm.201810-1972OC. Erratum in: Am J Respir Crit Care Med. 2019 Oct 15;200(8):1074.

PMID:
30973754
6.

Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis.

Esther CR Jr, Muhlebach MS, Ehre C, Hill DB, Wolfgang MC, Kesimer M, Ramsey KA, Markovetz MR, Garbarine IC, Forest MG, Seim I, Zorn B, Morrison CB, Delion MF, Thelin WR, Villalon D, Sabater JR, Turkovic L, Ranganathan S, Stick SM, Boucher RC.

Sci Transl Med. 2019 Apr 3;11(486). pii: eaav3488. doi: 10.1126/scitranslmed.aav3488.

7.

Assessment of stability and fluctuations of cultured lower airway bacterial communities in people with cystic fibrosis.

Sherrard LJ, Einarsson GG, Johnston E, O'Neill K, McIlreavey L, McGrath SJ, Gilpin DF, Downey DG, Reid A, McElvaney NG, Boucher RC, Muhlebach MS, Elborn JS, Tunney MM.

J Cyst Fibros. 2019 Mar 21. pii: S1569-1993(19)30052-9. doi: 10.1016/j.jcf.2019.02.012. [Epub ahead of print]

PMID:
30905581
8.

Mucus Hydration in Subjects with Stable Chronic Bronchitis: A Comparison of Spontaneous and Induced Sputum.

Henderson AG, Anderson WH, Ceppe A, Coakley RD, Button B, Alexis NE, Peden DB, Lazarowski ER, Davis CW, Fuller F, Almond M, Qaqish B, Kesimer M, Boucher RC.

COPD. 2018 Dec;15(6):572-580. doi: 10.1080/15412555.2019.1566892. Epub 2019 Feb 4.

PMID:
30712400
9.

Emerging Concepts and Therapies for Mucoobstructive Lung Disease.

Mall MA, Danahay H, Boucher RC.

Ann Am Thorac Soc. 2018 Nov;15(Suppl 3):S216-S226. doi: 10.1513/AnnalsATS.201806-368AW. Review.

10.

Roles of mucus adhesion and cohesion in cough clearance.

Button B, Goodell HP, Atieh E, Chen YC, Williams R, Shenoy S, Lackey E, Shenkute NT, Cai LH, Dennis RG, Boucher RC, Rubinstein M.

Proc Natl Acad Sci U S A. 2018 Dec 4;115(49):12501-12506. doi: 10.1073/pnas.1811787115. Epub 2018 Nov 12.

11.

An airway epithelial IL-17A response signature identifies a steroid-unresponsive COPD patient subgroup.

Christenson SA, van den Berge M, Faiz A, Inkamp K, Bhakta N, Bonser LR, Zlock LT, Barjaktarevic IZ, Barr RG, Bleecker ER, Boucher RC, Bowler RP, Comellas AP, Curtis JL, Han MK, Hansel NN, Hiemstra PS, Kaner RJ, Krishnanm JA, Martinez FJ, O'Neal WK, Paine R 3rd, Timens W, Wells JM, Spira A, Erle DJ, Woodruff PG.

J Clin Invest. 2019 Jan 2;129(1):169-181. doi: 10.1172/JCI121087. Epub 2018 Nov 26.

12.

Pathological mucus and impaired mucus clearance in cystic fibrosis patients result from increased concentration, not altered pH.

Hill DB, Long RF, Kissner WJ, Atieh E, Garbarine IC, Markovetz MR, Fontana NC, Christy M, Habibpour M, Tarran R, Forest MG, Boucher RC, Button B.

Eur Respir J. 2018 Dec 6;52(6). pii: 1801297. doi: 10.1183/13993003.01297-2018. Print 2018 Dec.

PMID:
30361244
13.

Localization of Secretory Mucins MUC5AC and MUC5B in Normal/Healthy Human Airways.

Okuda K, Chen G, Subramani DB, Wolf M, Gilmore RC, Kato T, Radicioni G, Kesimer M, Chua M, Dang H, Livraghi-Butrico A, Ehre C, Doerschuk CM, Randell SH, Matsui H, Nagase T, O'Neal WK, Boucher RC.

Am J Respir Crit Care Med. 2019 Mar 15;199(6):715-727. doi: 10.1164/rccm.201804-0734OC.

PMID:
30352166
14.

An Improved Inhaled Mucolytic to Treat Airway Muco-obstructive Diseases.

Ehre C, Rushton ZL, Wang B, Hothem LN, Morrison CB, Fontana NC, Markovetz MR, Delion MF, Kato T, Villalon D, Thelin WR, Esther CR Jr, Hill DB, Grubb BR, Livraghi-Butrico A, Donaldson SH, Boucher RC.

Am J Respir Crit Care Med. 2019 Jan 15;199(2):171-180. doi: 10.1164/rccm.201802-0245OC.

PMID:
30212240
15.

Mucin Concentrations and Peripheral Airway Obstruction in Chronic Obstructive Pulmonary Disease.

Kesimer M, Smith BM, Ceppe A, Ford AA, Anderson WH, Barr RG, O'Neal WK, Boucher RC; SPIROMICS Investigative Group.

Am J Respir Crit Care Med. 2018 Dec 1;198(11):1453-1456. doi: 10.1164/rccm.201806-1016LE. No abstract available.

PMID:
30130124
16.

An Adeno-Associated Viral Vector Capable of Penetrating the Mucus Barrier to Inhaled Gene Therapy.

Duncan GA, Kim N, Colon-Cortes Y, Rodriguez J, Mazur M, Birket SE, Rowe SM, West NE, Livraghi-Butrico A, Boucher RC, Hanes J, Aslanidi G, Suk JS.

Mol Ther Methods Clin Dev. 2018 Mar 22;9:296-304. doi: 10.1016/j.omtm.2018.03.006. eCollection 2018 Jun 15.

17.

The N terminus of α-ENaC mediates ENaC cleavage and activation by furin.

Kota P, Gentzsch M, Dang YL, Boucher RC, Stutts MJ.

J Gen Physiol. 2018 Aug 6;150(8):1179-1187. doi: 10.1085/jgp.201711860. Epub 2018 Jul 6.

18.

Anaerobic bacteria cultured from cystic fibrosis airways correlate to milder disease: a multisite study.

Muhlebach MS, Hatch JE, Einarsson GG, McGrath SJ, Gilipin DF, Lavelle G, Mirkovic B, Murray MA, McNally P, Gotman N, Davis Thomas S, Wolfgang MC, Gilligan PH, McElvaney NG, Elborn JS, Boucher RC, Tunney MM.

Eur Respir J. 2018 Jul 11;52(1). pii: 1800242. doi: 10.1183/13993003.00242-2018. Print 2018 Jul.

19.

Effect of LysM+ macrophage depletion on lung pathology in mice with chronic bronchitis.

Saini Y, Lewis BW, Yu D, Dang H, Livraghi-Butrico A, Del Piero F, O'Neal WK, Boucher RC.

Physiol Rep. 2018 Apr;6(8):e13677. doi: 10.14814/phy2.13677.

20.

The in vitro effect of nebulised hypertonic saline on human bronchial epithelium.

Goralski JL, Wu D, Thelin WR, Boucher RC, Button B.

Eur Respir J. 2018 May 17;51(5). pii: 1702652. doi: 10.1183/13993003.02652-2017. Print 2018 May.

21.

Role of Spdef in the Regulation of Muc5b Expression in the Airways of Naive and Mucoobstructed Mice.

Chen G, Volmer AS, Wilkinson KJ, Deng Y, Jones LC, Yu D, Bustamante-Marin XM, Burns KA, Grubb BR, O'Neal WK, Livraghi-Butrico A, Boucher RC.

Am J Respir Cell Mol Biol. 2018 Sep;59(3):383-396. doi: 10.1165/rcmb.2017-0127OC.

22.

Association between acute respiratory disease events and the MUC5B promoter polymorphism in smokers.

Ash SY, Harmouche R, Putman RK, Ross JC, Martinez FJ, Choi AM, Bowler RP, Regan EA, Curtis JL, Han MK, Boucher RC, O'Neal WK, Hatabu H, Lynch DA, Rosas IO, Hunninghake GM, San Jose Estepar R, Washko GR; COPDGene Investigators.

Thorax. 2018 Nov;73(11):1071-1074. doi: 10.1136/thoraxjnl-2017-211208. Epub 2018 Feb 13.

23.

At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease.

Martinez FJ, Han MK, Allinson JP, Barr RG, Boucher RC, Calverley PMA, Celli BR, Christenson SA, Crystal RG, Fagerås M, Freeman CM, Groenke L, Hoffman EA, Kesimer M, Kostikas K, Paine R 3rd, Rafii S, Rennard SI, Segal LN, Shaykhiev R, Stevenson C, Tal-Singer R, Vestbo J, Woodruff PG, Curtis JL, Wedzicha JA.

Am J Respir Crit Care Med. 2018 Jun 15;197(12):1540-1551. doi: 10.1164/rccm.201710-2028PP. No abstract available. Erratum in: Am J Respir Crit Care Med. 2018 Dec 1;198(11):1463.

24.

Initial acquisition and succession of the cystic fibrosis lung microbiome is associated with disease progression in infants and preschool children.

Muhlebach MS, Zorn BT, Esther CR, Hatch JE, Murray CP, Turkovic L, Ranganathan SC, Boucher RC, Stick SM, Wolfgang MC.

PLoS Pathog. 2018 Jan 18;14(1):e1006798. doi: 10.1371/journal.ppat.1006798. eCollection 2018 Jan.

25.

Zinc Deficiency via a Splice Switch in Zinc Importer ZIP2/SLC39A2 Causes Cystic Fibrosis-Associated MUC5AC Hypersecretion in Airway Epithelial Cells.

Kamei S, Fujikawa H, Nohara H, Ueno-Shuto K, Maruta K, Nakashima R, Kawakami T, Matsumoto C, Sakaguchi Y, Ono T, Suico MA, Boucher RC, Gruenert DC, Takeo T, Nakagata N, Li JD, Kai H, Shuto T.

EBioMedicine. 2018 Jan;27:304-316. doi: 10.1016/j.ebiom.2017.12.025. Epub 2017 Dec 20.

26.

An integrated mathematical epithelial cell model for airway surface liquid regulation by mechanical forces.

Wu D, Boucher RC, Button B, Elston T, Lin CL.

J Theor Biol. 2018 Feb 7;438:34-45. doi: 10.1016/j.jtbi.2017.11.010. Epub 2017 Nov 15.

27.

Loss of β Epithelial Sodium Channel Function in Meibomian Glands Produces Pseudohypoaldosteronism 1-Like Ocular Disease in Mice.

Yu D, Saini Y, Chen G, Ghio AJ, Dang H, Burns KA, Wang Y, Davis RM, Randell SH, Esther CR Jr, Paulsen F, Boucher RC.

Am J Pathol. 2018 Jan;188(1):95-110. doi: 10.1016/j.ajpath.2017.09.016. Epub 2017 Oct 26.

28.

Mucin Production and Hydration Responses to Mucopurulent Materials in Normal versus Cystic Fibrosis Airway Epithelia.

Abdullah LH, Coakley R, Webster MJ, Zhu Y, Tarran R, Radicioni G, Kesimer M, Boucher RC, Davis CW, Ribeiro CMP.

Am J Respir Crit Care Med. 2018 Feb 15;197(4):481-491. doi: 10.1164/rccm.201706-1139OC.

29.

Automated segmentation and quantification of airway mucus with endobronchial optical coherence tomography.

Adams DC, Pahlevaninezhad H, Szabari MV, Cho JL, Hamilos DL, Kesimer M, Boucher RC, Luster AD, Medoff BD, Suter MJ.

Biomed Opt Express. 2017 Sep 26;8(10):4729-4741. doi: 10.1364/BOE.8.004729. eCollection 2017 Oct 1.

30.

Lung disease phenotypes caused by overexpression of combinations of α-, β-, and γ-subunits of the epithelial sodium channel in mouse airways.

Livraghi-Butrico A, Wilkinson KJ, Volmer AS, Gilmore RC, Rogers TD, Caldwell RA, Burns KA, Esther CR Jr, Mall MA, Boucher RC, O'Neal WK, Grubb BR.

Am J Physiol Lung Cell Mol Physiol. 2018 Feb 1;314(2):L318-L331. doi: 10.1152/ajplung.00382.2017. Epub 2017 Oct 26.

31.

Airway Mucin Concentration as a Marker of Chronic Bronchitis.

Kesimer M, Ford AA, Ceppe A, Radicioni G, Cao R, Davis CW, Doerschuk CM, Alexis NE, Anderson WH, Henderson AG, Barr RG, Bleecker ER, Christenson SA, Cooper CB, Han MK, Hansel NN, Hastie AT, Hoffman EA, Kanner RE, Martinez F, Paine R 3rd, Woodruff PG, O'Neal WK, Boucher RC.

N Engl J Med. 2017 Sep 7;377(10):911-922. doi: 10.1056/NEJMoa1701632.

32.

Identification of trans Protein QTL for Secreted Airway Mucins in Mice and a Causal Role for Bpifb1.

Donoghue LJ, Livraghi-Butrico A, McFadden KM, Thomas JM, Chen G, Grubb BR, O'Neal WK, Boucher RC, Kelada SNP.

Genetics. 2017 Oct;207(2):801-812. doi: 10.1534/genetics.117.300211. Epub 2017 Aug 29.

33.

Mathematical model reveals role of nucleotide signaling in airway surface liquid homeostasis and its dysregulation in cystic fibrosis.

Sandefur CI, Boucher RC, Elston TC.

Proc Natl Acad Sci U S A. 2017 Aug 29;114(35):E7272-E7281. doi: 10.1073/pnas.1617383114. Epub 2017 Aug 14.

34.

American Thoracic Society/National Heart, Lung, and Blood Institute Asthma-Chronic Obstructive Pulmonary Disease Overlap Workshop Report.

Woodruff PG, van den Berge M, Boucher RC, Brightling C, Burchard EG, Christenson SA, Han MK, Holtzman MJ, Kraft M, Lynch DA, Martinez FD, Reddel HK, Sin DD, Washko GR, Wenzel SE, Punturieri A, Freemer MM, Wise RA.

Am J Respir Crit Care Med. 2017 Aug 1;196(3):375-381. doi: 10.1164/rccm.201705-0973WS.

35.

Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease.

Livraghi-Butrico A, Grubb BR, Wilkinson KJ, Volmer AS, Burns KA, Evans CM, O'Neal WK, Boucher RC.

Mucosal Immunol. 2017 May;10(3):829. doi: 10.1038/mi.2017.29. No abstract available.

PMID:
28435155
36.

A Trans-Nasal Aerosol Delivery Device for Efficient Pulmonary Deposition.

Zeman KL, Balcazar JR, Fuller F, Donn KH, Boucher RC, Bennett WD, Donaldson SH.

J Aerosol Med Pulm Drug Deliv. 2017 Aug;30(4):223-229. doi: 10.1089/jamp.2016.1333. Epub 2017 Feb 3.

37.

Sialic acid-to-urea ratio as a measure of airway surface hydration.

Esther CR Jr, Hill DB, Button B, Shi S, Jania C, Duncan EA, Doerschuk CM, Chen G, Ranganathan S, Stick SM, Boucher RC.

Am J Physiol Lung Cell Mol Physiol. 2017 Mar 1;312(3):L398-L404. doi: 10.1152/ajplung.00398.2016. Epub 2017 Jan 6.

38.

Metabolomic biomarkers predictive of early structural lung disease in cystic fibrosis.

Esther CR Jr, Turkovic L, Rosenow T, Muhlebach MS, Boucher RC, Ranganathan S, Stick SM; AREST CF.

Eur Respir J. 2016 Dec;48(6):1612-1621. doi: 10.1183/13993003.00524-2016. Epub 2016 Nov 11.

39.

Measuring Airway Mucin 2 in Patients with Severe Chronic Obstructive Pulmonary Disease with Bacterial Colonization.

Dickey BF, Fahy JV, Kesimer M, Boucher RC, Evans CM, Thornton D.

Ann Am Thorac Soc. 2016 Nov;13(11):2103-2104. No abstract available.

40.

Quantification of heterogeneity in lung disease with image-based pulmonary function testing.

Stahr CS, Samarage CR, Donnelley M, Farrow N, Morgan KS, Zosky G, Boucher RC, Siu KK, Mall MA, Parsons DW, Dubsky S, Fouras A.

Sci Rep. 2016 Jul 27;6:29438. doi: 10.1038/srep29438.

41.

Contribution of mucus concentration and secreted mucins Muc5ac and Muc5b to the pathogenesis of muco-obstructive lung disease.

Livraghi-Butrico A, Grubb BR, Wilkinson KJ, Volmer AS, Burns KA, Evans CM, O'Neal WK, Boucher RC.

Mucosal Immunol. 2017 Mar;10(2):395-407. doi: 10.1038/mi.2016.63. Epub 2016 Jul 20.

42.

Mucus Hyperconcentration as a Unifying Aspect of the Chronic Bronchitic Phenotype.

Button B, Anderson WH, Boucher RC.

Ann Am Thorac Soc. 2016 Apr;13 Suppl 2:S156-62. doi: 10.1513/AnnalsATS.201507-455KV. Review.

43.

On the Pathogenesis of Acute Exacerbations of Mucoobstructive Lung Diseases.

Boucher RC.

Ann Am Thorac Soc. 2015 Nov;12 Suppl 2:S160-3. doi: 10.1513/AnnalsATS.201507-460AW.

44.

X-Box-Binding Protein 1 and Innate Immune Responses of Human Cystic Fibrosis Alveolar Macrophages.

Lubamba BA, Jones LC, O'Neal WK, Boucher RC, Ribeiro CM.

Am J Respir Crit Care Med. 2015 Dec 15;192(12):1449-61. doi: 10.1164/rccm.201504-0657OC.

45.

Neonatal Pulmonary Macrophage Depletion Coupled to Defective Mucus Clearance Increases Susceptibility to Pneumonia and Alters Pulmonary Immune Responses.

Saini Y, Wilkinson KJ, Terrell KA, Burns KA, Livraghi-Butrico A, Doerschuk CM, O'Neal WK, Boucher RC.

Am J Respir Cell Mol Biol. 2016 Feb;54(2):210-21. doi: 10.1165/rcmb.2014-0111OC.

46.

Airway hydration and COPD.

Ghosh A, Boucher RC, Tarran R.

Cell Mol Life Sci. 2015 Oct;72(19):3637-52. doi: 10.1007/s00018-015-1946-7. Epub 2015 Jun 12. Review.

47.

Duration of action of hypertonic saline on mucociliary clearance in the normal lung.

Bennett WD, Wu J, Fuller F, Balcazar JR, Zeman KL, Duckworth H, Donn KH, O'Riordan TG, Boucher RC, Donaldson SH.

J Appl Physiol (1985). 2015 Jun 15;118(12):1483-90. doi: 10.1152/japplphysiol.00404.2014. Epub 2015 Apr 24.

48.

The Relationship of Mucus Concentration (Hydration) to Mucus Osmotic Pressure and Transport in Chronic Bronchitis.

Anderson WH, Coakley RD, Button B, Henderson AG, Zeman KL, Alexis NE, Peden DB, Lazarowski ER, Davis CW, Bailey S, Fuller F, Almond M, Qaqish B, Bordonali E, Rubinstein M, Bennett WD, Kesimer M, Boucher RC.

Am J Respir Crit Care Med. 2015 Jul 15;192(2):182-90. doi: 10.1164/rccm.201412-2230OC.

49.

Metabolomic Evaluation of Neutrophilic Airway Inflammation in Cystic Fibrosis.

Esther CR Jr, Coakley RD, Henderson AG, Zhou YH, Wright FA, Boucher RC.

Chest. 2015 Aug;148(2):507-515. doi: 10.1378/chest.14-1800.

50.

Gene expression in whole lung and pulmonary macrophages reflects the dynamic pathology associated with airway surface dehydration.

Saini Y, Dang H, Livraghi-Butrico A, Kelly EJ, Jones LC, O'Neal WK, Boucher RC.

BMC Genomics. 2014 Sep 10;15:726. doi: 10.1186/1471-2164-15-726.

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