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Items: 9


Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature.

Boucher JI, Bolon DNA, Tawfik DS.

Protein Sci. 2019 Mar;28(3):671. doi: 10.1002/pro.3476. No abstract available.


Constrained Mutational Sampling of Amino Acids in HIV-1 Protease Evolution.

Boucher JI, Whitfield TW, Dauphin A, Nachum G, Hollins C, Zeldovich KB, Swanstrom R, Schiffer CA, Luban J, Bolon DNA.

Mol Biol Evol. 2019 Apr 1;36(4):798-810. doi: 10.1093/molbev/msz022.


Functional and Structural Resilience of the Active Site Loop in the Evolution of Plasmodium Lactate Dehydrogenase.

Wirth JD, Boucher JI, Jacobowitz JR, Classen S, Theobald DL.

Biochemistry. 2018 Nov 13;57(45):6434-6442. doi: 10.1021/acs.biochem.8b00913. Epub 2018 Nov 2.


CRISPR-Cas9-mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy.

Ma L, Boucher JI, Paulsen J, Matuszewski S, Eide CA, Ou J, Eickelberg G, Press RD, Zhu LJ, Druker BJ, Branford S, Wolfe SA, Jensen JD, Schiffer CA, Green MR, Bolon DN.

Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):11751-11756. doi: 10.1073/pnas.1708268114. Epub 2017 Oct 16.


Quantifying and understanding the fitness effects of protein mutations: Laboratory versus nature.

Boucher JI, Bolon DN, Tawfik DS.

Protein Sci. 2016 Jul;25(7):1219-26. doi: 10.1002/pro.2928. Epub 2016 Apr 6. Review. Erratum in: Protein Sci. 2019 Mar;28(3):671.


Viewing protein fitness landscapes through a next-gen lens.

Boucher JI, Cote P, Flynn J, Jiang L, Laban A, Mishra P, Roscoe BP, Bolon DN.

Genetics. 2014 Oct;198(2):461-71. doi: 10.1534/genetics.114.168351. Review.


An atomic-resolution view of neofunctionalization in the evolution of apicomplexan lactate dehydrogenases.

Boucher JI, Jacobowitz JR, Beckett BC, Classen S, Theobald DL.

Elife. 2014 Jun 25;3. doi: 10.7554/eLife.02304.


Quantitative measurement of epidermal growth factor receptor-mitogen-activated protein kinase signal transduction using a nine-plex, peptide-based immunoassay.

Rauh-Adelmann C, Moskow JM, Graham JR, Yen LG, Boucher JI, Murphy CE, Nadler TK, Gordon NF, Radding JA.

Anal Biochem. 2008 Apr 15;375(2):255-64. doi: 10.1016/j.ab.2007.12.038. Epub 2008 Jan 16.


Expression in yeast and purification of functional macrophage nitric oxide synthase. Evidence for cysteine-194 as iron proximal ligand.

Sari MA, Booker S, Jaouen M, Vadon S, Boucher JI, Pompon D, Mansuy D.

Biochemistry. 1996 Jun 4;35(22):7204-13.


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