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Items: 41


Dysregulation of Rac or Rho elicits death of motor neurons and activation of these GTPases is altered in the G93A mutant hSOD1 mouse model of amyotrophic lateral sclerosis.

Stankiewicz TR, Pena C, Bouchard RJ, Linseman DA.

Neurobiol Dis. 2020 Mar;136:104743. doi: 10.1016/j.nbd.2020.104743. Epub 2020 Jan 10.


The Bcl-2 Homology-3 Domain (BH3)-Only Proteins, Bid, DP5/Hrk, and BNip3L, Are Upregulated in Reactive Astrocytes of End-Stage Mutant SOD1 Mouse Spinal Cord.

Duval N, Sumner WA, Andrianakos AG, Gray JJ, Bouchard RJ, Wilkins HM, Linseman DA.

Front Cell Neurosci. 2018 Jan 30;12:15. doi: 10.3389/fncel.2018.00015. eCollection 2018.


Corrigendum: depletion of tumor-associated macrophages slows the growth of chemically induced mouse lung adenocarcinomas.

Fritz JM, Tennis MA, Orlicky DJ, Yin H, Ju C, Redente EF, Choo KS, Staab TA, Bouchard RJ, Merrick DT, Malkinson AM, Dwyer-Nield LD.

Front Immunol. 2015 Mar 3;6:88. doi: 10.3389/fimmu.2015.00088. eCollection 2015.


Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades.

Stankiewicz TR, Ramaswami SA, Bouchard RJ, Aktories K, Linseman DA.

J Biol Chem. 2015 Apr 10;290(15):9363-76. doi: 10.1074/jbc.M114.575217. Epub 2015 Feb 9.


Depletion of tumor-associated macrophages slows the growth of chemically induced mouse lung adenocarcinomas.

Fritz JM, Tennis MA, Orlicky DJ, Lin H, Ju C, Redente EF, Choo KS, Staab TA, Bouchard RJ, Merrick DT, Malkinson AM, Dwyer-Nield LD.

Front Immunol. 2014 Nov 25;5:587. doi: 10.3389/fimmu.2014.00587. eCollection 2014. Erratum in: Front Immunol. 2015;6:88.


C-terminal binding proteins are essential pro-survival factors that undergo caspase-dependent downregulation during neuronal apoptosis.

Stankiewicz TR, Schroeder EK, Kelsey NA, Bouchard RJ, Linseman DA.

Mol Cell Neurosci. 2013 Sep;56:322-332. doi: 10.1016/j.mcn.2013.07.004. Epub 2013 Jul 13.


N-terminal cleavage of the mitochondrial fusion GTPase OPA1 occurs via a caspase-independent mechanism in cerebellar granule neurons exposed to oxidative or nitrosative stress.

Gray JJ, Zommer AE, Bouchard RJ, Duval N, Blackstone C, Linseman DA.

Brain Res. 2013 Feb 4;1494:28-43. doi: 10.1016/j.brainres.2012.12.001. Epub 2012 Dec 7.


Signal transducer and activator of transcription-5 mediates neuronal apoptosis induced by inhibition of Rac GTPase activity.

Stankiewicz TR, Loucks FA, Schroeder EK, Nevalainen MT, Tyler KL, Aktories K, Bouchard RJ, Linseman DA.

J Biol Chem. 2012 May 11;287(20):16835-48. doi: 10.1074/jbc.M111.302166. Epub 2012 Feb 29.


Calpain plays a central role in 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in cerebellar granule neurons.

Harbison RA, Ryan KR, Wilkins HM, Schroeder EK, Loucks FA, Bouchard RJ, Linseman DA.

Neurotox Res. 2011 Apr;19(3):374-88. doi: 10.1007/s12640-010-9172-4. Epub 2010 Mar 24.


Caspases indirectly regulate cleavage of the mitochondrial fusion GTPase OPA1 in neurons undergoing apoptosis.

Loucks FA, Schroeder EK, Zommer AE, Hilger S, Kelsey NA, Bouchard RJ, Blackstone C, Brewster JL, Linseman DA.

Brain Res. 2009 Jan 23;1250:63-74. doi: 10.1016/j.brainres.2008.10.081. Epub 2008 Nov 18.


Green tea epigallocatechin 3-gallate accumulates in mitochondria and displays a selective antiapoptotic effect against inducers of mitochondrial oxidative stress in neurons.

Schroeder EK, Kelsey NA, Doyle J, Breed E, Bouchard RJ, Loucks FA, Harbison RA, Linseman DA.

Antioxid Redox Signal. 2009 Mar;11(3):469-80. doi: 10.1089/ARS.2008.2215.


Glutathione binding to the Bcl-2 homology-3 domain groove: a molecular basis for Bcl-2 antioxidant function at mitochondria.

Zimmermann AK, Loucks FA, Schroeder EK, Bouchard RJ, Tyler KL, Linseman DA.

J Biol Chem. 2007 Oct 5;282(40):29296-304. Epub 2007 Aug 9.


Adhesion-related kinase induction of migration requires phosphatidylinositol-3-kinase and ras stimulation of rac activity in immortalized gonadotropin-releasing hormone neuronal cells.

Nielsen-Preiss SM, Allen MP, Xu M, Linseman DA, Pawlowski JE, Bouchard RJ, Varnum BC, Heidenreich KA, Wierman ME.

Endocrinology. 2007 Jun;148(6):2806-14. Epub 2007 Mar 1.


Endoplasmic reticulum stress and trophic factor withdrawal activate distinct signaling cascades that induce glycogen synthase kinase-3 beta and a caspase-9-dependent apoptosis in cerebellar granule neurons.

Brewster JL, Linseman DA, Bouchard RJ, Loucks FA, Precht TA, Esch EA, Heidenreich KA.

Mol Cell Neurosci. 2006 Jul;32(3):242-53. Epub 2006 Jun 9.


Proteasome inhibition elicits a biphasic effect on neuronal apoptosis via differential regulation of pro-survival and pro-apoptotic transcription factors.

Butts BD, Hudson HR, Linseman DA, Le SS, Ryan KR, Bouchard RJ, Heidenreich KA.

Mol Cell Neurosci. 2005 Oct;30(2):279-89.


Inhibition of Rac GTPase triggers a c-Jun- and Bim-dependent mitochondrial apoptotic cascade in cerebellar granule neurons.

Le SS, Loucks FA, Udo H, Richardson-Burns S, Phelps RA, Bouchard RJ, Barth H, Aktories K, Tyler KL, Kandel ER, Heidenreich KA, Linseman DA.

J Neurochem. 2005 Aug;94(4):1025-39.


Distinct mechanisms of neuronal apoptosis are triggered by antagonism of Bcl-2/Bcl-x(L) versus induction of the BH3-only protein Bim.

Zimmermann AK, Loucks FA, Le SS, Butts BD, Florez-McClure ML, Bouchard RJ, Heidenreich KA, Linseman DA.

J Neurochem. 2005 Jul;94(1):22-36.


The permeability transition pore triggers Bax translocation to mitochondria during neuronal apoptosis.

Precht TA, Phelps RA, Linseman DA, Butts BD, Le SS, Laessig TA, Bouchard RJ, Heidenreich KA.

Cell Death Differ. 2005 Mar;12(3):255-65.


Glycogen synthase kinase-3beta phosphorylates Bax and promotes its mitochondrial localization during neuronal apoptosis.

Linseman DA, Butts BD, Precht TA, Phelps RA, Le SS, Laessig TA, Bouchard RJ, Florez-McClure ML, Heidenreich KA.

J Neurosci. 2004 Nov 3;24(44):9993-10002.


Novel nuclear herniations induced by nuclear localization of a viral protein.

Hoyt CC, Bouchard RJ, Tyler KL.

J Virol. 2004 Jun;78(12):6360-9.


The p75 neurotrophin receptor can induce autophagy and death of cerebellar Purkinje neurons.

Florez-McClure ML, Linseman DA, Chu CT, Barker PA, Bouchard RJ, Le SS, Laessig TA, Heidenreich KA.

J Neurosci. 2004 May 12;24(19):4498-509.


The pesticide rotenone induces caspase-3-mediated apoptosis in ventral mesencephalic dopaminergic neurons.

Ahmadi FA, Linseman DA, Grammatopoulos TN, Jones SM, Bouchard RJ, Freed CR, Heidenreich KA, Zawada WM.

J Neurochem. 2003 Nov;87(4):914-21.


Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival.

Linseman DA, Bartley CM, Le SS, Laessig TA, Bouchard RJ, Meintzer MK, Li M, Heidenreich KA.

J Biol Chem. 2003 Oct 17;278(42):41472-81. Epub 2003 Aug 1.


A myocyte enhancer factor 2D (MEF2D) kinase activated during neuronal apoptosis is a novel target inhibited by lithium.

Linseman DA, Cornejo BJ, Le SS, Meintzer MK, Laessig TA, Bouchard RJ, Heidenreich KA.

J Neurochem. 2003 Jun;85(6):1488-99.


Insulin-like growth factor-I blocks Bcl-2 interacting mediator of cell death (Bim) induction and intrinsic death signaling in cerebellar granule neurons.

Linseman DA, Phelps RA, Bouchard RJ, Le SS, Laessig TA, McClure ML, Heidenreich KA.

J Neurosci. 2002 Nov 1;22(21):9287-97.


Suppression of death receptor signaling in cerebellar Purkinje neurons protects neighboring granule neurons from apoptosis via an insulin-like growth factor I-dependent mechanism.

Linseman DA, McClure ML, Bouchard RJ, Laessig TA, Ahmadi FA, Heidenreich KA.

J Biol Chem. 2002 Jul 5;277(27):24546-53. Epub 2002 Apr 18.


Objective evidence of occult myocardial dysfunction in patients with frequent ventricular ectopy without clinically apparent heart disease.

Kennedy HL, Pescarmona JE, Bouchard RJ, Goldberg RJ, Caralis DG.

Am Heart J. 1982 Jul;104(1):57-65.


Coronary artery status of apparently healthy subjects with frequent and complex ventricular ectopy.

Kennedy HL, Pescarmona JE, Bouchard RJ, Goldberg RJ.

Ann Intern Med. 1980 Feb;92(2 Pt 1):179-85.


The prognostic value of systolic time intervals in angina pectoris patients.

Gillilan RE, Parnes WP, Khan MA, Bouchard RJ, Warbasse JR.

Circulation. 1979 Aug;60(2):268-75. No abstract available.


Systolic time intervals before and after maximal exercise treadmill testing for evaluation of chest pain.

Gillilan RE, Parnes WD, Mondell BE, Bouchard RJ, Warbasse JR.

Chest. 1977 Apr;71(4):479-85.


Radiation-related pericarditis.

Martin RG, Ruckdeschel JC, Chang P, Byhardt R, Bouchard RJ, Wiernik PH.

Am J Cardiol. 1975 Feb;35(2):216-20.


Factors influencing the ejection fraction and the mean rate of circumferential fibre shortening during atrial fibrillation in man.

Karliner JS, Gault JH, Bouchard RJ, Holzer J.

Cardiovasc Res. 1974 Jan;8(1):18-25. No abstract available.


Diagnosis of obstructive coronary disease by maximal exercise and atrial pacing.

Kelemen MH, Gillilan RE, Bouchard RJ, Heppner RL, Warbasse JR.

Circulation. 1973 Dec;48(6):1127-33. No abstract available.


Myocardial infarction associated with thyrotoxicosis.

Kotler MN, Michaelides KM, Bouchard RJ, Warbasse JR.

Arch Intern Med. 1973 Nov;132(5):723-8. No abstract available.


The diagnostic value of ventricular volume measurements.

Bouchard RJ.

W V Med J. 1973 Feb;69(2):32-4. No abstract available.


Haemodynamic effects of angiographic contrast material in man. A beat-by-beat analysis.

Karliner JS, Bouchard RJ, Gault JH.

Br Heart J. 1972 Apr;34(4):347-55. No abstract available.


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