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Selectively high efficacy of eribulin against high-grade invasive recurrent and/or metastatic squamous cell carcinoma of the head and neck.

Kobayashi Y, Kitahara H, Hirai M, Tanaka A, Jokaji R, Kobayashi K, Bou-Gharios G, Nakamura H, Kawashiri S.

Oncol Lett. 2019 Jun;17(6):5064-5072. doi: 10.3892/ol.2019.10165. Epub 2019 Mar 19.


Correction to: Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging.

Davison AS, Strittmatter N, Sutherland H, Hughes AT, Hughes J, Bou-Gharios G, Milan AM, Goodwin RJA, Ranganath LR, Gallagher JA.

Metabolomics. 2019 May 18;15(5):81. doi: 10.1007/s11306-019-1540-3.


Assessing the effect of nitisinone induced hypertyrosinaemia on monoamine neurotransmitters in brain tissue from a murine model of alkaptonuria using mass spectrometry imaging.

Davison AS, Strittmatter N, Sutherland H, Hughes AT, Hughes J, Bou-Gharios G, Milan AM, Goodwin RJA, Ranganath LR, Gallagher JA.

Metabolomics. 2019 Apr 29;15(5):68. doi: 10.1007/s11306-019-1531-4. Erratum in: Metabolomics. 2019 May 18;15(5):81.


Venous identity requires BMP signalling through ALK3.

Neal A, Nornes S, Payne S, Wallace MD, Fritzsche M, Louphrasitthiphol P, Wilkinson RN, Chouliaras KM, Liu K, Plant K, Sholapurkar R, Ratnayaka I, Herzog W, Bond G, Chico T, Bou-Gharios G, De Val S.

Nat Commun. 2019 Jan 28;10(1):453. doi: 10.1038/s41467-019-08315-w.


Targeted Inhibition of Aggrecanases Prevents Articular Cartilage Degradation and Augments Bone Mass in the STR/Ort Mouse Model of Spontaneous Osteoarthritis.

Kanakis I, Liu K, Poulet B, Javaheri B, van 't Hof RJ, Pitsillides AA, Bou-Gharios G.

Arthritis Rheumatol. 2019 Apr;71(4):571-582. doi: 10.1002/art.40765. Epub 2019 Feb 14.


The Chondro-Osseous Continuum: Is It Possible to Unlock the Potential Assigned Within?

Javaheri B, Caetano-Silva SP, Kanakis I, Bou-Gharios G, Pitsillides AA.

Front Bioeng Biotechnol. 2018 Mar 21;6:28. doi: 10.3389/fbioe.2018.00028. eCollection 2018. Review.


Regulation of programmed-death ligand in the human head and neck squamous cell carcinoma microenvironment is mediated through matrix metalloproteinase-mediated proteolytic cleavage.

Hira-Miyazawa M, Nakamura H, Hirai M, Kobayashi Y, Kitahara H, Bou-Gharios G, Kawashiri S.

Int J Oncol. 2018 Feb;52(2):379-388. doi: 10.3892/ijo.2017.4221. Epub 2017 Dec 11.


Differential tissue specific, temporal and spatial expression patterns of the Aggrecan gene is modulated by independent enhancer elements.

Li IMH, Liu K, Neal A, Clegg PD, De Val S, Bou-Gharios G.

Sci Rep. 2018 Jan 17;8(1):950. doi: 10.1038/s41598-018-19186-4.


Multiple enhancer regions govern the transcription of CCN2 during embryonic development.

Frost SL, Liu K, Li IMH, Poulet B, Comerford E, De Val S, Bou-Gharios G.

J Cell Commun Signal. 2018 Mar;12(1):231-243. doi: 10.1007/s12079-017-0440-4. Epub 2017 Dec 18.


Correction: SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development. Development doi: 10.1242/dev.146241.

Chiang IK, Fritzsche M, Pichol-Thievend C, Neal A, Holmes K, Lagendijk A, Overman J, D'Angelo D, Omini A, Hermkens D, Lesieur E, Fossat N, Radziewic T, Liu K, Ratnayaka I, Corada M, Bou-Gharios G, Tam PPL, Carroll J, Dejana E, Schulte-Merker S, Hogan BM, Beltrame M, De Val S, Francois M.

Development. 2017 Oct 15;144(20):3847-3848. doi: 10.1242/dev.159715. No abstract available.


Characterization of Mesenchymal-Fibroblast Cells Using the Col1a2 Promoter/Enhancer.

Li IMH, Horwell AL, Chu G, de Crombrugghe B, Bou-Gharios G.

Methods Mol Biol. 2017;1627:139-161. doi: 10.1007/978-1-4939-7113-8_10.


SoxF factors induce Notch1 expression via direct transcriptional regulation during early arterial development.

Chiang IK, Fritzsche M, Pichol-Thievend C, Neal A, Holmes K, Lagendijk A, Overman J, D'Angelo D, Omini A, Hermkens D, Lesieur E, Liu K, Ratnayaka I, Corada M, Bou-Gharios G, Carroll J, Dejana E, Schulte-Merker S, Hogan B, Beltrame M, De Val S, Francois M.

Development. 2017 Jul 15;144(14):2629-2639. doi: 10.1242/dev.146241. Epub 2017 Jun 15. Erratum in: Development. 2017 Oct 15;144(20):3847-3848.


Altered Bone Mechanics, Architecture and Composition in the Skeleton of TIMP-3-Deficient Mice.

Miller B, Spevak L, Lukashova L, Javaheri B, Pitsillides AA, Boskey A, Bou-Gharios G, Carriero A.

Calcif Tissue Int. 2017 Jun;100(6):631-640. doi: 10.1007/s00223-017-0248-5. Epub 2017 Feb 24.


Overexpression of TIMP-3 in Chondrocytes Produces Transient Reduction in Growth Plate Length but Permanently Reduces Adult Bone Quality and Quantity.

Poulet B, Liu K, Plumb D, Vo P, Shah M, Staines K, Sampson A, Nakamura H, Nagase H, Carriero A, Shefelbine S, Pitsillides AA, Bou-Gharios G.

PLoS One. 2016 Dec 21;11(12):e0167971. doi: 10.1371/journal.pone.0167971. eCollection 2016.


Regulation of PD-L1 expression in a high-grade invasive human oral squamous cell carcinoma microenvironment.

Hirai M, Kitahara H, Kobayashi Y, Kato K, Bou-Gharios G, Nakamura H, Kawashiri S.

Int J Oncol. 2017 Jan;50(1):41-48. doi: 10.3892/ijo.2016.3785. Epub 2016 Dec 2.


MEF2 transcription factors are key regulators of sprouting angiogenesis.

Sacilotto N, Chouliaras KM, Nikitenko LL, Lu YW, Fritzsche M, Wallace MD, Nornes S, García-Moreno F, Payne S, Bridges E, Liu K, Biggs D, Ratnayaka I, Herbert SP, Molnár Z, Harris AL, Davies B, Bond GL, Bou-Gharios G, Schwarz JJ, De Val S.

Genes Dev. 2016 Oct 15;30(20):2297-2309.


Eribulin sensitizes oral squamous cell carcinoma cells to cetuximab via induction of mesenchymal-to-epithelial transition.

Kitahara H, Hirai M, Kato K, Bou-Gharios G, Nakamura H, Kawashiri S.

Oncol Rep. 2016 Dec;36(6):3139-3144. doi: 10.3892/or.2016.5189. Epub 2016 Oct 21.


Data on CUX1 isoforms in idiopathic pulmonary fibrosis lung and systemic sclerosis skin tissue sections.

Ikeda T, Fragiadaki M, Shi-Wen X, Ponticos M, Khan K, Denton C, Garcia P, Bou-Gharios G, Yamakawa A, Morimoto C, Abraham D.

Data Brief. 2016 Aug 10;8:1377-80. doi: 10.1016/j.dib.2016.08.014. eCollection 2016 Sep.


Deficiency and Also Transgenic Overexpression of Timp-3 Both Lead to Compromised Bone Mass and Architecture In Vivo.

Javaheri B, Hopkinson M, Poulet B, Pollard AS, Shefelbine SJ, Chang YM, Francis-West P, Bou-Gharios G, Pitsillides AA.

PLoS One. 2016 Aug 12;11(8):e0159657. doi: 10.1371/journal.pone.0159657. eCollection 2016.


Transforming growth factor-β-induced CUX1 isoforms are associated with fibrosis in systemic sclerosis lung fibroblasts.

Ikeda T, Fragiadaki M, Shi-Wen X, Ponticos M, Khan K, Denton C, Garcia P, Bou-Gharios G, Yamakawa A, Morimoto C, Abraham D.

Biochem Biophys Rep. 2016 Jul 2;7:246-252. doi: 10.1016/j.bbrep.2016.06.022. eCollection 2016 Sep.


An Intronic Flk1 Enhancer Directs Arterial-Specific Expression via RBPJ-Mediated Venous Repression.

Becker PW, Sacilotto N, Nornes S, Neal A, Thomas MO, Liu K, Preece C, Ratnayaka I, Davies B, Bou-Gharios G, De Val S.

Arterioscler Thromb Vasc Biol. 2016 Jun;36(6):1209-19. doi: 10.1161/ATVBAHA.116.307517. Epub 2016 Apr 14.


RNA binding proteins regulate anabolic and catabolic gene expression in chondrocytes.

McDermott BT, Ellis S, Bou-Gharios G, Clegg PD, Tew SR.

Osteoarthritis Cartilage. 2016 Jul;24(7):1263-73. doi: 10.1016/j.joca.2016.01.988. Epub 2016 Feb 4.


Human Chorionic Stem Cells: Podocyte Differentiation and Potential for the Treatment of Alport Syndrome.

Moschidou D, Corcelli M, Hau KL, Ekwalla VJ, Behmoaras JV, De Coppi P, David AL, Bou-Gharios G, Cook HT, Pusey CD, Fisk NM, Guillot PV.

Stem Cells Dev. 2016 Mar 1;25(5):395-404. doi: 10.1089/scd.2015.0305. Epub 2016 Feb 18.


Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis.

Gardiner MD, Vincent TL, Driscoll C, Burleigh A, Bou-Gharios G, Saklatvala J, Nagase H, Chanalaris A.

Osteoarthritis Cartilage. 2015 Apr;23(4):616-28. doi: 10.1016/j.joca.2014.12.014. Epub 2014 Dec 26.


Failed degradation of JunB contributes to overproduction of type I collagen and development of dermal fibrosis in patients with systemic sclerosis.

Ponticos M, Papaioannou I, Xu S, Holmes AM, Khan K, Denton CP, Bou-Gharios G, Abraham DJ.

Arthritis Rheumatol. 2015 Jan;67(1):243-53. doi: 10.1002/art.38897.


Transforming growth factor-β-independent role of connective tissue growth factor in the development of liver fibrosis.

Sakai K, Jawaid S, Sasaki T, Bou-Gharios G, Sakai T.

Am J Pathol. 2014 Oct;184(10):2611-7. doi: 10.1016/j.ajpath.2014.06.009. Epub 2014 Aug 7.


In vivo imaging of MMP-13 activity in the murine destabilised medial meniscus surgical model of osteoarthritis.

Lim NH, Meinjohanns E, Meldal M, Bou-Gharios G, Nagase H.

Osteoarthritis Cartilage. 2014 Jun;22(6):862-8. doi: 10.1016/j.joca.2014.04.006. Epub 2014 Apr 18.


In vivo imaging of matrix metalloproteinase 12 and matrix metalloproteinase 13 activities in the mouse model of collagen-induced arthritis.

Lim NH, Meinjohanns E, Bou-Gharios G, Gompels LL, Nuti E, Rossello A, Devel L, Dive V, Meldal M, Nagase H.

Arthritis Rheumatol. 2014 Mar;66(3):589-98. doi: 10.1002/art.38295.


Generation of a mouse line harboring a Bi-transgene expressing luciferase and tamoxifen-activatable creER(T2) recombinase in cartilage.

Lo Cascio L, Liu K, Nakamura H, Chu G, Lim NH, Chanalaris A, Saklatvala J, Nagase H, Bou-Gharios G.

Genesis. 2014 Feb;52(2):110-9. doi: 10.1002/dvg.22734. Epub 2013 Dec 27.


Biphasic recruitment of microchimeric fetal mesenchymal cells in fibrosis following acute kidney injury.

Roy E, Seppanen E, Ellis R, Lee ES, Khosrotehrani K, Fisk NM, Bou-Gharios G.

Kidney Int. 2014 Mar;85(3):600-10. doi: 10.1038/ki.2013.459. Epub 2013 Dec 4. Erratum in: Kidney Int. 2014 Dec;86(6):1273. Khosroterani, Kiarash [Corrected to Khosrotehrani, Kiarash].


Heat shock protein B1-deficient mice display impaired wound healing.

Crowe J, Aubareda A, McNamee K, Przybycien PM, Lu X, Williams RO, Bou-Gharios G, Saklatvala J, Dean JL.

PLoS One. 2013 Oct 15;8(10):e77383. doi: 10.1371/journal.pone.0077383. eCollection 2013.


Microarray profiling reveals suppressed interferon stimulated gene program in fibroblasts from scleroderma-associated interstitial lung disease.

Lindahl GE, Stock CJ, Shi-Wen X, Leoni P, Sestini P, Howat SL, Bou-Gharios G, Nicholson AG, Denton CP, Grutters JC, Maher TM, Wells AU, Abraham DJ, Renzoni EA.

Respir Res. 2013 Aug 2;14:80. doi: 10.1186/1465-9921-14-80.


Analysis of Dll4 regulation reveals a combinatorial role for Sox and Notch in arterial development.

Sacilotto N, Monteiro R, Fritzsche M, Becker PW, Sanchez-Del-Campo L, Liu K, Pinheiro P, Ratnayaka I, Davies B, Goding CR, Patient R, Bou-Gharios G, De Val S.

Proc Natl Acad Sci U S A. 2013 Jul 16;110(29):11893-8. doi: 10.1073/pnas.1300805110. Epub 2013 Jul 1.


Distant mesenchymal progenitors contribute to skin wound healing and produce collagen: evidence from a murine fetal microchimerism model.

Seppanen E, Roy E, Ellis R, Bou-Gharios G, Fisk NM, Khosrotehrani K.

PLoS One. 2013 May 1;8(5):e62662. doi: 10.1371/journal.pone.0062662. Print 2013.


Wound-associated macrophages control collagen 1α2 transcription during the early stages of skin wound healing.

Rodero MP, Legrand JM, Bou-Gharios G, Khosrotehrani K.

Exp Dermatol. 2013 Feb;22(2):143-5. doi: 10.1111/exd.12068. Epub 2013 Jan 2.


Ontological differences in first compared to third trimester human fetal placental chorionic stem cells.

Jones GN, Moschidou D, Puga-Iglesias TI, Kuleszewicz K, Vanleene M, Shefelbine SJ, Bou-Gharios G, Fisk NM, David AL, De Coppi P, Guillot PV.

PLoS One. 2012;7(9):e43395. doi: 10.1371/journal.pone.0043395. Epub 2012 Sep 4.


Fetal microchimeric cells in a fetus-treats-its-mother paradigm do not contribute to dystrophin production in serially parous mdx females.

Seppanen EJ, Hodgson SS, Khosrotehrani K, Bou-Gharios G, Fisk NM.

Stem Cells Dev. 2012 Oct 10;21(15):2809-16. doi: 10.1089/scd.2012.0047. Epub 2012 Aug 6.


Hyperglycemia causes renal cell damage via CCN2-induced activation of the TrkA receptor: implications for diabetic nephropathy.

Fragiadaki M, Hill N, Hewitt R, Bou-Gharios G, Cook T, Tam FW, Domin J, Mason RM.

Diabetes. 2012 Sep;61(9):2280-8. doi: 10.2337/db11-1138. Epub 2012 May 14.


TGF-b signaling in cartilage homeostasis and osteoarthritis.

Finnson KW, Chi Y, Bou-Gharios G, Leask A, Philip A.

Front Biosci (Schol Ed). 2012 Jan 1;4:251-68. Review.


Interstitial fibrosis is associated with increased COL1A2 transcription in AA-injured renal tubular epithelial cells in vivo.

Fragiadaki M, Witherden AS, Kaneko T, Sonnylal S, Pusey CD, Bou-Gharios G, Mason RM.

Matrix Biol. 2011 Sep;30(7-8):396-403. doi: 10.1016/j.matbio.2011.07.004. Epub 2011 Aug 12.


High doses of TGF-β potently suppress type I collagen via the transcription factor CUX1.

Fragiadaki M, Ikeda T, Witherden A, Mason RM, Abraham D, Bou-Gharios G.

Mol Biol Cell. 2011 Jun 1;22(11):1836-44. doi: 10.1091/mbc.E10-08-0669. Epub 2011 Apr 6.


Microchimeric fetal cells are recruited to maternal kidney following injury and activate collagen type I transcription.

Bou-Gharios G, Amin F, Hill P, Nakamura H, Maxwell P, Fisk NM.

Cells Tissues Organs. 2011;193(6):379-92. doi: 10.1159/000321172. Epub 2010 Dec 11.


Transplantation of human fetal blood stem cells in the osteogenesis imperfecta mouse leads to improvement in multiscale tissue properties.

Vanleene M, Saldanha Z, Cloyd KL, Jell G, Bou-Gharios G, Bassett JH, Williams GR, Fisk NM, Oyen ML, Stevens MM, Guillot PV, Shefelbine SJ.

Blood. 2011 Jan 20;117(3):1053-60. doi: 10.1182/blood-2010-05-287565. Epub 2010 Nov 18.


Differential contribution of dermal resident and bone marrow-derived cells to collagen production during wound healing and fibrogenesis in mice.

Higashiyama R, Nakao S, Shibusawa Y, Ishikawa O, Moro T, Mikami K, Fukumitsu H, Ueda Y, Minakawa K, Tabata Y, Bou-Gharios G, Inagaki Y.

J Invest Dermatol. 2011 Feb;131(2):529-36. doi: 10.1038/jid.2010.314. Epub 2010 Oct 21.


Fetal stem cell microchimerism: natural-born healers or killers?

Lee ES, Bou-Gharios G, Seppanen E, Khosrotehrani K, Fisk NM.

Mol Hum Reprod. 2010 Nov;16(11):869-78. doi: 10.1093/molehr/gaq067. Epub 2010 Jul 27. Review.


Selective expression of connective tissue growth factor in fibroblasts in vivo promotes systemic tissue fibrosis.

Sonnylal S, Shi-Wen X, Leoni P, Naff K, Van Pelt CS, Nakamura H, Leask A, Abraham D, Bou-Gharios G, de Crombrugghe B.

Arthritis Rheum. 2010 May;62(5):1523-32. doi: 10.1002/art.27382.


Negligible contribution of bone marrow-derived cells to collagen production during hepatic fibrogenesis in mice.

Higashiyama R, Moro T, Nakao S, Mikami K, Fukumitsu H, Ueda Y, Ikeda K, Adachi E, Bou-Gharios G, Okazaki I, Inagaki Y.

Gastroenterology. 2009 Oct;137(4):1459-66.e1. doi: 10.1053/j.gastro.2009.07.006. Epub 2009 Jul 29.


Pivotal role of connective tissue growth factor in lung fibrosis: MAPK-dependent transcriptional activation of type I collagen.

Ponticos M, Holmes AM, Shi-wen X, Leoni P, Khan K, Rajkumar VS, Hoyles RK, Bou-Gharios G, Black CM, Denton CP, Abraham DJ, Leask A, Lindahl GE.

Arthritis Rheum. 2009 Jul;60(7):2142-55. doi: 10.1002/art.24620.


JunB mediates enhancer/promoter activity of COL1A2 following TGF-beta induction.

Ponticos M, Harvey C, Ikeda T, Abraham D, Bou-Gharios G.

Nucleic Acids Res. 2009 Sep;37(16):5378-89. doi: 10.1093/nar/gkp544. Epub 2009 Jun 26.


Transplantation of human fetal mesenchymal stem cells improves glomerulopathy in a collagen type I alpha 2-deficient mouse.

Guillot PV, Cook HT, Pusey CD, Fisk NM, Harten S, Moss J, Shore I, Bou-Gharios G.

J Pathol. 2008 Apr;214(5):627-36. doi: 10.1002/path.2325.


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