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Analysis of HLA-G expression in renal tissue in lupus nephritis: a pilot study.

Foschi V, Bortolotti D, Doyle AF, Stratigou V, Stephens L, Trivedi P, Rinaldi R, Padovan M, Bortoluzzi A, Lightstone L, Cairns TD, Botto M, Cook TH, Rizzo R, Govoni M, Pickering MC.

Lupus. 2019 Aug;28(9):1091-1100. doi: 10.1177/0961203319860582. Epub 2019 Jul 10.


Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody.

Gulati S, Beurskens FJ, de Kreuk BJ, Roza M, Zheng B, DeOliveira RB, Shaughnessy J, Nowak NA, Taylor RP, Botto M, He X, Ingalls RR, Woodruff TM, Song WC, Schuurman J, Rice PA, Ram S.

PLoS Biol. 2019 Jun 19;17(6):e3000323. doi: 10.1371/journal.pbio.3000323. eCollection 2019 Jun.


Tumor Cells Hijack Macrophage-Produced Complement C1q to Promote Tumor Growth.

Roumenina LT, Daugan MV, Noé R, Petitprez F, Vano YA, Sanchez-Salas R, Becht E, Meilleroux J, Clec'h BL, Giraldo NA, Merle NS, Sun CM, Verkarre V, Validire P, Selves J, Lacroix L, Delfour O, Vandenberghe I, Thuilliez C, Keddani S, Sakhi IB, Barret E, Ferré P, Corvaïa N, Passioukov A, Chetaille E, Botto M, de Reynies A, Oudard SM, Mejean A, Cathelineau X, Sautès-Fridman C, Fridman WH.

Cancer Immunol Res. 2019 Jul;7(7):1091-1105. doi: 10.1158/2326-6066.CIR-18-0891. Epub 2019 Jun 4.


Correction: Bacillus anthracis Spore Surface Protein BclA Mediates Complement Factor H Binding to Spores and Promotes Spore Persistence.

Wang Y, Jenkins SA, Gu C, Shree A, Martinez-Moczygemba M, Herold J, Botto M, Wetsel RA, Xu Y.

PLoS Pathog. 2019 Feb 8;15(2):e1007579. doi: 10.1371/journal.ppat.1007579. eCollection 2019 Feb.


Human Factor H Domains 6 and 7 Fused to IgG1 Fc Are Immunotherapeutic against Neisseria gonorrhoeae.

Shaughnessy J, Lewis LA, Zheng B, Carr C, Bass I, Gulati S, DeOliveira RB, Gose S, Reed GW, Botto M, Rice PA, Ram S.

J Immunol. 2018 Nov 1;201(9):2700-2709. doi: 10.4049/jimmunol.1701666. Epub 2018 Sep 28.


Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response.

Crawford G, Hayes MD, Seoane RC, Ward S, Dalessandri T, Lai C, Healy E, Kipling D, Proby C, Moyes C, Green K, Best K, Haniffa M, Botto M, Dunn-Walters D, Strid J.

Nat Immunol. 2018 Aug;19(8):859-870. doi: 10.1038/s41590-018-0161-8. Epub 2018 Jul 16.


CD93 regulates central nervous system inflammation in two mouse models of autoimmune encephalomyelitis.

Griffiths MR, Botto M, Morgan BP, Neal JW, Gasque P.

Immunology. 2018 Nov;155(3):346-355. doi: 10.1111/imm.12974. Epub 2018 Jul 11.


Tissue-Restricted Adaptive Type 2 Immunity Is Orchestrated by Expression of the Costimulatory Molecule OX40L on Group 2 Innate Lymphoid Cells.

Halim TYF, Rana BMJ, Walker JA, Kerscher B, Knolle MD, Jolin HE, Serrao EM, Haim-Vilmovsky L, Teichmann SA, Rodewald HR, Botto M, Vyse TJ, Fallon PG, Li Z, Withers DR, McKenzie ANJ.

Immunity. 2018 Jun 19;48(6):1195-1207.e6. doi: 10.1016/j.immuni.2018.05.003. Epub 2018 Jun 12.


Attenuation and efficacy of live-attenuated Rift Valley fever virus vaccine candidates in non-human primates.

Smith DR, Johnston SC, Piper A, Botto M, Donnelly G, Shamblin J, Albariño CG, Hensley LE, Schmaljohn C, Nichol ST, Bird BH.

PLoS Negl Trop Dis. 2018 May 9;12(5):e0006474. doi: 10.1371/journal.pntd.0006474. eCollection 2018 May.


C1q restrains autoimmunity and viral infection by regulating CD8+ T cell metabolism.

Ling GS, Crawford G, Buang N, Bartok I, Tian K, Thielens NM, Bally I, Harker JA, Ashton-Rickardt PG, Rutschmann S, Strid J, Botto M.

Science. 2018 May 4;360(6388):558-563. doi: 10.1126/science.aao4555.


Virus-encoded miRNAs in Ebola virus disease.

Duy J, Honko AN, Altamura LA, Bixler SL, Wollen-Roberts S, Wauquier N, O'Hearn A, Mucker EM, Johnson JC, Shamblin JD, Zelko J, Botto MA, Bangura J, Coomber M, Pitt ML, Gonzalez JP, Schoepp RJ, Goff AJ, Minogue TD.

Sci Rep. 2018 Apr 24;8(1):6480. doi: 10.1038/s41598-018-23916-z.


Determinants of antibody persistence across doses and continents after single-dose rVSV-ZEBOV vaccination for Ebola virus disease: an observational cohort study.

Huttner A, Agnandji ST, Combescure C, Fernandes JF, Bache EB, Kabwende L, Ndungu FM, Brosnahan J, Monath TP, Lemaître B, Grillet S, Botto M, Engler O, Portmann J, Siegrist D, Bejon P, Silvera P, Kremsner P, Siegrist CA; VEBCON; VSV-EBOVAC; VSV-EBOPLUS Consortia.

Lancet Infect Dis. 2018 Jul;18(7):738-748. doi: 10.1016/S1473-3099(18)30165-8. Epub 2018 Apr 5.


A triglyceride-rich lipoprotein environment exacerbates renal injury in the accelerated nephrotoxic nephritis model.

Saja MF, Cook HT, Ruseva MM, Szajna M, Pickering MC, Woollard KJ, Botto M.

Clin Exp Immunol. 2018 Jun;192(3):337-347. doi: 10.1111/cei.13111. Epub 2018 Mar 9.


Hyposialylated IgG activates endothelial IgG receptor FcγRIIB to promote obesity-induced insulin resistance.

Tanigaki K, Sacharidou A, Peng J, Chambliss KL, Yuhanna IS, Ghosh D, Ahmed M, Szalai AJ, Vongpatanasin W, Mattrey RF, Chen Q, Azadi P, Lingvay I, Botto M, Holland WL, Kohler JJ, Sirsi SR, Hoyt K, Shaul PW, Mineo C.

J Clin Invest. 2018 Jan 2;128(1):309-322. doi: 10.1172/JCI89333. Epub 2017 Nov 27.


B cell OX40L supports T follicular helper cell development and contributes to SLE pathogenesis.

Cortini A, Ellinghaus U, Malik TH, Cunninghame Graham DS, Botto M, Vyse TJ.

Ann Rheum Dis. 2017 Dec;76(12):2095-2103. doi: 10.1136/annrheumdis-2017-211499. Epub 2017 Aug 17.


Multi-functional mechanisms of immune evasion by the streptococcal complement inhibitor C5a peptidase.

Lynskey NN, Reglinski M, Calay D, Siggins MK, Mason JC, Botto M, Sriskandan S.

PLoS Pathog. 2017 Aug 14;13(8):e1006493. doi: 10.1371/journal.ppat.1006493. eCollection 2017 Aug.


Complement C1q is hydroxylated by collagen prolyl 4 hydroxylase and is sensitive to off-target inhibition by prolyl hydroxylase domain inhibitors that stabilize hypoxia-inducible factor.

Kiriakidis S, Hoer SS, Burrows N, Biddlecome G, Khan MN, Thinnes CC, Schofield CJ, Rogers N, Botto M, Paleolog E, Maxwell PH.

Kidney Int. 2017 Oct;92(4):900-908. doi: 10.1016/j.kint.2017.03.008. Epub 2017 May 12.


Altered expression of signalling lymphocyte activation molecule receptors in T-cells from lupus nephritis patients-a potential biomarker of disease activity.

Stratigou V, Doyle AF, Carlucci F, Stephens L, Foschi V, Castelli M, McKenna N, Cook HT, Lightstone L, Cairns TD, Pickering MC, Botto M.

Rheumatology (Oxford). 2017 Jul 1;56(7):1206-1216. doi: 10.1093/rheumatology/kex078.


Complement C3 Exacerbates Imiquimod-Induced Skin Inflammation and Psoriasiform Dermatitis.

Giacomassi C, Buang N, Ling GS, Crawford G, Cook HT, Scott D, Dazzi F, Strid J, Botto M.

J Invest Dermatol. 2017 Mar;137(3):760-763. doi: 10.1016/j.jid.2016.11.011. Epub 2016 Nov 19. No abstract available.


Correction: Bacillus anthracis Spore Surface Protein BclA Mediates Complement Factor H Binding to Spores and Promotes Spore Persistence.

Wang Y, Jenkins SA, Gu C, Shree A, Martinez-Moczygemba M, Herold J, Botto M, Wetsel RA, Xu Y.

PLoS Pathog. 2016 Oct 13;12(10):e1005968. doi: 10.1371/journal.ppat.1005968. eCollection 2016 Oct.


Effect of irradiation/bone marrow transplantation on alveolar epithelial type II cells is aggravated in surfactant protein D deficient mice.

Mühlfeld C, Madsen J, Mackay RM, Schneider JP, Schipke J, Lutz D, Birkelbach B, Knudsen L, Botto M, Ochs M, Clark H.

Histochem Cell Biol. 2017 Jan;147(1):49-61. doi: 10.1007/s00418-016-1479-7. Epub 2016 Aug 26.


Bacillus anthracis Spore Surface Protein BclA Mediates Complement Factor H Binding to Spores and Promotes Spore Persistence.

Wang Y, Jenkins SA, Gu C, Shree A, Martinez-Moczygemba M, Herold J, Botto M, Wetsel RA, Xu Y.

PLoS Pathog. 2016 Jun 15;12(6):e1005678. doi: 10.1371/journal.ppat.1005678. eCollection 2016 Jun. Erratum in: PLoS Pathog. 2016 Oct 13;12 (10 ):e1005968. PLoS Pathog. 2019 Feb 8;15(2):e1007579.


Natural History of Aerosol Exposure with Marburg Virus in Rhesus Macaques.

Ewers EC, Pratt WD, Twenhafel NA, Shamblin J, Donnelly G, Esham H, Wlazlowski C, Johnson JC, Botto M, Hensley LE, Goff AJ.

Viruses. 2016 Mar 30;8(4):87. doi: 10.3390/v8040087.


Complement receptor 3 mediates renal protection in experimental C3 glomerulopathy.

Barbour TD, Ling GS, Ruseva MM, Fossati-Jimack L, Cook HT, Botto M, Pickering MC.

Kidney Int. 2016 Apr;89(4):823-32. doi: 10.1016/j.kint.2015.11.024. Epub 2016 Feb 3.


C1q acts in the tumour microenvironment as a cancer-promoting factor independently of complement activation.

Bulla R, Tripodo C, Rami D, Ling GS, Agostinis C, Guarnotta C, Zorzet S, Durigutto P, Botto M, Tedesco F.

Nat Commun. 2016 Feb 1;7:10346. doi: 10.1038/ncomms10346.


C1q Modulates the Response to TLR7 Stimulation by Pristane-Primed Macrophages: Implications for Pristane-Induced Lupus.

Carlucci F, Ishaque A, Ling GS, Szajna M, Sandison A, Donatien P, Cook HT, Botto M.

J Immunol. 2016 Feb 15;196(4):1488-94. doi: 10.4049/jimmunol.1401009. Epub 2016 Jan 15.


Dose Response of MARV/Angola Infection in Cynomolgus Macaques following IM or Aerosol Exposure.

Johnston SC, Lin KL, Twenhafel NA, Raymond JL, Shamblin JD, Wollen SE, Wlazlowski CB, Wilkinson ER, Botto MA, Goff AJ.

PLoS One. 2015 Sep 28;10(9):e0138843. doi: 10.1371/journal.pone.0138843. eCollection 2015.


Partial Complement Factor H Deficiency Associates with C3 Glomerulopathy and Thrombotic Microangiopathy.

Vernon KA, Ruseva MM, Cook HT, Botto M, Malik TH, Pickering MC.

J Am Soc Nephrol. 2016 May;27(5):1334-42. doi: 10.1681/ASN.2015030295. Epub 2015 Sep 15.


Triglyceride-Rich Lipoproteins Modulate the Distribution and Extravasation of Ly6C/Gr1(low) Monocytes.

Saja MF, Baudino L, Jackson WD, Cook HT, Malik TH, Fossati-Jimack L, Ruseva M, Pickering MC, Woollard KJ, Botto M.

Cell Rep. 2015 Sep 22;12(11):1802-15. doi: 10.1016/j.celrep.2015.08.020. Epub 2015 Sep 3.


Temporal Characterization of Marburg Virus Angola Infection following Aerosol Challenge in Rhesus Macaques.

Lin KL, Twenhafel NA, Connor JH, Cashman KA, Shamblin JD, Donnelly GC, Esham HL, Wlazlowski CB, Johnson JC, Honko AN, Botto MA, Yen J, Hensley LE, Goff AJ.

J Virol. 2015 Oct;89(19):9875-85. doi: 10.1128/JVI.01147-15. Epub 2015 Jul 22.


Time and interference: Effects on working memory.

Botto M, Palladino P.

Br J Psychol. 2016 May;107(2):239-58. doi: 10.1111/bjop.12140. Epub 2015 Jun 18.


The paradoxical roles of C1q and C3 in autoimmunity.

Scott D, Botto M.

Immunobiology. 2016 Jun;221(6):719-25. doi: 10.1016/j.imbio.2015.05.001. Epub 2015 May 11. Review.


The exaggerated inflammatory response in Behçet's syndrome: identification of dysfunctional post-transcriptional regulation of the IFN-γ/CXCL10 IP-10 pathway.

Ambrose N, Khan E, Ravindran R, Lightstone L, Abraham S, Botto M, Johns M, Haskard DO.

Clin Exp Immunol. 2015 Sep;181(3):427-33. doi: 10.1111/cei.12655. Epub 2015 Jul 14.


Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling.

Sumida T, Naito AT, Nomura S, Nakagawa A, Higo T, Hashimoto A, Okada K, Sakai T, Ito M, Yamaguchi T, Oka T, Akazawa H, Lee JK, Minamino T, Offermanns S, Noda T, Botto M, Kobayashi Y, Morita H, Manabe I, Nagai T, Shiojima I, Komuro I.

Nat Commun. 2015 Feb 26;6:6241. doi: 10.1038/ncomms7241.


CD55 deposited on synovial collagen fibers protects from immune complex-mediated arthritis.

Karpus ON, Kiener HP, Niederreiter B, Yilmaz-Elis AS, van der Kaa J, Ramaglia V, Arens R, Smolen JS, Botto M, Tak PP, Verbeek JS, Hamann J.

Arthritis Res Ther. 2015 Jan 17;17:6. doi: 10.1186/s13075-015-0518-4.


Association between insulin resistance and risk of complications in children and adolescents with type 1 diabetes.

Krochik AG, Botto M, Bravo M, Hepner M, Frontroth JP, Miranda M, Mazza C.

Diabetes Metab Syndr. 2015 Jan-Mar;9(1):14-8. doi: 10.1016/j.dsx.2014.09.013. Epub 2014 Oct 18.


Dysregulation of adaptive immune responses in complement C3-deficient patients.

Pekkarinen PT, Heikkilä N, Kisand K, Peterson P, Botto M, Daha MR, Drouet C, Isaac L, Helminen M, Haahtela T, Meri S, Jarva H, Arstila TP.

Eur J Immunol. 2015 Mar;45(3):915-21. doi: 10.1002/eji.201444948. Epub 2015 Jan 19.


Mechanisms of complement activation by dextran-coated superparamagnetic iron oxide (SPIO) nanoworms in mouse versus human serum.

Banda NK, Mehta G, Chao Y, Wang G, Inturi S, Fossati-Jimack L, Botto M, Wu L, Moghimi SM, Simberg D.

Part Fibre Toxicol. 2014 Nov 26;11:64. doi: 10.1186/s12989-014-0064-2.


Intranasal peptide-induced tolerance and linked suppression: consequences of complement deficiency.

Fossati-Jimack L, Ling GS, Baudino L, Szajna M, Manivannan K, Zhao JC, Midgley R, Chai JG, Simpson E, Botto M, Scott D.

Immunology. 2015 Jan;144(1):149-57. doi: 10.1111/imm.12358.


Application of age estimation methods based on teeth eruption: how easy is Olze method to use?

De Angelis D, Gibelli D, Merelli V, Botto M, Ventura F, Cattaneo C.

Int J Legal Med. 2014 Sep;128(5):841-4. doi: 10.1007/s00414-014-1006-0. Epub 2014 Apr 30.


C1q as a unique player in angiogenesis with therapeutic implication in wound healing.

Bossi F, Tripodo C, Rizzi L, Bulla R, Agostinis C, Guarnotta C, Munaut C, Baldassarre G, Papa G, Zorzet S, Ghebrehiwet B, Ling GS, Botto M, Tedesco F.

Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4209-14. doi: 10.1073/pnas.1311968111. Epub 2014 Mar 3.


When working memory updating requires updating: analysis of serial position in a running memory task.

Botto M, Basso D, Ferrari M, Palladino P.

Acta Psychol (Amst). 2014 May;148:123-9. doi: 10.1016/j.actpsy.2014.01.012. Epub 2014 Feb 10.


IL-10-producing regulatory B cells induced by IL-33 (Breg(IL-33)) effectively attenuate mucosal inflammatory responses in the gut.

Sattler S, Ling GS, Xu D, Hussaarts L, Romaine A, Zhao H, Fossati-Jimack L, Malik T, Cook HT, Botto M, Lau YL, Smits HH, Liew FY, Huang FP.

J Autoimmun. 2014 May;50:107-22. doi: 10.1016/j.jaut.2014.01.032. Epub 2014 Feb 1.


C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens.

Baudino L, Sardini A, Ruseva MM, Fossati-Jimack L, Cook HT, Scott D, Simpson E, Botto M.

Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1503-8. doi: 10.1073/pnas.1316877111. Epub 2014 Jan 13.


Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages.

Ling GS, Bennett J, Woollard KJ, Szajna M, Fossati-Jimack L, Taylor PR, Scott D, Franzoso G, Cook HT, Botto M.

Nat Commun. 2014;5:3039. doi: 10.1038/ncomms4039.


Autophagy is activated in systemic lupus erythematosus and required for plasmablast development.

Clarke AJ, Ellinghaus U, Cortini A, Stranks A, Simon AK, Botto M, Vyse TJ.

Ann Rheum Dis. 2015 May;74(5):912-20. doi: 10.1136/annrheumdis-2013-204343. Epub 2014 Jan 13.


Complement alternative pathway genetic variation and Dengue infection in the Thai population.

Kraivong R, Vasanawathana S, Limpitikul W, Malasit P, Tangthawornchaikul N, Botto M, Screaton GR, Mongkolsapaya J, Pickering MC.

Clin Exp Immunol. 2013 Nov;174(2):326-34. doi: 10.1111/cei.12184.


Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells.

Fossati-Jimack L, Ling GS, Cortini A, Szajna M, Malik TH, McDonald JU, Pickering MC, Cook HT, Taylor PR, Botto M.

PLoS One. 2013;8(2):e57082. doi: 10.1371/journal.pone.0057082. Epub 2013 Feb 22.


Loss of properdin exacerbates C3 glomerulopathy resulting from factor H deficiency.

Ruseva MM, Vernon KA, Lesher AM, Schwaeble WJ, Ali YM, Botto M, Cook T, Song W, Stover CM, Pickering MC.

J Am Soc Nephrol. 2013 Jan;24(1):43-52. doi: 10.1681/ASN.2012060571. Epub 2012 Nov 26.


Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes.

Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I.

Cell. 2012 Jun 8;149(6):1298-313. doi: 10.1016/j.cell.2012.03.047. Erratum in: Cell. 2012 Aug 3;150(3):659-60.

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