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Items: 1 to 50 of 160

1.

Asparagine synthetase is highly expressed at baseline in the pancreas through heightened PERK signaling.

Mukherjee A, Ahmed N, Rose F, Ahmad AN, Javed TA, Wen L, Bottino R, Xiao X, Kilberg MS, Husain SZ.

Cell Mol Gastroenterol Hepatol. 2019 Aug 14. pii: S2352-345X(19)30109-2. doi: 10.1016/j.jcmgh.2019.08.003. [Epub ahead of print]

2.

Is the renal subcapsular space the preferred site for clinical porcine islet xenotransplantation? Review article.

Smood B, Bottino R, Hara H, Cooper DKC.

Int J Surg. 2019 Jul 30;69:100-107. doi: 10.1016/j.ijsu.2019.07.032. [Epub ahead of print] Review.

PMID:
31369877
3.

Change in Functional Beta Cell Capacity With Time Following Autologous Islet Transplantation.

Ali KF, San Martin VT, Walsh RM, Bottino R, Stevens T, Trucco M, Hatipoglu B.

Pancreas. 2019 May/Jun;48(5):656-661. doi: 10.1097/MPA.0000000000001315.

PMID:
31091212
4.

Mesenteric lymph nodes as alternative site for pancreatic islet transplantation in a diabetic rat model.

Veroux M, Bottino R, Santini R, Bertera S, Corona D, Zerbo D, Li Volti G, Ekser B, Puzzo L, Raffaele M, Lo Bianco S, Giaquinta A, Veroux P, Vanella L.

BMC Surg. 2019 Apr 24;18(Suppl 1):126. doi: 10.1186/s12893-018-0452-x.

5.

Immunological aspects of allogeneic pancreatic islet transplantation: a comparison between mouse and human.

Montanari E, Gonelle-Gispert C, Seebach JD, Knoll MF, Bottino R, Bühler LH.

Transpl Int. 2019 Apr 29. doi: 10.1111/tri.13445. [Epub ahead of print] Review.

PMID:
31033036
6.

Third WHO Global Consultation on Regulatory Requirements for Xenotransplantation Clinical Trials, Changsha, Hunan, China December 12-14, 2018: "The 2018 Changsha Communiqué" The 10-Year Anniversary of The International Consultation on Xenotransplantation.

Hawthorne WJ, Cowan PJ, Bühler LH, Yi S, Bottino R, Pierson RN 3rd, Ahn C, Azimzadeh A, Cozzi E, Gianello P, Lakey JRT, Luo M, Miyagawa S, Mohiuddin MM, Park CG, Schuurman HJ, Scobie L, Sykes M, Tector J, Tönjes RR, Wolf E, Nuñez JR, Wang W.

Xenotransplantation. 2019 Mar;26(2):e12513. doi: 10.1111/xen.12513. Epub 2019 Apr 13. No abstract available.

PMID:
30980428
7.

Xenotransplantation literature update, January/February 2019.

Bottino R, Burlak C.

Xenotransplantation. 2019 Mar;26(2):e12518. doi: 10.1111/xen.12518. Epub 2019 Apr 11. No abstract available.

PMID:
30977167
8.

HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes.

Russell MA, Redick SD, Blodgett DM, Richardson SJ, Leete P, Krogvold L, Dahl-Jørgensen K, Bottino R, Brissova M, Spaeth JM, Babon JAB, Haliyur R, Powers AC, Yang C, Kent SC, Derr AG, Kucukural A, Garber MG, Morgan NG, Harlan DM.

Diabetes. 2019 May;68(5):988-1001. doi: 10.2337/db18-0686. Epub 2019 Mar 4.

PMID:
30833470
9.

A Method for Islet Transplantation to the Omentum in Mouse.

Lu Y, Zou S, Bertera S, Bottino R, Cooper DKC, Liu Z, Huang Y, Wang C, Hong C, He T, Zhang H, Huo Q, Fu H, Cai Z, Mou L.

J Vis Exp. 2019 Jan 7;(143). doi: 10.3791/57160.

PMID:
30663661
10.

Human islets expressing HNF1A variant have defective β cell transcriptional regulatory networks.

Haliyur R, Tong X, Sanyoura M, Shrestha S, Lindner J, Saunders DC, Aramandla R, Poffenberger G, Redick SD, Bottino R, Prasad N, Levy SE, Blind RD, Harlan DM, Philipson LH, Stein RW, Brissova M, Powers AC.

J Clin Invest. 2019 Jan 2;129(1):246-251. doi: 10.1172/JCI121994. Epub 2018 Dec 3.

11.

Discovering human diabetes-risk gene function with genetics and physiological assays.

Peiris H, Park S, Louis S, Gu X, Lam JY, Asplund O, Ippolito GC, Bottino R, Groop L, Tucker H, Kim SK.

Nat Commun. 2018 Sep 21;9(1):3855. doi: 10.1038/s41467-018-06249-3.

12.

A Chromatin Basis for Cell Lineage and Disease Risk in the Human Pancreas.

Arda HE, Tsai J, Rosli YR, Giresi P, Bottino R, Greenleaf WJ, Chang HY, Kim SK.

Cell Syst. 2018 Sep 26;7(3):310-322.e4. doi: 10.1016/j.cels.2018.07.007. Epub 2018 Aug 22.

PMID:
30145115
13.

Atrial Fibrillation and Malignancy: The Clinical Performance of Non-Vitamin K Oral Anticoagulants-A Systematic Review.

Russo V, Bottino R, Rago A, Micco PD, D' Onofrio A, Liccardo B, Golino P, Nigro G.

Semin Thromb Hemost. 2019 Mar;45(2):205-214. doi: 10.1055/s-0038-1661386. Epub 2018 Aug 17.

PMID:
30119139
14.

The Future of Islet Transplantation Is Now.

Bottino R, Knoll MF, Knoll CA, Bertera S, Trucco MM.

Front Med (Lausanne). 2018 Jul 13;5:202. doi: 10.3389/fmed.2018.00202. eCollection 2018. Review.

15.

Nasal high-frequency oscillatory ventilation and CO2 removal: A randomized controlled crossover trial.

Bottino R, Pontiggia F, Ricci C, Gambacorta A, Paladini A, Chijenas V, Liubsys A, Navikiene J, Pliauckiene A, Mercadante D, Colnaghi M, Tana M, Tirone C, Lio A, Aurilia C, Pastorino R, Purcaro V, Maffei G, Liberatore P, Consigli C, Haass C, Lista G, Agosti M, Mosca F, Vento G.

Pediatr Pulmonol. 2018 Sep;53(9):1245-1251. doi: 10.1002/ppul.24120. Epub 2018 Jul 12.

PMID:
29999596
16.

Total pancreaticoduodenectomy with autologous islet transplantation 14 years after liver-contained composite visceral transplantation.

Nassar A, Quintini C, Costa G, Lennon E, Bottino R, Hatipoglu B, Hashimoto K, Fujiki M, Kandeel F, Walsh RM, Abu-Elmagd K.

Am J Transplant. 2018 Aug;18(8):2068-2074. doi: 10.1111/ajt.14880. Epub 2018 May 14.

17.

Cystic fibrosis-related diabetes is caused by islet loss and inflammation.

Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Bautista A, Spigelman AF, Babon JAB, DeNicola ME, Dadi PK, Bush WS, Balamurugan AN, Brissova M, Dai C, Prasad N, Bottino R, Jacobson DA, Drumm ML, Kent SC, MacDonald PE, Powers AC.

JCI Insight. 2018 Apr 19;3(8). pii: 98240. doi: 10.1172/jci.insight.98240. eCollection 2018 Apr 19.

18.

Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes.

Marre ML, McGinty JW, Chow IT, DeNicola ME, Beck NW, Kent SC, Powers AC, Bottino R, Harlan DM, Greenbaum CJ, Kwok WW, Piganelli JD, James EA.

Diabetes. 2018 Jul;67(7):1356-1368. doi: 10.2337/db17-1166. Epub 2018 Apr 13.

19.

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.

Brissova M, Haliyur R, Saunders D, Shrestha S, Dai C, Blodgett DM, Bottino R, Campbell-Thompson M, Aramandla R, Poffenberger G, Lindner J, Pan FC, von Herrath MG, Greiner DL, Shultz LD, Sanyoura M, Philipson LH, Atkinson M, Harlan DM, Levy SE, Prasad N, Stein R, Powers AC.

Cell Rep. 2018 Mar 6;22(10):2667-2676. doi: 10.1016/j.celrep.2018.02.032.

20.

Single-Cell Analysis of Human Pancreas Reveals Transcriptional Signatures of Aging and Somatic Mutation Patterns.

Enge M, Arda HE, Mignardi M, Beausang J, Bottino R, Kim SK, Quake SR.

Cell. 2017 Oct 5;171(2):321-330.e14. doi: 10.1016/j.cell.2017.09.004. Epub 2017 Sep 28.

21.

Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling.

Dai C, Hang Y, Shostak A, Poffenberger G, Hart N, Prasad N, Phillips N, Levy SE, Greiner DL, Shultz LD, Bottino R, Kim SK, Powers AC.

J Clin Invest. 2017 Oct 2;127(10):3835-3844. doi: 10.1172/JCI91761. Epub 2017 Sep 18.

22.

Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.

Babon JAB, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC.

Nat Med. 2017 Aug 4;23(8):1004. doi: 10.1038/nm0817-1004a. No abstract available.

23.

Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.

Babon JA, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC.

Nat Med. 2017 Feb 7;23(2):264. doi: 10.1038/nm0217-264a. No abstract available.

PMID:
28170374
24.

Pig-to-Primate Islet Xenotransplantation: Past, Present, and Future.

Liu Z, Hu W, He T, Dai Y, Hara H, Bottino R, Cooper DKC, Cai Z, Mou L.

Cell Transplant. 2017 Jun 9;26(6):925-947. doi: 10.3727/096368917X694859. Epub 2017 Feb 3. Review.

25.

Safe use of anti-CD154 monoclonal antibody in pig islet xenotransplantation in monkeys.

Bottino R, Knoll MF, Graeme-Wilson J, Klein EC, Ayares D, Trucco M, Cooper DK.

Xenotransplantation. 2017 Jan;24(1). doi: 10.1111/xen.12283. Epub 2017 Jan 6.

26.

Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.

Babon JA, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC.

Nat Med. 2016 Dec;22(12):1482-1487. doi: 10.1038/nm.4203. Epub 2016 Oct 31. Erratum in: Nat Med. 2017 Feb 7;23 (2):264. Nat Med. 2017 Aug 4;23 (8):1004.

27.

Clinical Islet Xenotransplantation: A Step Forward.

Ekser B, Bottino R, Cooper DKC.

EBioMedicine. 2016 Oct;12:22-23. doi: 10.1016/j.ebiom.2016.09.023. Epub 2016 Sep 24. No abstract available.

28.

Spontaneous Hypoglycemia After Islet Autotransplantation for Chronic Pancreatitis.

Lin YK, Faiman C, Johnston PC, Walsh RM, Stevens T, Bottino R, Hatipoglu BA.

J Clin Endocrinol Metab. 2016 Oct;101(10):3669-3675. Epub 2016 Aug 22.

PMID:
27548105
29.

Efficacy of a new technique - INtubate-RECruit-SURfactant-Extubate - "IN-REC-SUR-E" - in preterm neonates with respiratory distress syndrome: study protocol for a randomized controlled trial.

Vento G, Pastorino R, Boni L, Cota F, Carnielli V, Cools F, Dani C, Mosca F, Pillow J, Polglase G, Tagliabue P, van Kaam AH, Ventura ML, Tana M, Tirone C, Aurilia C, Lio A, Ricci C, Gambacorta A, Consigli C, D'Onofrio D, Gizzi C, Massenzi L, Cardilli V, Casati A, Bottino R, Pontiggia F, Ciarmoli E, Martinelli S, Ilardi L, Colnaghi M, Matassa PG, Vendettuoli V, Villani P, Fusco F, Gazzolo D, Ricotti A, Ferrero F, Stasi I, Magaldi R, Maffei G, Presta G, Perniola R, Messina F, Montesano G, Poggi C, Giordano L, Roma E, Grassia C, Ausanio G, Sandri F, Mescoli G, Giura F, Garani G, Solinas A, Lucente M, Nigro G, Del Vecchio A, Petrillo F, Orfeo L, Grappone L, Quartulli L, Scorrano A, Messner H, Staffler A, Gargano G, Balestri E, Nobile S, Cacace C, Meli V, Dallaglio S, Pasqua B, Mattia L, Gitto E, Vitaliti M, Re MP, Vedovato S, Grison A, Berardi A, Torcetta F, Guidotti I, di Fabio S, Maranella E, Mondello I, Visentin S, Tormena F.

Trials. 2016 Aug 18;17:414. doi: 10.1186/s13063-016-1498-7.

30.

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function.

Arda HE, Li L, Tsai J, Torre EA, Rosli Y, Peiris H, Spitale RC, Dai C, Gu X, Qu K, Wang P, Wang J, Grompe M, Scharfmann R, Snyder MS, Bottino R, Powers AC, Chang HY, Kim SK.

Cell Metab. 2016 May 10;23(5):909-20. doi: 10.1016/j.cmet.2016.04.002. Epub 2016 Apr 28.

31.

Initial in vitro studies on tissues and cells from GTKO/CD46/NeuGcKO pigs.

Lee W, Hara H, Ezzelarab MB, Iwase H, Bottino R, Long C, Ramsoondar J, Ayares D, Cooper DK.

Xenotransplantation. 2016 Mar;23(2):137-50. doi: 10.1111/xen.12229. Epub 2016 Mar 14.

32.

A Multicenter Study: North American Islet Donor Score in Donor Pancreas Selection for Human Islet Isolation for Transplantation.

Wang LJ, Kin T, O'Gorman D, Shapiro AMJ, Naziruddin B, Takita M, Levy MF, Posselt AM, Szot GL, Savari O, Barbaro B, McGarrigle J, Yeh CC, Oberholzer J, Lei J, Chen T, Lian M, Markmann JF, Alvarez A, Linetsky E, Ricordi C, Balamurugan AN, Loganathan G, Wilhelm JJ, Hering BJ, Bottino R, Trucco M, Liu C, Min Z, Li Y, Naji A, Fernandez LA, Ziemelis M, Danobeitia JS, Millis JM, Witkowski P.

Cell Transplant. 2016;25(8):1515-1523. doi: 10.3727/096368916X691141. Epub 2016 Feb 26.

33.

First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes--Chapter 4: pre-clinical efficacy and complication data required to justify a clinical trial.

Cooper DK, Bottino R, Gianello P, Graham M, Hawthorne WJ, Kirk AD, Korsgren O, Park CG, Weber C.

Xenotransplantation. 2016 Jan-Feb;23(1):46-52. doi: 10.1111/xen.12226. Epub 2016 Feb 25.

PMID:
26916706
34.

Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion.

Delong T, Wiles TA, Baker RL, Bradley B, Barbour G, Reisdorph R, Armstrong M, Powell RL, Reisdorph N, Kumar N, Elso CM, DeNicola M, Bottino R, Powers AC, Harlan DM, Kent SC, Mannering SI, Haskins K.

Science. 2016 Feb 12;351(6274):711-4. doi: 10.1126/science.aad2791.

35.

Distinct activation of primary human BDCA1(+) dendritic cells upon interaction with stressed or infected β cells.

Schulte BM, Kers-Rebel ED, Bottino R, Piganelli JD, Galama JM, Engelse MA, de Koning EJ, Adema GJ.

Clin Exp Immunol. 2016 Jun;184(3):293-307. doi: 10.1111/cei.12779. Epub 2016 Mar 23.

36.

Endoscopic biopsy of islet transplants in the gastric submucosal space provides evidence of islet graft rejection in diabetic pigs.

Tanaka T, Fujita M, Bottino R, Piganelli JD, McGrath K, Li J, Lee W, Iwase H, Wijkstrom M, Bertera S, Long C, Landsittel D, Haruma K, Cooper DK, Hara H.

Islets. 2016;8(1):1-12. doi: 10.1080/19382014.2016.1149283. Epub 2016 Feb 8.

37.

The pathobiology of pig-to-primate xenotransplantation: a historical review.

Cooper DK, Ezzelarab MB, Hara H, Iwase H, Lee W, Wijkstrom M, Bottino R.

Xenotransplantation. 2016 Mar;23(2):83-105. doi: 10.1111/xen.12219. Epub 2016 Jan 27. Review.

PMID:
26813438
38.

FoxO1 Plays an Important Role in Regulating β-Cell Compensation for Insulin Resistance in Male Mice.

Zhang T, Kim DH, Xiao X, Lee S, Gong Z, Muzumdar R, Calabuig-Navarro V, Yamauchi J, Harashima H, Wang R, Bottino R, Alvarez-Perez JC, Garcia-Ocaña A, Gittes G, Dong HH.

Endocrinology. 2016 Mar;157(3):1055-70. doi: 10.1210/en.2015-1852. Epub 2016 Jan 4.

39.

Use of genetically-engineered pig donors in islet transplantation.

Bottino R, Trucco M.

World J Transplant. 2015 Dec 24;5(4):243-50. doi: 10.5500/wjt.v5.i4.243. Review.

40.

Recent advances in understanding xenotransplantation: implications for the clinic.

Cooper DK, Bottino R.

Expert Rev Clin Immunol. 2015;11(12):1379-90. doi: 10.1586/1744666X.2015.1083861. Epub 2015 Sep 1.

41.

Current status of islet xenotransplantation.

Park CG, Bottino R, Hawthorne WJ.

Int J Surg. 2015 Nov;23(Pt B):261-266. doi: 10.1016/j.ijsu.2015.07.703. Epub 2015 Aug 4. Review.

42.

In vitro exposure of pig neonatal isletlike cell clusters to human blood.

Nagaraju S, Bertera S, Tanaka T, Hara H, Rayat GR, Wijkstrom M, Ayares D, Trucco M, Cooper DK, Bottino R.

Xenotransplantation. 2015 Jul-Aug;22(4):317-24. doi: 10.1111/xen.12178. Epub 2015 Jul 14.

PMID:
26179209
43.

Author Response to Letter by Delibasi T., et al.

Johnston PC, Bottino R, Trucco M, Lin YK, Walsh RM, Stevens TK, Bena J, Hatipoglu BA.

J Clin Endocrinol Metab. 2015 Jul;100(7):L62. doi: 10.1210/jc.2015-2293. No abstract available.

PMID:
26151405
44.

Clinical implementation of islet transplantation: A current assessment.

Bottino R, Trucco M.

Pediatr Diabetes. 2015 Sep;16(6):393-401. doi: 10.1111/pedi.12287. Epub 2015 Jun 18. Review.

PMID:
26084669
45.

Exposure to Radiocontrast Agents Induces Pancreatic Inflammation by Activation of Nuclear Factor-κB, Calcium Signaling, and Calcineurin.

Jin S, Orabi AI, Le T, Javed TA, Sah S, Eisses JF, Bottino R, Molkentin JD, Husain SZ.

Gastroenterology. 2015 Sep;149(3):753-64.e11. doi: 10.1053/j.gastro.2015.05.004. Epub 2015 May 14.

46.

Bioengineering Thymus Organoids to Restore Thymic Function and Induce Donor-Specific Immune Tolerance to Allografts.

Fan Y, Tajima A, Goh SK, Geng X, Gualtierotti G, Grupillo M, Coppola A, Bertera S, Rudert WA, Banerjee I, Bottino R, Trucco M.

Mol Ther. 2015 Jul;23(7):1262-1277. doi: 10.1038/mt.2015.77. Epub 2015 Apr 23.

47.

Factors associated with islet yield and insulin independence after total pancreatectomy and islet cell autotransplantation in patients with chronic pancreatitis utilizing off-site islet isolation: Cleveland Clinic experience.

Johnston PC, Lin YK, Walsh RM, Bottino R, Stevens TK, Trucco M, Bena J, Faiman C, Hatipoglu BA.

J Clin Endocrinol Metab. 2015 May;100(5):1765-70. doi: 10.1210/jc.2014-4298. Epub 2015 Mar 17.

PMID:
25781357
48.

Generation of antigen-specific Foxp3+ regulatory T-cells in vivo following administration of diabetes-reversing tolerogenic microspheres does not require provision of antigen in the formulation.

Engman C, Wen Y, Meng WS, Bottino R, Trucco M, Giannoukakis N.

Clin Immunol. 2015 Sep;160(1):103-23. doi: 10.1016/j.clim.2015.03.004. Epub 2015 Mar 12.

PMID:
25773782
49.

Glucose metabolism in pigs expressing human genes under an insulin promoter.

Wijkstrom M, Bottino R, Iwase H, Hara H, Ekser B, van der Windt D, Long C, Toledo FG, Phelps CJ, Trucco M, Cooper DK, Ayares D.

Xenotransplantation. 2015 Jan-Feb;22(1):70-9. doi: 10.1111/xen.12145. Epub 2014 Nov 10.

50.

Streptozotocin-associated lymphopenia in cynomolgus monkeys.

Nagaraju S, Bertera S, Funair A, Wijkstrom M, Trucco M, Cooper DK, Bottino R.

Islets. 2014;6(3):e944441. doi: 10.4161/19382014.2014.944441.

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