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Items: 44

2.
3.

Activation of macrophage peroxisome proliferator-activated receptor-gamma by diclofenac results in the induction of cyclooxygenase-2 protein and the synthesis of anti-inflammatory cytokines.

Ayoub SS, Botting RM, Joshi AN, Seed MP, Colville-Nash PR.

Mol Cell Biochem. 2009 Jul;327(1-2):101-10. doi: 10.1007/s11010-009-0048-y. Epub 2009 Feb 15.

PMID:
19219624
4.

Inhibitors of cyclooxygenases: mechanisms, selectivity and uses.

Botting RM.

J Physiol Pharmacol. 2006 Nov;57 Suppl 5:113-24. Review.

PMID:
17218763
5.

The involvement of a cyclooxygenase 1 gene-derived protein in the antinociceptive action of paracetamol in mice.

Ayoub SS, Colville-Nash PR, Willoughby DA, Botting RM.

Eur J Pharmacol. 2006 May 24;538(1-3):57-65. Epub 2006 Apr 1.

PMID:
16674937
6.

Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition.

Simmons DL, Botting RM, Hla T.

Pharmacol Rev. 2004 Sep;56(3):387-437. Review.

PMID:
15317910
7.

Acetaminophen-induced hypothermia in mice is mediated by a prostaglandin endoperoxide synthase 1 gene-derived protein.

Ayoub SS, Botting RM, Goorha S, Colville-Nash PR, Willoughby DA, Ballou LR.

Proc Natl Acad Sci U S A. 2004 Jul 27;101(30):11165-9. Epub 2004 Jul 19.

8.

The mechanism of action of aspirin.

Vane JR, Botting RM.

Thromb Res. 2003 Jun 15;110(5-6):255-8. Review.

PMID:
14592543
9.

Actions of paracetamol on cyclooxygenases in tissue and cell homogenates of mouse and rabbit.

Swierkosz TA, Jordan L, McBride M, McGough K, Devlin J, Botting RM.

Med Sci Monit. 2002 Dec;8(12):BR496-503.

PMID:
12503027
10.

Mechanism of action of acetaminophen: is there a cyclooxygenase 3?

Botting RM.

Clin Infect Dis. 2000 Oct;31 Suppl 5:S202-10. Review.

PMID:
11113024
11.

Nociception in cyclooxygenase isozyme-deficient mice.

Ballou LR, Botting RM, Goorha S, Zhang J, Vane JR.

Proc Natl Acad Sci U S A. 2000 Aug 29;97(18):10272-6.

12.

The future of NSAID therapy: selective COX-2 inhibitors.

Vane JR, Botting RM.

Int J Clin Pract. 2000 Jan-Feb;54(1):7-9. No abstract available. Erratum in: Int J Clin Pract 2000 Mar;54(2):73.

PMID:
10750251
13.

Induction of an acetaminophen-sensitive cyclooxygenase with reduced sensitivity to nonsteroid antiinflammatory drugs.

Simmons DL, Botting RM, Robertson PM, Madsen ML, Vane JR.

Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3275-80.

14.

Anti-inflammatory drugs and their mechanism of action.

Vane JR, Botting RM.

Inflamm Res. 1998 Oct;47 Suppl 2:S78-87. Review.

PMID:
9831328
15.

Cyclooxygenases 1 and 2.

Vane JR, Bakhle YS, Botting RM.

Annu Rev Pharmacol Toxicol. 1998;38:97-120. Review.

PMID:
9597150
16.

Mechanism of action of nonsteroidal anti-inflammatory drugs.

Vane JR, Botting RM.

Am J Med. 1998 Mar 30;104(3A):2S-8S; discussion 21S-22S. Review.

PMID:
9572314
17.

Mechanism of action of antiinflammatory drugs.

Vane JR, Botting RM.

Int J Tissue React. 1998;20(1):3-15. Review.

PMID:
9561441
18.

Mechanism of action of aspirin-like drugs.

Vane JR, Botting RM.

Semin Arthritis Rheum. 1997 Jun;26(6 Suppl 1):2-10. Review.

PMID:
9219313
19.

Mechanism of action of anti-inflammatory drugs.

Vane JR, Botting RM.

Adv Exp Med Biol. 1997;433:131-8. Review. No abstract available.

PMID:
9561120
20.

Cyclooxygenase-2 and its regulation in inflammation.

Bakhle YS, Botting RM.

Mediators Inflamm. 1996;5(5):305-23. No abstract available.

21.

Mechanism of action of anti-inflammatory drugs.

Vane JR, Botting RM.

Scand J Rheumatol Suppl. 1996;102:9-21. Review.

PMID:
8628981
22.

Co-induction of nitric oxide synthase and cyclo-oxygenase: interactions between nitric oxide and prostanoids.

Swierkosz TA, Mitchell JA, Warner TD, Botting RM, Vane JR.

Br J Pharmacol. 1995 Apr;114(7):1335-42.

23.

Pharmacodynamic profile of prostacyclin.

Vane JR, Botting RM.

Am J Cardiol. 1995 Jan 19;75(3):3A-10A. Review.

PMID:
7840052
24.

New insights into the mode of action of anti-inflammatory drugs.

Vane JR, Botting RM.

Inflamm Res. 1995 Jan;44(1):1-10. Review.

PMID:
7664022
25.

A better understanding of anti-inflammatory drugs based on isoforms of cyclooxygenase (COX-1 and COX-2).

Vane JR, Botting RM.

Adv Prostaglandin Thromboxane Leukot Res. 1995;23:41-8. Review. No abstract available.

PMID:
7537433
26.

Regulatory mechanisms of the vascular endothelium: an update.

Vane JR, Botting RM.

Pol J Pharmacol. 1994 Nov-Dec;46(6):499-21. Review.

PMID:
7620513
27.

Relationship between different isoforms of nitric oxide synthase and cyclooxygenase in various cell types.

Swierkosz TA, Mitchell JA, Tomlinson A, Botting RM, Warner TD, Vane JR.

Pol J Pharmacol. 1994 Nov-Dec;46(6):587-92.

PMID:
7542521
28.

Control of the circulation by vasoactive mediators from endothelial cells.

Vane JR, Botting RM.

J Lipid Mediat Cell Signal. 1994 Feb;9(1):1-8. Review. No abstract available.

PMID:
8032711
29.

Mediators from the endothelial cell and their participation in inflammation.

Vane JR, Botting RM.

Int J Tissue React. 1994;16(1):19-49. Review. No abstract available.

PMID:
7960499
30.

Formation by the endothelium of prostacyclin, nitric oxide and endothelin.

Vane JR, Botting RM.

J Lipid Mediat. 1993 Mar-Apr;6(1-3):395-404. Review.

PMID:
8357997
31.

Secretory functions of the vascular endothelium.

Vane JR, Botting RM.

J Physiol Pharmacol. 1992 Sep;43(3):195-207. Review.

PMID:
1493252
32.

The role of chemical mediators released by the endothelium in the control of the cardiovascular system.

Vane JR, Botting RM.

Int J Tissue React. 1992;14(2):55-64. Review.

PMID:
1399322
33.

Heart disease, aspirin, and fish oil.

Vane JR, Botting RM.

Circulation. 1991 Dec;84(6):2588-90. No abstract available.

PMID:
1959207
34.

Endothelium-derived vasoactive factors and the control of the circulation.

Vane JR, Botting RM.

Semin Perinatol. 1991 Feb;15(1):4-10. Review. No abstract available.

PMID:
2063229
35.

Endothelium--thromboresistance.

Vane JR, Botting RM.

Wien Klin Wochenschr. 1991;103(14):403-4. No abstract available.

PMID:
1926866
36.

The present status of eicosanoids and related substances in the control of the cardiovascular system.

Vane JR, Botting RM.

Wien Klin Wochenschr. 1991;103(18):541-2. No abstract available.

PMID:
1750221
37.

History of aspirin and its mechanism of action.

Vane JR, Flower RJ, Botting RM.

Stroke. 1990 Dec;21(12 Suppl):IV12-23. No abstract available.

PMID:
2124385
38.

Regulatory functions of the vascular endothelium.

Vane JR, Anggård EE, Botting RM.

N Engl J Med. 1990 Jul 5;323(1):27-36. Review. No abstract available.

PMID:
2113184
39.

Endothelins: potent releasers of prostacyclin and EDRF.

Botting RM, Vane JR.

Pol J Pharmacol Pharm. 1990 May-Jun;42(3):203-18. Review.

PMID:
2263532
40.

Endothelins.

Anggård EE, Botting RM, Vane JR.

Blood Vessels. 1990;27(2-5):269-81. Review.

PMID:
2146982
41.

The mode of action of anti-inflammatory drugs.

Vane JR, Botting RM.

Postgrad Med J. 1990;66 Suppl 4:S2-17. Review.

PMID:
2126623
42.

Mediators produced by the endothelial cell.

Gryglewski RJ, Botting RM, Vane JR.

Hypertension. 1988 Dec;12(6):530-48. Review.

PMID:
3060428
43.

Audio-visual teaching material used on courses for new Home Office Licensees.

Botting RM, Tuffery AA.

Br J Pharmacol. 1979 Nov;67(3):504P. No abstract available.

44.

Potentiation of the actions of pentobarbitone by nikethamide.

Botting RM, Burden D.

J Pharm Pharmacol. 1969 Jun;21(6):400-1. No abstract available.

PMID:
4389177

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