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Items: 42


Maternal and fetal cardiometabolic recovery following ultrasound-guided high-intensity focused ultrasound placental vascular occlusion.

Shaw CJ, Rivens I, Civale J, Botting KJ, Allison BJ, Brain KL, Niu Y, Ter Haar G, Giussani DA, Lees CC.

J R Soc Interface. 2019 May 31;16(154):20190013. doi: 10.1098/rsif.2019.0013.


Intervention against hypertension in the next generation programmed by developmental hypoxia.

Brain KL, Allison BJ, Niu Y, Cross CM, Itani N, Kane AD, Herrera EA, Skeffington KL, Botting KJ, Giussani DA.

PLoS Biol. 2019 Jan 22;17(1):e2006552. doi: 10.1371/journal.pbio.2006552. eCollection 2019 Jan.


Improving pregnancy outcomes in humans through studies in sheep.

Morrison JL, Berry MJ, Botting KJ, Darby JRT, Frasch MG, Gatford KL, Giussani DA, Gray CL, Harding R, Herrera EA, Kemp MW, Lock MC, McMillen IC, Moss TJ, Musk GC, Oliver MH, Regnault TRH, Roberts CT, Soo JY, Tellam RL.

Am J Physiol Regul Integr Comp Physiol. 2018 Dec 1;315(6):R1123-R1153. doi: 10.1152/ajpregu.00391.2017. Epub 2018 Oct 16.


Trans-abdominal in vivo placental vessel occlusion using High Intensity Focused Ultrasound.

Shaw CJ, Rivens I, Civale J, Botting KJ, Ter Haar G, Giussani DA, Lees CC.

Sci Rep. 2018 Sep 11;8(1):13631. doi: 10.1038/s41598-018-31914-4.


Near to One's Heart: The Intimate Relationship Between the Placenta and Fetal Heart.

Camm EJ, Botting KJ, Sferruzzi-Perri AN.

Front Physiol. 2018 Jun 26;9:629. doi: 10.3389/fphys.2018.00629. eCollection 2018. Review.


The role of miRNA regulation in fetal cardiomyocytes, cardiac maturation and the risk of heart disease in adults.

Lock MC, Tellam RL, Botting KJ, Wang KCW, Selvanayagam JB, Brooks DA, Seed M, Morrison JL.

J Physiol. 2018 Dec;596(23):5625-5640. doi: 10.1113/JP276072. Epub 2018 Jun 28.


Guinea pig models for translation of the developmental origins of health and disease hypothesis into the clinic.

Morrison JL, Botting KJ, Darby JRT, David AL, Dyson RM, Gatford KL, Gray C, Herrera EA, Hirst JJ, Kim B, Kind KL, Krause BJ, Matthews SG, Palliser HK, Regnault TRH, Richardson BS, Sasaki A, Thompson LP, Berry MJ.

J Physiol. 2018 Dec;596(23):5535-5569. doi: 10.1113/JP274948. Epub 2018 May 30.


Altered autonomic control of heart rate variability in the chronically hypoxic fetus.

Shaw CJ, Allison BJ, Itani N, Botting KJ, Niu Y, Lees CC, Giussani DA.

J Physiol. 2018 Dec;596(23):6105-6119. doi: 10.1113/JP275659. Epub 2018 Apr 29.


IUGR decreases cardiomyocyte endowment and alters cardiac metabolism in a sex- and cause-of-IUGR-specific manner.

Botting KJ, Loke XY, Zhang S, Andersen JB, Nyengaard JR, Morrison JL.

Am J Physiol Regul Integr Comp Physiol. 2018 Jul 1;315(1):R48-R67. doi: 10.1152/ajpregu.00180.2017. Epub 2018 Mar 21.


Adverse Intrauterine Environment and Cardiac miRNA Expression.

Lock MC, Botting KJ, Tellam RL, Brooks D, Morrison JL.

Int J Mol Sci. 2017 Dec 6;18(12). pii: E2628. doi: 10.3390/ijms18122628. Review.


Akt signaling as a mediator of cardiac adaptation to low birth weight.

Wang KC, Botting KJ, Zhang S, McMillen IC, Brooks DA, Morrison JL.

J Endocrinol. 2017 May;233(2):R81-R94. doi: 10.1530/JOE-17-0039. Epub 2017 Feb 20. Review.


At the heart of accelerated old matter.

Botting KJ, Giussani DA.

J Physiol. 2017 Feb 15;595(4):1009-1010. doi: 10.1113/JP273656. No abstract available.


Early restriction of placental growth results in placental structural and gene expression changes in late gestation independent of fetal hypoxemia.

Zhang S, Barker P, Botting KJ, Roberts CT, McMillan CM, McMillen IC, Morrison JL.

Physiol Rep. 2016 Dec;4(23). pii: e13049.


Noninvasive high-intensity focused ultrasound treatment of twin-twin transfusion syndrome: A preliminary in vivo study.

Shaw CJ, Civale J, Botting KJ, Niu Y, Ter Haar G, Rivens I, Giussani DA, Lees CC.

Sci Transl Med. 2016 Jul 13;8(347):347ra95. doi: 10.1126/scitranslmed.aaf2135.


Fetal in vivo continuous cardiovascular function during chronic hypoxia.

Allison BJ, Brain KL, Niu Y, Kane AD, Herrera EA, Thakor AS, Botting KJ, Cross CM, Itani N, Skeffington KL, Beck C, Giussani DA.

J Physiol. 2016 Mar 1;594(5):1247-64. doi: 10.1113/JP271091.


Regulation of microRNA during cardiomyocyte maturation in sheep.

Morrison JL, Zhang S, Tellam RL, Brooks DA, McMillen IC, Porrello ER, Botting KJ.

BMC Genomics. 2015 Jul 22;16:541. doi: 10.1186/s12864-015-1693-z.


Increased lung prolyl hydroxylase and decreased glucocorticoid receptor are related to decreased surfactant protein in the growth-restricted sheep fetus.

Orgeig S, McGillick EV, Botting KJ, Zhang S, McMillen IC, Morrison JL.

Am J Physiol Lung Cell Mol Physiol. 2015 Jul 1;309(1):L84-97. doi: 10.1152/ajplung.00275.2014. Epub 2015 May 1.


Melatonin modulates the fetal cardiovascular defense response to acute hypoxia.

Thakor AS, Allison BJ, Niu Y, Botting KJ, Serón-Ferré M, Herrera EA, Giussani DA.

J Pineal Res. 2015 Aug;59(1):80-90. doi: 10.1111/jpi.12242. Epub 2015 May 13.


The periconceptional environment and cardiovascular disease: does in vitro embryo culture and transfer influence cardiovascular development and health?

Padhee M, Zhang S, Lie S, Wang KC, Botting KJ, McMillen IC, MacLaughlin SM, Morrison JL.

Nutrients. 2015 Feb 18;7(3):1378-425. doi: 10.3390/nu7031378. Review.


Low birth weight activates the renin-angiotensin system, but limits cardiac angiogenesis in early postnatal life.

Wang KC, Brooks DA, Summers-Pearce B, Bobrovskaya L, Tosh DN, Duffield JA, Botting KJ, Zhang S, Caroline McMillen I, Morrison JL.

Physiol Rep. 2015 Feb 3;3(2). pii: e12270. doi: 10.14814/phy2.12270. Print 2015 Feb 1.


Placental adaptations in growth restriction.

Zhang S, Regnault TR, Barker PL, Botting KJ, McMillen IC, McMillan CM, Roberts CT, Morrison JL.

Nutrients. 2015 Jan 8;7(1):360-89. doi: 10.3390/nu7010360. Review.


Chronic hypoxemia in late gestation decreases cardiomyocyte number but does not change expression of hypoxia-responsive genes.

Botting KJ, McMillen IC, Forbes H, Nyengaard JR, Morrison JL.

J Am Heart Assoc. 2014 Jul 28;3(4). pii: e000531. doi: 10.1161/JAHA.113.000531.


Effects of Maternal Hypoxia during Pregnancy on Bone Development in Offspring: A Guinea Pig Model.

Lee AM, Morrison JL, Botting KJ, Shandala T, Xian CJ.

Int J Endocrinol. 2014;2014:916918. doi: 10.1155/2014/916918. Epub 2014 May 14.


Exposure to rosiglitazone, a PPAR-γ agonist, in late gestation reduces the abundance of factors regulating cardiac metabolism and cardiomyocyte size in the sheep fetus.

Lie S, Hui M, McMillen IC, Muhlhausler BS, Posterino GS, Dunn SL, Wang KC, Botting KJ, Morrison JL.

Am J Physiol Regul Integr Comp Physiol. 2014 Mar 15;306(6):R429-37. doi: 10.1152/ajpregu.00431.2013. Epub 2014 Jan 29.


Cross-bridged cyclen or cyclam Co(III) complexes containing cytotoxic ligands as hypoxia-activated prodrugs.

Chang JY, Lu GL, Stevenson RJ, Brothers PJ, Clark GR, Botting KJ, Ferry DM, Tercel M, Wilson WR, Denny WA, Ware DC.

Inorg Chem. 2013 Jul 1;52(13):7688-98. doi: 10.1021/ic4006967. Epub 2013 Jun 17.


Antenatal steroids and the IUGR fetus: are exposure and physiological effects on the lung and cardiovascular system the same as in normally grown fetuses?

Morrison JL, Botting KJ, Soo PS, McGillick EV, Hiscock J, Zhang S, McMillen IC, Orgeig S.

J Pregnancy. 2012;2012:839656. doi: 10.1155/2012/839656. Epub 2012 Nov 22. Review.


Early origins of heart disease: low birth weight and the role of the insulin-like growth factor system in cardiac hypertrophy.

Wang KC, Botting KJ, Padhee M, Zhang S, McMillen IC, Suter CM, Brooks DA, Morrison JL.

Clin Exp Pharmacol Physiol. 2012 Nov;39(11):958-64. doi: 10.1111/j.1440-1681.2012.05743.x. Review.


IGF-2R-mediated signaling results in hypertrophy of cultured cardiomyocytes from fetal sheep.

Wang KC, Brooks DA, Botting KJ, Morrison JL.

Biol Reprod. 2012 Jun 22;86(6):183. doi: 10.1095/biolreprod.112.100388. Print 2012 Jun.


Maternal undernutrition reduces P-glycoprotein in guinea pig placenta and developing brain in late gestation.

Soo PS, Hiscock J, Botting KJ, Roberts CT, Davey AK, Morrison JL.

Reprod Toxicol. 2012 Jun;33(3):374-81. doi: 10.1016/j.reprotox.2012.01.013. Epub 2012 Feb 9.


Early origins of heart disease: low birth weight and determinants of cardiomyocyte endowment.

Botting KJ, Wang KC, Padhee M, McMillen IC, Summers-Pearce B, Rattanatray L, Cutri N, Posterino GS, Brooks DA, Morrison JL.

Clin Exp Pharmacol Physiol. 2012 Sep;39(9):814-23. doi: 10.1111/j.1440-1681.2011.05649.x. Review.


Fetal growth restriction and the programming of heart growth and cardiac insulin-like growth factor 2 expression in the lamb.

Wang KC, Zhang L, McMillen IC, Botting KJ, Duffield JA, Zhang S, Suter CM, Brooks DA, Morrison JL.

J Physiol. 2011 Oct 1;589(Pt 19):4709-22. doi: 10.1113/jphysiol.2011.211185. Epub 2011 Aug 1.


Changes in cardiac troponins with gestational age explain changes in cardiac muscle contractility in the sheep fetus.

Posterino GS, Dunn SL, Botting KJ, Wang W, Gentili S, Morrison JL.

J Appl Physiol (1985). 2011 Jul;111(1):236-43. doi: 10.1152/japplphysiol.00067.2011. Epub 2011 Apr 14.


Selective treatment of hypoxic tumor cells in vivo: phosphate pre-prodrugs of nitro analogues of the duocarmycins.

Tercel M, Atwell GJ, Yang S, Ashoorzadeh A, Stevenson RJ, Botting KJ, Gu Y, Mehta SY, Denny WA, Wilson WR, Pruijn FB.

Angew Chem Int Ed Engl. 2011 Mar 7;50(11):2606-9. doi: 10.1002/anie.201004456. Epub 2011 Feb 17. No abstract available.


Maternal undernutrition alters fat cell size distribution, but not lipogenic gene expression, in the visceral fat of the late gestation guinea pig fetus.

Nguyen LT, Muhlhausler BS, Botting KJ, Morrison JL.

Placenta. 2010 Oct;31(10):902-9. doi: 10.1016/j.placenta.2010.07.014. Epub 2010 Aug 21.


Hypoxia-activated prodrugs: substituent effects on the properties of nitro seco-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (nitroCBI) prodrugs of DNA minor groove alkylating agents.

Tercel M, Atwell GJ, Yang S, Stevenson RJ, Botting KJ, Boyd M, Smith E, Anderson RF, Denny WA, Wilson WR, Pruijn FB.

J Med Chem. 2009 Nov 26;52(22):7258-72. doi: 10.1021/jm901202b.


Nitro-chloromethylbenzindolines: hypoxia-activated prodrugs of potent adenine N3 DNA minor groove alkylators.

Wilson WR, Stribbling SM, Pruijn FB, Syddall SP, Patterson AV, Liyanage HD, Smith E, Botting KJ, Tercel M.

Mol Cancer Ther. 2009 Oct;8(10):2903-13. doi: 10.1158/1535-7163.MCT-09-0571. Epub 2009 Oct 6.


Second-harmonic generation and two-photon-excited autofluorescence microscopy of cardiomyocytes: quantification of cell volume and myosin filaments.

Wallace SJ, Morrison JL, Botting KJ, Kee TW.

J Biomed Opt. 2008 Nov-Dec;13(6):064018. doi: 10.1117/1.3027970.


Restriction of placental function alters heart development in the sheep fetus.

Morrison JL, Botting KJ, Dyer JL, Williams SJ, Thornburg KL, McMillen IC.

Am J Physiol Regul Integr Comp Physiol. 2007 Jul;293(1):R306-13. Epub 2007 Apr 11.


Contractile and Ca2+-handling properties of the right ventricular papillary muscle in the late-gestation sheep fetus.

Spencer TN, Botting KJ, Morrison JL, Posterino GS.

J Appl Physiol (1985). 2006 Sep;101(3):728-33. Epub 2006 May 25.


Radiolytic and cellular reduction of a novel hypoxia-activated cobalt(III) prodrug of a chloromethylbenzindoline DNA minor groove alkylator.

Ahn GO, Botting KJ, Patterson AV, Ware DC, Tercel M, Wilson WR.

Biochem Pharmacol. 2006 Jun 14;71(12):1683-94. Epub 2006 Mar 14.


Unsymmetrical DNA cross-linking agents: combination of the CBI and PBD pharmacophores.

Tercel M, Stribbling SM, Sheppard H, Siim BG, Wu K, Pullen SM, Botting KJ, Wilson WR, Denny WA.

J Med Chem. 2003 May 22;46(11):2132-51.


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