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Items: 1 to 50 of 201

1.

Can targeted metabolomics predict depression recovery? Results from the CO-MED trial.

Czysz AH, South C, Gadad BS, Arning E, Soyombo A, Bottiglieri T, Trivedi MH.

Transl Psychiatry. 2019 Jan 16;9(1):11. doi: 10.1038/s41398-018-0349-6.

2.

Ultrasound-Guided Hip Injections.

Lynch TS, Oshlag BL, Bottiglieri TS, Desai NN.

J Am Acad Orthop Surg. 2019 Jan 11. doi: 10.5435/JAAOS-D-17-00908. [Epub ahead of print]

PMID:
30640742
3.

Targeted metabolomics to understand the association between arsenic metabolism and diabetes-related outcomes: Preliminary evidence from the Strong Heart Family Study.

Spratlen MJ, Grau-Perez M, Umans JG, Yracheta J, Best LG, Francesconi K, Goessler W, Bottiglieri T, Gamble MV, Cole SA, Zhao J, Navas-Acien A.

Environ Res. 2019 Jan;168:146-157. doi: 10.1016/j.envres.2018.09.034. Epub 2018 Sep 27.

PMID:
30316100
4.

Neuropathology of vitamin B12 deficiency in the Cd320-/- mouse.

Arora K, Sequeira JM, Alarcon JM, Wasek B, Arning E, Bottiglieri T, Quadros EV.

FASEB J. 2019 Feb;33(2):2563-2573. doi: 10.1096/fj.201800754RR. Epub 2018 Oct 10.

PMID:
30303736
5.

Drug-Penetration Gradients Associated with Acquired Drug Resistance in Patients with Tuberculosis.

Dheda K, Lenders L, Magombedze G, Srivastava S, Raj P, Arning E, Ashcraft P, Bottiglieri T, Wainwright H, Pennel T, Linegar A, Moodley L, Pooran A, Pasipanodya JG, Sirgel FA, van Helden PD, Wakeland E, Warren RM, Gumbo T.

Am J Respir Crit Care Med. 2018 Nov 1;198(9):1208-1219. doi: 10.1164/rccm.201711-2333OC.

PMID:
29877726
6.

Methylenetetrahydrofolate Reductase Deficiency Deregulates Regional Brain Amyloid-β Protein Precursor Expression and Phosphorylation Levels.

Hoffman A, Taleski G, Qian H, Wasek B, Arning E, Bottiglieri T, Sontag JM, Sontag E.

J Alzheimers Dis. 2018;64(1):223-237. doi: 10.3233/JAD-180032.

PMID:
29865064
7.

The use of microwave irradiation for quantitative analysis of neurotransmitters in the mouse brain.

Wasek B, Arning E, Bottiglieri T.

J Neurosci Methods. 2018 Sep 1;307:188-193. doi: 10.1016/j.jneumeth.2018.05.016. Epub 2018 May 23.

PMID:
29802857
8.

High prevalence of greater trochanteric pain syndrome among patients presenting to spine clinic for evaluation of degenerative lumbar pathologies.

Tan LA, Benkli B, Tuchman A, Li XJ, Desai NN, Bottiglieri TS, Pavel J, Lenke LG, Lehman RA Jr.

J Clin Neurosci. 2018 Jul;53:89-91. doi: 10.1016/j.jocn.2018.04.030. Epub 2018 Apr 20.

PMID:
29685405
9.

Low Dietary Folate Interacts with MTHFD1 Synthetase Deficiency in Mice, a Model for the R653Q Variant, to Increase Incidence of Developmental Delays and Defects.

Christensen KE, Bahous RH, Hou W, Deng L, Malysheva OV, Arning E, Bottiglieri T, Caudill MA, Jerome-Majewska LA, Rozen R.

J Nutr. 2018 Apr 1;148(4):501-509. doi: 10.1093/jn/nxy013.

PMID:
29659962
10.

Metabolomic studies identify changes in transmethylation and polyamine metabolism in a brain-specific mouse model of tuberous sclerosis complex.

McKenna J 3rd, Kapfhamer D, Kinchen JM, Wasek B, Dunworth M, Murray-Stewart T, Bottiglieri T, Casero RA Jr, Gambello MJ.

Hum Mol Genet. 2018 Jun 15;27(12):2113-2124. doi: 10.1093/hmg/ddy118.

PMID:
29635516
11.

Pharmacokinetics and pharmacodynamics of PEGylated truncated human cystathionine beta-synthase for treatment of homocystinuria.

Majtan T, Bublil EM, Park I, Arning E, Bottiglieri T, Glavin F, Kraus JP.

Life Sci. 2018 May 1;200:15-25. doi: 10.1016/j.lfs.2018.03.018. Epub 2018 Mar 9.

PMID:
29526799
12.

Medical retirement from sport after concussions: A practical guide for a difficult discussion.

Davis-Hayes C, Baker DR, Bottiglieri TS, Levine WN, Desai N, Gossett JD, Noble JM.

Neurol Clin Pract. 2018 Feb;8(1):40-47. doi: 10.1212/CPJ.0000000000000424. Review.

13.

Homocysteine and Dementia: An International Consensus Statement.

Smith AD, Refsum H, Bottiglieri T, Fenech M, Hooshmand B, McCaddon A, Miller JW, Rosenberg IH, Obeid R.

J Alzheimers Dis. 2018;62(2):561-570. doi: 10.3233/JAD-171042.

14.

Gene Environment Interactions and Predictors of Colorectal Cancer in Family-Based, Multi-Ethnic Groups.

Shiao SPK, Grayson J, Yu CH, Wasek B, Bottiglieri T.

J Pers Med. 2018 Feb 16;8(1). pii: E10. doi: 10.3390/jpm8010010.

15.

Circulating Dkk1 and TRAIL Are Associated With Cognitive Decline in Community-Dwelling, Older Adults With Cognitive Concerns.

Ross RD, Shah RC, Leurgans S, Bottiglieri T, Wilson RS, Sumner DR.

J Gerontol A Biol Sci Med Sci. 2018 Nov 10;73(12):1688-1694. doi: 10.1093/gerona/glx252.

PMID:
29432613
16.

Prognostic value of urinary 11-dehydro-thromboxane B2 for mortality: A cohort study of stable coronary artery disease patients treated with aspirin.

Vasudevan A, Tecson KM, Bennett-Firmin J, Bottiglieri T, Lopez LR, Peterson M, Sathyamoorthy M, Schiffmann R, Schussler JM, Swift C, Velasco CE, McCullough PA.

Catheter Cardiovasc Interv. 2018 Oct 1;92(4):653-658. doi: 10.1002/ccd.27437. Epub 2017 Nov 29.

PMID:
29193683
17.

Priapism in a Fabry disease mouse model is associated with upregulated penile nNOS and eNOS expression.

Meng XL, Arning E, Wight-Carter M, Day TS, Jabbarzadeh-Tabrizi S, Chen S, Ziegler RJ, Bottiglieri T, Schneider JW, Cheng SH, Schiffmann R, Shen JS.

J Inherit Metab Dis. 2018 Mar;41(2):231-238. doi: 10.1007/s10545-017-0107-6. Epub 2017 Nov 6.

PMID:
29110178
18.

Dysregulation of methionine metabolism in multiple sclerosis.

Singhal NK, Freeman E, Arning E, Wasek B, Clements R, Sheppard C, Blake P, Bottiglieri T, McDonough J.

Neurochem Int. 2018 Jan;112:1-4. doi: 10.1016/j.neuint.2017.10.011. Epub 2017 Oct 26.

PMID:
29080803
19.

A comprehensive data mining study shows that most nuclear receptors act as newly proposed homeostasis-associated molecular pattern receptors.

Wang L, Nanayakkara G, Yang Q, Tan H, Drummer C, Sun Y, Shao Y, Fu H, Cueto R, Shan H, Bottiglieri T, Li YF, Johnson C, Yang WY, Yang F, Xu Y, Xi H, Liu W, Yu J, Choi ET, Cheng X, Wang H, Yang X.

J Hematol Oncol. 2017 Oct 24;10(1):168. doi: 10.1186/s13045-017-0526-8.

20.

Urinary metabolites in patients undergoing coronary catheterization via the radial versus femoral artery approach.

Vasudevan A, Schussler JM, Won JI, Ashcraft P, Bolanos I, Williams M, Bottiglieri T, Velasco CE, McCullough PA.

Proc (Bayl Univ Med Cent). 2017 Oct;30(4):404-409.

21.

Confirmation that MAT1A p.Ala259Val mutation causes autosomal dominant hypermethioninemia.

Muriello MJ, Viall S, Bottiglieri T, Cusmano-Ozog K, Ferreira CR.

Mol Genet Metab Rep. 2017 Jul 15;13:9-12. doi: 10.1016/j.ymgmr.2017.07.004. eCollection 2017 Dec.

22.

S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research.

Sharma A, Gerbarg P, Bottiglieri T, Massoumi L, Carpenter LL, Lavretsky H, Muskin PR, Brown RP, Mischoulon D; as Work Group of the American Psychiatric Association Council on Research.

J Clin Psychiatry. 2017 Jun;78(6):e656-e667. doi: 10.4088/JCP.16r11113. Review.

23.

The Central Role of Endothelial Dysfunction in Cardiorenal Syndrome.

Zhang J, Bottiglieri T, McCullough PA.

Cardiorenal Med. 2017 Feb;7(2):104-117. doi: 10.1159/000452283. Epub 2016 Dec 29. Review.

24.

Deficiency of superoxide dismutase promotes cerebral vascular hypertrophy and vascular dysfunction in hyperhomocysteinemia.

Dayal S, Baumbach GL, Arning E, Bottiglieri T, Faraci FM, Lentz SR.

PLoS One. 2017 Apr 17;12(4):e0175732. doi: 10.1371/journal.pone.0175732. eCollection 2017.

25.

Corrigendum: Intestinal microbiota as a tetrahydrobiopterin exogenous source in hph-1 mice.

Belik J, Shifrin Y, Arning E, Bottiglieri T, Pan J, Daigneault MC, Allen-Vercoe E.

Sci Rep. 2017 Apr 11;7:44161. doi: 10.1038/srep44161. No abstract available.

26.

Biochemical, physiological and clinical effects of l-methylfolate in schizophrenia: a randomized controlled trial.

Roffman JL, Petruzzi LJ, Tanner AS, Brown HE, Eryilmaz H, Ho NF, Giegold M, Silverstein NJ, Bottiglieri T, Manoach DS, Smoller JW, Henderson DC, Goff DC.

Mol Psychiatry. 2018 Feb;23(2):316-322. doi: 10.1038/mp.2017.41. Epub 2017 Mar 14.

27.

Tetrahydrobiopterin deficiency in the pathogenesis of Fabry disease.

Shen JS, Arning E, West ML, Day TS, Chen S, Meng XL, Forni S, McNeill N, Goker-Alpan O, Wang X, Ashcraft P, Moore DF, Cheng SH, Schiffmann R, Bottiglieri T.

Hum Mol Genet. 2017 Mar 15;26(6):1182-1192. doi: 10.1093/hmg/ddx032.

PMID:
28158561
28.

Urinary 11-Dehydro-Thromboxane B2 and Mortality in Patients With Stable Coronary Artery Disease.

McCullough PA, Vasudevan A, Sathyamoorthy M, Schussler JM, Velasco CE, Lopez LR, Swift C, Peterson M, Bennett-Firmin J, Schiffmann R, Bottiglieri T.

Am J Cardiol. 2017 Apr 1;119(7):972-977. doi: 10.1016/j.amjcard.2016.12.004. Epub 2017 Jan 5.

PMID:
28139223
29.

Intestinal microbiota as a tetrahydrobiopterin exogenous source in hph-1 mice.

Belik J, Shifrin Y, Arning E, Bottiglieri T, Pan J, Daigneault MC, Allen-Vercoe E.

Sci Rep. 2017 Jan 12;7:39854. doi: 10.1038/srep39854. Erratum in: Sci Rep. 2017 Apr 11;7:44161.

30.

Residual thromboxane activity and oxidative stress: influence on mortality in patients with stable coronary artery disease.

Vasudevan A, Bottiglieri T, Tecson KM, Sathyamoorthy M, Schussler JM, Velasco CE, Lopez LR, Swift C, Peterson M, Bennett-Firmin J, Schiffmann R, McCullough PA.

Coron Artery Dis. 2017 Jun;28(4):287-293. doi: 10.1097/MCA.0000000000000461.

PMID:
28005558
31.

Chronic Kidney Disease Induces Inflammatory CD40+ Monocyte Differentiation via Homocysteine Elevation and DNA Hypomethylation.

Yang J, Fang P, Yu D, Zhang L, Zhang D, Jiang X, Yang WY, Bottiglieri T, Kunapuli SP, Yu J, Choi ET, Ji Y, Yang X, Wang H.

Circ Res. 2016 Nov 11;119(11):1226-1241.

32.

Evaluation, management and prevention of lower extremity youth ice hockey injuries.

Popkin CA, Schulz BM, Park CN, Bottiglieri TS, Lynch TS.

Open Access J Sports Med. 2016 Nov 21;7:167-176. eCollection 2016. Review.

33.

Oxidative stress reflected by increased F2-isoprostanes is associated with increasing urinary 11-dehydro thromboxane B2 levels in patients with coronary artery disease.

McCullough PA, Vasudevan A, Lopez LR, Swift C, Peterson M, Bennett-Firmin J, Schiffmann R, Bottiglieri T.

Thromb Res. 2016 Dec;148:85-88. doi: 10.1016/j.thromres.2016.10.022. Epub 2016 Oct 26. No abstract available.

PMID:
27815971
34.

Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development.

Christensen KE, Hou W, Bahous RH, Deng L, Malysheva OV, Arning E, Bottiglieri T, Caudill MA, Jerome-Majewska LA, Rozen R.

Am J Clin Nutr. 2016 Nov;104(5):1459-1469. Epub 2016 Oct 5.

PMID:
27707701
35.

Multicompartment analysis of protein-restricted phenylketonuric mice reveals amino acid imbalances in brain.

Vogel KR, Arning E, Bottiglieri T, Gibson KM.

J Inherit Metab Dis. 2017 Mar;40(2):227-235. doi: 10.1007/s10545-016-9984-3. Epub 2016 Oct 19.

PMID:
27761676
36.

Methionine Metabolites in Patients With Sepsis.

Wexler O, Gough MS, Morgan MAM, Mack CM, Apostolakos MJ, Doolin KP, Mooney RA, Arning E, Bottiglieri T, Pietropaoli AP.

J Intensive Care Med. 2018 Jan;33(1):37-47. doi: 10.1177/0885066616666002. Epub 2016 Sep 2.

PMID:
27591199
37.

Erratum to: LC-MS/MS Analysis of Cerebrospinal Fluid Metabolites in the Pterin Biosynthetic Pathway.

Arning E, Bottiglieri T.

JIMD Rep. 2016;29:115. Epub 2016 Jun 8. No abstract available.

38.

PP2A methylation controls sensitivity and resistance to β-amyloid-induced cognitive and electrophysiological impairments.

Nicholls RE, Sontag JM, Zhang H, Staniszewski A, Yan S, Kim CY, Yim M, Woodruff CM, Arning E, Wasek B, Yin D, Bottiglieri T, Sontag E, Kandel ER, Arancio O.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3347-52. doi: 10.1073/pnas.1521018113. Epub 2016 Mar 7.

39.

Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice.

Ejaz A, Martinez-Guino L, Goldfine AB, Ribas-Aulinas F, De Nigris V, Ribó S, Gonzalez-Franquesa A, Garcia-Roves PM, Li E, Dreyfuss JM, Gall W, Kim JK, Bottiglieri T, Villarroya F, Gerszten RE, Patti ME, Lerin C.

Diabetes. 2016 Apr;65(4):902-12. doi: 10.2337/db15-1094. Epub 2016 Feb 8.

40.

Quantitation of S-Adenosylmethionine and S-Adenosylhomocysteine in Plasma Using Liquid Chromatography-Electrospray Tandem Mass Spectrometry.

Arning E, Bottiglieri T.

Methods Mol Biol. 2016;1378:255-62. doi: 10.1007/978-1-4939-3182-8_27.

PMID:
26602137
41.

Quantitation of 5-Methyltetrahydrofolate in Cerebrospinal Fluid Using Liquid Chromatography-Electrospray Tandem Mass Spectrometry.

Arning E, Bottiglieri T.

Methods Mol Biol. 2016;1378:175-82. doi: 10.1007/978-1-4939-3182-8_19.

PMID:
26602129
42.

Quantification of γ-Aminobutyric Acid in Cerebrospinal Fluid Using Liquid Chromatography-Electrospray Tandem Mass Spectrometry.

Arning E, Bottiglieri T.

Methods Mol Biol. 2016;1378:109-18. doi: 10.1007/978-1-4939-3182-8_13.

PMID:
26602123
43.

Changes in Methionine Metabolism and Histone H3 Trimethylation Are Linked to Mitochondrial Defects in Multiple Sclerosis.

Singhal NK, Li S, Arning E, Alkhayer K, Clements R, Sarcyk Z, Dassanayake RS, Brasch NE, Freeman EJ, Bottiglieri T, McDonough J.

J Neurosci. 2015 Nov 11;35(45):15170-86. doi: 10.1523/JNEUROSCI.4349-14.2015.

44.

A Phase II Randomized, Controlled Trial of S-Adenosylmethionine in Reducing Serum α-Fetoprotein in Patients with Hepatitis C Cirrhosis and Elevated AFP.

Morgan TR, Osann K, Bottiglieri T, Pimstone N, Hoefs JC, Hu KQ, Hassanein T, Boyer TD, Kong L, Chen WP, Richmond E, Gonzalez R, Rodriguez LM, Meyskens FL.

Cancer Prev Res (Phila). 2015 Sep;8(9):864-72. doi: 10.1158/1940-6207.CAPR-15-0029. Epub 2015 Jun 30.

45.

Physiological Competition of Brain Phenylalanine Accretion: Initial Pharmacokinetic Analyses of Aminoisobutyric and Methylaminoisobutyric Acids in Pahenu2-/- Mice.

Vogel KR, Ainslie GR, Phillips B, Arning E, Bottiglieri T, Shen DD, Gibson KM.

Mol Genet Metab Rep. 2015 Jun 1;3:80-87.

46.

Liver transplantation for treatment of severe S-adenosylhomocysteine hydrolase deficiency.

Strauss KA, Ferreira C, Bottiglieri T, Zhao X, Arning E, Zhang S, Zeisel SH, Escolar ML, Presnick N, Puffenberger EG, Vugrek O, Kovacevic L, Wagner C, Mazariegos GV, Mudd SH, Soltys K.

Mol Genet Metab. 2015 Sep-Oct;116(1-2):44-52. doi: 10.1016/j.ymgme.2015.06.005. Epub 2015 Jun 19.

PMID:
26095522
47.

Failed studies should not be used to malign good treatments.

Gerbarg PL, Muskin PR, Bottiglieri T, Brown RP.

J Clin Psychiatry. 2014 Nov;75(11):e1328. doi: 10.4088/JCP.14lr09266. No abstract available.

PMID:
25470102
48.

Protective vascular and cardiac effects of inducible nitric oxide synthase in mice with hyperhomocysteinemia.

Dayal S, Blokhin IO, Erger RA, Jensen M, Arning E, Stevens JW, Bottiglieri T, Faraci FM, Lentz SR.

PLoS One. 2014 Sep 16;9(9):e107734. doi: 10.1371/journal.pone.0107734. eCollection 2014.

49.

LC-MS/MS Analysis of Cerebrospinal Fluid Metabolites in the Pterin Biosynthetic Pathway.

Arning E, Bottiglieri T.

JIMD Rep. 2016;29:1-9. Epub 2014 Sep 12. Erratum in: JIMD Rep. 2016;29:115.

50.

Altered protein phosphatase 2A methylation and Tau phosphorylation in the young and aged brain of methylenetetrahydrofolate reductase (MTHFR) deficient mice.

Sontag JM, Wasek B, Taleski G, Smith J, Arning E, Sontag E, Bottiglieri T.

Front Aging Neurosci. 2014 Aug 22;6:214. doi: 10.3389/fnagi.2014.00214. eCollection 2014.

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