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Items: 42


PTPRC Expression in Blood is Downregulated in Parkinson's and Progressive Supranuclear Palsy Disorders.

Bottero V, Santiago JA, Potashkin JA.

J Parkinsons Dis. 2018;8(4):529-537. doi: 10.3233/JPD-181391.


Evaluation of RNA Blood Biomarkers in the Parkinson's Disease Biomarkers Program.

Santiago JA, Bottero V, Potashkin JA.

Front Aging Neurosci. 2018 May 29;10:157. doi: 10.3389/fnagi.2018.00157. eCollection 2018.


Correction: IFI16 Restricts HSV-1 Replication by Accumulating on the HSV-1 Genome, Repressing HSV-1 Gene Expression, and Directly or Indirectly Modulating Histone Modifications.

Johnson KE, Bottero V, Flaherty S, Dutta S, Singh VV, Chandran B.

PLoS Pathog. 2018 Jun 6;14(6):e1007113. doi: 10.1371/journal.ppat.1007113. eCollection 2018 Jun.


Biological and Clinical Implications of Comorbidities in Parkinson's Disease.

Santiago JA, Bottero V, Potashkin JA.

Front Aging Neurosci. 2017 Dec 4;9:394. doi: 10.3389/fnagi.2017.00394. eCollection 2017. Review.


Dissecting the Molecular Mechanisms of Neurodegenerative Diseases through Network Biology.

Santiago JA, Bottero V, Potashkin JA.

Front Aging Neurosci. 2017 May 29;9:166. doi: 10.3389/fnagi.2017.00166. eCollection 2017.


ESCRT-0 Component Hrs Promotes Macropinocytosis of Kaposi's Sarcoma-Associated Herpesvirus in Human Dermal Microvascular Endothelial Cells.

Veettil MV, Kumar B, Ansari MA, Dutta D, Iqbal J, Gjyshi O, Bottero V, Chandran B.

J Virol. 2016 Mar 28;90(8):3860-3872. doi: 10.1128/JVI.02704-15. Print 2016 Apr.


Kaposi's sarcoma-associated herpesvirus induces Nrf2 activation in latently infected endothelial cells through SQSTM1 phosphorylation and interaction with polyubiquitinated Keap1.

Gjyshi O, Flaherty S, Veettil MV, Johnson KE, Chandran B, Bottero V.

J Virol. 2015 Feb;89(4):2268-86. doi: 10.1128/JVI.02742-14. Epub 2014 Dec 10.


IFI16 restricts HSV-1 replication by accumulating on the hsv-1 genome, repressing HSV-1 gene expression, and directly or indirectly modulating histone modifications.

Johnson KE, Bottero V, Flaherty S, Dutta S, Singh VV, Chandran B.

PLoS Pathog. 2014 Nov 6;10(11):e1004503. doi: 10.1371/journal.ppat.1004503. eCollection 2014 Nov. Erratum in: PLoS Pathog. 2018 Jun 6;14(6):e1007113.


Kaposi's sarcoma-associated herpesvirus induces Nrf2 during de novo infection of endothelial cells to create a microenvironment conducive to infection.

Gjyshi O, Bottero V, Veettil MV, Dutta S, Singh VV, Chikoti L, Chandran B.

PLoS Pathog. 2014 Oct 23;10(10):e1004460. doi: 10.1371/journal.ppat.1004460. eCollection 2014 Oct.


Glutamate secretion and metabotropic glutamate receptor 1 expression during Kaposi's sarcoma-associated herpesvirus infection promotes cell proliferation.

Valiya Veettil M, Dutta D, Bottero V, Bandyopadhyay C, Gjyshi O, Sharma-Walia N, Dutta S, Chandran B.

PLoS Pathog. 2014 Oct 9;10(10):e1004389. doi: 10.1371/journal.ppat.1004389. eCollection 2014 Oct.


Angiogenin interacts with the plasminogen activation system at the cell surface of breast cancer cells to regulate plasmin formation and cell migration.

Dutta S, Bandyopadhyay C, Bottero V, Veettil MV, Wilson L, Pins MR, Johnson KE, Warshall C, Chandran B.

Mol Oncol. 2014 May;8(3):483-507. doi: 10.1016/j.molonc.2013.12.017. Epub 2014 Jan 4.


Kaposi's sarcoma-associated herpesvirus-positive primary effusion lymphoma tumor formation in NOD/SCID mice is inhibited by neomycin and neamine blocking angiogenin's nuclear translocation.

Bottero V, Sadagopan S, Johnson KE, Dutta S, Veettil MV, Chandran B.

J Virol. 2013 Nov;87(21):11806-20. doi: 10.1128/JVI.01920-13. Epub 2013 Aug 28.


Kaposi's sarcoma-associated herpesvirus latency in endothelial and B cells activates gamma interferon-inducible protein 16-mediated inflammasomes.

Singh VV, Kerur N, Bottero V, Dutta S, Chakraborty S, Ansari MA, Paudel N, Chikoti L, Chandran B.

J Virol. 2013 Apr;87(8):4417-31. doi: 10.1128/JVI.03282-12. Epub 2013 Feb 6.


Reactive oxygen species are induced by Kaposi's sarcoma-associated herpesvirus early during primary infection of endothelial cells to promote virus entry.

Bottero V, Chakraborty S, Chandran B.

J Virol. 2013 Feb;87(3):1733-49. doi: 10.1128/JVI.02958-12. Epub 2012 Nov 21.


Kaposi's sarcoma-associated herpesvirus interacts with EphrinA2 receptor to amplify signaling essential for productive infection.

Chakraborty S, Veettil MV, Bottero V, Chandran B.

Proc Natl Acad Sci U S A. 2012 May 8;109(19):E1163-72. doi: 10.1073/pnas.1119592109. Epub 2012 Apr 16.


Angiogenin functionally interacts with p53 and regulates p53-mediated apoptosis and cell survival.

Sadagopan S, Veettil MV, Chakraborty S, Sharma-Walia N, Paudel N, Bottero V, Chandran B.

Oncogene. 2012 Nov 15;31(46):4835-47. doi: 10.1038/onc.2011.648. Epub 2012 Jan 23.


COX-2/PGE2: molecular ambassadors of Kaposi's sarcoma-associated herpes virus oncoprotein-v-FLIP.

Sharma-Walia N, Patel K, Chandran K, Marginean A, Bottero V, Kerur N, Paul AG.

Oncogenesis. 2012 Apr 2;1:e5. doi: 10.1038/oncsis.2012.5.


IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection.

Kerur N, Veettil MV, Sharma-Walia N, Bottero V, Sadagopan S, Otageri P, Chandran B.

Cell Host Microbe. 2011 May 19;9(5):363-75. doi: 10.1016/j.chom.2011.04.008.


Phosphorylation and polyubiquitination of transforming growth factor beta-activated kinase 1 are necessary for activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor.

Bottero V, Kerur N, Sadagopan S, Patel K, Sharma-Walia N, Chandran B.

J Virol. 2011 Mar;85(5):1980-93. doi: 10.1128/JVI.01911-10. Epub 2010 Dec 15.


Characterization of entry and infection of monocytic THP-1 cells by Kaposi's sarcoma associated herpesvirus (KSHV): role of heparan sulfate, DC-SIGN, integrins and signaling.

Kerur N, Veettil MV, Sharma-Walia N, Sadagopan S, Bottero V, Paul AG, Chandran B.

Virology. 2010 Oct 10;406(1):103-16. doi: 10.1016/j.virol.2010.07.012. Epub 2010 Aug 1.


Kaposi's sarcoma associated herpes virus (KSHV) induced COX-2: a key factor in latency, inflammation, angiogenesis, cell survival and invasion.

Sharma-Walia N, Paul AG, Bottero V, Sadagopan S, Veettil MV, Kerur N, Chandran B.

PLoS Pathog. 2010 Feb 12;6(2):e1000777. doi: 10.1371/journal.ppat.1000777.


Kaposi sarcoma-associated herpes virus (KSHV) G protein-coupled receptor (vGPCR) activates the ORF50 lytic switch promoter: a potential positive feedback loop for sustained ORF50 gene expression.

Bottero V, Sharma-Walia N, Kerur N, Paul AG, Sadagopan S, Cannon M, Chandran B.

Virology. 2009 Sep 15;392(1):34-51. doi: 10.1016/j.virol.2009.07.002. Epub 2009 Jul 28.


Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP.

Xia Y, Padre RC, De Mendoza TH, Bottero V, Tergaonkar VB, Verma IM.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2629-34. doi: 10.1073/pnas.0812256106. Epub 2009 Feb 5.


Kaposi's sarcoma-associated herpesvirus upregulates angiogenin during infection of human dermal microvascular endothelial cells, which induces 45S rRNA synthesis, antiapoptosis, cell proliferation, migration, and angiogenesis.

Sadagopan S, Sharma-Walia N, Veettil MV, Bottero V, Levine R, Vart RJ, Chandran B.

J Virol. 2009 Apr;83(7):3342-64. doi: 10.1128/JVI.02052-08. Epub 2009 Jan 21.


Kaposi's sarcoma-associated herpesvirus induces sustained levels of vascular endothelial growth factors A and C early during in vitro infection of human microvascular dermal endothelial cells: biological implications.

Sivakumar R, Sharma-Walia N, Raghu H, Veettil MV, Sadagopan S, Bottero V, Varga L, Levine R, Chandran B.

J Virol. 2008 Feb;82(4):1759-76. Epub 2007 Dec 5.


Inhibition of the NF-kappaB survival pathway via caspase-dependent cleavage of the IKK complex scaffold protein and NF-kappaB essential modulator NEMO.

Frelin C, Imbert V, Bottero V, Gonthier N, Samraj AK, Schulze-Osthoff K, Auberger P, Courtois G, Peyron JF.

Cell Death Differ. 2008 Jan;15(1):152-60. Epub 2007 Oct 12.


Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival.

Ghosh S, Tergaonkar V, Rothlin CV, Correa RG, Bottero V, Bist P, Verma IM, Hunter T.

Cancer Cell. 2006 Sep;10(3):215-26.


UV-mediated NF-kappaB activation is abolished in deficient XPC/D primary fibroblasts.

Muotri AR, Bottero V, Tergaonkar V, Correa RG.

Cell Cycle. 2006 May;5(10):1085-9. Epub 2006 May 15.


Gene therapy: therapeutic gene causing lymphoma.

Woods NB, Bottero V, Schmidt M, von Kalle C, Verma IM.

Nature. 2006 Apr 27;440(7088):1123.


NF-kappaB and the regulation of hematopoiesis.

Bottero V, Withoff S, Verma IM.

Cell Death Differ. 2006 May;13(5):785-97. Review.


NF-kappaB modulation and ionizing radiation: mechanisms and future directions for cancer treatment.

Magné N, Toillon RA, Bottero V, Didelot C, Houtte PV, Gérard JP, Peyron JF.

Cancer Lett. 2006 Jan 18;231(2):158-68. Review.


Enhanced NF-kappaB activation and cellular function in macrophages lacking IkappaB kinase 1 (IKK1).

Li Q, Lu Q, Bottero V, Estepa G, Morrison L, Mercurio F, Verma IM.

Proc Natl Acad Sci U S A. 2005 Aug 30;102(35):12425-30. Epub 2005 Aug 22.


Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit.

Ducut Sigala JL, Bottero V, Young DB, Shevchenko A, Mercurio F, Verma IM.

Science. 2004 Jun 25;304(5679):1963-7.


Monitoring NF-kappa B transactivation potential via real-time PCR quantification of I kappa B-alpha gene expression.

Bottero V, Imbert V, Frelin C, Formento JL, Peyron JF.

Mol Diagn. 2003;7(3-4):187-94.


Blocking NF-kappaB activation in Jurkat leukemic T cells converts the survival agent and tumor promoter PMA into an apoptotic effector.

Busuttil V, Bottero V, Frelin C, Imbert V, Ricci JE, Auberger P, Peyron JF.

Oncogene. 2002 May 9;21(20):3213-24.


Rat liver injury after normothermic ischemia is prevented by a phosphinic matrix metalloproteinase inhibitor.

Cursio R, Mari B, Louis K, Rostagno P, Saint-Paul MC, Giudicelli J, Bottero V, Anglard P, Yiotakis A, Dive V, Gugenheim J, Auberger P.

FASEB J. 2002 Jan;16(1):93-5. Epub 2001 Nov 14.


Activation of nuclear factor kappaB through the IKK complex by the topoisomerase poisons SN38 and doxorubicin: a brake to apoptosis in HeLa human carcinoma cells.

Bottero V, Busuttil V, Loubat A, Magné N, Fischel JL, Milano G, Peyron JF.

Cancer Res. 2001 Nov 1;61(21):7785-91.


Ikappa b-alpha, the NF-kappa B inhibitory subunit, interacts with ANT, the mitochondrial ATP/ADP translocator.

Bottero V, Rossi F, Samson M, Mari M, Hofman P, Peyron JF.

J Biol Chem. 2001 Jun 15;276(24):21317-24. Epub 2001 Apr 3.

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