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Functional Diversity of Myeloid-Derived Suppressor Cells: The Multitasking Hydra of Cancer.

Jayakumar A, Bothwell ALM.

J Immunol. 2019 Sep 1;203(5):1095-1103. doi: 10.4049/jimmunol.1900500. Review.


Dickkopf1: An immunomodulatory ligand and Wnt antagonist in pathological inflammation.

Chae WJ, Bothwell ALM.

Differentiation. 2019 Jul - Aug;108:33-39. doi: 10.1016/j.diff.2019.05.003. Epub 2019 Jun 12. Review.


RIPK3-Induced Inflammation by I-MDSCs Promotes Intestinal Tumors.

Jayakumar A, Bothwell ALM.

Cancer Res. 2019 Apr 1;79(7):1587-1599. doi: 10.1158/0008-5472.CAN-18-2153. Epub 2019 Feb 20.


Canonical and Non-Canonical Wnt Signaling in Immune Cells.

Chae WJ, Bothwell ALM.

Trends Immunol. 2018 Oct;39(10):830-847. doi: 10.1016/ Epub 2018 Sep 10. Review.


Regulation of human T cell responses by dNP2-ctCTLA-4 inhibits human skin and microvessel graft rejection.

Lim S, Kirkiles-Smith NC, Pober JS, Bothwell ALM, Choi JM.

Biomaterials. 2018 Nov;183:128-138. doi: 10.1016/j.biomaterials.2018.08.049. Epub 2018 Aug 21.


Therapeutic Potential of Gene-Modified Regulatory T Cells: From Bench to Bedside.

Chae WJ, Bothwell ALM.

Front Immunol. 2018 Feb 16;9:303. doi: 10.3389/fimmu.2018.00303. eCollection 2018. Review.


DKK2 imparts tumor immunity evasion through β-catenin-independent suppression of cytotoxic immune-cell activation.

Xiao Q, Wu J, Wang WJ, Chen S, Zheng Y, Yu X, Meeth K, Sahraei M, Bothwell ALM, Chen L, Bosenberg M, Chen J, Sexl V, Sun L, Li L, Tang W, Wu D.

Nat Med. 2018 Mar;24(3):262-270. doi: 10.1038/nm.4496. Epub 2018 Feb 12.


Intranuclear delivery of the transcription modulation domain of Tbet-improved lupus nephritis in (NZB/NZW) F1 lupus-prone mice.

Moon JS, Mun CH, Kim JH, Cho JY, Park SD, Park TY, Shin JS, Ho CC, Park YB, Ghosh S, Bothwell ALM, Lee SW, Lee SK.

Kidney Int. 2018 May;93(5):1118-1130. doi: 10.1016/j.kint.2017.11.017. Epub 2018 Mar 2.


Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein can reflect systemic lupus erythematosus activity.

Ahn SS, Park Y, Lee DD, Bothwell ALM, Jung SM, Song JJ, Park YB, Lee SW.

Lupus. 2018 Apr;27(5):771-779. doi: 10.1177/0961203317747719. Epub 2017 Dec 12.


Stat6 Promotes Intestinal Tumorigenesis in a Mouse Model of Adenomatous Polyposis by Expansion of MDSCs and Inhibition of Cytotoxic CD8 Response.

Jayakumar A, Bothwell ALM.

Neoplasia. 2017 Aug;19(8):595-605. doi: 10.1016/j.neo.2017.04.006. Epub 2017 Jun 24.


Membrane-bound Dickkopf-1 in Foxp3+ regulatory T cells suppresses T-cell-mediated autoimmune colitis.

Chae WJ, Park JH, Henegariu O, Yilmaz S, Hao L, Bothwell ALM.

Immunology. 2017 Oct;152(2):265-275. doi: 10.1111/imm.12766. Epub 2017 Jun 27.


Snapshots of CD4+ T cell plasticity in the pathogenesis of allergic asthma.

Chae WJ, Bothwell AL.

J Thorac Dis. 2016 Sep;8(9):E1010-E1012. No abstract available.


Sex-Based Selectivity of PPARγ Regulation in Th1, Th2, and Th17 Differentiation.

Park HJ, Park HS, Lee JU, Bothwell AL, Choi JM.

Int J Mol Sci. 2016 Aug 18;17(8). pii: E1347. doi: 10.3390/ijms17081347.


Gender-specific differences in PPARγ regulation of follicular helper T cell responses with estrogen.

Park HJ, Park HS, Lee JU, Bothwell AL, Choi JM.

Sci Rep. 2016 Jun 23;6:28495. doi: 10.1038/srep28495.


Blocking MHC class II on human endothelium mitigates acute rejection.

Abrahimi P, Qin L, Chang WG, Bothwell AL, Tellides G, Saltzman WM, Pober JS.

JCI Insight. 2016;1(1). pii: e85293. Epub 2016 Jan 21.


The Wnt Antagonist Dickkopf-1 Promotes Pathological Type 2 Cell-Mediated Inflammation.

Chae WJ, Ehrlich AK, Chan PY, Teixeira AM, Henegariu O, Hao L, Shin JH, Park JH, Tang WH, Kim ST, Maher SE, Goldsmith-Pestana K, Shan P, Hwa J, Lee PJ, Krause DS, Rothlin CV, McMahon-Pratt D, Bothwell AL.

Immunity. 2016 Feb 16;44(2):246-58. doi: 10.1016/j.immuni.2016.01.008. Epub 2016 Feb 9.


dNP2 is a blood-brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis.

Lim S, Kim WJ, Kim YH, Lee S, Koo JH, Lee JA, Yoon H, Kim DH, Park HJ, Kim HM, Lee HG, Yun Kim J, Lee JU, Hun Shin J, Kyun Kim L, Doh J, Kim H, Lee SK, Bothwell ALM, Suh M, Choi JM.

Nat Commun. 2015 Sep 15;6:8244. doi: 10.1038/ncomms9244.


Spontaneous Intestinal Tumorigenesis in Apc (/Min+) Mice Requires Altered T Cell Development with IL-17A.

Chae WJ, Bothwell AL.

J Immunol Res. 2015;2015:860106. doi: 10.1155/2015/860106. Epub 2015 Jun 3.


RORγt-specific transcriptional interactomic inhibition suppresses autoimmunity associated with TH17 cells.

Park TY, Park SD, Cho JY, Moon JS, Kim NY, Park K, Seong RH, Lee SW, Morio T, Bothwell AL, Lee SK.

Proc Natl Acad Sci U S A. 2014 Dec 30;111(52):18673-8. doi: 10.1073/pnas.1413687112. Epub 2014 Dec 19. Erratum in: Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E2115.


The immunotherapeutic role of regulatory T cells in Leishmania (Viannia) panamensis infection.

Ehrlich A, Castilho TM, Goldsmith-Pestana K, Chae WJ, Bothwell AL, Sparwasser T, McMahon-Pratt D.

J Immunol. 2014 Sep 15;193(6):2961-70. doi: 10.4049/jimmunol.1400728. Epub 2014 Aug 6.


Intranuclear interactomic inhibition of FoxP3 suppresses functions of Treg cells.

Park JH, Ko JS, Shin Y, Cho JY, Oh HA, Bothwell AL, Lee SK.

Biochem Biophys Res Commun. 2014 Aug 15;451(1):1-7. doi: 10.1016/j.bbrc.2014.06.141. Epub 2014 Jul 17. Erratum in: Biochem Biophys Res Commun. 2014 Sep 12;452(1):205. Bothwell, Alfred M [corrected to Bothwell, Alfred L M].


PPARγ negatively regulates T cell activation to prevent follicular helper T cells and germinal center formation.

Park HJ, Kim DH, Choi JY, Kim WJ, Kim JY, Senejani AG, Hwang SS, Kim LK, Tobiasova Z, Lee GR, Craft J, Bothwell AL, Choi JM.

PLoS One. 2014 Jun 12;9(6):e99127. doi: 10.1371/journal.pone.0099127. eCollection 2014.


A humanized mouse model of autoimmune insulitis.

Viehmann Milam AA, Maher SE, Gibson JA, Lebastchi J, Wen L, Ruddle NH, Herold KC, Bothwell AL.

Diabetes. 2014 May;63(5):1712-24. doi: 10.2337/db13-1141. Epub 2014 Jan 29.


Interplay between DNA repair and inflammation, and the link to cancer.

Kidane D, Chae WJ, Czochor J, Eckert KA, Glazer PM, Bothwell AL, Sweasy JB.

Crit Rev Biochem Mol Biol. 2014 Mar-Apr;49(2):116-39. doi: 10.3109/10409238.2013.875514. Epub 2014 Jan 13. Review.


Mutation of POLB causes lupus in mice.

Senejani AG, Liu Y, Kidane D, Maher SE, Zeiss CJ, Park HJ, Kashgarian M, McNiff JM, Zelterman D, Bothwell AL, Sweasy JB.

Cell Rep. 2014 Jan 16;6(1):1-8. doi: 10.1016/j.celrep.2013.12.017. Epub 2014 Jan 2.


Neuroprotection against neuroblastoma cell death induced by depletion of mitochondrial glutathione.

Dukhande VV, Kawikova I, Bothwell AL, Lai JC.

Apoptosis. 2013 Jun;18(6):702-12. doi: 10.1007/s10495-013-0836-4.


An electrospun scaffold integrating nucleic acid delivery for treatment of full-thickness wounds.

Kobsa S, Kristofik NJ, Sawyer AJ, Bothwell AL, Kyriakides TR, Saltzman WM.

Biomaterials. 2013 May;34(15):3891-901. doi: 10.1016/j.biomaterials.2013.02.016. Epub 2013 Feb 27.


The nuclear receptor PPARs as important regulators of T-cell functions and autoimmune diseases.

Choi JM, Bothwell AL.

Mol Cells. 2012 Mar;33(3):217-22. doi: 10.1007/s10059-012-2297-y. Epub 2012 Feb 28. Review.


Risperidone-related improvement of irritability in children with autism is not associated with changes in serum of epidermal growth factor and interleukin-13.

Tobiasova Z, van der Lingen KH, Scahill L, Leckman JF, Zhang Y, Chae W, McCracken JT, McDougle CJ, Vitiello B, Tierney E, Aman MG, Arnold LE, Katsovich L, Hoekstra PJ, Volkmar F, Bothwell AL, Kawikova I.

J Child Adolesc Psychopharmacol. 2011 Dec;21(6):555-64. doi: 10.1089/cap.2010.0134. Epub 2011 Nov 9.


Reperfusion injury intensifies the adaptive human T cell alloresponse in a human-mouse chimeric artery model.

Yi T, Fogal B, Hao Z, Tobiasova Z, Wang C, Rao DA, Al-Lamki RS, Kirkiles-Smith NC, Kulkarni S, Bradley JR, Bothwell AL, Sessa WC, Tellides G, Pober JS.

Arterioscler Thromb Vasc Biol. 2012 Feb;32(2):353-60. doi: 10.1161/ATVBAHA.111.239285. Epub 2011 Nov 3.


IL-17F deficiency inhibits small intestinal tumorigenesis in ApcMin/+ mice.

Chae WJ, Bothwell AL.

Biochem Biophys Res Commun. 2011 Oct 14;414(1):31-6. doi: 10.1016/j.bbrc.2011.09.016. Epub 2011 Sep 12.


Peroxisome proliferator-activated receptor-γ agonists prevent in vivo remodeling of human artery induced by alloreactive T cells.

Tobiasova Z, Zhang L, Yi T, Qin L, Manes TD, Kulkarni S, Lorber MI, Rodriguez FC, Choi JM, Tellides G, Pober JS, Kawikova I, Bothwell AL.

Circulation. 2011 Jul 12;124(2):196-205. doi: 10.1161/CIRCULATIONAHA.110.015396. Epub 2011 Jun 20.


Altered immunoglobulin profiles in children with Tourette syndrome.

Bos-Veneman NG, Olieman R, Tobiasova Z, Hoekstra PJ, Katsovich L, Bothwell AL, Leckman JF, Kawikova I.

Brain Behav Immun. 2011 Mar;25(3):532-8. doi: 10.1016/j.bbi.2010.12.003. Epub 2010 Dec 13.


Cell-permeable Foxp3 protein alleviates autoimmune disease associated with inflammatory bowel disease and allergic airway inflammation.

Choi JM, Shin JH, Sohn MH, Harding MJ, Park JH, Tobiasova Z, Kim DY, Maher SE, Chae WJ, Park SH, Lee CG, Lee SK, Bothwell AL.

Proc Natl Acad Sci U S A. 2010 Oct 26;107(43):18575-80. doi: 10.1073/pnas.1000400107. Epub 2010 Oct 11. Erratum in: Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21943.


An implantable vascularized protein gel construct that supports human fetal hepatoblast survival and infection by hepatitis C virus in mice.

Harding MJ, Lepus CM, Gibson TF, Shepherd BR, Gerber SA, Graham M, Paturzo FX, Rahner C, Madri JA, Bothwell AL, Lindenbach BD, Pober JS.

PLoS One. 2010 Apr 1;5(4):e9987. doi: 10.1371/journal.pone.0009987.


Ablation of IL-17A abrogates progression of spontaneous intestinal tumorigenesis.

Chae WJ, Gibson TF, Zelterman D, Hao L, Henegariu O, Bothwell AL.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5540-4. doi: 10.1073/pnas.0912675107. Epub 2010 Mar 8.


Elevated expression of MCP-1, IL-2 and PTPR-N in basal ganglia of Tourette syndrome cases.

Morer A, Chae W, Henegariu O, Bothwell AL, Leckman JF, Kawikova I.

Brain Behav Immun. 2010 Oct;24(7):1069-73. doi: 10.1016/j.bbi.2010.02.007. Epub 2010 Mar 1.


Children with Tourette's syndrome may suffer immunoglobulin A dysgammaglobulinemia: preliminary report.

Kawikova I, Grady BP, Tobiasova Z, Zhang Y, Vojdani A, Katsovich L, Richmand BJ, Park TW, Bothwell AL, Leckman JF.

Biol Psychiatry. 2010 Apr 1;67(7):679-83. doi: 10.1016/j.biopsych.2009.09.034. Epub 2009 Dec 14.


Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiation.

Das J, Ren G, Zhang L, Roberts AI, Zhao X, Bothwell AL, Van Kaer L, Shi Y, Das G.

J Exp Med. 2009 Oct 26;206(11):2407-16. doi: 10.1084/jem.20082286. Epub 2009 Sep 28. Erratum in: J Exp Med. 2009 Dec 21;206(13):3157.


Comparison of human fetal liver, umbilical cord blood, and adult blood hematopoietic stem cell engraftment in NOD-scid/gammac-/-, Balb/c-Rag1-/-gammac-/-, and C.B-17-scid/bg immunodeficient mice.

Lepus CM, Gibson TF, Gerber SA, Kawikova I, Szczepanik M, Hossain J, Ablamunits V, Kirkiles-Smith N, Herold KC, Donis RO, Bothwell AL, Pober JS, Harding MJ.

Hum Immunol. 2009 Oct;70(10):790-802. doi: 10.1016/j.humimm.2009.06.005. Epub 2009 Jun 12.


Transduction of the cytoplasmic domain of CTLA-4 inhibits TcR-specific activation signals and prevents collagen-induced arthritis.

Choi JM, Kim SH, Shin JH, Gibson T, Yoon BS, Lee DH, Lee SK, Bothwell AL, Lim JS, Lee SK.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19875-80. doi: 10.1073/pnas.0805198105. Epub 2008 Dec 9.


Promotion of beta-cell differentiation in pancreatic precursor cells by adult islet cells.

Chen W, Begum S, Opare-Addo L, Garyu J, Gibson TF, Bothwell AL, Papaioannou VE, Herold KC.

Endocrinology. 2009 Feb;150(2):570-9. doi: 10.1210/en.2008-1009. Epub 2008 Oct 9.


Amelioration of human allograft arterial injury by atorvastatin or simvastatin correlates with reduction of interferon-gamma production by infiltrating T cells.

Yi T, Rao DA, Tang PC, Wang Y, Cuchara LA, Bothwell AL, Colangelo CM, Tellides G, Pober JS, Lorber MI.

Transplantation. 2008 Sep 15;86(5):719-27. doi: 10.1097/TP.0b013e318183eefa.


Pax5 and linker histone H1 coordinate DNA methylation and histone modifications in the 3' regulatory region of the immunoglobulin heavy chain locus.

Giambra V, Volpi S, Emelyanov AV, Pflugh D, Bothwell AL, Norio P, Fan Y, Ju Z, Skoultchi AI, Hardy RR, Frezza D, Birshtein BK.

Mol Cell Biol. 2008 Oct;28(19):6123-33. doi: 10.1128/MCB.00233-08. Epub 2008 Jul 21.


Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation.

Bai Y, Ahmad U, Wang Y, Li JH, Choy JC, Kim RW, Kirkiles-Smith N, Maher SE, Karras JG, Bennett CF, Bothwell AL, Pober JS, Tellides G.

J Biol Chem. 2008 Mar 14;283(11):6832-42. doi: 10.1074/jbc.M706021200. Epub 2008 Jan 11.


Regulatory transplantation tolerance and "stemness": evidence that Foxp3 may play a regulatory role in SOCS-3 gene transcription.

Muthukumarana P, Chae WJ, Maher S, Rosengard BR, Bothwell AL, Metcalfe SM.

Transplantation. 2007 Jul 15;84(1 Suppl):S6-11.


Pivotal roles of CD8+ T cells restricted by MHC class I-like molecules in autoimmune diseases.

Das G, Das J, Eynott P, Zhang Y, Bothwell AL, Van Kaer L, Shi Y.

J Exp Med. 2006 Nov 27;203(12):2603-11. Epub 2006 Nov 6.


Manganese treatment modulates the expression of peroxisome proliferator-activated receptors in astrocytoma and neuroblastoma cells.

Isaac AO, Kawikova I, Bothwell AL, Daniels CK, Lai JC.

Neurochem Res. 2006 Nov;31(11):1305-16. Epub 2006 Oct 20.


Decreased numbers of regulatory T cells suggest impaired immune tolerance in children with tourette syndrome: a preliminary study.

Kawikova I, Leckman JF, Kronig H, Katsovich L, Bessen DE, Ghebremichael M, Bothwell AL.

Biol Psychiatry. 2007 Feb 1;61(3):273-8. Epub 2006 Sep 25.


A limited number of genes are involved in the differentiation of germinal center B cells.

Nakayama Y, Stabach P, Maher SE, Mahajan MC, Masiar P, Liao C, Zhang X, Ye ZJ, Tuck D, Bothwell AL, Newburger PE, Weissman SM.

J Cell Biochem. 2006 Dec 1;99(5):1308-25.


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