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Items: 19

1.

Folding Status Is Determinant over Traffic-Competence in Defining CFTR Interactors in the Endoplasmic Reticulum.

Santos JD, Canato S, Carvalho AS, Botelho HM, Aloria K, Amaral MD, Matthiesen R, Falcao AO, Farinha CM.

Cells. 2019 Apr 14;8(4). pii: E353. doi: 10.3390/cells8040353.

2.

Unravelling the antitumoral potential of novel bis(thiosemicarbazonato) Zn(II) complexes: structural and cellular studies.

Palma E, Botelho HM, Morais GR, Rodrigues I, Santos IC, Campello MPC, Raposinho P, Belchior A, Gomes SS, Araújo MF, Correia I, Ribeiro N, Gama S, Mendes F, Paulo A.

J Biol Inorg Chem. 2019 Feb;24(1):71-89. doi: 10.1007/s00775-018-1629-6. Epub 2018 Nov 24.

PMID:
30474755
3.

R560S: A class II CFTR mutation that is not rescued by current modulators.

Awatade NT, Ramalho S, Silva IAL, Felício V, Botelho HM, de Poel E, Vonk A, Beekman JM, Farinha CM, Amaral MD.

J Cyst Fibros. 2019 Mar;18(2):182-189. doi: 10.1016/j.jcf.2018.07.001. Epub 2018 Jul 18.

PMID:
30030066
4.

The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation.

Cristóvão JS, Morris VK, Cardoso I, Leal SS, Martínez J, Botelho HM, Göbl C, David R, Kierdorf K, Alemi M, Madl T, Fritz G, Reif B, Gomes CM.

Sci Adv. 2018 Jun 29;4(6):eaaq1702. doi: 10.1126/sciadv.aaq1702. eCollection 2018 Jun.

5.

A novel microscopy-based assay identifies extended synaptotagmin-1 (ESYT1) as a positive regulator of anoctamin 1 traffic.

Lérias JR, Pinto MC, Botelho HM, Awatade NT, Quaresma MC, Silva IAL, Wanitchakool P, Schreiber R, Pepperkok R, Kunzelmann K, Amaral MD.

Biochim Biophys Acta Mol Cell Res. 2018 Feb;1865(2):421-431. doi: 10.1016/j.bbamcr.2017.11.009. Epub 2017 Nov 15.

6.

Investigating Alternative Transport of Integral Plasma Membrane Proteins from the ER to the Golgi: Lessons from the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).

Amaral MD, Farinha CM, Matos P, Botelho HM.

Methods Mol Biol. 2016;1459:105-26. doi: 10.1007/978-1-4939-3804-9_7.

PMID:
27665554
7.

Correction of a Cystic Fibrosis Splicing Mutation by Antisense Oligonucleotides.

Igreja S, Clarke LA, Botelho HM, Marques L, Amaral MD.

Hum Mutat. 2016 Feb;37(2):209-15. doi: 10.1002/humu.22931. Epub 2015 Dec 2.

PMID:
26553470
8.

Transcriptome meta-analysis reveals common differential and global gene expression profiles in cystic fibrosis and other respiratory disorders and identifies CFTR regulators.

Clarke LA, Botelho HM, Sousa L, Falcao AO, Amaral MD.

Genomics. 2015 Nov;106(5):268-77. doi: 10.1016/j.ygeno.2015.07.005. Epub 2015 Jul 29.

9.

Protein traffic disorders: an effective high-throughput fluorescence microscopy pipeline for drug discovery.

Botelho HM, Uliyakina I, Awatade NT, Proença MC, Tischer C, Sirianant L, Kunzelmann K, Pepperkok R, Amaral MD.

Sci Rep. 2015 Mar 12;5:9038. doi: 10.1038/srep09038.

10.

Intrinsically disordered and aggregation prone regions underlie β-aggregation in S100 proteins.

Carvalho SB, Botelho HM, Leal SS, Cardoso I, Fritz G, Gomes CM.

PLoS One. 2013 Oct 1;8(10):e76629. doi: 10.1371/journal.pone.0076629. eCollection 2013.

11.

Biochemical and biophysical characterization of recombinant yeast proteasome maturation factor ump1.

Sá-Moura B, Simões AM, Fraga J, Fernandes H, Abreu IA, Botelho HM, Gomes CM, Marques AJ, Dohmen RJ, Ramos PC, Macedo-Ribeiro S.

Comput Struct Biotechnol J. 2013 Sep 10;7:e201304006. doi: 10.5936/csbj.201304006. eCollection 2013.

12.

S100A6 amyloid fibril formation is calcium-modulated and enhances superoxide dismutase-1 (SOD1) aggregation.

Botelho HM, Leal SS, Cardoso I, Yanamandra K, Morozova-Roche LA, Fritz G, Gomes CM.

J Biol Chem. 2012 Dec 7;287(50):42233-42. doi: 10.1074/jbc.M112.396416. Epub 2012 Oct 17.

13.

Analysis of S100 oligomers and amyloids.

Botelho HM, Fritz G, Gomes CM.

Methods Mol Biol. 2012;849:373-86. doi: 10.1007/978-1-61779-551-0_25.

PMID:
22528103
14.

The sulfur oxygenase reductase from the mesophilic bacterium Halothiobacillus neapolitanus is a highly active thermozyme.

Veith A, Botelho HM, Kindinger F, Gomes CM, Kletzin A.

J Bacteriol. 2012 Feb;194(3):677-85. doi: 10.1128/JB.06531-11. Epub 2011 Dec 2.

15.

Structural reorganization renders enhanced metalloprotein stability.

Botelho HM, Gomes CM.

Chem Commun (Camb). 2011 Oct 21;47(39):11149-51. doi: 10.1039/c1cc13354c. Epub 2011 Sep 6.

PMID:
21894348
16.

Natural and amyloid self-assembly of S100 proteins: structural basis of functional diversity.

Fritz G, Botelho HM, Morozova-Roche LA, Gomes CM.

FEBS J. 2010 Nov;277(22):4578-90. doi: 10.1111/j.1742-4658.2010.07887.x. Review.

17.

Role of a novel disulfide bridge within the all-beta fold of soluble Rieske proteins.

Botelho HM, Leal SS, Veith A, Prosinecki V, Bauer C, Fröhlich R, Kletzin A, Gomes CM.

J Biol Inorg Chem. 2010 Feb;15(2):271-81. doi: 10.1007/s00775-009-0596-3. Epub 2009 Oct 28.

PMID:
19862563
18.

Metal ions modulate the folding and stability of the tumor suppressor protein S100A2.

Botelho HM, Koch M, Fritz G, Gomes CM.

FEBS J. 2009 Mar;276(6):1776-86. doi: 10.1111/j.1742-4658.2009.06912.x.

19.

A proteomic approach toward the selection of proteins with enhanced intrinsic conformational stability.

Prosinecki V, Botelho HM, Francese S, Mastrobuoni G, Moneti G, Urich T, Kletzin A, Gomes CM.

J Proteome Res. 2006 Oct;5(10):2720-6.

PMID:
17022643

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