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Items: 1 to 50 of 141

1.

Conformational control and DNA-binding mechanism of the metazoan origin recognition complex.

Bleichert F, Leitner A, Aebersold R, Botchan MR, Berger JM.

Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5906-E5915. doi: 10.1073/pnas.1806315115. Epub 2018 Jun 13.

2.

Not just Salk.

Greider C, Hopkins N, Steitz J, Amon A, Asai D, Barres B, Bass B, Bassler B, Birgeneau R, Bjorkman P, Botchan M, Brugge J, Cech T, Colwell R, Craig N, deLange T, Eisen M, Gottesman S, Green R, Handelsman J, Kimble J, King MC, Lehmann R, Marder E, Mullins D, O'Shea E, Schmid S, Seydoux G, Spradling A, Storz G, Szostak J, Telesnitsky A, Tilghman S, Tjian R, Vale R, Wolberger C, Zakian V.

Science. 2017 Sep 15;357(6356):1105-1106. doi: 10.1126/science.aao6221. No abstract available.

PMID:
28912235
3.

Mechanisms for initiating cellular DNA replication.

Bleichert F, Botchan MR, Berger JM.

Science. 2017 Feb 24;355(6327). pii: eaah6317. doi: 10.1126/science.aah6317. Epub 2017 Feb 16. Review.

PMID:
28209641
4.

Mechanisms and regulation of DNA replication initiation in eukaryotes.

Parker MW, Botchan MR, Berger JM.

Crit Rev Biochem Mol Biol. 2017 Apr;52(2):107-144. doi: 10.1080/10409238.2016.1274717. Epub 2017 Jan 17. Review.

5.

CRISPR germline engineering--the community speaks.

Bosley KS, Botchan M, Bredenoord AL, Carroll D, Charo RA, Charpentier E, Cohen R, Corn J, Doudna J, Feng G, Greely HT, Isasi R, Ji W, Kim JS, Knoppers B, Lanphier E, Li J, Lovell-Badge R, Martin GS, Moreno J, Naldini L, Pera M, Perry AC, Venter JC, Zhang F, Zhou Q.

Nat Biotechnol. 2015 May;33(5):478-86. doi: 10.1038/nbt.3227. No abstract available.

PMID:
25965754
6.

Biotechnology. A prudent path forward for genomic engineering and germline gene modification.

Baltimore D, Berg P, Botchan M, Carroll D, Charo RA, Church G, Corn JE, Daley GQ, Doudna JA, Fenner M, Greely HT, Jinek M, Martin GS, Penhoet E, Puck J, Sternberg SH, Weissman JS, Yamamoto KR.

Science. 2015 Apr 3;348(6230):36-8. doi: 10.1126/science.aab1028. Epub 2015 Mar 19. No abstract available.

7.

Crystal structure of the eukaryotic origin recognition complex.

Bleichert F, Botchan MR, Berger JM.

Nature. 2015 Mar 19;519(7543):321-6. doi: 10.1038/nature14239. Epub 2015 Mar 11.

8.

Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement.

Petojevic T, Pesavento JJ, Costa A, Liang J, Wang Z, Berger JM, Botchan MR.

Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):E249-58. doi: 10.1073/pnas.1422003112. Epub 2015 Jan 5.

9.

Chromatin reader L(3)mbt requires the Myb-MuvB/DREAM transcriptional regulatory complex for chromosomal recruitment.

Blanchard DP, Georlette D, Antoszewski L, Botchan MR.

Proc Natl Acad Sci U S A. 2014 Oct 7;111(40):E4234-43. doi: 10.1073/pnas.1416321111. Epub 2014 Sep 23.

10.

DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome.

Costa A, Renault L, Swuec P, Petojevic T, Pesavento JJ, Ilves I, MacLellan-Gibson K, Fleck RA, Botchan MR, Berger JM.

Elife. 2014 Aug 12;3:e03273. doi: 10.7554/eLife.03273.

11.

A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation.

Bleichert F, Balasov M, Chesnokov I, Nogales E, Botchan MR, Berger JM.

Elife. 2013 Oct 8;2:e00882. doi: 10.7554/eLife.00882.

12.

The minichromosome maintenance replicative helicase.

Bell SD, Botchan MR.

Cold Spring Harb Perspect Biol. 2013 Nov 1;5(11):a012807. doi: 10.1101/cshperspect.a012807. Review.

13.

Checkpoint kinase 2 (Chk2) inhibits the activity of the Cdc45/MCM2-7/GINS (CMG) replicative helicase complex.

Ilves I, Tamberg N, Botchan MR.

Proc Natl Acad Sci U S A. 2012 Aug 14;109(33):13163-70. doi: 10.1073/pnas.1211525109. Epub 2012 Aug 1.

14.

ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote.

Lyubimov AY, Costa A, Bleichert F, Botchan MR, Berger JM.

Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):11999-2004. doi: 10.1073/pnas.1209406109. Epub 2012 Jul 9.

15.

Drosophila lin-52 acts in opposition to repressive components of the Myb-MuvB/dREAM complex.

Lewis PW, Sahoo D, Geng C, Bell M, Lipsick JS, Botchan MR.

Mol Cell Biol. 2012 Aug;32(16):3218-27. doi: 10.1128/MCB.00432-12. Epub 2012 Jun 11.

16.

Zelda binding in the early Drosophila melanogaster embryo marks regions subsequently activated at the maternal-to-zygotic transition.

Harrison MM, Li XY, Kaplan T, Botchan MR, Eisen MB.

PLoS Genet. 2011 Oct;7(10):e1002266. doi: 10.1371/journal.pgen.1002266. Epub 2011 Oct 20.

17.

The structural basis for MCM2-7 helicase activation by GINS and Cdc45.

Costa A, Ilves I, Tamberg N, Petojevic T, Nogales E, Botchan MR, Berger JM.

Nat Struct Mol Biol. 2011 Apr;18(4):471-7. doi: 10.1038/nsmb.2004. Epub 2011 Mar 6.

18.

Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression.

Kawabata T, Luebben SW, Yamaguchi S, Ilves I, Matise I, Buske T, Botchan MR, Shima N.

Mol Cell. 2011 Mar 4;41(5):543-53. doi: 10.1016/j.molcel.2011.02.006.

19.

DNA replication: making two forks from one prereplication complex.

Botchan M, Berger J.

Mol Cell. 2010 Dec 22;40(6):860-1. doi: 10.1016/j.molcel.2010.12.014.

20.

Grainyhead and Zelda compete for binding to the promoters of the earliest-expressed Drosophila genes.

Harrison MM, Botchan MR, Cline TW.

Dev Biol. 2010 Sep 15;345(2):248-55. doi: 10.1016/j.ydbio.2010.06.026. Epub 2010 Jul 1.

21.

Climate change and the integrity of science.

Gleick PH, Adams RM, Amasino RM, Anders E, Anderson DJ, Anderson WW, Anselin LE, Arroyo MK, Asfaw B, Ayala FJ, Bax A, Bebbington AJ, Bell G, Bennett MV, Bennetzen JL, Berenbaum MR, Berlin OB, Bjorkman PJ, Blackburn E, Blamont JE, Botchan MR, Boyer JS, Boyle EA, Branton D, Briggs SP, Briggs WR, Brill WJ, Britten RJ, Broecker WS, Brown JH, Brown PO, Brunger AT, Cairns J Jr, Canfield DE, Carpenter SR, Carrington JC, Cashmore AR, Castilla JC, Cazenave A, Chapin FS 3rd, Ciechanover AJ, Clapham DE, Clark WC, Clayton RN, Coe MD, Conwell EM, Cowling EB, Cowling RM, Cox CS, Croteau RB, Crothers DM, Crutzen PJ, Daily GC, Dalrymple GB, Dangl JL, Darst SA, Davies DR, Davis MB, De Camilli PV, Dean C, DeFries RS, Deisenhofer J, Delmer DP, DeLong EF, DeRosier DJ, Diener TO, Dirzo R, Dixon JE, Donoghue MJ, Doolittle RF, Dunne T, Ehrlich PR, Eisenstadt SN, Eisner T, Emanuel KA, Englander SW, Ernst WG, Falkowski PG, Feher G, Ferejohn JA, Fersht A, Fischer EH, Fischer R, Flannery KV, Frank J, Frey PA, Fridovich I, Frieden C, Futuyma DJ, Gardner WR, Garrett CJ, Gilbert W, Goldberg RB, Goodenough WH, Goodman CS, Goodman M, Greengard P, Hake S, Hammel G, Hanson S, Harrison SC, Hart SR, Hartl DL, Haselkorn R, Hawkes K, Hayes JM, Hille B, Hökfelt T, House JS, Hout M, Hunten DM, Izquierdo IA, Jagendorf AT, Janzen DH, Jeanloz R, Jencks CS, Jury WA, Kaback HR, Kailath T, Kay P, Kay SA, Kennedy D, Kerr A, Kessler RC, Khush GS, Kieffer SW, Kirch PV, Kirk K, Kivelson MG, Klinman JP, Klug A, Knopoff L, Kornberg H, Kutzbach JE, Lagarias JC, Lambeck K, Landy A, Langmuir CH, Larkins BA, Le Pichon XT, Lenski RE, Leopold EB, Levin SA, Levitt M, Likens GE, Lippincott-Schwartz J, Lorand L, Lovejoy CO, Lynch M, Mabogunje AL, Malone TF, Manabe S, Marcus J, Massey DS, McWilliams JC, Medina E, Melosh HJ, Meltzer DJ, Michener CD, Miles EL, Mooney HA, Moore PB, Morel FM, Mosley-Thompson ES, Moss B, Munk WH, Myers N, Nair GB, Nathans J, Nester EW, Nicoll RA, Novick RP, O'Connell JF, Olsen PE, Opdyke ND, Oster GF, Ostrom E, Pace NR, Paine RT, Palmiter RD, Pedlosky J, Petsko GA, Pettengill GH, Philander SG, Piperno DR, Pollard TD, Price PB Jr, Reichard PA, Reskin BF, Ricklefs RE, Rivest RL, Roberts JD, Romney AK, Rossmann MG, Russell DW, Rutter WJ, Sabloff JA, Sagdeev RZ, Sahlins MD, Salmond A, Sanes JR, Schekman R, Schellnhuber J, Schindler DW, Schmitt J, Schneider SH, Schramm VL, Sederoff RR, Shatz CJ, Sherman F, Sidman RL, Sieh K, Simons EL, Singer BH, Singer MF, Skyrms B, Sleep NH, Smith BD, Snyder SH, Sokal RR, Spencer CS, Steitz TA, Strier KB, Südhof TC, Taylor SS, Terborgh J, Thomas DH, Thompson LG, Tjian RT, Turner MG, Uyeda S, Valentine JW, Valentine JS, Van Etten JL, van Holde KE, Vaughan M, Verba S, von Hippel PH, Wake DB, Walker A, Walker JE, Watson EB, Watson PJ, Weigel D, Wessler SR, West-Eberhard MJ, White TD, Wilson WJ, Wolfenden RV, Wood JA, Woodwell GM, Wright HE Jr, Wu C, Wunsch C, Zoback ML.

Science. 2010 May 7;328(5979):689-90. doi: 10.1126/science.328.5979.689. No abstract available. Erratum in: Science. 2010 May 14;328(5980):826.

22.

Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins.

Ilves I, Petojevic T, Pesavento JJ, Botchan MR.

Mol Cell. 2010 Jan 29;37(2):247-58. doi: 10.1016/j.molcel.2009.12.030.

23.

Single particle EM studies of the Drosophila melanogaster origin recognition complex and evidence for DNA wrapping.

Clarey MG, Botchan M, Nogales E.

J Struct Biol. 2008 Dec;164(3):241-9. doi: 10.1016/j.jsb.2008.08.006. Epub 2008 Sep 11.

24.

Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells.

Georlette D, Ahn S, MacAlpine DM, Cheung E, Lewis PW, Beall EL, Bell SP, Speed T, Manak JR, Botchan MR.

Genes Dev. 2007 Nov 15;21(22):2880-96. Epub 2007 Oct 31.

25.

Discovery of tMAC: a Drosophila testis-specific meiotic arrest complex paralogous to Myb-Muv B.

Beall EL, Lewis PW, Bell M, Rocha M, Jones DL, Botchan MR.

Genes Dev. 2007 Apr 15;21(8):904-19. Epub 2007 Apr 2.

26.

Cell biology: a switch for S phase.

Botchan M.

Nature. 2007 Jan 18;445(7125):272-4. No abstract available.

PMID:
17230184
27.
28.

Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex.

Clarey MG, Erzberger JP, Grob P, Leschziner AE, Berger JM, Nogales E, Botchan M.

Nat Struct Mol Biol. 2006 Aug;13(8):684-90. Epub 2006 Jul 9.

PMID:
16829958
29.

Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase.

Moyer SE, Lewis PW, Botchan MR.

Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10236-10241. doi: 10.1073/pnas.0602400103. Epub 2006 Jun 23.

30.

CDK phosphorylation inhibits the DNA-binding and ATP-hydrolysis activities of the Drosophila origin recognition complex.

Remus D, Blanchette M, Rio DC, Botchan MR.

J Biol Chem. 2005 Dec 2;280(48):39740-51. Epub 2005 Sep 27.

31.

humpty dumpty is required for developmental DNA amplification and cell proliferation in Drosophila.

Bandura JL, Beall EL, Bell M, Silver HR, Botchan MR, Calvi BR.

Curr Biol. 2005 Apr 26;15(8):755-9.

32.

Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex.

Lewis PW, Beall EL, Fleischer TC, Georlette D, Link AJ, Botchan MR.

Genes Dev. 2004 Dec 1;18(23):2929-40. Epub 2004 Nov 15.

33.

The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2.

Abbate EA, Berger JM, Botchan MR.

Genes Dev. 2004 Aug 15;18(16):1981-96. Epub 2004 Aug 2.

34.
35.

Hitchhiking without covalent integration.

Botchan M.

Cell. 2004 Apr 30;117(3):280-1.

36.

DNA topology, not DNA sequence, is a critical determinant for Drosophila ORC-DNA binding.

Remus D, Beall EL, Botchan MR.

EMBO J. 2004 Feb 25;23(4):897-907. Epub 2004 Feb 5.

37.

A genome analysis of endoreplication in the Drosophila ovary.

Botchan M, Levine M.

Dev Cell. 2004 Jan;6(1):4-5.

38.

A cytokinetic function of Drosophila ORC6 protein resides in a domain distinct from its replication activity.

Chesnokov IN, Chesnokova ON, Botchan M.

Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9150-5. Epub 2003 Jul 23.

39.

Role for a Drosophila Myb-containing protein complex in site-specific DNA replication.

Beall EL, Manak JR, Zhou S, Bell M, Lipsick JS, Botchan MR.

Nature. 2002 Dec 19-26;420(6917):833-7.

PMID:
12490953
40.

Characterization of simian virus 40 T-antigen double hexamers bound to a replication fork. The active form of the helicase.

Alexandrov AI, Botchan MR, Cozzarelli NR.

J Biol Chem. 2002 Nov 22;277(47):44886-97. Epub 2002 Sep 19.

42.

Functional analysis of mutant and wild-type Drosophila origin recognition complex.

Chesnokov I, Remus D, Botchan M.

Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):11997-2002. Epub 2001 Oct 2.

43.

Origin recognition complex binding to a metazoan replication origin.

Bielinsky AK, Blitzblau H, Beall EL, Ezrokhi M, Smith HS, Botchan MR, Gerbi SA.

Curr Biol. 2001 Sep 18;11(18):1427-31.

44.

Orc mutants arrest in metaphase with abnormally condensed chromosomes.

Pflumm MF, Botchan MR.

Development. 2001 May;128(9):1697-707.

45.

The bovine papillomavirus E2 transactivator is stimulated by the E1 initiator through the E2 activation domain.

Parker LM, Harris S, Gossen M, Botchan MR.

Virology. 2000 May 10;270(2):430-43.

46.

The genome sequence of Drosophila melanogaster.

Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, Sutton GG, Wortman JR, Yandell MD, Zhang Q, Chen LX, Brandon RC, Rogers YH, Blazej RG, Champe M, Pfeiffer BD, Wan KH, Doyle C, Baxter EG, Helt G, Nelson CR, Gabor GL, Abril JF, Agbayani A, An HJ, Andrews-Pfannkoch C, Baldwin D, Ballew RM, Basu A, Baxendale J, Bayraktaroglu L, Beasley EM, Beeson KY, Benos PV, Berman BP, Bhandari D, Bolshakov S, Borkova D, Botchan MR, Bouck J, Brokstein P, Brottier P, Burtis KC, Busam DA, Butler H, Cadieu E, Center A, Chandra I, Cherry JM, Cawley S, Dahlke C, Davenport LB, Davies P, de Pablos B, Delcher A, Deng Z, Mays AD, Dew I, Dietz SM, Dodson K, Doup LE, Downes M, Dugan-Rocha S, Dunkov BC, Dunn P, Durbin KJ, Evangelista CC, Ferraz C, Ferriera S, Fleischmann W, Fosler C, Gabrielian AE, Garg NS, Gelbart WM, Glasser K, Glodek A, Gong F, Gorrell JH, Gu Z, Guan P, Harris M, Harris NL, Harvey D, Heiman TJ, Hernandez JR, Houck J, Hostin D, Houston KA, Howland TJ, Wei MH, Ibegwam C, Jalali M, Kalush F, Karpen GH, Ke Z, Kennison JA, Ketchum KA, Kimmel BE, Kodira CD, Kraft C, Kravitz S, Kulp D, Lai Z, Lasko P, Lei Y, Levitsky AA, Li J, Li Z, Liang Y, Lin X, Liu X, Mattei B, McIntosh TC, McLeod MP, McPherson D, Merkulov G, Milshina NV, Mobarry C, Morris J, Moshrefi A, Mount SM, Moy M, Murphy B, Murphy L, Muzny DM, Nelson DL, Nelson DR, Nelson KA, Nixon K, Nusskern DR, Pacleb JM, Palazzolo M, Pittman GS, Pan S, Pollard J, Puri V, Reese MG, Reinert K, Remington K, Saunders RD, Scheeler F, Shen H, Shue BC, Sidén-Kiamos I, Simpson M, Skupski MP, Smith T, Spier E, Spradling AC, Stapleton M, Strong R, Sun E, Svirskas R, Tector C, Turner R, Venter E, Wang AH, Wang X, Wang ZY, Wassarman DA, Weinstock GM, Weissenbach J, Williams SM, WoodageT, Worley KC, Wu D, Yang S, Yao QA, Ye J, Yeh RF, Zaveri JS, Zhan M, Zhang G, Zhao Q, Zheng L, Zheng XH, Zhong FN, Zhong W, Zhou X, Zhu S, Zhu X, Smith HO, Gibbs RA, Myers EW, Rubin GM, Venter JC.

Science. 2000 Mar 24;287(5461):2185-95.

PMID:
10731132
47.

Crystal structure of the human papillomavirus type 18 E2 activation domain.

Harris SF, Botchan MR.

Science. 1999 Jun 4;284(5420):1673-7.

48.

Assembly of functionally active Drosophila origin recognition complex from recombinant proteins.

Chesnokov I, Gossen M, Remus D, Botchan M.

Genes Dev. 1999 May 15;13(10):1289-96.

49.

Biochemical and electron microscopic image analysis of the hexameric E1 helicase.

Fouts ET, Yu X, Egelman EH, Botchan MR.

J Biol Chem. 1999 Feb 12;274(7):4447-58.

50.

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