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Items: 1 to 50 of 126

1.

A Comparative Study of Black and White Allium sativum L.: Nutritional Composition and Bioactive Properties.

Botas J, Fernandes Â, Barros L, Alves MJ, Carvalho AM, Ferreira ICFR.

Molecules. 2019 Jun 11;24(11). pii: E2194. doi: 10.3390/molecules24112194.

2.

Cross-species genetic screens to identify kinase targets for APP reduction in Alzheimer's disease.

Huichalaf CH, Al-Ramahi I, Park KW, Grunke SD, Lu N, de Haro M, El-Zein K, Gallego-Flores T, Perez AM, Jung SY, Botas J, Zoghbi HY, Jankowsky JL.

Hum Mol Genet. 2019 Jun 15;28(12):2014-2029. doi: 10.1093/hmg/ddz034.

PMID:
30753434
3.

Novel and Versatile Cobalt Azobenzene-Based Metal-Organic Framework as Hydrogen Adsorbent.

Montes-Andrés H, Leo P, Orcajo G, Rodríguez-Diéguez A, Choquesillo-Lazarte D, Martos C, Botas JÁ, Martínez F, Calleja G.

Chemphyschem. 2019 May 16;20(10):1334-1339. doi: 10.1002/cphc.201801151. Epub 2019 Feb 12.

PMID:
30657621
4.

Baseline Risk Stratification of Patients Older Than 75 Years With Infarction and Cardiogenic Shock Undergoing Primary Angioplasty.

de la Torre Hernández JM, Brugaletta S, Gómez Hospital JA, Baz JA, Pérez de Prado A, López Palop R, Cid B, García Camarero T, Diego A, Gutiérrez H, Fernández Diaz JA, Sanchis J, Alfonso F, Blanco R, Botas J, Navarro Cuartero J, Moreu J, Bosa F, Vegas Valle JM, Elízaga J, Arrebola AL, Ruiz Arroyo JR, Hernández F, Salvatella N, Monteagudo M, Gómez Jaume A, Carrillo X, Martín Reyes R, Lozano F, Rumoroso JR, Andraka L, Domínguez AJ.

Rev Esp Cardiol (Engl Ed). 2018 Oct 5. pii: S1885-5857(18)30375-X. doi: 10.1016/j.rec.2018.09.001. [Epub ahead of print] English, Spanish.

PMID:
30297278
5.

A Druggable Genome Screen Identifies Modifiers of α-Synuclein Levels via a Tiered Cross-Species Validation Approach.

Rousseaux MWC, Vázquez-Vélez GE, Al-Ramahi I, Jeong HH, Bajić A, Revelli JP, Ye H, Phan ET, Deger JM, Perez AM, Kim JY, Lavery LA, Xu Q, Li MZ, Kang H, Kim JJ, Shulman JM, Westbrook TF, Elledge SJ, Liu Z, Botas J, Zoghbi HY.

J Neurosci. 2018 Oct 24;38(43):9286-9301. doi: 10.1523/JNEUROSCI.0254-18.2018. Epub 2018 Sep 24.

6.

High-Throughput Functional Analysis Distinguishes Pathogenic, Nonpathogenic, and Compensatory Transcriptional Changes in Neurodegeneration.

Al-Ramahi I, Lu B, Di Paola S, Pang K, de Haro M, Peluso I, Gallego-Flores T, Malik NT, Erikson K, Bleiberg BA, Avalos M, Fan G, Rivers LE, Laitman AM, Diaz-García JR, Hild M, Palacino J, Liu Z, Medina DL, Botas J.

Cell Syst. 2018 Jul 25;7(1):28-40.e4. doi: 10.1016/j.cels.2018.05.010. Epub 2018 Jun 20.

7.

PAK1 regulates ATXN1 levels providing an opportunity to modify its toxicity in spinocerebellar ataxia type 1.

Bondar VV, Adamski CJ, Onur TS, Tan Q, Wang L, Diaz-Garcia J, Park J, Orr HT, Botas J, Zoghbi HY.

Hum Mol Genet. 2018 Aug 15;27(16):2863-2873. doi: 10.1093/hmg/ddy200.

8.

Idiopathic chylous ascites in a patient with HIV infection: response to total parenteral nutrition and octreotide therapy.

Nunes G, Fonseca C, Barosa R, Patita M, Gomes A, Botas J, Coelho H, Brito MJ, Fonseca J.

Clin J Gastroenterol. 2018 Jun;11(3):235-239. doi: 10.1007/s12328-018-0832-x. Epub 2018 Feb 9.

PMID:
29427281
9.

Multivessel disease in patients over 75years old with ST elevated myocardial infarction. Current management strategies and related clinical outcomes in the ESTROFA MI+75 nation-wide registry.

de La Torre Hernandez JM, Gomez Hospital JA, Baz JA, Brugaletta S, Perez de Prado A, Linares JA, Lopez Palop R, Cid B, Garcia Camarero T, Diego A, Gutierrez H, Fernandez Diaz JA, Sanchis J, Alfonso F, Blanco R, Botas J, Navarro Cuartero J, Moreu J, Bosa F, Vegas JM, Elizaga J, Arrebola AL, Hernandez F, Salvatella N, Monteagudo M, Gomez Jaume A, Carrillo X, Martin Reyes R, Lozano F, Rumoroso JR, Andraka L, Dominguez AJ.

Cardiovasc Revasc Med. 2018 Jul - Aug;19(5 Pt B):580-588. doi: 10.1016/j.carrev.2017.12.004. Epub 2017 Dec 6.

PMID:
29306670
10.

Sildenafil for improving outcomes in patients with corrected valvular heart disease and persistent pulmonary hypertension: a multicenter, double-blind, randomized clinical trial.

Bermejo J, Yotti R, García-Orta R, Sánchez-Fernández PL, Castaño M, Segovia-Cubero J, Escribano-Subías P, San Román JA, Borrás X, Alonso-Gómez A, Botas J, Crespo-Leiro MG, Velasco S, Bayés-Genís A, López A, Muñoz-Aguilera R, de Teresa E, González-Juanatey JR, Evangelista A, Mombiela T, González-Mansilla A, Elízaga J, Martín-Moreiras J, González-Santos JM, Moreno-Escobar E, Fernández-Avilés F; Sildenafil for Improving Outcomes after VAlvular Correction (SIOVAC) investigators.

Eur Heart J. 2018 Apr 14;39(15):1255-1264. doi: 10.1093/eurheartj/ehx700.

11.

Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein.

Al-Ramahi I, Giridharan SSP, Chen YC, Patnaik S, Safren N, Hasegawa J, de Haro M, Wagner Gee AK, Titus SA, Jeong H, Clarke J, Krainc D, Zheng W, Irvine RF, Barmada S, Ferrer M, Southall N, Weisman LS, Botas J, Marugan JJ.

Elife. 2017 Dec 26;6. pii: e29123. doi: 10.7554/eLife.29123.

12.

Primary Angioplasty in Patients Older Than 75 Years. Profile of Patients and Procedures, Outcomes, and Predictors of Prognosis in the ESTROFA IM+75 Registry.

de la Torre Hernández JM, Brugaletta S, Gómez Hospital JA, Baz JA, Pérez de Prado A, López Palop R, Cid B, García Camarero T, Diego A, Gimeno de Carlos F, Fernández Díaz JA, Sanchis J, Alfonso F, Blanco R, Botas J, Navarro Cuartero J, Moreu J, Bosa F, Vegas Valle JM, Elízaga J, Arrebola AL, Ruiz Arroyo JR, Hernández-Hernández F, Salvatella N, Monteagudo M, Gómez Jaume A, Carrillo X, Martín Reyes R, Lozano F, Rumoroso JR, Andraka L, Domínguez AJ.

Rev Esp Cardiol (Engl Ed). 2017 Feb;70(2):81-87. doi: 10.1016/j.rec.2016.06.012. Epub 2016 Nov 11. English, Spanish.

PMID:
27840148
13.

TRIM28 regulates the nuclear accumulation and toxicity of both alpha-synuclein and tau.

Rousseaux MW, de Haro M, Lasagna-Reeves CA, De Maio A, Park J, Jafar-Nejad P, Al-Ramahi I, Sharma A, See L, Lu N, Vilanova-Velez L, Klisch TJ, Westbrook TF, Troncoso JC, Botas J, Zoghbi HY.

Elife. 2016 Oct 25;5. pii: e19809. doi: 10.7554/eLife.19809.

14.

Reduction of Nuak1 Decreases Tau and Reverses Phenotypes in a Tauopathy Mouse Model.

Lasagna-Reeves CA, de Haro M, Hao S, Park J, Rousseaux MW, Al-Ramahi I, Jafar-Nejad P, Vilanova-Velez L, See L, De Maio A, Nitschke L, Wu Z, Troncoso JC, Westbrook TF, Tang J, Botas J, Zoghbi HY.

Neuron. 2016 Oct 19;92(2):407-418. doi: 10.1016/j.neuron.2016.09.022. Epub 2016 Oct 6.

15.

Metal Homeostasis Regulators Suppress FRDA Phenotypes in a Drosophila Model of the Disease.

Soriano S, Calap-Quintana P, Llorens JV, Al-Ramahi I, Gutiérrez L, Martínez-Sebastián MJ, Botas J, Moltó MD.

PLoS One. 2016 Jul 19;11(7):e0159209. doi: 10.1371/journal.pone.0159209. eCollection 2016.

16.

Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease.

Chouhan AK, Guo C, Hsieh YC, Ye H, Senturk M, Zuo Z, Li Y, Chatterjee S, Botas J, Jackson GR, Bellen HJ, Shulman JM.

Acta Neuropathol Commun. 2016 Jun 23;4(1):62. doi: 10.1186/s40478-016-0333-4.

17.

Early Intravenous Beta-Blockers in Patients With ST-Segment Elevation Myocardial Infarction Before Primary Percutaneous Coronary Intervention.

Roolvink V, Ibáñez B, Ottervanger JP, Pizarro G, van Royen N, Mateos A, Dambrink JE, Escalera N, Lipsic E, Albarran A, Fernández-Ortiz A, Fernández-Avilés F, Goicolea J, Botas J, Remkes W, Hernandez-Jaras V, Kedhi E, Zamorano JL, Navarro F, Alfonso F, García-Lledó A, Alonso J, van Leeuwen M, Nijveldt R, Postma S, Kolkman E, Gosselink M, de Smet B, Rasoul S, Piek JJ, Fuster V, van 't Hof AWJ; EARLY-BAMI Investigators.

J Am Coll Cardiol. 2016 Jun 14;67(23):2705-2715. doi: 10.1016/j.jacc.2016.03.522. Epub 2016 Apr 3.

18.

Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice.

Langfelder P, Cantle JP, Chatzopoulou D, Wang N, Gao F, Al-Ramahi I, Lu XH, Ramos EM, El-Zein K, Zhao Y, Deverasetty S, Tebbe A, Schaab C, Lavery DJ, Howland D, Kwak S, Botas J, Aaronson JS, Rosinski J, Coppola G, Horvath S, Yang XW.

Nat Neurosci. 2016 Apr;19(4):623-33. doi: 10.1038/nn.4256. Epub 2016 Feb 22.

19.

Drosophila Mitf regulates the V-ATPase and the lysosomal-autophagic pathway.

Bouché V, Espinosa AP, Leone L, Sardiello M, Ballabio A, Botas J.

Autophagy. 2016;12(3):484-98. doi: 10.1080/15548627.2015.1134081.

20.

Dysphagia and esophageal ulcerations in HIV patient.

Carvalho TM, Vieira A, Borralho P, Botas J, Freitas J.

Acta Gastroenterol Belg. 2015 Jul-Sep;78(3):355-6. No abstract available.

PMID:
26448425
21.

Immediate and Long-Term Results of Drug-Eluting Stents in Mammary Artery Grafts.

Lozano I, Serrador A, Lopez-Palop R, Lasa G, Moreu J, Pinar E, de Prado AP, Alfonso F, Jimenez Navarro M, Quero MF, Pineda J, Martin Moreiras J, Garcia San Roman K, Lopez Minguez JR, Suarez Cuervo A, Gutierrez A, Hernandez F, Baz JA, Benedicto A, Rumoroso JR, Gomez-Hospital JA, Serra V, de la Torre JM, Ruiz-Quevedo V, Botas J, Fernandez JA, Sanchez-Recalde A.

Am J Cardiol. 2015 Dec 1;116(11):1695-9. doi: 10.1016/j.amjcard.2015.08.040. Epub 2015 Sep 10.

PMID:
26433270
22.

Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation.

El-Daher MT, Hangen E, Bruyère J, Poizat G, Al-Ramahi I, Pardo R, Bourg N, Souquere S, Mayet C, Pierron G, Lévêque-Fort S, Botas J, Humbert S, Saudou F.

EMBO J. 2015 Sep 2;34(17):2255-71. doi: 10.15252/embj.201490808. Epub 2015 Jul 12.

23.

TORC1 Inhibition by Rapamycin Promotes Antioxidant Defences in a Drosophila Model of Friedreich's Ataxia.

Calap-Quintana P, Soriano S, Llorens JV, Al-Ramahi I, Botas J, Moltó MD, Martínez-Sebastián MJ.

PLoS One. 2015 Jul 9;10(7):e0132376. doi: 10.1371/journal.pone.0132376. eCollection 2015.

24.

Reverse or inverted apical ballooning in a case of refeeding syndrome.

Robles P, Monedero I, Rubio A, Botas J.

World J Cardiol. 2015 Jun 26;7(6):361-6. doi: 10.4330/wjc.v7.i6.361.

25.

A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity.

Yao Y, Cui X, Al-Ramahi I, Sun X, Li B, Hou J, Difiglia M, Palacino J, Wu ZY, Ma L, Botas J, Lu B.

Elife. 2015 Mar 4;4. doi: 10.7554/eLife.05449.

26.

Intensified-Fenton process for the treatment of phenol aqueous solutions.

Pariente MI, Molina R, Melero JA, Botas JÁ, Martínez F.

Water Sci Technol. 2015;71(3):359-65. doi: 10.2166/wst.2014.515.

PMID:
25714634
27.

Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.

Lu XH, Mattis VB, Wang N, Al-Ramahi I, van den Berg N, Fratantoni SA, Waldvogel H, Greiner E, Osmand A, Elzein K, Xiao J, Dijkstra S, de Pril R, Vinters HV, Faull R, Signer E, Kwak S, Marugan JJ, Botas J, Fischer DF, Svendsen CN, Munoz-Sanjuan I, Yang XW.

Sci Transl Med. 2014 Dec 24;6(268):268ra178. doi: 10.1126/scitranslmed.3010523.

PMID:
25540325
28.

Prevalence and prognosis of percutaneous coronary intervention-associated nephropathy in patients with acute coronary syndrome and normal kidney function.

Hernando L, Canovas E, Freites A, de la Rosa A, Alonso J, del Castillo R, Salinas P, Montalvo GB, Huelmos AI, Botas J.

Rev Esp Cardiol (Engl Ed). 2015 Apr;68(4):310-6. doi: 10.1016/j.rec.2014.04.016. Epub 2014 Sep 26.

PMID:
25263104
29.

Delayed cardiac tamponade after stent fracture.

Hernando L, del Castillo R, Botas J.

Rev Esp Cardiol (Engl Ed). 2014 Jan;67(1):59. doi: 10.1016/j.rec.2012.03.016. Epub 2012 Jun 30. No abstract available.

PMID:
24774266
30.

[Experience with the use of an implantable loop recorder in a series of older people with falls and suspected arrhythmic syncopes].

Martínez P, Pilar Sáez M, Rubio JA, Cánovas E, Esteban E, Botas J.

Rev Esp Geriatr Gerontol. 2014 May-Jun;49(3):121-4. doi: 10.1016/j.regg.2013.07.005. Epub 2014 Feb 16. Spanish.

PMID:
24548525
31.

RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1.

Park J, Al-Ramahi I, Tan Q, Mollema N, Diaz-Garcia JR, Gallego-Flores T, Lu HC, Lagalwar S, Duvick L, Kang H, Lee Y, Jafar-Nejad P, Sayegh LS, Richman R, Liu X, Gao Y, Shaw CA, Arthur JSC, Orr HT, Westbrook TF, Botas J, Zoghbi HY.

Nature. 2013 Jun 20;498(7454):325-331. doi: 10.1038/nature12204. Epub 2013 May 29.

32.

Smaug/SAMD4A restores translational activity of CUGBP1 and suppresses CUG-induced myopathy.

de Haro M, Al-Ramahi I, Jones KR, Holth JK, Timchenko LT, Botas J.

PLoS Genet. 2013 Apr;9(4):e1003445. doi: 10.1371/journal.pgen.1003445. Epub 2013 Apr 18.

33.

Identification of NUB1 as a suppressor of mutant Huntington toxicity via enhanced protein clearance.

Lu B, Al-Ramahi I, Valencia A, Wang Q, Berenshteyn F, Yang H, Gallego-Flores T, Ichcho S, Lacoste A, Hild M, Difiglia M, Botas J, Palacino J.

Nat Neurosci. 2013 May;16(5):562-70. doi: 10.1038/nn.3367. Epub 2013 Mar 24.

PMID:
23525043
34.

Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy.

Holth JK, Bomben VC, Reed JG, Inoue T, Younkin L, Younkin SG, Pautler RG, Botas J, Noebels JL.

J Neurosci. 2013 Jan 23;33(4):1651-9. doi: 10.1523/JNEUROSCI.3191-12.2013.

35.

A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease.

Miller JP, Yates BE, Al-Ramahi I, Berman AE, Sanhueza M, Kim E, de Haro M, DeGiacomo F, Torcassi C, Holcomb J, Gafni J, Mooney SD, Botas J, Ellerby LM, Hughes RE.

PLoS Genet. 2012;8(11):e1003042. doi: 10.1371/journal.pgen.1003042. Epub 2012 Nov 29.

36.

Network organization of the huntingtin proteomic interactome in mammalian brain.

Shirasaki DI, Greiner ER, Al-Ramahi I, Gray M, Boontheung P, Geschwind DH, Botas J, Coppola G, Horvath S, Loo JA, Yang XW.

Neuron. 2012 Jul 12;75(1):41-57. doi: 10.1016/j.neuron.2012.05.024.

37.

Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity.

Zhang N, Li B, Al-Ramahi I, Cong X, Held JM, Kim E, Botas J, Gibson BW, Ellerby LM.

J Biol Chem. 2012 Jun 15;287(25):21204-13. doi: 10.1074/jbc.M111.321661. Epub 2012 Apr 16.

38.

Thrombosis of second-generation drug-eluting stents in real practice results from the multicenter Spanish registry ESTROFA-2 (Estudio Español Sobre Trombosis de Stents Farmacoactivos de Segunda Generacion-2).

de la Torre Hernández JM, Alfonso F, Gimeno F, Diarte JA, Lopez-Palop R, Pérez de Prado A, Rivero F, Sanchis J, Larman M, Diaz JF, Elizaga J, Moreiras JM, Gomez Jaume A, Hernández JM, Mauri J, Recalde AS, Bullones JA, Rumoroso JR, Del Blanco BG, Baz JA, Bosa F, Botas J, Hernández F; ESTROFA-2 Study Group.

JACC Cardiovasc Interv. 2010 Sep;3(9):911-9. doi: 10.1016/j.jcin.2010.06.010.

39.

Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease.

Miller JP, Holcomb J, Al-Ramahi I, de Haro M, Gafni J, Zhang N, Kim E, Sanhueza M, Torcassi C, Kwak S, Botas J, Hughes RE, Ellerby LM.

Neuron. 2010 Jul 29;67(2):199-212. doi: 10.1016/j.neuron.2010.06.021.

40.

Catalytic wet hydrogen peroxide oxidation of a petrochemical wastewater.

Pariente MI, Melero JA, Martínez F, Botas JA, Gallego AI.

Water Sci Technol. 2010;61(7):1829-36. doi: 10.2166/wst.2010.875.

PMID:
20371942
41.

Cobalt doping of the MOF-5 framework and its effect on gas-adsorption properties.

Botas JA, Calleja G, Sánchez-Sánchez M, Orcajo MG.

Langmuir. 2010 Apr 20;26(8):5300-3. doi: 10.1021/la100423a.

PMID:
20334392
42.

Molecular subtyping of Treponema pallidum subsp. pallidum in Lisbon, Portugal.

Castro R, Prieto E, Aguas MJ, Manata MJ, Botas J, Pereira FM.

J Clin Microbiol. 2009 Aug;47(8):2510-2. doi: 10.1128/JCM.00287-08. Epub 2009 Jun 3.

43.

Heterogeneous catalytic wet peroxide oxidation systems for the treatment of an industrial pharmaceutical wastewater.

Melero JA, Martínez F, Botas JA, Molina R, Pariente MI.

Water Res. 2009 Sep;43(16):4010-8. doi: 10.1016/j.watres.2009.04.012. Epub 2009 Apr 19.

PMID:
19447465
44.

Ordered mesoporous carbons as highly active catalysts for hydrogen production by CH(4) decomposition.

Serrano DP, Botas JA, Pizarro P, Guil-López R, Gómez G.

Chem Commun (Camb). 2008 Dec 28;(48):6585-7. doi: 10.1039/b811800k. Epub 2008 Nov 12.

PMID:
19057787
45.

The Drosophila FMRP and LARK RNA-binding proteins function together to regulate eye development and circadian behavior.

Sofola O, Sundram V, Ng F, Kleyner Y, Morales J, Botas J, Jackson FR, Nelson DL.

J Neurosci. 2008 Oct 8;28(41):10200-5. doi: 10.1523/JNEUROSCI.2786-08.2008.

46.

Bifurcation lesions: the last great frontier for coronary interventions.

Botas J.

Rev Esp Cardiol. 2008 Sep;61(9):911-3. English, Spanish. No abstract available.

47.

Genetic modifiers of MeCP2 function in Drosophila.

Cukier HN, Perez AM, Collins AL, Zhou Z, Zoghbi HY, Botas J.

PLoS Genet. 2008 Sep 5;4(9):e1000179. doi: 10.1371/journal.pgen.1000179.

48.

Drug-eluting stent thrombosis: results from the multicenter Spanish registry ESTROFA (Estudio ESpañol sobre TROmbosis de stents FArmacoactivos).

de la Torre-Hernández JM, Alfonso F, Hernández F, Elizaga J, Sanmartin M, Pinar E, Lozano I, Vazquez JM, Botas J, Perez de Prado A, Hernández JM, Sanchis J, Nodar JM, Gomez-Jaume A, Larman M, Diarte JA, Rodríguez-Collado J, Rumoroso JR, Lopez-Minguez JR, Mauri J; ESTROFA Study Group.

J Am Coll Cardiol. 2008 Mar 11;51(10):986-90. doi: 10.1016/j.jacc.2007.10.057.

49.

Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm.

Romero E, Cha GH, Verstreken P, Ly CV, Hughes RE, Bellen HJ, Botas J.

Neuron. 2008 Jan 10;57(1):27-40. doi: 10.1016/j.neuron.2007.11.025.

50.

dAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1.

Al-Ramahi I, Pérez AM, Lim J, Zhang M, Sorensen R, de Haro M, Branco J, Pulst SM, Zoghbi HY, Botas J.

PLoS Genet. 2007 Dec 28;3(12):e234. doi: 10.1371/journal.pgen.0030234. Epub 2007 Nov 16.

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