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Items: 1 to 50 of 313

1.

Gracilin A Derivatives Target Early Events in Alzheimer's Disease: in Vitro Effects on Neuroinflammation and Oxidative Stress.

Alvariño R, Alonso E, Abbasov ME, Chaheine CM, Conner ML, Romo D, Alfonso A, Botana LM.

ACS Chem Neurosci. 2019 Sep 18;10(9):4102-4111. doi: 10.1021/acschemneuro.9b00329. Epub 2019 Aug 23.

PMID:
31387354
2.

High Serum Cyclophilin C levels as a risk factor marker for Coronary Artery Disease.

Alfonso A, Bayón J, Gegunde S, Alonso E, Alvariño R, Santás-Álvarez M, Testa-Fernández A, Rios-Vázquez R, González-Juanatey C, Botana LM.

Sci Rep. 2019 Jul 22;9(1):10576. doi: 10.1038/s41598-019-46988-x.

3.

LC-MS/MS Analysis of the Emerging Toxin Pinnatoxin-G and High Levels of Esterified OA Group Toxins in Galician Commercial Mussels.

Otero P, Miguéns N, Rodríguez I, Botana LM.

Toxins (Basel). 2019 Jul 5;11(7). pii: E394. doi: 10.3390/toxins11070394.

4.

Gambierol Potently Increases Evoked Quantal Transmitter Release and Reverses Pre- and Post-Synaptic Blockade at Vertebrate Neuromuscular Junctions.

Molgó J, Schlumberger S, Sasaki M, Fuwa H, Louzao MC, Botana LM, Servent D, Benoit E.

Neuroscience. 2019 Jun 28. pii: S0306-4522(19)30441-5. doi: 10.1016/j.neuroscience.2019.06.024. [Epub ahead of print]

PMID:
31255710
5.

Bromotryptamine and Bromotyramine Derivatives from the Tropical Southwestern Pacific Sponge Narrabeena nigra.

Miguel-Gordo M, Gegunde S, Calabro K, Jennings LK, Alfonso A, Genta-Jouve G, Vacelet J, Botana LM, Thomas OP.

Mar Drugs. 2019 May 30;17(6). pii: E319. doi: 10.3390/md17060319.

6.

Tetrodotoxins Occurrence in Non-Traditional Vectors of the North Atlantic Waters (Portuguese Maritime Territory, and Morocco Coast).

Silva M, Rodríguez I, Barreiro A, Kaufmann M, Neto AI, Hassouani M, Sabour B, Alfonso A, Botana LM, Vasconcelos V.

Toxins (Basel). 2019 May 29;11(6). pii: E306. doi: 10.3390/toxins11060306.

7.

Acute Toxicity Assessment: Macroscopic and Ultrastructural Effects in Mice Treated with Oral Tetrodotoxin.

Abal P, Louzao MC, Vilariño N, Vieytes MR, Botana LM.

Toxins (Basel). 2019 May 29;11(6). pii: E305. doi: 10.3390/toxins11060305.

8.

Detoxification agents based on magnetic nanostructured particles as a novel strategy for mycotoxin mitigation in food.

González-Jartín JM, de Castro Alves L, Alfonso A, Piñeiro Y, Vilar SY, Gomez MG, Osorio ZV, Sainz MJ, Vieytes MR, Rivas J, Botana LM.

Food Chem. 2019 Oct 1;294:60-66. doi: 10.1016/j.foodchem.2019.05.013. Epub 2019 May 3.

PMID:
31126505
9.

Structure and biological evaluation of new cyclic and acyclic laxaphycin-A type peptides.

Bornancin L, Alonso E, Alvariño R, Inguimbert N, Bonnard I, Botana LM, Banaigs B.

Bioorg Med Chem. 2019 May 15;27(10):1966-1980. doi: 10.1016/j.bmc.2019.03.046. Epub 2019 Mar 26.

PMID:
30929947
10.

Simplified immunosuppressive and neuroprotective agents based on gracilin A.

Abbasov ME, Alvariño R, Chaheine CM, Alonso E, Sánchez JA, Conner ML, Alfonso A, Jaspars M, Botana LM, Romo D.

Nat Chem. 2019 Apr;11(4):342-350. doi: 10.1038/s41557-019-0230-0. Epub 2019 Mar 22.

PMID:
30903037
11.

Caniferolide A, a Macrolide from Streptomyces caniferus, Attenuates Neuroinflammation, Oxidative Stress, Amyloid-Beta, and Tau Pathology in Vitro.

Alvariño R, Alonso E, Lacret R, Oves-Costales D, Genilloud O, Reyes F, Alfonso A, Botana LM.

Mol Pharm. 2019 Apr 1;16(4):1456-1466. doi: 10.1021/acs.molpharmaceut.8b01090. Epub 2019 Mar 11.

PMID:
30821469
12.

Chronic In Vivo Effects of Repeated Exposure to Low Oral Doses of Tetrodotoxin: Preliminary Evidence of Nephrotoxicity and Cardiotoxicity.

Boente-Juncal A, Vale C, Cifuentes M, Otero P, Camiña M, Rodriguez-Vieytes M, Botana LM.

Toxins (Basel). 2019 Feb 6;11(2). pii: E96. doi: 10.3390/toxins11020096.

13.

A QuEChERS based extraction procedure coupled to UPLC-MS/MS detection for mycotoxins analysis in beer.

González-Jartín JM, Alfonso A, Rodríguez I, Sainz MJ, Vieytes MR, Botana LM.

Food Chem. 2019 Mar 1;275:703-710. doi: 10.1016/j.foodchem.2018.09.162. Epub 2018 Sep 27.

PMID:
30724252
14.

Structure Elucidation and Biological Evaluation of Maitotoxin-3, a Homologue of Gambierone, from Gambierdiscus belizeanus.

Boente-Juncal A, Álvarez M, Antelo Á, Rodríguez I, Calabro K, Vale C, Thomas OP, Botana LM.

Toxins (Basel). 2019 Feb 1;11(2). pii: E79. doi: 10.3390/toxins11020079.

15.

First report of Fusarium foetens as a mycotoxin producer.

González-Jartín JM, Alfonso A, Sainz MJ, Vieytes MR, Aguín O, Ferreiroa V, Botana LM.

Mycotoxin Res. 2019 May;35(2):177-186. doi: 10.1007/s12550-019-00341-3. Epub 2019 Jan 31.

PMID:
30706436
16.

Treasures from the Deep: Characellides as Anti-Inflammatory Lipoglycotripeptides from the Sponge Characella pachastrelloides.

Afoullouss S, Calabro K, Genta-Jouve G, Gegunde S, Alfonso A, Nesbitt R, Morrow C, Alonso E, Botana LM, Allcock AL, Thomas OP.

Org Lett. 2019 Jan 4;21(1):246-251. doi: 10.1021/acs.orglett.8b03684. Epub 2018 Dec 20.

PMID:
30571134
17.

Streptocyclinones A and B ameliorate Alzheimer's disease pathological processes in vitro.

Alvariño R, Alonso E, Lacret R, Oves-Costales D, Genilloud O, Reyes F, Alfonso A, Botana LM.

Neuropharmacology. 2018 Oct;141:283-295. doi: 10.1016/j.neuropharm.2018.09.008. Epub 2018 Sep 8.

PMID:
30205103
18.

Paralytic Shellfish Toxins Occurrence in Non-Traditional Invertebrate Vectors from North Atlantic Waters (Azores, Madeira, and Morocco).

Silva M, Rey V, Barreiro A, Kaufmann M, Neto AI, Hassouani M, Sabour B, Botana A, Botana LM, Vasconcelos V.

Toxins (Basel). 2018 Sep 6;10(9). pii: E362. doi: 10.3390/toxins10090362.

19.

Toxic Action Reevaluation of Okadaic Acid, Dinophysistoxin-1 and Dinophysistoxin-2: Toxicity Equivalency Factors Based on the Oral Toxicity Study.

Abal P, Louzao MC, Suzuki T, Watanabe R, Vilariño N, Carrera C, Botana AM, Vieytes MR, Botana LM.

Cell Physiol Biochem. 2018;49(2):743-757. doi: 10.1159/000493039. Epub 2018 Sep 3.

20.

From Marine Origin to Therapeutics: The Antitumor Potential of Marine Algae-Derived Compounds.

Alves C, Silva J, Pinteus S, Gaspar H, Alpoim MC, Botana LM, Pedrosa R.

Front Pharmacol. 2018 Aug 6;9:777. doi: 10.3389/fphar.2018.00777. eCollection 2018. Review.

21.

Rapid analysis of paralytic shellfish toxins and tetrodotoxins by liquid chromatography-tandem mass spectrometry using a porous graphitic carbon column.

Rey V, Botana AM, Antelo A, Alvarez M, Botana LM.

Food Chem. 2018 Dec 15;269:166-172. doi: 10.1016/j.foodchem.2018.07.008. Epub 2018 Jul 2.

PMID:
30100420
22.

Human Poisoning from Marine Toxins: Unknowns for Optimal Consumer Protection.

Vilariño N, Louzao MC, Abal P, Cagide E, Carrera C, Vieytes MR, Botana LM.

Toxins (Basel). 2018 Aug 9;10(8). pii: E324. doi: 10.3390/toxins10080324. Review.

23.

A single run UPLC-MS/MS method for detection of all EU-regulated marine toxins.

Rodríguez I, Alfonso A, González-Jartín JM, Vieytes MR, Botana LM.

Talanta. 2018 Nov 1;189:622-628. doi: 10.1016/j.talanta.2018.07.050. Epub 2018 Jul 18.

PMID:
30086968
24.

Zoanthamine Alkaloids from the Zoantharian Zoanthus cf. pulchellus and Their Effects in Neuroinflammation.

Guillen PO, Gegunde S, Jaramillo KB, Alfonso A, Calabro K, Alonso E, Rodriguez J, Botana LM, Thomas OP.

Mar Drugs. 2018 Jul 20;16(7). pii: E242. doi: 10.3390/md16070242.

25.

Transcriptomic Analysis of Ciguatoxin-Induced Changes in Gene Expression in Primary Cultures of Mice Cortical Neurons.

Rubiolo JA, Vale C, Boente-Juncal A, Hirama M, Yamashita S, Camiña M, Vieytes MR, Botana LM.

Toxins (Basel). 2018 May 10;10(5). pii: E192. doi: 10.3390/toxins10050192.

26.

Synergistic Effect of Transient Receptor Potential Antagonist and Amiloride against Maitotoxin Induced Calcium Increase and Cytotoxicity in Human Neuronal Stem Cells.

Boente-Juncal A, Vale C, Alfonso A, Botana LM.

ACS Chem Neurosci. 2018 Nov 21;9(11):2667-2678. doi: 10.1021/acschemneuro.8b00128. Epub 2018 May 16.

PMID:
29733572
27.

In Vitro Effects of Chronic Spirolide Treatment on Human Neuronal Stem Cell Differentiation and Cholinergic System Development.

Boente-Juncal A, Méndez AG, Vale C, Vieytes MR, Botana LM.

ACS Chem Neurosci. 2018 Jun 20;9(6):1441-1452. doi: 10.1021/acschemneuro.8b00036. Epub 2018 Mar 14.

PMID:
29518322
28.

Molecular detection of harmful cyanobacteria and expression of their toxin genes in Dutch lakes using multi-probe RNA chips.

Van de Waal DB, Guillebault D, Alfonso A, Rodríguez I, Botana LM, Bijkerk R, Medlin LK.

Harmful Algae. 2018 Feb;72:25-35. doi: 10.1016/j.hal.2017.12.007. Epub 2018 Jan 6.

PMID:
29413382
29.

The impact of depuration on mussel hepatopancreas bacteriome composition and predicted metagenome.

Rubiolo JA, Lozano-Leon A, Rodriguez-Souto R, Fol Rodríguez N, Vieytes MR, Botana LM.

Antonie Van Leeuwenhoek. 2018 Jul;111(7):1117-1129. doi: 10.1007/s10482-018-1015-y. Epub 2018 Jan 17.

PMID:
29340947
30.

Improving zebrafish embryo xenotransplantation conditions by increasing incubation temperature and establishing a proliferation index with ZFtool.

Cabezas-Sainz P, Guerra-Varela J, Carreira MJ, Mariscal J, Roel M, Rubiolo JA, Sciara AA, Abal M, Botana LM, López R, Sánchez L.

BMC Cancer. 2018 Jan 2;18(1):3. doi: 10.1186/s12885-017-3919-8.

31.

Detection of new emerging type-A trichothecenes by untargeted mass spectrometry.

González-Jartín JM, Alfonso A, Sainz MJ, Vieytes MR, Botana LM.

Talanta. 2018 Feb 1;178:37-42. doi: 10.1016/j.talanta.2017.09.009. Epub 2017 Sep 6.

PMID:
29136836
32.

Absorption and Effect of Azaspiracid-1 Over the Human Intestinal Barrier.

Abal P, Louzao MC, Fraga M, Vilariño N, Ferreiro S, Vieytes MR, Botana LM.

Cell Physiol Biochem. 2017;43(1):136-146. doi: 10.1159/000480331. Epub 2017 Aug 28.

33.

Remembering Dr. Rex Munday.

Botana LM, Vasconcelos V.

Toxins (Basel). 2017 Aug 24;9(9). pii: E257. doi: 10.3390/toxins9090257.

34.

First Identification of Palytoxin-Like Molecules in the Atlantic Coral Species Palythoa canariensis.

Fraga M, Vilariño N, Louzao MC, Molina L, López Y, Poli M, Botana LM.

Anal Chem. 2017 Jul 18;89(14):7438-7446. doi: 10.1021/acs.analchem.7b01003. Epub 2017 Jul 7.

PMID:
28648045
35.

UPLC-MS-IT-TOF Identification of Circumdatins Produced by Aspergillus ochraceus.

González-Jartı N JM, Alfonso A, Sainz MJ, Vieytes MR, Botana LM.

J Agric Food Chem. 2017 Jun 14;65(23):4843-4852. doi: 10.1021/acs.jafc.7b01845. Epub 2017 Jun 5.

PMID:
28535676
36.

Evaluation of the Protective Effects of Sarains on H2O2-Induced Mitochondrial Dysfunction and Oxidative Stress in SH-SY5Y Neuroblastoma Cells.

Alvariño R, Alonso E, Tribalat MA, Gegunde S, Thomas OP, Botana LM.

Neurotox Res. 2017 Oct;32(3):368-380. doi: 10.1007/s12640-017-9748-3. Epub 2017 May 6.

PMID:
28478531
37.

The Marine Guanidine Alkaloid Crambescidin 816 Induces Calcium Influx and Cytotoxicity in Primary Cultures of Cortical Neurons through Glutamate Receptors.

Mendez AG, Juncal AB, Silva SBL, Thomas OP, Martín Vázquez V, Alfonso A, Vieytes MR, Vale C, Botana LM.

ACS Chem Neurosci. 2017 Jul 19;8(7):1609-1617. doi: 10.1021/acschemneuro.7b00096. Epub 2017 Apr 24.

PMID:
28375602
38.

Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL).

Abal P, Louzao MC, Antelo A, Alvarez M, Cagide E, Vilariño N, Vieytes MR, Botana LM.

Toxins (Basel). 2017 Feb 24;9(3). pii: E75. doi: 10.3390/toxins9030075.

39.

Characterization of the dinophysistoxin-2 acute oral toxicity in mice to define the Toxicity Equivalency Factor.

Abal P, Louzao MC, Cifuentes JM, Vilariño N, Rodriguez I, Alfonso A, Vieytes MR, Botana LM.

Food Chem Toxicol. 2017 Apr;102:166-175. doi: 10.1016/j.fct.2017.02.023. Epub 2017 Feb 20.

PMID:
28223118
40.

Subacute immunotoxicity of the marine phycotoxin yessotoxin in rats.

Ferreiro SF, Vilariño N, Carrera C, Louzao MC, Santamarina G, Cantalapiedra AG, Cifuentes JM, Vieira AC, Botana LM.

Toxicon. 2017 Apr;129:74-80. doi: 10.1016/j.toxicon.2017.02.009. Epub 2017 Feb 14.

PMID:
28209479
42.

Tetracyclic Truncated Analogue of the Marine Toxin Gambierol Modifies NMDA, Tau, and Amyloid β Expression in Mice Brains: Implications in AD Pathology.

Alonso E, Vieira AC, Rodriguez I, Alvariño R, Gegunde S, Fuwa H, Suga Y, Sasaki M, Alfonso A, Cifuentes JM, Botana LM.

ACS Chem Neurosci. 2017 Jun 21;8(6):1358-1367. doi: 10.1021/acschemneuro.7b00012. Epub 2017 Feb 13.

PMID:
28125211
43.

The association of bacterial C9-based TTX-like compounds with Prorocentrum minimum opens new uncertainties about shellfish seafood safety.

Rodríguez I, Alfonso A, Alonso E, Rubiolo JA, Roel M, Vlamis A, Katikou P, Jackson SA, Menon ML, Dobson A, Botana LM.

Sci Rep. 2017 Jan 20;7:40880. doi: 10.1038/srep40880.

44.

Yessotoxin, a Marine Toxin, Exhibits Anti-Allergic and Anti-Tumoural Activities Inhibiting Melanoma Tumour Growth in a Preclinical Model.

Tobío A, Alfonso A, Madera-Salcedo I, Botana LM, Blank U.

PLoS One. 2016 Dec 14;11(12):e0167572. doi: 10.1371/journal.pone.0167572. eCollection 2016.

45.

Marine guanidine alkaloids crambescidins inhibit tumor growth and activate intrinsic apoptotic signaling inducing tumor regression in a colorectal carcinoma zebrafish xenograft model.

Roel M, Rubiolo JA, Guerra-Varela J, Silva SB, Thomas OP, Cabezas-Sainz P, Sánchez L, López R, Botana LM.

Oncotarget. 2016 Dec 13;7(50):83071-83087. doi: 10.18632/oncotarget.13068.

46.

Spongionella Secondary Metabolites, Promising Modulators of Immune Response through CD147 Receptor Modulation.

Sánchez JA, Alfonso A, Rodriguez I, Alonso E, Cifuentes JM, Bermudez R, Rateb ME, Jaspars M, Houssen WE, Ebel R, Tabudravu J, Botana LM.

Front Immunol. 2016 Oct 24;7:452. eCollection 2016.

47.

Evaluation of the Antioxidant Activity of the Marine Pyrroloiminoquinone Makaluvamines.

Alonso E, Alvariño R, Leirós M, Tabudravu JN, Feussner K, Dam MA, Rateb ME, Jaspars M, Botana LM.

Mar Drugs. 2016 Oct 27;14(11). pii: E197.

48.

Autumnalamide targeted proteins of the immunophilin family.

Sánchez JA, Alfonso A, Thomas OP, Botana LM.

Immunobiology. 2017 Feb;222(2):241-250. doi: 10.1016/j.imbio.2016.09.016. Epub 2016 Sep 28.

PMID:
27720433
49.

In vivo cardiomyocyte response to YTX- and AZA-1-induced damage: autophagy versus apoptosis.

Ferreiro SF, Vilariño N, Carrera C, Louzao MC, Santamarina G, Cantalapiedra AG, Cifuentes JM, Crespo A, Botana LM.

Arch Toxicol. 2017 Apr;91(4):1859-1870. doi: 10.1007/s00204-016-1862-0. Epub 2016 Oct 5.

PMID:
27709272
50.

Monitoring of freshwater toxins in European environmental waters by using novel multi-detection methods.

Rodriguez I, Fraga M, Alfonso A, Guillebault D, Medlin L, Baudart J, Jacob P, Helmi K, Meyer T, Breitenbach U, Holden NM, Boots B, Spurio R, Cimarelli L, Mancini L, Marcheggiani S, Albay M, Akcaalan R, Köker L, Botana LM.

Environ Toxicol Chem. 2017 Mar;36(3):645-654. doi: 10.1002/etc.3577. Epub 2016 Sep 2.

PMID:
27505279

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