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Items: 1 to 50 of 153

1.

Deep Reinforcement Learning for Multiparameter Optimization in de novo Drug Design.

Ståhl N, Falkman G, Karlsson A, Mathiason G, Boström J.

J Chem Inf Model. 2019 Jul 22;59(7):3166-3176. doi: 10.1021/acs.jcim.9b00325. Epub 2019 Jul 5.

PMID:
31273995
2.

Spontaneous Aneurysmal Subarachnoid Hemorrhage and Related Cortisol and Immunologic Alterations: Impact on Patients' Health-related Quality of Life.

Ridwan S, Greschus S, Boström J, Barrera J, Esche J, Zur B, Klingmüller D, Boström A.

J Neurol Surg A Cent Eur Neurosurg. 2019 Sep;80(5):371-380. doi: 10.1055/s-0039-1677827. Epub 2019 Jul 4.

PMID:
31272120
3.

Impact of vitamin D and vitamin D receptor TaqI polymorphism in primary human myoblasts.

Saini A, Björkhem-Bergman L, Boström J, Lilja M, Melin M, Olsson K, Ekström L, Bergman P, Altun M, Rullman E, Gustafsson T.

Endocr Connect. 2019 Jul 29;8(7):1070-1081. doi: 10.1530/EC-19-0194.

4.

Representation of abstract semantic knowledge in populations of human single neurons in the medial temporal lobe.

Reber TP, Bausch M, Mackay S, Boström J, Elger CE, Mormann F.

PLoS Biol. 2019 Jun 3;17(6):e3000290. doi: 10.1371/journal.pbio.3000290. eCollection 2019 Jun.

5.

Recollection in the human hippocampal-entorhinal cell circuitry.

Staresina BP, Reber TP, Niediek J, Boström J, Elger CE, Mormann F.

Nat Commun. 2019 Apr 3;10(1):1503. doi: 10.1038/s41467-019-09558-3.

6.

Superolateral medial forebrain bundle deep brain stimulation in major depression: a gateway trial.

Coenen VA, Bewernick BH, Kayser S, Kilian H, Boström J, Greschus S, Hurlemann R, Klein ME, Spanier S, Sajonz B, Urbach H, Schlaepfer TE.

Neuropsychopharmacology. 2019 Jun;44(7):1224-1232. doi: 10.1038/s41386-019-0369-9. Epub 2019 Mar 13.

PMID:
30867553
7.

The Hippo Pathway Regulates Caveolae Expression and Mediates Flow Response via Caveolae.

Rausch V, Bostrom JR, Park J, Bravo IR, Feng Y, Hay DC, Link BA, Hansen CG.

Curr Biol. 2019 Jan 21;29(2):242-255.e6. doi: 10.1016/j.cub.2018.11.066. Epub 2018 Dec 27.

8.

Deep Convolutional Neural Networks for the Prediction of Molecular Properties: Challenges and Opportunities Connected to the Data.

Ståhl N, Falkman G, Karlsson A, Mathiason G, Boström J.

J Integr Bioinform. 2018 Dec 5;16(1). pii: /j/jib.2019.16.issue-1/jib-2018-0065/jib-2018-0065.xml. doi: 10.1515/jib-2018-0065.

PMID:
30517077
9.

Expanding the medicinal chemistry synthetic toolbox.

Boström J, Brown DG, Young RJ, Keserü GM.

Nat Rev Drug Discov. 2018 Nov 28;17(12):922. doi: 10.1038/nrd.2018.217.

PMID:
30482954
10.

Expanding the medicinal chemistry synthetic toolbox.

Boström J, Brown DG, Young RJ, Keserü GM.

Nat Rev Drug Discov. 2018 Oct;17(10):709-727. doi: 10.1038/nrd.2018.116. Epub 2018 Aug 24. Review. Erratum in: Nat Rev Drug Discov. 2018 Nov 28;17(12):922.

PMID:
30140018
11.

LINAC stereotactic radiosurgery for trigeminal neuralgia -retrospective two-institutional examination of treatment outcomes.

Rashid A, Pintea B, Kinfe TM, Surber G, Hamm K, Boström JP.

Radiat Oncol. 2018 Aug 22;13(1):153. doi: 10.1186/s13014-018-1102-2.

12.

The histone chaperone NAP1L3 is required for haematopoietic stem cell maintenance and differentiation.

Heshmati Y, Kharazi S, Türköz G, Chang D, Kamali Dolatabadi E, Boström J, Krstic A, Boukoura T, Wagner E, Kadri N, Månsson R, Altun M, Qian H, Walfridsson J.

Sci Rep. 2018 Jul 25;8(1):11202. doi: 10.1038/s41598-018-29518-z.

13.

SRCP1 Conveys Resistance to Polyglutamine Aggregation.

Santarriaga S, Haver HN, Kanack AJ, Fikejs AS, Sison SL, Egner JM, Bostrom JR, Seminary ER, Hill RB, Link BA, Ebert AD, Scaglione KM.

Mol Cell. 2018 Jul 19;71(2):216-228.e7. doi: 10.1016/j.molcel.2018.07.008.

14.

Where Do Recent Small Molecule Clinical Development Candidates Come From?

Brown DG, Boström J.

J Med Chem. 2018 Nov 8;61(21):9442-9468. doi: 10.1021/acs.jmedchem.8b00675. Epub 2018 Jul 9. Review.

PMID:
29920198
15.

The impact of MRI steady-state sequences as an additional assessment modality in vestibular schwannoma patients after LINAC stereotactic radiotherapy or radiosurgery.

Sauer JP, Kinfe TM, Pintea B, Schäfer A, Boström JP.

Strahlenther Onkol. 2018 Dec;194(12):1103-1113. doi: 10.1007/s00066-018-1317-z. Epub 2018 May 23.

PMID:
29796695
16.

ReFlex3D: Refined Flexible Alignment of Molecules Using Shape and Electrostatics.

Schmidt TC, Cosgrove DA, Boström J.

J Chem Inf Model. 2018 Apr 23;58(4):747-760. doi: 10.1021/acs.jcim.7b00618. Epub 2018 Apr 13.

PMID:
29600850
17.

The chromatin-remodeling factor CHD4 is required for maintenance of childhood acute myeloid leukemia.

Heshmati Y, Türköz G, Harisankar A, Kharazi S, Boström J, Dolatabadi EK, Krstic A, Chang D, Månsson R, Altun M, Qian H, Walfridsson J.

Haematologica. 2018 Jul;103(7):1169-1181. doi: 10.3324/haematol.2017.183970. Epub 2018 Mar 29.

18.

Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors.

Azimi A, Caramuta S, Seashore-Ludlow B, Boström J, Robinson JL, Edfors F, Tuominen R, Kemper K, Krijgsman O, Peeper DS, Nielsen J, Hansson J, Egyhazi Brage S, Altun M, Uhlen M, Maddalo G.

Mol Syst Biol. 2018 Mar 5;14(3):e7858. doi: 10.15252/msb.20177858.

19.

Factors of influence upon the SF-36-based health related quality of life of patients following surgery for petroclival and lateral posterior surface of pyramid meningiomas.

Pintea B, Kandenwein JA, Lorenzen H, Boström JP, Daher F, Velazquez V, Kristof RA.

Clin Neurol Neurosurg. 2018 Mar;166:36-43. doi: 10.1016/j.clineuro.2018.01.016. Epub 2018 Jan 31.

PMID:
29408770
20.

Study protocol for Smartphone Monitoring for Atrial fibrillation in Real-Time in India (SMART-India): a community-based screening and referral programme.

Soni A, Karna S, Patel H, Fahey N, Raithatha S, Handorf A, Bostrom J, Bashar S, Talati K, Shah R, Goldberg RJ, Thanvi S, Phatak AG, Allison JJ, Chon K, Nimbalkar SM, McManus DD.

BMJ Open. 2017 Dec 14;7(12):e017668. doi: 10.1136/bmjopen-2017-017668.

21.

Comparative cell cycle transcriptomics reveals synchronization of developmental transcription factor networks in cancer cells.

Boström J, Sramkova Z, Salašová A, Johard H, Mahdessian D, Fedr R, Marks C, Medalová J, Souček K, Lundberg E, Linnarsson S, Bryja V, Sekyrova P, Altun M, Andäng M.

PLoS One. 2017 Dec 11;12(12):e0188772. doi: 10.1371/journal.pone.0188772. eCollection 2017.

22.
23.

Single-Neuron Correlates of Conscious Perception in the Human Medial Temporal Lobe.

Reber TP, Faber J, Niediek J, Boström J, Elger CE, Mormann F.

Curr Biol. 2017 Oct 9;27(19):2991-2998.e2. doi: 10.1016/j.cub.2017.08.025. Epub 2017 Sep 21.

24.

Discovery and Evaluation of Anti-Fibrinolytic Plasmin Inhibitors Derived from 5-(4-Piperidyl)isoxazol-3-ol (4-PIOL).

Schmidt TC, Eriksson PO, Gustafsson D, Cosgrove D, Frølund B, Boström J.

J Chem Inf Model. 2017 Jul 24;57(7):1703-1714. doi: 10.1021/acs.jcim.7b00255. Epub 2017 Jul 12.

PMID:
28653850
25.

A multimodal concept for invasive diagnostics and surgery based on neuronavigated voxel-based morphometric MRI postprocessing data in previously nonlesional epilepsy.

Delev D, Quesada CM, Grote A, Boström JP, Elger C, Vatter H, Surges R.

J Neurosurg. 2018 Apr;128(4):1178-1186. doi: 10.3171/2016.12.JNS161676. Epub 2017 Jun 16.

PMID:
28621626
26.

Burden of Psychosocial and Cognitive Impairment in Patients With Atrial Fibrillation.

Bostrom JA, Saczynski JS, Hajduk A, Donahue K, Rosenthal LS, Browning C, Ennis C, Floyd KC, Richardson H, Esa N, Ogarek J, McManus DD.

Crit Pathw Cardiol. 2017 Jun;16(2):71-75. doi: 10.1097/HPC.0000000000000101.

27.

Society for Vascular Surgery Wound, Ischemia, foot Infection (WIfI) score correlates with the intensity of multimodal limb treatment and patient-centered outcomes in patients with threatened limbs managed in a limb preservation center.

Robinson WP, Loretz L, Hanesian C, Flahive J, Bostrom J, Lunig N, Schanzer A, Messina L.

J Vasc Surg. 2017 Aug;66(2):488-498.e2. doi: 10.1016/j.jvs.2017.01.063. Epub 2017 Apr 11.

28.

RAHI-SATHI Indo-U.S. Collaboration: The Evolution of a Trainee-Led Twinning Model in Global Health Into a Multidisciplinary Collaborative Program.

Soni A, Fahey N, Jaffe A, Raithatha S, Raithatha N, Prabhakaran A, Moore Simas TA, Byatt N, Vankar J, Chin M, Phatak AG, Srivastava S, McManus DD, O'Keefe E, Patel H, Patel N, Patel D, Tracey M, Khubchandani JA, Newman H, Earon A, Rosenfield H, Handorf A, Novak B, Bostrom J, Deb A, Desai S, Patel D, Nimbalkar A, Talati K, Rosal M, McQuilkin P, Pandya H, Santry HP, Thanvi S, Kharod U, Fischer M, Allison J, Nimbalkar SM.

Glob Health Sci Pract. 2017 Mar 28;5(1):152-163. doi: 10.9745/GHSP-D-16-00190. Print 2017 Mar 24.

29.

Women's Experiences of Undergoing Total Knee Joint Replacement Surgery.

Engström Å, Boström J, Karlsson AC.

J Perianesth Nurs. 2017 Apr;32(2):86-95. doi: 10.1016/j.jopan.2015.11.009. Epub 2016 Jul 27.

PMID:
28343648
30.

Cos2/Kif7 and Osm-3/Kif17 regulate onset of outer segment development in zebrafish photoreceptors through distinct mechanisms.

Lewis TR, Kundinger SR, Pavlovich AL, Bostrom JR, Link BA, Besharse JC.

Dev Biol. 2017 May 15;425(2):176-190. doi: 10.1016/j.ydbio.2017.03.019. Epub 2017 Mar 22.

31.

Loss of Zebrafish Mfrp Causes Nanophthalmia, Hyperopia, and Accumulation of Subretinal Macrophages.

Collery RF, Volberding PJ, Bostrom JR, Link BA, Besharse JC.

Invest Ophthalmol Vis Sci. 2016 Dec 1;57(15):6805-6814. doi: 10.1167/iovs.16-19593.

32.

Reliable Analysis of Single-Unit Recordings from the Human Brain under Noisy Conditions: Tracking Neurons over Hours.

Niediek J, Boström J, Elger CE, Mormann F.

PLoS One. 2016 Dec 8;11(12):e0166598. doi: 10.1371/journal.pone.0166598. eCollection 2016.

33.

hMYH and hMTH1 cooperate for survival in mismatch repair defective T-cell acute lymphoblastic leukemia.

Eshtad S, Mavajian Z, Rudd SG, Visnes T, Boström J, Altun M, Helleday T.

Oncogenesis. 2016 Dec 5;5(12):e275. doi: 10.1038/oncsis.2016.72.

34.

Extended Long-Term Effects of Cervical Vagal Nerve Stimulation on Headache Intensity/Frequency and Affective/Cognitive Headache Perception in Drug Resistant Complex-Partial Seizure Patients.

Pintea B, Hampel K, Boström J, Surges R, Vatter H, Lendvai IS, Kinfe TM.

Neuromodulation. 2017 Jun;20(4):375-382. doi: 10.1111/ner.12540. Epub 2016 Nov 22.

PMID:
27873376
35.

The flicker fusion frequency of budgerigars (Melopsittacus undulatus) revisited.

Boström JE, Haller NK, Dimitrova M, Ödeen A, Kelber A.

J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2017 Jan;203(1):15-22. doi: 10.1007/s00359-016-1130-z. Epub 2016 Nov 11.

36.

High Burden of Unrecognized Atrial Fibrillation in Rural India: An Innovative Community-Based Cross-Sectional Screening Program.

Soni A, Earon A, Handorf A, Fahey N, Talati K, Bostrom J, Chon K, Napolitano C, Chin M, Sullivan J, Raithatha S, Goldberg R, Nimbalkar S, Allison J, Thanvi S, McManus D.

JMIR Public Health Surveill. 2016 Oct 13;2(2):e159.

37.

Burst firing of single neurons in the human medial temporal lobe changes before epileptic seizures.

Gast H, Niediek J, Schindler K, Boström J, Coenen VA, Beck H, Elger CE, Mormann F.

Clin Neurophysiol. 2016 Oct;127(10):3329-34. doi: 10.1016/j.clinph.2016.08.010. Epub 2016 Aug 20.

PMID:
27592159
38.

3D-Lab: a collaborative web-based platform for molecular modeling.

Grebner C, Norrby M, Enström J, Nilsson I, Hogner A, Henriksson J, Westin J, Faramarzi F, Werner P, Boström J.

Future Med Chem. 2016 Sep;8(14):1739-52. doi: 10.4155/fmc-2016-0081. Epub 2016 Aug 31.

39.

Lmx1b is required for the glutamatergic fates of a subset of spinal cord neurons.

Hilinski WC, Bostrom JR, England SJ, Juárez-Morales JL, de Jager S, Armant O, Legradi J, Strähle U, Link BA, Lewis KE.

Neural Dev. 2016 Aug 23;11(1):16. doi: 10.1186/s13064-016-0070-1.

40.

Treatment of Cerebral Arteriovenous Malformations with Radiosurgery or Hypofractionated Stereotactic Radiotherapy in a Consecutive Pooled Linear Accelerator Series.

Boström JP, Bruckermann R, Pintea B, Boström A, Surber G, Hamm K.

World Neurosurg. 2016 Oct;94:328-338. doi: 10.1016/j.wneu.2016.07.016. Epub 2016 Jul 15.

PMID:
27423196
41.

Ultra-Rapid Vision in Birds.

Boström JE, Dimitrova M, Canton C, Håstad O, Qvarnström A, Ödeen A.

PLoS One. 2016 Mar 18;11(3):e0151099. doi: 10.1371/journal.pone.0151099. eCollection 2016.

42.

Low-dose radiosurgery or hypofractionated stereotactic radiotherapy as treatment option in refractory epilepsy due to epileptogenic lesions in eloquent areas - Preliminary report of feasibility and safety.

Boström JP, Delev D, Quesada C, Widman G, Vatter H, Elger CE, Surges R.

Seizure. 2016 Mar;36:57-62. doi: 10.1016/j.seizure.2016.02.010. Epub 2016 Feb 27.

43.

Stuck in a rut with old chemistry.

Boström J, Brown DG.

Drug Discov Today. 2016 May;21(5):701-3. doi: 10.1016/j.drudis.2016.02.017. Epub 2016 Mar 3. No abstract available.

PMID:
26945942
44.

Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?

Brown DG, Boström J.

J Med Chem. 2016 May 26;59(10):4443-58. doi: 10.1021/acs.jmedchem.5b01409. Epub 2015 Dec 1.

45.

Molecular Rift: Virtual Reality for Drug Designers.

Norrby M, Grebner C, Eriksson J, Boström J.

J Chem Inf Model. 2015 Nov 23;55(11):2475-84. doi: 10.1021/acs.jcim.5b00544. Epub 2015 Nov 11.

PMID:
26558887
46.

Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2.

Carter M, Jemth AS, Hagenkort A, Page BD, Gustafsson R, Griese JJ, Gad H, Valerie NC, Desroses M, Boström J, Warpman Berglund U, Helleday T, Stenmark P.

Nat Commun. 2015 Aug 4;6:7871. doi: 10.1038/ncomms8871.

47.

Molecular classification of diffuse cerebral WHO grade II/III gliomas using genome- and transcriptome-wide profiling improves stratification of prognostically distinct patient groups.

Weller M, Weber RG, Willscher E, Riehmer V, Hentschel B, Kreuz M, Felsberg J, Beyer U, Löffler-Wirth H, Kaulich K, Steinbach JP, Hartmann C, Gramatzki D, Schramm J, Westphal M, Schackert G, Simon M, Martens T, Boström J, Hagel C, Sabel M, Krex D, Tonn JC, Wick W, Noell S, Schlegel U, Radlwimmer B, Pietsch T, Loeffler M, von Deimling A, Binder H, Reifenberger G.

Acta Neuropathol. 2015 May;129(5):679-93. doi: 10.1007/s00401-015-1409-0. Epub 2015 Mar 18.

48.

Sex differences in GABAergic gene expression occur in the anterior cingulate cortex in schizophrenia.

Bristow GC, Bostrom JA, Haroutunian V, Sodhi MS.

Schizophr Res. 2015 Sep;167(1-3):57-63. doi: 10.1016/j.schres.2015.01.025. Epub 2015 Feb 7.

49.

Understanding our love affair with p-chlorophenyl: present day implications from historical biases of reagent selection.

Brown DG, Gagnon MM, Boström J.

J Med Chem. 2015 Mar 12;58(5):2390-405. doi: 10.1021/jm501894t. Epub 2015 Feb 19.

PMID:
25658759
50.

The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages.

Altun M, Walter TS, Kramer HB, Herr P, Iphöfer A, Boström J, David Y, Komsany A, Ternette N, Navon A, Stuart DI, Ren J, Kessler BM.

PLoS One. 2015 Jan 15;10(1):e0115344. doi: 10.1371/journal.pone.0115344. eCollection 2015.

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