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Items: 1 to 50 of 71

1.

The Emergence and Functional Fitness of Memory CD4+ T Cells Require the Transcription Factor Thpok.

Ciucci T, Vacchio MS, Gao Y, Tomassoni Ardori F, Candia J, Mehta M, Zhao Y, Tran B, Pepper M, Tessarollo L, McGavern DB, Bosselut R.

Immunity. 2019 Jan 15;50(1):91-105.e4. doi: 10.1016/j.immuni.2018.12.019. Epub 2019 Jan 9.

PMID:
30638736
2.

A STAT3-dependent transcriptional circuitry inhibits cytotoxic gene expression in T cells.

Ciucci T, Vacchio MS, Bosselut R.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):13236-13241. doi: 10.1073/pnas.1711160114. Epub 2017 Nov 27.

3.

Control of Regulatory T Cell Differentiation by the Transcription Factors Thpok and LRF.

Carpenter AC, Wohlfert E, Chopp LB, Vacchio MS, Nie J, Zhao Y, Shetty J, Xiao Q, Deng C, Tran B, Cam M, Gaida MM, Belkaid Y, Bosselut R.

J Immunol. 2017 Sep 1;199(5):1716-1728. doi: 10.4049/jimmunol.1700181. Epub 2017 Jul 28.

4.

In vivo kinetics and nonradioactive imaging of rapidly proliferating cells in graft-versus-host disease.

Buxbaum NP, Farthing DE, Maglakelidze N, Lizak M, Merkle H, Carpenter AC, Oliver BU, Kapoor V, Castro E, Swan GA, Dos Santos LM, Bouladoux NJ, Bare CV, Flomerfelt FA, Eckhaus MA, Telford WG, Belkaid Y, Bosselut RJ, Gress RE.

JCI Insight. 2017 Jun 15;2(12). pii: 92851. doi: 10.1172/jci.insight.92851. eCollection 2017 Jun 15.

5.
6.

HMGN proteins modulate chromatin regulatory sites and gene expression during activation of naïve B cells.

Zhang S, Zhu I, Deng T, Furusawa T, Rochman M, Vacchio MS, Bosselut R, Yamane A, Casellas R, Landsman D, Bustin M.

Nucleic Acids Res. 2016 Sep 6;44(15):7144-58. doi: 10.1093/nar/gkw323. Epub 2016 Apr 25.

7.

A long journey coming to fruition: In sight of the preselection T-cell repertoire.

Ciucci T, Bosselut R.

Eur J Immunol. 2016 Mar;46(3):539-42. doi: 10.1002/eji.201646292. Epub 2016 Feb 22.

8.

Pleiotropic Functions of H3K27Me3 Demethylases in Immune Cell Differentiation.

Bosselut R.

Trends Immunol. 2016 Feb;37(2):102-113. doi: 10.1016/j.it.2015.12.004. Epub 2016 Jan 19. Review.

9.

Preface. T-Cell Development.

Bosselut R, Vacchio MS.

Methods Mol Biol. 2016;1323:v-vi. No abstract available.

PMID:
26512377
10.

Histone H3 Lysine 27 demethylases Jmjd3 and Utx are required for T-cell differentiation.

Manna S, Kim JK, Baugé C, Cam M, Zhao Y, Shetty J, Vacchio MS, Castro E, Tran B, Tessarollo L, Bosselut R.

Nat Commun. 2015 Sep 2;6:8152. doi: 10.1038/ncomms9152.

11.

In Vitro Analyses of T Cell Effector Differentiation.

Wohlfert EA, Carpenter AC, Belkaid Y, Bosselut R.

Methods Mol Biol. 2016;1323:117-28. doi: 10.1007/978-1-4939-2809-5_10.

PMID:
26294403
12.

Purification of Thymocyte and T Cell Subsets.

Carpenter AC, Kim JK, Bosselut R.

Methods Mol Biol. 2016;1323:87-97. doi: 10.1007/978-1-4939-2809-5_7.

PMID:
26294400
13.

Genetic Tools to Study T Cell Development.

Ciucci T, Vacchio MS, Bosselut R.

Methods Mol Biol. 2016;1323:35-45. doi: 10.1007/978-1-4939-2809-5_3. Review.

PMID:
26294396
14.

200 Million Thymocytes and I: A Beginner's Survival Guide to T Cell Development.

Vacchio MS, Ciucci T, Bosselut R.

Methods Mol Biol. 2016;1323:3-21. doi: 10.1007/978-1-4939-2809-5_1. Review.

PMID:
26294394
15.

Coupling of T cell receptor specificity to natural killer T cell development by bivalent histone H3 methylation.

Dobenecker MW, Kim JK, Marcello J, Fang TC, Prinjha R, Bosselut R, Tarakhovsky A.

J Exp Med. 2015 Mar 9;212(3):297-306. doi: 10.1084/jem.20141499. Epub 2015 Feb 16.

16.

The microRNA biogenesis machinery modulates lineage commitment during αβ T cell development.

Rupp LJ, Brady BL, Carpenter AC, De Obaldia ME, Bhandoola A, Bosselut R, Muljo SA, Bassing CH.

J Immunol. 2014 Oct 15;193(8):4032-42. doi: 10.4049/jimmunol.1401359. Epub 2014 Sep 12.

17.

A ThPOK-LRF transcriptional node maintains the integrity and effector potential of post-thymic CD4+ T cells.

Vacchio MS, Wang L, Bouladoux N, Carpenter AC, Xiong Y, Williams LC, Wohlfert E, Song KD, Belkaid Y, Love PE, Bosselut R.

Nat Immunol. 2014 Oct;15(10):947-56. doi: 10.1038/ni.2960. Epub 2014 Aug 17.

18.

Transcriptional and epigenetic networks of helper T and innate lymphoid cells.

Shih HY, Sciumè G, Poholek AC, Vahedi G, Hirahara K, Villarino AV, Bonelli M, Bosselut R, Kanno Y, Muljo SA, O'Shea JJ.

Immunol Rev. 2014 Sep;261(1):23-49. doi: 10.1111/imr.12208. Review.

19.

A ROG(ue) in charge of the (natural) killers.

Ciucci T, Bosselut R.

Nat Immunol. 2014 Jun;15(6):531-2. doi: 10.1038/ni.2895. No abstract available.

PMID:
24840990
20.

Gimap and T cells: a matter of life or death.

Ciucci T, Bosselut R.

Eur J Immunol. 2014 Feb;44(2):348-51. doi: 10.1002/eji.201344375.

21.

T cell metabolism: microRNAs cap PTEN to feed the expanding crowd.

Vacchio MS, Bosselut R.

Immunity. 2013 May 23;38(5):847-8. doi: 10.1016/j.immuni.2013.05.006. No abstract available.

22.

[Interleukin 22 may represent a new therapeutic tool towards thymic regeneration in vivo].

Williams L, Bosselut R.

Med Sci (Paris). 2013 Jan;29(1):11-4. doi: 10.1051/medsci/2013291003. Epub 2013 Jan 25. French. No abstract available.

23.

Thpok-independent repression of Runx3 by Gata3 during CD4+ T-cell differentiation in the thymus.

Xiong Y, Castro E, Yagi R, Zhu J, Lesourne R, Love PE, Feigenbaum L, Bosselut R.

Eur J Immunol. 2013 Apr;43(4):918-28. doi: 10.1002/eji.201242944. Epub 2013 Feb 12.

24.

The transcription factors Thpok and LRF are necessary and partly redundant for T helper cell differentiation.

Carpenter AC, Grainger JR, Xiong Y, Kanno Y, Chu HH, Wang L, Naik S, dos Santos L, Wei L, Jenkins MK, O'Shea JJ, Belkaid Y, Bosselut R.

Immunity. 2012 Oct 19;37(4):622-33. doi: 10.1016/j.immuni.2012.06.019. Epub 2012 Oct 4.

25.

CD4-CD8 differentiation in the thymus: connecting circuits and building memories.

Xiong Y, Bosselut R.

Curr Opin Immunol. 2012 Apr;24(2):139-45. doi: 10.1016/j.coi.2012.02.002. Epub 2012 Mar 2. Review.

26.

Coreceptor gene imprinting governs thymocyte lineage fate.

Adoro S, McCaughtry T, Erman B, Alag A, Van Laethem F, Park JH, Tai X, Kimura M, Wang L, Grinberg A, Kubo M, Bosselut R, Love P, Singer A.

EMBO J. 2012 Jan 18;31(2):366-77. doi: 10.1038/emboj.2011.388. Epub 2011 Oct 28.

27.

GATA3 controls Foxp3⁺ regulatory T cell fate during inflammation in mice.

Wohlfert EA, Grainger JR, Bouladoux N, Konkel JE, Oldenhove G, Ribeiro CH, Hall JA, Yagi R, Naik S, Bhairavabhotla R, Paul WE, Bosselut R, Wei G, Zhao K, Oukka M, Zhu J, Belkaid Y.

J Clin Invest. 2011 Nov;121(11):4503-15. doi: 10.1172/JCI57456. Epub 2011 Oct 3.

28.

Maintaining CD4-CD8 lineage integrity in T cells: where plasticity serves versatility.

Wang L, Xiong Y, Bosselut R.

Semin Immunol. 2011 Oct;23(5):360-7. doi: 10.1016/j.smim.2011.08.008. Epub 2011 Oct 1. Review.

29.

RUNX transcription factor-mediated association of Cd4 and Cd8 enables coordinate gene regulation.

Collins A, Hewitt SL, Chaumeil J, Sellars M, Micsinai M, Allinne J, Parisi F, Nora EP, Bolland DJ, Corcoran AE, Kluger Y, Bosselut R, Ellmeier W, Chong MM, Littman DR, Skok JA.

Immunity. 2011 Mar 25;34(3):303-14. doi: 10.1016/j.immuni.2011.03.004.

30.

The enigma of CD4-lineage specification.

Xiong Y, Bosselut R.

Eur J Immunol. 2011 Mar;41(3):568-74. doi: 10.1002/eji.201041098. Epub 2011 Feb 10. Review.

31.

Control of the development of CD8αα+ intestinal intraepithelial lymphocytes by TGF-β.

Konkel JE, Maruyama T, Carpenter AC, Xiong Y, Zamarron BF, Hall BE, Kulkarni AB, Zhang P, Bosselut R, Chen W.

Nat Immunol. 2011 Apr;12(4):312-9. doi: 10.1038/ni.1997. Epub 2011 Feb 6.

32.

The sequential activity of Gata3 and Thpok is required for the differentiation of CD1d-restricted CD4+ NKT cells.

Wang L, Carr T, Xiong Y, Wildt KF, Zhu J, Feigenbaum L, Bendelac A, Bosselut R.

Eur J Immunol. 2010 Sep;40(9):2385-90. doi: 10.1002/eji.201040534.

33.

Decision checkpoints in the thymus.

Carpenter AC, Bosselut R.

Nat Immunol. 2010 Aug;11(8):666-73. doi: 10.1038/ni.1887. Epub 2010 Jul 20. Review. Erratum in: Nat Immunol. 2011 Mar;12(3):271.

34.

Tenuous paths in unexplored territory: From T cell receptor signaling to effector gene expression during thymocyte selection.

Wang L, Xiong Y, Bosselut R.

Semin Immunol. 2010 Oct;22(5):294-302. doi: 10.1016/j.smim.2010.04.013. Review.

35.

The transcription factor Ets1 is important for CD4 repression and Runx3 up-regulation during CD8 T cell differentiation in the thymus.

Zamisch M, Tian L, Grenningloh R, Xiong Y, Wildt KF, Ehlers M, Ho IC, Bosselut R.

J Exp Med. 2009 Nov 23;206(12):2685-99. doi: 10.1084/jem.20092024. Epub 2009 Nov 16.

36.

CD4-CD8 lineage differentiation: Thpok-ing into the nucleus.

Wang L, Bosselut R.

J Immunol. 2009 Sep 1;183(5):2903-10. doi: 10.4049/jimmunol.0901041. Review.

37.

Themis, a T cell-specific protein important for late thymocyte development.

Lesourne R, Uehara S, Lee J, Song KD, Li L, Pinkhasov J, Zhang Y, Weng NP, Wildt KF, Wang L, Bosselut R, Love PE.

Nat Immunol. 2009 Aug;10(8):840-7. doi: 10.1038/ni.1768. Epub 2009 Jul 13. Erratum in: Nat Immunol. 2010 Jan;11(1):97.

38.

The zinc finger transcription factor Zbtb7b represses CD8-lineage gene expression in peripheral CD4+ T cells.

Wang L, Wildt KF, Castro E, Xiong Y, Feigenbaum L, Tessarollo L, Bosselut R.

Immunity. 2008 Dec 19;29(6):876-87. doi: 10.1016/j.immuni.2008.09.019. Epub 2008 Dec 8.

39.

Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells.

Wang L, Wildt KF, Zhu J, Zhang X, Feigenbaum L, Tessarollo L, Paul WE, Fowlkes BJ, Bosselut R.

Nat Immunol. 2008 Oct;9(10):1122-30. doi: 10.1038/ni.1647. Epub 2008 Sep 7.

40.

The transcription factor Zbtb7b promotes CD4 expression by antagonizing Runx-mediated activation of the CD4 silencer.

Wildt KF, Sun G, Grueter B, Fischer M, Zamisch M, Ehlers M, Bosselut R.

J Immunol. 2007 Oct 1;179(7):4405-14.

41.

'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR.

Park JH, Adoro S, Lucas PJ, Sarafova SD, Alag AS, Doan LL, Erman B, Liu X, Ellmeier W, Bosselut R, Feigenbaum L, Singer A.

Nat Immunol. 2007 Oct;8(10):1049-59. Epub 2007 Sep 16.

PMID:
17873878
42.

Hematopoiesis and thymic apoptosis are not affected by the loss of Cdk2.

Berthet C, Rodriguez-Galan MC, Hodge DL, Gooya J, Pascal V, Young HA, Keller J, Bosselut R, Kaldis P.

Mol Cell Biol. 2007 Jul;27(14):5079-89. Epub 2007 May 7.

43.

Expression of the transcription factor cKrox in peripheral CD8 T cells reveals substantial postthymic plasticity in CD4-CD8 lineage differentiation.

Jenkinson SR, Intlekofer AM, Sun G, Feigenbaum L, Reiner SL, Bosselut R.

J Exp Med. 2007 Feb 19;204(2):267-72. Epub 2007 Feb 12.

44.

CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus.

Zhao L, Cannons JL, Anderson S, Kirby M, Xu L, Castilla LH, Schwartzberg PL, Bosselut R, Liu PP.

Blood. 2007 Apr 15;109(8):3432-40. Epub 2006 Dec 21.

45.

Retroviral TCR gene transduction: 2A for two.

Bosselut R.

Nat Methods. 2006 Mar;3(3):162-4. No abstract available.

PMID:
16489331
47.

The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection.

Sun G, Liu X, Mercado P, Jenkinson SR, Kypriotou M, Feigenbaum L, Galéra P, Bosselut R.

Nat Immunol. 2005 Apr;6(4):373-81. Epub 2005 Mar 6.

PMID:
15750595
48.

CD4/CD8-lineage differentiation in the thymus: from nuclear effectors to membrane signals.

Bosselut R.

Nat Rev Immunol. 2004 Jul;4(7):529-40. Review. No abstract available.

PMID:
15229472
49.

CD4/CD8 coreceptors in thymocyte development, selection, and lineage commitment: analysis of the CD4/CD8 lineage decision.

Singer A, Bosselut R.

Adv Immunol. 2004;83:91-131. Review. No abstract available.

PMID:
15135629
50.

Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo.

Liu X, Bosselut R.

Nat Immunol. 2004 Mar;5(3):280-8. Epub 2004 Feb 8.

PMID:
14770180

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