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Items: 1 to 50 of 167

1.

Efficacy of Oral Administration of Sodium Thiosulfate and Glycine in a Large, Swine Model of Oral Cyanide Toxicity.

Ng PC, Hendry-Hofer TB, Witeof AE, Mahon SB, Brenner M, Boss GR, Bebarta VS.

Ann Emerg Med. 2019 May 9. pii: S0196-0644(19)30242-2. doi: 10.1016/j.annemergmed.2019.03.023. [Epub ahead of print]

PMID:
31080026
2.

Hydrogen Sulfide Toxicity: Mechanism of Action, Clinical Presentation, and Countermeasure Development.

Ng PC, Hendry-Hofer TB, Witeof AE, Brenner M, Mahon SB, Boss GR, Haouzi P, Bebarta VS.

J Med Toxicol. 2019 May 6. doi: 10.1007/s13181-019-00710-5. [Epub ahead of print] Review.

PMID:
31062177
3.

Intramuscular sodium tetrathionate as an antidote in a clinically relevant swine model of acute cyanide toxicity.

Hendry-Hofer TB, Witeof AE, Ng PC, Mahon SB, Brenner M, Boss GR, Bebarta VS.

Clin Toxicol (Phila). 2019 Apr 22:1-7. doi: 10.1080/15563650.2019.1602272. [Epub ahead of print]

PMID:
31008657
4.

Antidotal efficacies of the cyanide antidote candidate dimethyl trisulfide alone and in combination with cobinamide derivatives.

Petrikovics I, Kiss L, Chou CE, Ebrahimpour A, Kovács K, Kiss M, Logue B, Chan A, Manage ABW, Budai M, Boss GR, Rockwood GA.

Toxicol Mech Methods. 2019 Jul;29(6):438-444. doi: 10.1080/15376516.2019.1585504. Epub 2019 May 6.

PMID:
30822191
5.

A Review on Ingested Cyanide: Risks, Clinical Presentation, Diagnostics, and Treatment Challenges.

Hendry-Hofer TB, Ng PC, Witeof AE, Mahon SB, Brenner M, Boss GR, Bebarta VS.

J Med Toxicol. 2019 Apr;15(2):128-133. doi: 10.1007/s13181-018-0688-y. Epub 2018 Dec 11. Review.

PMID:
30539383
6.

Intramuscular cobinamide versus saline for treatment of severe hydrogen sulfide toxicity in swine.

Ng PC, Hendry-Hofer TB, Garrett N, Brenner M, Mahon SB, Maddry JK, Haouzi P, Boss GR, Gibbons TF, Araña AA, Bebarta VS.

Clin Toxicol (Phila). 2019 Mar;57(3):189-196. doi: 10.1080/15563650.2018.1504955. Epub 2018 Nov 15.

7.

Characterization of a Swine (Sus scrofa) Model of Oral Potassium Cyanide Intoxication.

Ng PC, Hendry-Hofer TB, Witeof AE, Brenner M, Mahon SB, Boss GR, Bebarta VS.

Comp Med. 2018 Oct 1;68(5):375-379. doi: 10.30802/AALAS-CM-18-000041. Epub 2018 Sep 12.

8.

Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning.

Sips PY, Shi X, Musso G, Nath AK, Zhao Y, Nielson J, Morningstar J, Kelly AE, Mikell B, Buys E, Bebarta V, Rutter J, Davisson VJ, Mahon S, Brenner M, Boss GR, Peterson RT, Gerszten RE, MacRae CA.

PLoS One. 2018 Jun 7;13(6):e0193889. doi: 10.1371/journal.pone.0193889. eCollection 2018.

9.

Cobinamide is effective for treatment of hydrogen sulfide-induced neurological sequelae in a mouse model.

Anantharam P, Whitley EM, Mahama B, Kim DS, Sarkar S, Santana C, Chan A, Kanthasamy AG, Kanthasamy A, Boss GR, Rumbeiha WK.

Ann N Y Acad Sci. 2017 Nov;1408(1):61-78. doi: 10.1111/nyas.13559.

10.

Development of an Inexpensive RGB Color Sensor for the Detection of Hydrogen Cyanide Gas.

Greenawald LA, Boss GR, Snyder JL, Reeder A, Bell S.

ACS Sens. 2017 Oct 27;2(10):1458-1466. doi: 10.1021/acssensors.7b00396. Epub 2017 Oct 12.

PMID:
28967741
11.

Oral Glycine and Sodium Thiosulfate for Lethal Cyanide Ingestion.

Brenner M, Azer SM, Oh KJ, Han CH, Lee J, Mahon SB, Du X, Mukai D, Burney T, Saidian M, Chan A, Straker DI, Bebarta VS, Boss GR.

J Clin Toxicol. 2017 Jun;7(3). pii: 355. doi: 10.4172/2167-7972.1000355. Epub 2017 Jun 27.

12.

Efficacy of Intravenous Cobinamide Versus Hydroxocobalamin or Saline for Treatment of Severe Hydrogen Sulfide Toxicity in a Swine (Sus scrofa) Model.

Bebarta VS, Garrett N, Brenner M, Mahon SB, Maddry JK, Boudreau S, Castaneda M, Boss GR.

Acad Emerg Med. 2017 Sep;24(9):1088-1098. doi: 10.1111/acem.13213. Epub 2017 Aug 9.

13.

Cisplatin Analogs Confer Protection against Cyanide Poisoning.

Nath AK, Shi X, Harrison DL, Morningstar JE, Mahon S, Chan A, Sips P, Lee J, MacRae CA, Boss GR, Brenner M, Gerszten RE, Peterson RT.

Cell Chem Biol. 2017 May 18;24(5):565-575.e4. doi: 10.1016/j.chembiol.2017.03.013. Epub 2017 Apr 13.

14.

Sodium Nitrite and Sodium Thiosulfate Are Effective Against Acute Cyanide Poisoning When Administered by Intramuscular Injection.

Bebarta VS, Brittain M, Chan A, Garrett N, Yoon D, Burney T, Mukai D, Babin M, Pilz RB, Mahon SB, Brenner M, Boss GR.

Ann Emerg Med. 2017 Jun;69(6):718-725.e4. doi: 10.1016/j.annemergmed.2016.09.034. Epub 2016 Dec 29.

15.

Argininosuccinate Synthetase 1 Loss in Invasive Bladder Cancer Regulates Survival through General Control Nonderepressible 2 Kinase-Mediated Eukaryotic Initiation Factor 2α Activity and Is Targetable by Pegylated Arginine Deiminase.

Sahu D, Gupta S, Hau AM, Nakashima K, Leivo MZ, Searles SC, Elson P, Bomalaski JS, Casteel DE, Boss GR, Hansel DE.

Am J Pathol. 2017 Jan;187(1):200-213. doi: 10.1016/j.ajpath.2016.09.004. Epub 2016 Dec 9.

16.

The Vitamin B12 Analog Cobinamide Is an Effective Antidote for Oral Cyanide Poisoning.

Lee J, Mahon SB, Mukai D, Burney T, Katebian BS, Chan A, Bebarta VS, Yoon D, Boss GR, Brenner M.

J Med Toxicol. 2016 Dec;12(4):370-379. Epub 2016 Sep 15.

17.

A Novel, Direct NO Donor Regulates Osteoblast and Osteoclast Functions and Increases Bone Mass in Ovariectomized Mice.

Kalyanaraman H, Ramdani G, Joshua J, Schall N, Boss GR, Cory E, Sah RL, Casteel DE, Pilz RB.

J Bone Miner Res. 2017 Jan;32(1):46-59. doi: 10.1002/jbmr.2909. Epub 2016 Sep 7.

18.

Lower sulfurtransferase detoxification rates of cyanide in konzo-A tropical spastic paralysis linked to cassava cyanogenic poisoning.

Kambale KJ, Ali ER, Sadiki NH, Kayembe KP, Mvumbi LG, Yandju DL, Boivin MJ, Boss GR, Stadler DD, Lambert WE, Lasarev MR, Okitundu LA, Mumba Ngoyi D, Banea JP, Tshala-Katumbay DD.

Neurotoxicology. 2017 Mar;59:256-262. doi: 10.1016/j.neuro.2016.05.016. Epub 2016 May 28.

19.

Development of a Hydrogen Sulfide End-of-Service-Life Indicator for Respirator Cartridges Using Cobinamide.

Greenawald LA, Boss GR, Reeder A, Bell S.

Sens Actuators B Chem. 2016 Jul;230:658-666.

20.

Hydrogen Sulfide--Mechanisms of Toxicity and Development of an Antidote.

Jiang J, Chan A, Ali S, Saha A, Haushalter KJ, Lam WL, Glasheen M, Parker J, Brenner M, Mahon SB, Patel HH, Ambasudhan R, Lipton SA, Pilz RB, Boss GR.

Sci Rep. 2016 Feb 15;6:20831. doi: 10.1038/srep20831.

21.

Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes.

Garcia-Carbonell R, Divakaruni AS, Lodi A, Vicente-Suarez I, Saha A, Cheroutre H, Boss GR, Tiziani S, Murphy AN, Guma M.

Arthritis Rheumatol. 2016 Jul;68(7):1614-26. doi: 10.1002/art.39608.

22.

Simultaneous determination of 3-mercaptopyruvate and cobinamide in plasma by liquid chromatography-tandem mass spectrometry.

Stutelberg MW, Dzisam JK, Monteil AR, Petrikovics I, Boss GR, Patterson SE, Rockwood GA, Logue BA.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jan 1;1008:181-188. doi: 10.1016/j.jchromb.2015.11.027. Epub 2015 Nov 21.

PMID:
26655110
23.
24.

Development of a cobinamide-based end-of-service-life indicator for detection of hydrogen cyanide gas.

Greenawald LA, Snyder JL, Fry NL, Sailor MJ, Boss GR, Finklea HO, Bell S.

Sens Actuators B Chem. 2015 Dec 31;221:379-385.

25.

Decellularized skeletal muscle as an in vitro model for studying drug-extracellular matrix interactions.

Wassenaar JW, Boss GR, Christman KL.

Biomaterials. 2015 Sep;64:108-14. doi: 10.1016/j.biomaterials.2015.06.033. Epub 2015 Jun 20.

26.

Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities.

Kollareddy M, Dimitrova E, Vallabhaneni KC, Chan A, Le T, Chauhan KM, Carrero ZI, Ramakrishnan G, Watabe K, Haupt Y, Haupt S, Pochampally R, Boss GR, Romero DG, Radu CG, Martinez LA.

Nat Commun. 2015 Jun 12;6:7389. doi: 10.1038/ncomms8389.

27.

Oxidation-Induced Trapping of Drugs in Porous Silicon Microparticles.

Fry NL, Boss GR, Sailor MJ.

Chem Mater. 2014 Apr 22;26(8):2758-2764. Epub 2014 Mar 20.

28.

Nitrocobinamide, a new cyanide antidote that can be administered by intramuscular injection.

Chan A, Jiang J, Fridman A, Guo LT, Shelton GD, Liu MT, Green C, Haushalter KJ, Patel HH, Lee J, Yoon D, Burney T, Mukai D, Mahon SB, Brenner M, Pilz RB, Boss GR.

J Med Chem. 2015 Feb 26;58(4):1750-9. doi: 10.1021/jm501565k. Epub 2015 Feb 16.

29.

In reply.

Bebarta VS, Tanen DA, Boudreau S, Castaneda M, Zarzabal LA, Vargas T, Boss GR.

Ann Emerg Med. 2015 Feb;65(2):235. doi: 10.1016/j.annemergmed.2014.10.014. No abstract available.

PMID:
25601262
30.

Kinetics and mechanism of the reaction of hydrogen sulfide with diaquacobinamide in aqueous solution.

Salnikov DS, Makarov SV, van Eldik R, Kucherenko PN, Boss GR.

Eur J Inorg Chem. 2014 Sep;2014(25):4123-4133.

31.

Combination of low level light therapy and nitrosyl-cobinamide accelerates wound healing.

Spitler R, Ho H, Norpetlian F, Kong X, Jiang J, Yokomori K, Andersen B, Boss GR, Berns MW.

J Biomed Opt. 2015 May;20(5):051022. doi: 10.1117/1.JBO.20.5.051022.

32.

Serum 8,12-iso-iPF2α-VI isoprostane marker of oxidative damage and cognition deficits in children with konzo.

Makila-Mabe BG, Kikandau KJ, Sombo TM, Okitundu DL, Mwanza JC, Boivin MJ, Ngoyi MD, Muyembe JJ, Banea JP, Boss GR, Tshala-Katumbay D.

PLoS One. 2014 Sep 15;9(9):e107191. doi: 10.1371/journal.pone.0107191. eCollection 2014.

33.

Soluble guanylate cyclase as a novel treatment target for osteoporosis.

Joshua J, Schwaerzer GK, Kalyanaraman H, Cory E, Sah RL, Li M, Vaida F, Boss GR, Pilz RB.

Endocrinology. 2014 Dec;155(12):4720-30. doi: 10.1210/en.2014-1343. Epub 2014 Sep 4.

34.

Akt phosphorylation and regulation of transketolase is a nodal point for amino acid control of purine synthesis.

Saha A, Connelly S, Jiang J, Zhuang S, Amador DT, Phan T, Pilz RB, Boss GR.

Mol Cell. 2014 Jul 17;55(2):264-76. doi: 10.1016/j.molcel.2014.05.028. Epub 2014 Jun 26.

35.

Nongenomic thyroid hormone signaling occurs through a plasma membrane-localized receptor.

Kalyanaraman H, Schwappacher R, Joshua J, Zhuang S, Scott BT, Klos M, Casteel DE, Frangos JA, Dillmann W, Boss GR, Pilz RB.

Sci Signal. 2014 May 20;7(326):ra48. doi: 10.1126/scisignal.2004911.

36.

Noninvasive optical cytochrome c oxidase redox state measurements using diffuse optical spectroscopy.

Lee J, Kim JG, Mahon SB, Mukai D, Yoon D, Boss GR, Patterson SE, Rockwood G, Isom G, Brenner M.

J Biomed Opt. 2014 May;19(5):055001. doi: 10.1117/1.JBO.19.5.055001.

37.

Intravenous cobinamide versus hydroxocobalamin for acute treatment of severe cyanide poisoning in a swine (Sus scrofa) model.

Bebarta VS, Tanen DA, Boudreau S, Castaneda M, Zarzabal LA, Vargas T, Boss GR.

Ann Emerg Med. 2014 Dec;64(6):612-9. doi: 10.1016/j.annemergmed.2014.02.009. Epub 2014 Apr 18.

38.

The vitamin B12 analog cobinamide is an effective hydrogen sulfide antidote in a lethal rabbit model.

Brenner M, Benavides S, Mahon SB, Lee J, Yoon D, Mukai D, Viseroi M, Chan A, Jiang J, Narula N, Azer SM, Alexander C, Boss GR.

Clin Toxicol (Phila). 2014 Jun;52(5):490-7. doi: 10.3109/15563650.2014.904045. Epub 2014 Apr 9. Erratum in: Clin Toxicol (Phila). 2015 Jan;53(1):77.

39.

Kinetics and mechanism of oxidation of super-reduced cobalamin and cobinamide species by thiosulfate, sulfite and dithionite.

Dereven'kov IA, Salnikov DS, Makarov SV, Boss GR, Koifman OI.

Dalton Trans. 2013 Nov 21;42(43):15307-16. doi: 10.1039/c3dt51714d.

40.

Nitrosyl-cobinamide (NO-Cbi), a new nitric oxide donor, improves wound healing through cGMP/cGMP-dependent protein kinase.

Spitler R, Schwappacher R, Wu T, Kong X, Yokomori K, Pilz RB, Boss GR, Berns MW.

Cell Signal. 2013 Dec;25(12):2374-82. doi: 10.1016/j.cellsig.2013.07.029. Epub 2013 Aug 3.

41.

Toxicokinetic profiles of α-ketoglutarate cyanohydrin, a cyanide detoxification product, following exposure to potassium cyanide.

Mitchell BL, Bhandari RK, Bebarta VS, Rockwood GA, Boss GR, Logue BA.

Toxicol Lett. 2013 Sep 12;222(1):83-9. doi: 10.1016/j.toxlet.2013.07.008. Epub 2013 Jul 15.

PMID:
23867915
42.

Cell cycle regulation of purine synthesis by phosphoribosyl pyrophosphate and inorganic phosphate.

Fridman A, Saha A, Chan A, Casteel DE, Pilz RB, Boss GR.

Biochem J. 2013 Aug 15;454(1):91-9. doi: 10.1042/BJ20130153.

PMID:
23734909
43.

Comparative study of reaction of cobalamin and cobinamide with thiocyanate.

Dereven'kov IA, Salnikov DS, Makarov SV, Surducan M, Silaghi-Dumitrescu R, Boss GR.

J Inorg Biochem. 2013 Aug;125:32-9. doi: 10.1016/j.jinorgbio.2013.04.011. Epub 2013 Apr 28.

PMID:
23685470
44.

Comparison of a new cobinamide-based method to a standard laboratory method for measuring cyanide in human blood.

Swezey R, Shinn W, Green C, Drover DR, Hammer GB, Schulman SR, Zajicek A, Jett DA, Boss GR.

J Anal Toxicol. 2013 Jul-Aug;37(6):382-5. doi: 10.1093/jat/bkt037. Epub 2013 May 6.

45.

A molecular mechanism for therapeutic effects of cGMP-elevating agents in pulmonary arterial hypertension.

Schwappacher R, Kilic A, Kojonazarov B, Lang M, Diep T, Zhuang S, Gawlowski T, Schermuly RT, Pfeifer A, Boss GR, Pilz RB.

J Biol Chem. 2013 Jun 7;288(23):16557-66. doi: 10.1074/jbc.M113.458729. Epub 2013 Apr 23.

46.

ACP Journal Club: allopurinol during acute gout attacks did not differ from delayed allopurinol for pain or recurrence.

Boss GR.

Ann Intern Med. 2013 Apr 16;158(8):JC6. doi: 10.7326/0003-4819-158-8-201304160-02006. No abstract available.

PMID:
23588771
47.

A disposable blood cyanide sensor.

Tian Y, Dasgupta PK, Mahon SB, Ma J, Brenner M, Wang JH, Boss GR.

Anal Chim Acta. 2013 Mar 20;768:129-35. doi: 10.1016/j.aca.2013.01.029. Epub 2013 Feb 1.

48.

Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure.

Nath AK, Roberts LD, Liu Y, Mahon SB, Kim S, Ryu JH, Werdich A, Januzzi JL, Boss GR, Rockwood GA, MacRae CA, Brenner M, Gerszten RE, Peterson RT.

FASEB J. 2013 May;27(5):1928-38. doi: 10.1096/fj.12-225037. Epub 2013 Jan 23.

49.

Noninvasive monitoring of treatment response in a rabbit cyanide toxicity model reveals differences in brain and muscle metabolism.

Kim JG, Lee J, Mahon SB, Mukai D, Patterson SE, Boss GR, Tromberg BJ, Brenner M.

J Biomed Opt. 2012 Oct;17(10):105005. doi: 10.1117/1.JBO.17.10.105005.

50.

Rho isoform-specific interaction with IQGAP1 promotes breast cancer cell proliferation and migration.

Casteel DE, Turner S, Schwappacher R, Rangaswami H, Su-Yuo J, Zhuang S, Boss GR, Pilz RB.

J Biol Chem. 2012 Nov 2;287(45):38367-78. doi: 10.1074/jbc.M112.377499. Epub 2012 Sep 19.

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