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Items: 1 to 50 of 63

1.

The scorpion toxin Bot IX is a potent member of the α-like family and has a unique N-terminal sequence extension.

Martin-Eauclaire MF, Salvatierra J, Mansuelle P, Bosmans F, Bougis PE.

FEBS Lett. 2018 Aug;592(15):2668. doi: 10.1002/1873-3468.13185. Epub 2018 Aug 3. No abstract available.

PMID:
30168598
2.

NaV1.1 inhibition can reduce visceral hypersensitivity.

Salvatierra J, Castro J, Erickson A, Li Q, Braz J, Gilchrist J, Grundy L, Rychkov GY, Deiteren A, Rais R, King GF, Slusher BS, Basbaum A, Pasricha PJ, Brierley SM, Bosmans F.

JCI Insight. 2018 Jun 7;3(11). pii: 121000. doi: 10.1172/jci.insight.121000. [Epub ahead of print]

3.

Spider toxin inhibits gating pore currents underlying periodic paralysis.

Männikkö R, Shenkarev ZO, Thor MG, Berkut AA, Myshkin MY, Paramonov AS, Kulbatskii DS, Kuzmin DA, Sampedro Castañeda M, King L, Wilson ER, Lyukmanova EN, Kirpichnikov MP, Schorge S, Bosmans F, Hanna MG, Kullmann DM, Vassilevski AA.

Proc Natl Acad Sci U S A. 2018 Apr 24;115(17):4495-4500. doi: 10.1073/pnas.1720185115. Epub 2018 Apr 10.

4.

Using voltage-sensor toxins and their molecular targets to investigate NaV 1.8 gating.

Gilchrist J, Bosmans F.

J Physiol. 2018 May 15;596(10):1863-1872. doi: 10.1113/JP275102. Epub 2018 Jan 6.

PMID:
29193176
5.

Pharmacology of the Nav1.1 domain IV voltage sensor reveals coupling between inactivation gating processes.

Osteen JD, Sampson K, Iyer V, Julius D, Bosmans F.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6836-6841. doi: 10.1073/pnas.1621263114. Epub 2017 Jun 12.

6.

Corrigendum: Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I.

Sci Rep. 2017 May 26;7:46816. doi: 10.1038/srep46816. No abstract available.

7.

Insect-Active Toxins with Promiscuous Pharmacology from the African Theraphosid Spider Monocentropus balfouri.

Smith JJ, Herzig V, Ikonomopoulou MP, Dziemborowicz S, Bosmans F, Nicholson GM, King GF.

Toxins (Basel). 2017 May 5;9(5). pii: E155. doi: 10.3390/toxins9050155.

8.

Sodium Channel Nav1.8 Underlies TTX-Resistant Axonal Action Potential Conduction in Somatosensory C-Fibers of Distal Cutaneous Nerves.

Klein AH, Vyshnevska A, Hartke TV, De Col R, Mankowski JL, Turnquist B, Bosmans F, Reeh PW, Schmelz M, Carr RW, Ringkamp M.

J Neurosci. 2017 May 17;37(20):5204-5214. doi: 10.1523/JNEUROSCI.3799-16.2017. Epub 2017 Apr 27.

9.

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

Wingerd JS, Mozar CA, Ussing CA, Murali SS, Chin YK, Cristofori-Armstrong B, Durek T, Gilchrist J, Vaughan CW, Bosmans F, Adams DJ, Lewis RJ, Alewood PF, Mobli M, Christie MJ, Rash LD.

Sci Rep. 2017 Apr 20;7(1):974. doi: 10.1038/s41598-017-01129-0.

10.

Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a.

Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, Christie MJ, King GF, Alewood PF, Lewis RJ, Wood JN, Vetter I.

Sci Rep. 2017 Jan 20;7:40883. doi: 10.1038/srep40883. Erratum in: Sci Rep. 2017 May 26;7:46816.

11.

Isolation of two insecticidal toxins from venom of the Australian theraphosid spider Coremiocnemis tropix.

Ikonomopoulou MP, Smith JJ, Herzig V, Pineda SS, Dziemborowicz S, Er SY, Durek T, Gilchrist J, Alewood PF, Nicholson GM, Bosmans F, King GF.

Toxicon. 2016 Dec 1;123:62-70. doi: 10.1016/j.toxicon.2016.10.013. Epub 2016 Oct 26.

12.

The scorpion toxin Bot IX is a potent member of the α-like family and has a unique N-terminal sequence extension.

Martin-Eauclaire MF, Salvatierra J, Bosmans F, Bougis PE.

FEBS Lett. 2016 Sep;590(18):3221-32. doi: 10.1002/1873-3468.12357. Epub 2016 Sep 1. Erratum in: FEBS Lett. 2018 Aug;592(15):2668.

13.

Molecular basis of the remarkable species selectivity of an insecticidal sodium channel toxin from the African spider Augacephalus ezendami.

Herzig V, Ikonomopoulou M, Smith JJ, Dziemborowicz S, Gilchrist J, Kuhn-Nentwig L, Rezende FO, Moreira LA, Nicholson GM, Bosmans F, King GF.

Sci Rep. 2016 Jul 7;6:29538. doi: 10.1038/srep29538.

14.

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain.

Osteen JD, Herzig V, Gilchrist J, Emrick JJ, Zhang C, Wang X, Castro J, Garcia-Caraballo S, Grundy L, Rychkov GY, Weyer AD, Dekan Z, Undheim EA, Alewood P, Stucky CL, Brierley SM, Basbaum AI, Bosmans F, King GF, Julius D.

Nature. 2016 Jun 23;534(7608):494-9. doi: 10.1038/nature17976. Epub 2016 Jun 6.

15.

Efficient enzymatic cyclization of an inhibitory cystine knot-containing peptide.

Kwon S, Bosmans F, Kaas Q, Cheneval O, Conibear AC, Rosengren KJ, Wang CK, Schroeder CI, Craik DJ.

Biotechnol Bioeng. 2016 Oct;113(10):2202-12. doi: 10.1002/bit.25993. Epub 2016 Aug 9.

16.

A painful tale about synthetic scorpion toxins.

Salvatierra J, Bosmans F.

Channels (Austin). 2016 Jul 3;10(4):256-7. doi: 10.1080/19336950.2016.1163956. Epub 2016 Mar 10. No abstract available.

17.

Binary architecture of the Nav1.2-β2 signaling complex.

Das S, Gilchrist J, Bosmans F, Van Petegem F.

Elife. 2016 Feb 19;5. pii: e10960. doi: 10.7554/eLife.10960.

18.

The hitchhiker's guide to the voltage-gated sodium channel galaxy.

Ahern CA, Payandeh J, Bosmans F, Chanda B.

J Gen Physiol. 2016 Jan;147(1):1-24. doi: 10.1085/jgp.201511492. Review.

19.

The Scorpion Toxin Tf2 from Tityus fasciolatus Promotes Nav1.3 Opening.

Camargos TS, Bosmans F, Rego SC, Mourão CB, Schwartz EF.

PLoS One. 2015 Jun 17;10(6):e0128578. doi: 10.1371/journal.pone.0128578. eCollection 2015.

20.

Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach.

Klint JK, Smith JJ, Vetter I, Rupasinghe DB, Er SY, Senff S, Herzig V, Mobli M, Lewis RJ, Bosmans F, King GF.

Br J Pharmacol. 2015 May;172(10):2445-58. doi: 10.1111/bph.13081. Epub 2015 Mar 4.

21.

MmTX1 and MmTX2 from coral snake venom potently modulate GABAA receptor activity.

Rosso JP, Schwarz JR, Diaz-Bustamante M, Céard B, Gutiérrez JM, Kneussel M, Pongs O, Bosmans F, Bougis PE.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):E891-900. doi: 10.1073/pnas.1415488112. Epub 2015 Feb 9.

22.

A surface plasmon resonance approach to monitor toxin interactions with an isolated voltage-gated sodium channel paddle motif.

Martin-Eauclaire MF, Ferracci G, Bosmans F, Bougis PE.

J Gen Physiol. 2015 Feb;145(2):155-62. doi: 10.1085/jgp.201411268.

23.

The insecticidal spider toxin SFI1 is a knottin peptide that blocks the pore of insect voltage-gated sodium channels via a large β-hairpin loop.

Bende NS, Dziemborowicz S, Herzig V, Ramanujam V, Brown GW, Bosmans F, Nicholson GM, King GF, Mobli M.

FEBS J. 2015 Mar;282(5):904-20. doi: 10.1111/febs.13189. Epub 2015 Jan 23.

24.

From foe to friend: using animal toxins to investigate ion channel function.

Kalia J, Milescu M, Salvatierra J, Wagner J, Klint JK, King GF, Olivera BM, Bosmans F.

J Mol Biol. 2015 Jan 16;427(1):158-175. doi: 10.1016/j.jmb.2014.07.027. Epub 2014 Aug 1. Review.

25.

A distinct sodium channel voltage-sensor locus determines insect selectivity of the spider toxin Dc1a.

Bende NS, Dziemborowicz S, Mobli M, Herzig V, Gilchrist J, Wagner J, Nicholson GM, King GF, Bosmans F.

Nat Commun. 2014 Jul 11;5:4350. doi: 10.1038/ncomms5350.

26.

Animal toxins influence voltage-gated sodium channel function.

Gilchrist J, Olivera BM, Bosmans F.

Handb Exp Pharmacol. 2014;221:203-29. doi: 10.1007/978-3-642-41588-3_10. Review.

27.

Nav1.1 modulation by a novel triazole compound attenuates epileptic seizures in rodents.

Gilchrist J, Dutton S, Diaz-Bustamante M, McPherson A, Olivares N, Kalia J, Escayg A, Bosmans F.

ACS Chem Biol. 2014 May 16;9(5):1204-12. doi: 10.1021/cb500108p. Epub 2014 Mar 31.

28.

A first exploration of the venom of the Buthus occitanus scorpion found in southern France.

Martin-Eauclaire MF, Bosmans F, Céard B, Diochot S, Bougis PE.

Toxicon. 2014 Mar;79:55-63. doi: 10.1016/j.toxicon.2014.01.002. Epub 2014 Jan 10.

29.

New rule(r)s for FRET.

Bosmans F.

Biophys J. 2013 Dec 17;105(12):2619-20. doi: 10.1016/j.bpj.2013.11.011. No abstract available.

30.

Crystallographic insights into sodium-channel modulation by the β4 subunit.

Gilchrist J, Das S, Van Petegem F, Bosmans F.

Proc Natl Acad Sci U S A. 2013 Dec 17;110(51):E5016-24. doi: 10.1073/pnas.1314557110. Epub 2013 Dec 2.

31.

The insecticidal neurotoxin Aps III is an atypical knottin peptide that potently blocks insect voltage-gated sodium channels.

Bende NS, Kang E, Herzig V, Bosmans F, Nicholson GM, Mobli M, King GF.

Biochem Pharmacol. 2013 May 15;85(10):1542-54. doi: 10.1016/j.bcp.2013.02.030. Epub 2013 Mar 6.

32.

Animal toxins can alter the function of Nav1.8 and Nav1.9.

Gilchrist J, Bosmans F.

Toxins (Basel). 2012 Aug;4(8):620-32. doi: 10.3390/toxins4080620. Epub 2012 Aug 14. Review.

33.

Palmitoylation influences the function and pharmacology of sodium channels.

Bosmans F, Milescu M, Swartz KJ.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20213-8. doi: 10.1073/pnas.1108497108. Epub 2011 Nov 28.

34.

Functional properties and toxin pharmacology of a dorsal root ganglion sodium channel viewed through its voltage sensors.

Bosmans F, Puopolo M, Martin-Eauclaire MF, Bean BP, Swartz KJ.

J Gen Physiol. 2011 Jul;138(1):59-72. doi: 10.1085/jgp.201110614. Epub 2011 Jun 13.

35.

Targeting voltage sensors in sodium channels with spider toxins.

Bosmans F, Swartz KJ.

Trends Pharmacol Sci. 2010 Apr;31(4):175-82. doi: 10.1016/j.tips.2009.12.007. Epub 2010 Jan 25. Review.

36.

Interactions between lipids and voltage sensor paddles detected with tarantula toxins.

Milescu M, Bosmans F, Lee S, Alabi AA, Kim JI, Swartz KJ.

Nat Struct Mol Biol. 2009 Oct;16(10):1080-5. doi: 10.1038/nsmb.1679. Epub 2009 Sep 27.

37.

Insecticidal peptides from the theraposid spider Brachypelma albiceps: an NMR-based model of Ba2.

Corzo G, Bernard C, Clement H, Villegas E, Bosmans F, Tytgat J, Possani LD, Darbon H, Alagón A.

Biochim Biophys Acta. 2009 Aug;1794(8):1190-6. doi: 10.1016/j.bbapap.2009.04.004. Epub 2009 Apr 15.

PMID:
19374957
38.

Deconstructing voltage sensor function and pharmacology in sodium channels.

Bosmans F, Martin-Eauclaire MF, Swartz KJ.

Nature. 2008 Nov 13;456(7219):202-8. doi: 10.1038/nature07473.

39.

Animal peptides targeting voltage-activated sodium channels.

Billen B, Bosmans F, Tytgat J.

Curr Pharm Des. 2008;14(24):2492-502. Review.

PMID:
18781997
40.

Biochemical characterization of cysteine-rich peptides from Oxyopes sp. venom that block calcium ion channels.

Villegas E, Adachi-Akahane S, Bosmans F, Tytgat J, Nakajima T, Corzo G.

Toxicon. 2008 Aug 1;52(2):228-36. doi: 10.1016/j.toxicon.2008.05.019. Epub 2008 Jun 11.

PMID:
18606178
41.

Spider peptide toxins as leads for drug development.

Escoubas P, Bosmans F.

Expert Opin Drug Discov. 2007 Jun;2(6):823-35. doi: 10.1517/17460441.2.6.823.

PMID:
23489000
42.

Sea anemone venom as a source of insecticidal peptides acting on voltage-gated Na+ channels.

Bosmans F, Tytgat J.

Toxicon. 2007 Mar 15;49(4):550-60. Epub 2006 Dec 5. Review.

43.

Solution structure and alanine scan of a spider toxin that affects the activation of mammalian voltage-gated sodium channels.

Corzo G, Sabo JK, Bosmans F, Billen B, Villegas E, Tytgat J, Norton RS.

J Biol Chem. 2007 Feb 16;282(7):4643-52. Epub 2006 Dec 5.

44.

Differential effects of five 'classical' scorpion beta-toxins on rNav1.2a and DmNav1 provide clues on species-selectivity.

Bosmans F, Martin-Eauclaire MF, Tytgat J.

Toxicol Appl Pharmacol. 2007 Jan 1;218(1):45-51. Epub 2006 Oct 14.

45.

Voltage-gated sodium channel modulation by scorpion alpha-toxins.

Bosmans F, Tytgat J.

Toxicon. 2007 Feb;49(2):142-58. Epub 2006 Sep 28. Review.

46.

The first potassium channel toxin from the venom of the Iranian scorpion Odonthobuthus doriae.

Abdel-Mottaleb Y, Clynen E, Jalali A, Bosmans F, Vatanpour H, Schoofs L, Tytgat J.

FEBS Lett. 2006 Nov 13;580(26):6254-8. Epub 2006 Oct 20.

47.

Four novel tarantula toxins as selective modulators of voltage-gated sodium channel subtypes.

Bosmans F, Rash L, Zhu S, Diochot S, Lazdunski M, Escoubas P, Tytgat J.

Mol Pharmacol. 2006 Feb;69(2):419-29. Epub 2005 Nov 2.

48.

Structural basis for the voltage-gated Na+ channel selectivity of the scorpion alpha-like toxin BmK M1.

Ye X, Bosmans F, Li C, Zhang Y, Wang DC, Tytgat J.

J Mol Biol. 2005 Nov 4;353(4):788-803. Epub 2005 Sep 22.

PMID:
16209876
49.

OD1, the first toxin isolated from the venom of the scorpion Odonthobuthus doriae active on voltage-gated Na+ channels.

Jalali A, Bosmans F, Amininasab M, Clynen E, Cuypers E, Zaremirakabadi A, Sarbolouki MN, Schoofs L, Vatanpour H, Tytgat J.

FEBS Lett. 2005 Aug 1;579(19):4181-6.

50.

New "Birtoxin analogs" from Androctonus australis venom.

Martin-Eauclaire MF, Ceard B, Bosmans F, Rosso JP, Tytgat J, Bougis PE.

Biochem Biophys Res Commun. 2005 Jul 29;333(2):524-30.

PMID:
15963953

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