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Items: 1 to 50 of 74

1.

Prevalence and Relevance of Pre-Existing Anti-Adeno-Associated Virus Immunity in the Context of Gene Therapy for Crigler-Najjar Syndrome.

Aronson SJ, Veron P, Collaud F, Hubert A, Delahais V, Honnet G, de Knegt RJ, Junge N, Baumann U, Di Giorgio A, D'Antiga L, Ginocchio VM, Brunetti-Pierri N, Labrune P, Beuers U, Bosma PJ, Mingozzi F.

Hum Gene Ther. 2019 Oct;30(10):1297-1305. doi: 10.1089/hum.2019.143.

2.

A novel UGT1A1 gene mutation causing severe unconjugated hyperbilirubinemia: a case report.

Shi X, Aronson S, Khan AS, Bosma PJ.

BMC Pediatr. 2019 May 29;19(1):173. doi: 10.1186/s12887-019-1555-y.

3.

The P4-ATPase ATP9A is a novel determinant of exosome release.

Naik J, Hau CM, Ten Bloemendaal L, Mok KS, Hajji N, Wehman AM, Meisner S, Muncan V, Paauw NJ, de Vries HE, Nieuwland R, Paulusma CC, Bosma PJ.

PLoS One. 2019 Apr 4;14(4):e0213069. doi: 10.1371/journal.pone.0213069. eCollection 2019.

4.

Liver-directed gene therapy results in long-term correction of progressive familial intrahepatic cholestasis type 3 in mice.

Aronson SJ, Bakker RS, Shi X, Duijst S, Ten Bloemendaal L, de Waart DR, Verheij J, Ronzitti G, Oude Elferink RP, Beuers U, Paulusma CC, Bosma PJ.

J Hepatol. 2019 Jul;71(1):153-162. doi: 10.1016/j.jhep.2019.03.021. Epub 2019 Mar 29.

5.

Preclinical Development of an AAV8-hUGT1A1 Vector for the Treatment of Crigler-Najjar Syndrome.

Collaud F, Bortolussi G, Guianvarc'h L, Aronson SJ, Bordet T, Veron P, Charles S, Vidal P, Sola MS, Rundwasser S, Dufour DG, Lacoste F, Luc C, Wittenberghe LV, Martin S, Le Bec C, Bosma PJ, Muro AF, Ronzitti G, Hebben M, Mingozzi F.

Mol Ther Methods Clin Dev. 2018 Dec 31;12:157-174. doi: 10.1016/j.omtm.2018.12.011. eCollection 2019 Mar 15.

6.

Cre Recombinase Mediates the Removal of Bacterial Backbone to Efficiently Generate rSV40.

Shi X, Ykema MR, Hazenoot J, Ten Bloemendaal L, Mancini I, Odijk M, de Haan P, Bosma PJ.

Mol Ther Methods Clin Dev. 2018 Feb 27;9:225-233. doi: 10.1016/j.omtm.2018.02.010. eCollection 2018 Jun 15.

7.

Biliverdin Reductase inhibitors did not improve severe unconjugated hyperbilirubinemia in vivo.

van Dijk R, Aronson SJ, de Waart DR, van de Graaf SF, Duijst S, Seppen J, Elferink RO, Beuers U, Bosma PJ.

Sci Rep. 2017 May 10;7(1):1646. doi: 10.1038/s41598-017-01602-w.

8.

A translationally optimized AAV-UGT1A1 vector drives safe and long-lasting correction of Crigler-Najjar syndrome.

Ronzitti G, Bortolussi G, van Dijk R, Collaud F, Charles S, Leborgne C, Vidal P, Martin S, Gjata B, Sola MS, van Wittenberghe L, Vignaud A, Veron P, Bosma PJ, Muro AF, Mingozzi F.

Mol Ther Methods Clin Dev. 2016 Jul 20;3:16049. eCollection 2016.

9.

ATP11C targets basolateral bile salt transporter proteins in mouse central hepatocytes.

de Waart DR, Naik J, Utsunomiya KS, Duijst S, Ho-Mok K, Bolier AR, Hiralall J, Bull LN, Bosma PJ, Oude Elferink RP, Paulusma CC.

Hepatology. 2016 Jul;64(1):161-74. doi: 10.1002/hep.28522. Epub 2016 Apr 6.

10.

Enteroendocrine cells are a potential source of serum autotaxin in men.

Bolier R, Tolenaars D, Kremer AE, Saris J, Parés A, Verheij J, Bosma PJ, Beuers U, Oude Elferink RPJ.

Biochim Biophys Acta. 2016 Apr;1862(4):696-704. doi: 10.1016/j.bbadis.2016.01.012. Epub 2016 Jan 14.

11.

De Novo Donor-Specific HLA Antibody Formation in Two Patients With Crigler-Najjar Syndrome Type I Following Human Hepatocyte Transplantation With Partial Hepatectomy Preconditioning.

Jorns C, Nowak G, Nemeth A, Zemack H, Mörk LM, Johansson H, Gramignoli R, Watanabe M, Karadagi A, Alheim M, Hauzenberger D, van Dijk R, Bosma PJ, Ebbesen F, Szakos A, Fischler B, Strom S, Ellis E, Ericzon BG.

Am J Transplant. 2016 Mar;16(3):1021-30. doi: 10.1111/ajt.13487. Epub 2015 Nov 2.

12.

Disruption of HNF1α binding site causes inherited severe unconjugated hyperbilirubinemia.

van Dijk R, Mayayo-Peralta I, Aronson SJ, Kattentidt-Mouravieva AA, van der Mark VA, de Knegt R, Oruc N, Beuers U, Bosma PJ.

J Hepatol. 2015 Dec;63(6):1525-9. doi: 10.1016/j.jhep.2015.07.027. Epub 2015 Jul 26.

PMID:
26220753
13.

ATP8B1 and ATP11C: Two Lipid Flippases Important for Hepatocyte Function.

Naik J, de Waart DR, Utsunomiya K, Duijst S, Mok KH, Oude Elferink RP, Bosma PJ, Paulusma CC.

Dig Dis. 2015;33(3):314-8. doi: 10.1159/000371665. Epub 2015 May 27.

PMID:
26045263
14.

Gene replacement therapy for genetic hepatocellular jaundice.

van Dijk R, Beuers U, Bosma PJ.

Clin Rev Allergy Immunol. 2015 Jun;48(2-3):243-53. doi: 10.1007/s12016-014-8454-7. Review.

PMID:
25315738
15.

Adeno-associated viral vector serotype 5 poorly transduces liver in rat models.

Montenegro-Miranda PS, Pañeda A, ten Bloemendaal L, Duijst S, de Waart DR, Gonzalez- Aseguinolaza G, Bosma PJ.

PLoS One. 2013 Dec 27;8(12):e82597. doi: 10.1371/journal.pone.0082597. eCollection 2013. Erratum in: PLoS One. 2015;10(3):e0119777. Aseguinolaza, Gloria Gonzalez [corrected to Gonzalez- Aseguinolaza, Gloria].

16.

In the rat liver, Adenoviral gene transfer efficiency is comparable to AAV.

Montenegro-Miranda PS, Pichard V, Aubert D, Ten Bloemendaal L, Duijst S, de Waart DR, Ferry N, Bosma PJ.

Gene Ther. 2014 Feb;21(2):168-74. doi: 10.1038/gt.2013.69. Epub 2013 Nov 28.

PMID:
24285217
17.

Polyinosinic acid blocks adeno-associated virus macrophage endocytosis in vitro and enhances adeno-associated virus liver-directed gene therapy in vivo.

van Dijk R, Montenegro-Miranda PS, Riviere C, Schilderink R, ten Bloemendaal L, van Gorp J, Duijst S, de Waart DR, Beuers U, Haisma HJ, Bosma PJ.

Hum Gene Ther. 2013 Sep;24(9):807-13. doi: 10.1089/hum.2013.086.

PMID:
24010701
18.

Insulin-like growth factor 1 enhances bile-duct proliferation and fibrosis in Abcb4(-/-) mice.

Sokolović A, Rodriguez-Ortigosa CM, Bloemendaal LT, Oude Elferink RP, Prieto J, Bosma PJ.

Biochim Biophys Acta. 2013 Jun;1832(6):697-704. doi: 10.1016/j.bbadis.2013.02.005. Epub 2013 Feb 14.

19.

Ezetimibe: A biomarker for efficacy of liver directed UGT1A1 gene therapy for inherited hyperbilirubinemia.

Montenegro-Miranda PS, Sneitz N, de Waart DR, Ten Bloemendaal L, Duijst S, de Knegt RJ, Beuers U, Finel M, Bosma PJ.

Biochim Biophys Acta. 2012 Aug;1822(8):1223-9. doi: 10.1016/j.bbadis.2012.04.013. Epub 2012 Apr 21.

20.

Overexpression of insulin like growth factor binding protein 5 reduces liver fibrosis in chronic cholangiopathy.

Sokolović A, Montenegro-Miranda PS, de Waart DR, Cappai RM, Duijst S, Sokolović M, Bosma PJ.

Biochim Biophys Acta. 2012 Jun;1822(6):996-1003. doi: 10.1016/j.bbadis.2012.02.022. Epub 2012 Mar 13.

21.

Mycophenolate mofetil impairs transduction of single-stranded adeno-associated viral vectors.

Montenegro-Miranda PS, ten Bloemendaal L, Kunne C, de Waart DR, Bosma PJ.

Hum Gene Ther. 2011 May;22(5):605-12. doi: 10.1089/hum.2010.222. Epub 2011 Apr 11.

PMID:
21222531
22.

Insulin-like growth factor binding protein 5 enhances survival of LX2 human hepatic stellate cells.

Sokolović A, Sokolović M, Boers W, Elferink RP, Bosma PJ.

Fibrogenesis Tissue Repair. 2010 Feb 17;3:3. doi: 10.1186/1755-1536-3-3.

23.

A fiber modified adenovirus vector that targets to the EphrinA2 receptor reveals enhanced gene transfer to ex vivo pancreatic cancer.

Van Geer MA, Brevoord D, Kuhlmann KF, Bakker CT, Mizuguchi H, Wesseling JG, Ten Kate FJ, Gouma DJ, Oude Elferink RP, Bosma PJ.

Int J Oncol. 2010 Jan;36(1):233-44.

PMID:
19956852
24.

Crigler-Najjar syndrome in The Netherlands: identification of four novel UGT1A1 alleles, genotype-phenotype correlation, and functional analysis of 10 missense mutants.

Sneitz N, Bakker CT, de Knegt RJ, Halley DJ, Finel M, Bosma PJ.

Hum Mutat. 2010 Jan;31(1):52-9. doi: 10.1002/humu.21133.

PMID:
19830808
25.

Ephrin A2 receptor targeting does not increase adenoviral pancreatic cancer transduction in vivo.

van Geer MA, Bakker CT, Koizumi N, Mizuguchi H, Wesseling JG, Oude Elferink RP, Bosma PJ.

World J Gastroenterol. 2009 Jun 14;15(22):2754-62.

26.

Towards liver-directed gene therapy for Crigler-Najjar syndrome.

Miranda PS, Bosma PJ.

Curr Gene Ther. 2009 Apr;9(2):72-82. Review.

PMID:
19355865
27.

Ex-vivo evaluation of gene therapy vectors in human pancreatic (cancer) tissue slices.

van Geer MA, Kuhlmann KF, Bakker CT, ten Kate FJ, Oude Elferink RP, Bosma PJ.

World J Gastroenterol. 2009 Mar 21;15(11):1359-66.

28.

Fiber-chimeric adenoviruses expressing fibers from serotype 16 and 50 improve gene transfer to human pancreatic adenocarcinoma.

Kuhlmann KF, van Geer MA, Bakker CT, Dekker JE, Havenga MJ, Elferink RP, Gouma DJ, Bosma PJ, Wesseling JG.

Cancer Gene Ther. 2009 Jul;16(7):585-97. doi: 10.1038/cgt.2009.4. Epub 2009 Jan 30.

PMID:
19180144
29.

Adenoviral serotypes in gene therapy for esophageal carcinoma.

Marsman WA, Wesseling JG, El Bouch A, Bosma PJ, van Lanschot JJ.

J Surg Res. 2007 Jun 1;140(1):50-4. Epub 2007 Apr 9.

PMID:
17418868
30.

The current state of cancer gene therapy and its application in esophageal carcinoma.

Buskens CJ, Marsman WA, Bosma PJ, van Lanschot JJ.

Dig Surg. 2005;22(4):222-33. Epub 2005 Sep 20. Review.

PMID:
16174979
31.

Selection of tumour specific promoters for adenoviral gene therapy of cholangiocarcinoma.

Lie-A-Ling M, Bakker CT, Deurholt T, Hoekstra R, Wesseling JG, Afford SC, Bosma PJ.

J Hepatol. 2006 Jan;44(1):126-33. Epub 2005 Jul 11.

PMID:
16168519
32.

Gene therapy for barrett's esophagus: adenoviral gene transfer in different intestinal models.

Marsman WA, Buskens CJ, Wesseling JG, Van Lanschot JJ, Bosma PJ.

Cancer Gene Ther. 2005 Sep;12(9):778-86.

PMID:
15877083
33.
34.

Loss of heterozygosity and immunohistochemistry of adenocarcinomas of the esophagus and gastric cardia.

Marsman WA, Birjmohun RS, van Rees BP, Caspers E, Johan G, Offerhaus A, Bosma PJ, Jan J, van Lanschot B.

Clin Cancer Res. 2004 Dec 15;10(24):8479-85.

35.

Crigler-Najjar syndrome type 1 associated with combined 1070A-->G, Q357R and (TA)7 mutation in Kuwaiti Bedouin families indicate a founder effect in Arabs.

Koshy A, Bosma PJ, Oude-Elferink RP.

J Clin Gastroenterol. 2004 May-Jun;38(5):465-7. No abstract available.

PMID:
15100530
36.

Gene therapy for esophageal carcinoma: the use of an explant model to test adenoviral vectors ex vivo.

Marsman WA, Buskens CJ, Wesseling JG, Offerhaus GJ, Bergman JJ, Tytgat GN, van Lanschot JJ, Bosma PJ.

Cancer Gene Ther. 2004 Apr;11(4):289-96.

PMID:
14765131
37.

Anion exchanger 2 is essential for spermiogenesis in mice.

Medina JF, Recalde S, Prieto J, Lecanda J, Saez E, Funk CD, Vecino P, van Roon MA, Ottenhoff R, Bosma PJ, Bakker CT, Elferink RP.

Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15847-52. Epub 2003 Dec 12.

38.

A genetically retargeted adenoviral vector enhances viral transduction in esophageal carcinoma cell lines and primary cultured esophageal resection specimens.

Buskens CJ, Marsman WA, Wesseling JG, Offerhaus GJ, Yamamoto M, Curiel DT, Bosma PJ, van Lanschot JJ.

Ann Surg. 2003 Dec;238(6):815-24; discussion 825-6.

39.

Induction of insolubility by herpes simplex virus VP22 precludes intercellular trafficking of N-terminal Apoptin-VP22 fusion proteins.

Rutjes SA, Bosma PJ, Rohn JL, Noteborn MH, Wesseling JG.

J Mol Med (Berl). 2003 Sep;81(9):558-65. Epub 2003 Jul 16.

PMID:
12879152
40.

UGT1A1*28 allele and coronary heart disease: the Rotterdam Study.

Bosma PJ, van der Meer IM, Bakker CT, Hofman A, Paul-Abrahamse M, Witteman JC.

Clin Chem. 2003 Jul;49(7):1180-1. No abstract available.

PMID:
12816916
41.

Inherited disorders of bilirubin metabolism.

Bosma PJ.

J Hepatol. 2003 Jan;38(1):107-17. Review. No abstract available.

PMID:
12480568
42.

Prognostic significance of elevated cyclooxygenase 2 expression in patients with adenocarcinoma of the esophagus.

Buskens CJ, Van Rees BP, Sivula A, Reitsma JB, Haglund C, Bosma PJ, Offerhaus GJ, Van Lanschot JJ, Ristimäki A.

Gastroenterology. 2002 Jun;122(7):1800-7.

PMID:
12055587
43.

Midkine and cyclooxygenase-2 promoters are promising for adenoviral vector gene delivery of pancreatic carcinoma.

Wesseling JG, Yamamoto M, Adachi Y, Bosma PJ, van Wijland M, Blackwell JL, Li H, Reynolds PN, Dmitriev I, Vickers SM, Huibregtse K, Curiel DT.

Cancer Gene Ther. 2001 Dec;8(12):990-6.

44.

Improved gene transfer efficiency to primary and established human pancreatic carcinoma target cells via epidermal growth factor receptor and integrin-targeted adenoviral vectors.

Wesseling JG, Bosma PJ, Krasnykh V, Kashentseva EA, Blackwell JL, Reynolds PN, Li H, Parameshwar M, Vickers SM, Jaffee EM, Huibregtse K, Curiel DT, Dmitriev I.

Gene Ther. 2001 Jul;8(13):969-76.

45.

The wide spectrum of multidrug resistance 3 deficiency: from neonatal cholestasis to cirrhosis of adulthood.

Jacquemin E, De Vree JM, Cresteil D, Sokal EM, Sturm E, Dumont M, Scheffer GL, Paul M, Burdelski M, Bosma PJ, Bernard O, Hadchouel M, Elferink RP.

Gastroenterology. 2001 May;120(6):1448-58.

PMID:
11313315
46.

Hepatic uptake of organic anions affects the plasma bilirubin level in subjects with Gilbert's syndrome mutations in UGT1A1.

Persico M, Persico E, Bakker CT, Rigato I, Amoroso A, Torella R, Bosma PJ, Tiribelli C, Ostrow JD.

Hepatology. 2001 Mar;33(3):627-32.

PMID:
11230743
47.

Correction of liver disease by hepatocyte transplantation in a mouse model of progressive familial intrahepatic cholestasis.

De Vree JM, Ottenhoff R, Bosma PJ, Smith AJ, Aten J, Oude Elferink RP.

Gastroenterology. 2000 Dec;119(6):1720-30.

PMID:
11113093
48.

Zonal down-regulation and redistribution of the multidrug resistance protein 2 during bile duct ligation in rat liver.

Paulusma CC, Kothe MJ, Bakker CT, Bosma PJ, van Bokhoven I, van Marle J, Bolder U, Tytgat GN, Oude Elferink RP.

Hepatology. 2000 Mar;31(3):684-93.

PMID:
10706559
49.

Long-term amelioration of bilirubin glucuronidation defect in Gunn rats by transplanting genetically modified immortalized autologous hepatocytes.

Tada K, Roy-Chowdhury N, Prasad V, Kim BH, Manchikalapudi P, Fox IJ, van Duijvendijk P, Bosma PJ, Roy-Chowdhury J.

Cell Transplant. 1998 Nov-Dec;7(6):607-16.

PMID:
9853589
50.

Splice-site mutations: a novel genetic mechanism of Crigler-Najjar syndrome type 1.

Gantla S, Bakker CT, Deocharan B, Thummala NR, Zweiner J, Sinaasappel M, Roy Chowdhury J, Bosma PJ, Roy Chowdhury N.

Am J Hum Genet. 1998 Mar;62(3):585-92.

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