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Items: 1 to 50 of 173

1.

Kidney cancer: The next decade.

Turajlic S, Swanton C, Boshoff C.

J Exp Med. 2018 Oct 1;215(10):2477-2479. doi: 10.1084/jem.20181617. Epub 2018 Sep 14.

2.

The biology and management of non-small cell lung cancer.

Herbst RS, Morgensztern D, Boshoff C.

Nature. 2018 Jan 24;553(7689):446-454. doi: 10.1038/nature25183. Review.

PMID:
29364287
3.

Parasites of domestic and wild animals in South Africa. XLIX. Ticks (Acari: Ixodidae) infesting white and black rhinoceroses in southern Africa.

Horak IG, Boshoff CR, Cooper DV, Foggin CM, Govender D, Harrison A, Hausler G, Hofmeyr M, Kilian JW, MacFadyen DN, Nel PJ, Peinke D, Squarre D, Zimmermann D.

Onderstepoort J Vet Res. 2017 Jan 30;84(1):e1-e11. doi: 10.4102/ojvr.v84i1.1301.

4.

Molecular Pathways: Targeting the Cyclin D-CDK4/6 Axis for Cancer Treatment.

VanArsdale T, Boshoff C, Arndt KT, Abraham RT.

Clin Cancer Res. 2015 Jul 1;21(13):2905-10. doi: 10.1158/1078-0432.CCR-14-0816. Epub 2015 May 4. Review.

5.

The effect of altruism on the spending behavior of elderly caregivers of family members with HIV/AIDS in South African townships.

Klemz BR, Boshoff C, Mazibuko NE, Asquith JA.

Health Mark Q. 2015;32(1):81-95. doi: 10.1080/07359683.2015.1000747.

PMID:
25751320
6.

Kaposi's sarcoma herpesvirus microRNAs induce metabolic transformation of infected cells.

Yogev O, Lagos D, Enver T, Boshoff C.

PLoS Pathog. 2014 Sep 25;10(9):e1004400. doi: 10.1371/journal.ppat.1004400. eCollection 2014 Sep.

7.

APOBEC-mediated cytosine deamination links PIK3CA helical domain mutations to human papillomavirus-driven tumor development.

Henderson S, Chakravarthy A, Su X, Boshoff C, Fenton TR.

Cell Rep. 2014 Jun 26;7(6):1833-41. doi: 10.1016/j.celrep.2014.05.012. Epub 2014 Jun 5.

8.

Recurrent PTPRB and PLCG1 mutations in angiosarcoma.

Behjati S, Tarpey PS, Sheldon H, Martincorena I, Van Loo P, Gundem G, Wedge DC, Ramakrishna M, Cooke SL, Pillay N, Vollan HKM, Papaemmanuil E, Koss H, Bunney TD, Hardy C, Joseph OR, Martin S, Mudie L, Butler A, Teague JW, Patil M, Steers G, Cao Y, Gumbs C, Ingram D, Lazar AJ, Little L, Mahadeshwar H, Protopopov A, Al Sannaa GA, Seth S, Song X, Tang J, Zhang J, Ravi V, Torres KE, Khatri B, Halai D, Roxanis I, Baumhoer D, Tirabosco R, Amary MF, Boshoff C, McDermott U, Katan M, Stratton MR, Futreal PA, Flanagan AM, Harris A, Campbell PJ.

Nat Genet. 2014 Apr;46(4):376-379. doi: 10.1038/ng.2921. Epub 2014 Mar 16.

9.

Oncogenic transformation of mesenchymal stem cells decreases Nrf2 expression favoring in vivo tumor growth and poorer survival.

Funes JM, Henderson S, Kaufman R, Flanagan JM, Robson M, Pedley B, Moncada S, Boshoff C.

Mol Cancer. 2014 Feb 3;13:20. doi: 10.1186/1476-4598-13-20.

10.

First molecular assessment of the African swine fever virus status of Ornithodoros ticks from Swaziland.

Boshoff CI, Bastos AD, Dube MM, Heath L.

Onderstepoort J Vet Res. 2014 Dec 3;81(1):E1-5. doi: 10.4102/ojvr.v81i1.846.

PMID:
26304186
11.

Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing.

Frampton GM, Fichtenholtz A, Otto GA, Wang K, Downing SR, He J, Schnall-Levin M, White J, Sanford EM, An P, Sun J, Juhn F, Brennan K, Iwanik K, Maillet A, Buell J, White E, Zhao M, Balasubramanian S, Terzic S, Richards T, Banning V, Garcia L, Mahoney K, Zwirko Z, Donahue A, Beltran H, Mosquera JM, Rubin MA, Dogan S, Hedvat CV, Berger MF, Pusztai L, Lechner M, Boshoff C, Jarosz M, Vietz C, Parker A, Miller VA, Ross JS, Curran J, Cronin MT, Stephens PJ, Lipson D, Yelensky R.

Nat Biotechnol. 2013 Nov;31(11):1023-31. doi: 10.1038/nbt.2696. Epub 2013 Oct 20.

12.

Integrated virus-host methylome analysis in head and neck squamous cell carcinoma.

Wilson GA, Lechner M, Köferle A, Caren H, Butcher LM, Feber A, Fenton T, Jay A, Boshoff C, Beck S.

Epigenetics. 2013 Sep;8(9):953-61. doi: 10.4161/epi.25614. Epub 2013 Jul 18.

13.

Expression of FUS-CHOP fusion protein in immortalized/transformed human mesenchymal stem cells drives mixoid liposarcoma formation.

Rodriguez R, Tornin J, Suarez C, Astudillo A, Rubio R, Yauk C, Williams A, Rosu-Myles M, Funes JM, Boshoff C, Menendez P.

Stem Cells. 2013 Oct;31(10):2061-72. doi: 10.1002/stem.1472.

14.

Targeted next-generation sequencing of head and neck squamous cell carcinoma identifies novel genetic alterations in HPV+ and HPV- tumors.

Lechner M, Frampton GM, Fenton T, Feber A, Palmer G, Jay A, Pillay N, Forster M, Cronin MT, Lipson D, Miller VA, Brennan TA, Henderson S, Vaz F, O'Flynn P, Kalavrezos N, Yelensky R, Beck S, Stephens PJ, Boshoff C.

Genome Med. 2013 May 29;5(5):49. doi: 10.1186/gm453. eCollection 2013.

15.

Cellular origin of Kaposi's sarcoma and Kaposi's sarcoma-associated herpesvirus-induced cell reprogramming.

Cancian L, Hansen A, Boshoff C.

Trends Cell Biol. 2013 Sep;23(9):421-32. doi: 10.1016/j.tcb.2013.04.001. Epub 2013 May 17. Review.

PMID:
23685018
16.

Redefining KSHV latency.

Yogev O, Boshoff C.

Cell Host Microbe. 2013 Apr 17;13(4):373-4. doi: 10.1016/j.chom.2013.04.003.

17.

Identification and functional validation of HPV-mediated hypermethylation in head and neck squamous cell carcinoma.

Lechner M, Fenton T, West J, Wilson G, Feber A, Henderson S, Thirlwell C, Dibra HK, Jay A, Butcher L, Chakravarthy AR, Gratrix F, Patel N, Vaz F, O'Flynn P, Kalavrezos N, Teschendorff AE, Boshoff C, Beck S.

Genome Med. 2013 Feb 5;5(2):15. doi: 10.1186/gm419. eCollection 2013.

18.

Adrenomedullin haploinsufficiency predisposes to secondary lymphedema.

Nikitenko LL, Shimosawa T, Henderson S, Mäkinen T, Shimosawa H, Qureshi U, Pedley RB, Rees MC, Fujita T, Boshoff C.

J Invest Dermatol. 2013 Jul;133(7):1768-76. doi: 10.1038/jid.2013.47. Epub 2013 Jan 30.

19.

The microRNA-30 family targets DLL4 to modulate endothelial cell behavior during angiogenesis.

Bridge G, Monteiro R, Henderson S, Emuss V, Lagos D, Georgopoulou D, Patient R, Boshoff C.

Blood. 2012 Dec 13;120(25):5063-72. doi: 10.1182/blood-2012-04-423004. Epub 2012 Oct 18.

20.

First-line erlotinib in patients with advanced non-small-cell lung cancer unsuitable for chemotherapy (TOPICAL): a double-blind, placebo-controlled, phase 3 trial.

Lee SM, Khan I, Upadhyay S, Lewanski C, Falk S, Skailes G, Marshall E, Woll PJ, Hatton M, Lal R, Jones R, Toy E, Chao D, Middleton G, Bulley S, Ngai Y, Rudd R, Hackshaw A, Boshoff C.

Lancet Oncol. 2012 Nov;13(11):1161-70. doi: 10.1016/S1470-2045(12)70412-6. Epub 2012 Oct 16.

21.

Ephrin receptor: a door to KSHV infection.

Boshoff C.

Nat Med. 2012 Jun 6;18(6):861-3. doi: 10.1038/nm.2803. No abstract available.

PMID:
22673996
22.

KSHV-initiated notch activation leads to membrane-type-1 matrix metalloproteinase-dependent lymphatic endothelial-to-mesenchymal transition.

Cheng F, Pekkonen P, Laurinavicius S, Sugiyama N, Henderson S, Günther T, Rantanen V, Kaivanto E, Aavikko M, Sarek G, Hautaniemi S, Biberfeld P, Aaltonen L, Grundhoff A, Boshoff C, Alitalo K, Lehti K, Ojala PM.

Cell Host Microbe. 2011 Dec 15;10(6):577-90. doi: 10.1016/j.chom.2011.10.011.

23.

Exploring the interaction between siRNA and the SMoC biomolecule transporters: implications for small molecule-mediated delivery of siRNA.

Gooding M, Tudzarova S, Worthington RJ, Kingsbury SR, Rebstock AS, Dube H, Simone MI, Visintin C, Lagos D, Quesada JM, Laman H, Boshoff C, Williams GH, Stoeber K, Selwood DL.

Chem Biol Drug Des. 2012 Jan;79(1):9-21. doi: 10.1111/j.1747-0285.2011.01249.x. Epub 2011 Nov 4.

PMID:
21981778
24.

Focal adhesion kinase is required for KSHV vGPCR signaling.

He M, Bakken T, Kassimova A, Boshoff C, Philpott N, Cannon ML.

Mol Carcinog. 2012 Apr;51(4):339-51. doi: 10.1002/mc.20790. Epub 2011 May 2.

PMID:
21538577
25.

Experimental infection of giraffe (Giraffa camelopardalis) with SAT-1 and SAT-2 foot-and-mouth disease virus.

Vosloo W, Swanepoel SP, Bauman M, Botha B, Esterhuysen JJ, Boshoff CI, Keet DF, Dekker A.

Transbound Emerg Dis. 2011 Apr;58(2):173-8. doi: 10.1111/j.1865-1682.2010.01188.x. Epub 2010 Dec 19.

PMID:
26353052
26.

Immunobiology and host response to KSHV infection.

Lagos D, Boshoff C.

In: Arvin A, Campadelli-Fiume G, Mocarski E, Moore PS, Roizman B, Whitley R, Yamanishi K, editors. Human Herpesviruses: Biology, Therapy, and Immunoprophylaxis. Cambridge: Cambridge University Press; 2007. Chapter 52.

27.

Unraveling virus-induced lymphomagenesis.

Boshoff C.

J Clin Invest. 2011 Mar;121(3):838-41. doi: 10.1172/JCI46499. Epub 2011 Feb 21.

28.

Genomic and epigenomic integration identifies a prognostic signature in colon cancer.

Yi JM, Dhir M, Van Neste L, Downing SR, Jeschke J, Glöckner SC, de Freitas Calmon M, Hooker CM, Funes JM, Boshoff C, Smits KM, van Engeland M, Weijenberg MP, Iacobuzio-Donahue CA, Herman JG, Schuebel KE, Baylin SB, Ahuja N.

Clin Cancer Res. 2011 Mar 15;17(6):1535-45. doi: 10.1158/1078-0432.CCR-10-2509. Epub 2011 Jan 28.

29.

A model for harmonizing flow cytometry in clinical trials.

Maecker HT, McCoy JP Jr; FOCIS Human Immunophenotyping Consortium, Amos M, Elliott J, Gaigalas A, Wang L, Aranda R, Banchereau J, Boshoff C, Braun J, Korin Y, Reed E, Cho J, Hafler D, Davis M, Fathman CG, Robinson W, Denny T, Weinhold K, Desai B, Diamond B, Gregersen P, Di Meglio P, Nestle FO, Peakman M, Villanova F, Ferbas J, Field E, Kantor A, Kawabata T, Komocsar W, Lotze M, Nepom J, Ochs H, O'Lone R, Phippard D, Plevy S, Rich S, Roederer M, Rotrosen D, Yeh JH.

Nat Immunol. 2010 Nov;11(11):975-8. doi: 10.1038/ni1110-975. Erratum in: Nat Immunol. 2010 Nov;11(11):979. DiMeglio, Paola [corrected to Di Meglio, Paola]; Nestle, Frank [corrected to Nestle, Frank O]; Villnova, Federica [corrected to Villanova, Federica]. Nat Immunol. 2011 Mar;12(3):271.

30.

Cancer epigenome.

Lechner M, Boshoff C, Beck S.

Adv Genet. 2010;70:247-76. doi: 10.1016/B978-0-12-380866-0.60009-5. Review.

PMID:
20920751
31.

Kaposi's sarcoma and its associated herpesvirus.

Mesri EA, Cesarman E, Boshoff C.

Nat Rev Cancer. 2010 Oct;10(10):707-19. doi: 10.1038/nrc2888. Review.

32.

In vitro transformation of mesenchymal stem cells induces gradual genomic hypomethylation.

Wild L, Funes JM, Boshoff C, Flanagan JM.

Carcinogenesis. 2010 Oct;31(10):1854-62. doi: 10.1093/carcin/bgq080. Epub 2010 May 13.

PMID:
20466760
33.

miR-132 regulates antiviral innate immunity through suppression of the p300 transcriptional co-activator.

Lagos D, Pollara G, Henderson S, Gratrix F, Fabani M, Milne RS, Gotch F, Boshoff C.

Nat Cell Biol. 2010 May;12(5):513-9. doi: 10.1038/ncb2054. Epub 2010 Apr 25.

PMID:
20418869
34.

DNA methylome of familial breast cancer identifies distinct profiles defined by mutation status.

Flanagan JM, Cocciardi S, Waddell N, Johnstone CN, Marsh A, Henderson S, Simpson P, da Silva L; kConFab Investigators, Khanna K, Lakhani S, Boshoff C, Chenevix-Trench G.

Am J Hum Genet. 2010 Mar 12;86(3):420-33. doi: 10.1016/j.ajhg.2010.02.008. Epub 2010 Mar 4.

35.

KSHV-encoded miRNAs target MAF to induce endothelial cell reprogramming.

Hansen A, Henderson S, Lagos D, Nikitenko L, Coulter E, Roberts S, Gratrix F, Plaisance K, Renne R, Bower M, Kellam P, Boshoff C.

Genes Dev. 2010 Jan 15;24(2):195-205. doi: 10.1101/gad.553410.

36.

KSHV manipulates Notch signaling by DLL4 and JAG1 to alter cell cycle genes in lymphatic endothelia.

Emuss V, Lagos D, Pizzey A, Gratrix F, Henderson SR, Boshoff C.

PLoS Pathog. 2009 Oct;5(10):e1000616. doi: 10.1371/journal.ppat.1000616. Epub 2009 Oct 9.

37.

The CD8 and CD4 T-cell response against Kaposi's sarcoma-associated herpesvirus is skewed towards early and late lytic antigens.

Robey RC, Lagos D, Gratrix F, Henderson S, Matthews NC, Vart RJ, Bower M, Boshoff C, Gotch FM.

PLoS One. 2009 Jun 17;4(6):e5890. doi: 10.1371/journal.pone.0005890.

38.

Targeting EGFR in head and neck cancer: a decade of progress.

Boshoff C, Posner M.

Nat Clin Pract Oncol. 2009 Mar;6(3):123. doi: 10.1038/ncponc1328. No abstract available.

PMID:
19247309
39.

Gene-body hypermethylation of ATM in peripheral blood DNA of bilateral breast cancer patients.

Flanagan JM, Munoz-Alegre M, Henderson S, Tang T, Sun P, Johnson N, Fletcher O, Dos Santos Silva I, Peto J, Boshoff C, Narod S, Petronis A.

Hum Mol Genet. 2009 Apr 1;18(7):1332-42. doi: 10.1093/hmg/ddp033. Epub 2009 Jan 19.

40.

Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets.

Flanagan JM, Funes JM, Henderson S, Wild L, Carey N, Boshoff C.

Mol Cancer Ther. 2009 Jan;8(1):249-60. doi: 10.1158/1535-7163.MCT-08-0636.

41.

Toll-like receptor 4 mediates innate immunity to Kaposi sarcoma herpesvirus.

Lagos D, Vart RJ, Gratrix F, Westrop SJ, Emuss V, Wong PP, Robey R, Imami N, Bower M, Gotch F, Boshoff C.

Cell Host Microbe. 2008 Nov 13;4(5):470-83. doi: 10.1016/j.chom.2008.09.012.

42.

Associations between Burkitt lymphoma among children in Malawi and infection with HIV, EBV and malaria: results from a case-control study.

Mutalima N, Molyneux E, Jaffe H, Kamiza S, Borgstein E, Mkandawire N, Liomba G, Batumba M, Lagos D, Gratrix F, Boshoff C, Casabonne D, Carpenter LM, Newton R.

PLoS One. 2008 Jun 18;3(6):e2505. doi: 10.1371/journal.pone.0002505.

43.

Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome.

Bagnéris C, Ageichik AV, Cronin N, Wallace B, Collins M, Boshoff C, Waksman G, Barrett T.

Mol Cell. 2008 Jun 6;30(5):620-31. doi: 10.1016/j.molcel.2008.04.029.

44.

KSHV LANA inhibits TGF-beta signaling through epigenetic silencing of the TGF-beta type II receptor.

Di Bartolo DL, Cannon M, Liu YF, Renne R, Chadburn A, Boshoff C, Cesarman E.

Blood. 2008 May 1;111(9):4731-40. doi: 10.1182/blood-2007-09-110544. Epub 2008 Jan 16.

45.

Chondroblastomas but not chondromyxoid fibromas express cytokeratins: an unusual presentation of a chondroblastoma in the metaphyseal cortex of the tibia.

Bousdras K, O'Donnell P, Vujovic S, Henderson S, Boshoff C, Flanagan AM.

Histopathology. 2007 Sep;51(3):414-6. No abstract available.

PMID:
17727486
46.

Characterisation of the anti-apoptotic function of survivin-DeltaEx3 during TNFalpha-mediated cell death.

Malcles MH, Wang HW, Koumi A, Tsai YH, Yu M, Godfrey A, Boshoff C.

Br J Cancer. 2007 Jun 4;96(11):1659-66. Epub 2007 May 15.

47.

Kaposi's sarcoma-associated herpesvirus-encoded interleukin-6 and G-protein-coupled receptor regulate angiopoietin-2 expression in lymphatic endothelial cells.

Vart RJ, Nikitenko LL, Lagos D, Trotter MW, Cannon M, Bourboulia D, Gratrix F, Takeuchi Y, Boshoff C.

Cancer Res. 2007 May 1;67(9):4042-51.

48.

Transformation of human mesenchymal stem cells increases their dependency on oxidative phosphorylation for energy production.

Funes JM, Quintero M, Henderson S, Martinez D, Qureshi U, Westwood C, Clements MO, Bourboulia D, Pedley RB, Moncada S, Boshoff C.

Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6223-8. Epub 2007 Mar 23.

49.

Kaposi sarcoma as a model of oncogenesis and cancer treatment.

Hansen A, Boshoff C, Lagos D.

Expert Rev Anticancer Ther. 2007 Feb;7(2):211-20. Review.

PMID:
17288530
50.

Small-molecule mimics of an alpha-helix for efficient transport of proteins into cells.

Okuyama M, Laman H, Kingsbury SR, Visintin C, Leo E, Eward KL, Stoeber K, Boshoff C, Williams GH, Selwood DL.

Nat Methods. 2007 Feb;4(2):153-9. Epub 2007 Jan 14.

PMID:
17220893

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