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Items: 23


Defining hrHPV genotypes in cervical intraepithelial neoplasia by laser capture microdissection supports reflex triage of self-samples using HPV16/18 and FAM19A4/miR124-2 methylation.

Leeman A, Ebisch RMF, Kasius A, Bosgraaf RP, Jenkins D, van de Sandt MM, de Strooper LMA, Heideman DAM, Snijders PJF, Massuger LFAG, Bekkers RLM, Meijer CJLM, van Kemenade FJ, Quint WGV, Melchers WJG.

Gynecol Oncol. 2018 Nov;151(2):311-318. doi: 10.1016/j.ygyno.2018.09.006. Epub 2018 Sep 13.


The effect of video information on anxiety levels in women attending colposcopy: a randomized controlled trial.

Ketelaars PJW, Buskes MHM, Bosgraaf RP, van Hamont D, Prins JB, Massuger LFAG, Melchers WJG, Bekkers RLM.

Acta Oncol. 2017 Dec;56(12):1728-1733. doi: 10.1080/0284186X.2017.1355108. Epub 2017 Aug 1.


High-risk human papillomavirus detection in self-sampling compared to physician-taken smear in a responder population of the Dutch cervical screening: Results of the VERA study.

Ketelaars PJW, Bosgraaf RP, Siebers AG, Massuger LFAG, van der Linden JC, Wauters CAP, Rahamat-Langendoen JC, van den Brule AJC, IntHout J, Melchers WJG, Bekkers RLM.

Prev Med. 2017 Aug;101:96-101. doi: 10.1016/j.ypmed.2017.05.021. Epub 2017 Jun 1.


Evaluation of p16/Ki-67 dual-stained cytology as triage test for high-risk human papillomavirus-positive women.

Ebisch RM, van der Horst J, Hermsen M, Rijstenberg LL, Vedder JE, Bulten J, Bosgraaf RP, Verhoef VM, Heideman DA, Snijders PJ, Meijer CJ, van Kemenade FJ, Massuger LF, Melchers WJ, Bekkers RL, Siebers AG.

Mod Pathol. 2017 Jul;30(7):1021-1031. doi: 10.1038/modpathol.2017.16. Epub 2017 Mar 17.


Triage of high-risk HPV positive women in cervical cancer screening.

Ebisch RM, Siebers AG, Bosgraaf RP, Massuger LF, Bekkers RL, Melchers WJ.

Expert Rev Anticancer Ther. 2016 Oct;16(10):1073-85. doi: 10.1080/14737140.2016.1232166. Epub 2016 Sep 12. Review.


The clinical value of HPV genotyping in triage of women with high-risk-HPV-positive self-samples.

Ebisch RM, de Kuyper-de Ridder GM, Bosgraaf RP, Massuger LF, IntHout J, Verhoef VM, Heideman DA, Snijders PJ, Meijer CJ, van Kemenade FJ, Bulten J, Siebers AG, Bekkers RL, Melchers WJ.

Int J Cancer. 2016 Aug 1;139(3):691-9. doi: 10.1002/ijc.30090. Epub 2016 Apr 7.


Validation of the FAM19A4/mir124-2 DNA methylation test for both lavage- and brush-based self-samples to detect cervical (pre)cancer in HPV-positive women.

De Strooper LMA, Verhoef VMJ, Berkhof J, Hesselink AT, de Bruin HME, van Kemenade FJ, Bosgraaf RP, Bekkers RLM, Massuger LFAG, Melchers WJG, Steenbergen RDM, Snijders PJF, Meijer CJLM, Heideman DAM.

Gynecol Oncol. 2016 May;141(2):341-347. doi: 10.1016/j.ygyno.2016.02.012. Epub 2016 Mar 3.


Evidence supporting see-and-treat management of cervical intraepithelial neoplasia: a systematic review and meta-analysis.

Ebisch RM, Rovers MM, Bosgraaf RP, van der Pluijm-Schouten HW, Melchers WJ, van den Akker PA, Massuger LF, Bekkers RL.

BJOG. 2016 Jan;123(1):59-66. doi: 10.1111/1471-0528.13530. Epub 2015 Jul 14. Review.


Follow-up of high-risk HPV positive women by combined cytology and bi-marker CADM1/MAL methylation analysis on cervical scrapes.

Verhoef VM, van Kemenade FJ, Rozendaal L, Heideman DA, Bosgraaf RP, Hesselink AT, Melchers WJ, Massuger LF, Bekkers RL, Steenbergen RD, Berkhof J, Snijders PJ, Meijer CJ.

Gynecol Oncol. 2015 Apr;137(1):55-9. doi: 10.1016/j.ygyno.2015.01.550. Epub 2015 Feb 8.


Methylation marker analysis and HPV16/18 genotyping in high-risk HPV positive self-sampled specimens to identify women with high grade CIN or cervical cancer.

Verhoef VM, Heideman DA, van Kemenade FJ, Rozendaal L, Bosgraaf RP, Hesselink AT, Bekkers RL, Massuger LF, Steenbergen RD, Snijders PJ, Berkhof J, Meijer CJ.

Gynecol Oncol. 2014 Oct;135(1):58-63. doi: 10.1016/j.ygyno.2014.08.003. Epub 2014 Aug 8.


DNA methylation analysis in self-sampled brush material as a triage test in hrHPV-positive women.

Boers A, Bosgraaf RP, van Leeuwen RW, Schuuring E, Heideman DA, Massuger LF, Verhoef VM, Bulten J, Melchers WJ, van der Zee AG, Bekkers RL, Wisman GB.

Br J Cancer. 2014 Sep 9;111(6):1095-101. doi: 10.1038/bjc.2014.392. Epub 2014 Jul 17.


Comparative performance of novel self-sampling methods in detecting high-risk human papillomavirus in 30,130 women not attending cervical screening.

Bosgraaf RP, Verhoef VM, Massuger LF, Siebers AG, Bulten J, de Kuyper-de Ridder GM, Meijer CJ, Snijders PJ, Heideman DA, IntHout J, van Kemenade FJ, Melchers WJ, Bekkers RL.

Int J Cancer. 2015 Feb 1;136(3):646-55. doi: 10.1002/ijc.29026. Epub 2014 Jun 26.


Reasons for non-attendance to cervical screening and preferences for HPV self-sampling in Dutch women.

Bosgraaf RP, Ketelaars PJ, Verhoef VM, Massuger LF, Meijer CJ, Melchers WJ, Bekkers RL.

Prev Med. 2014 Jul;64:108-13. doi: 10.1016/j.ypmed.2014.04.011. Epub 2014 Apr 13.


Triage by methylation-marker testing versus cytology in women who test HPV-positive on self-collected cervicovaginal specimens (PROHTECT-3): a randomised controlled non-inferiority trial.

Verhoef VM, Bosgraaf RP, van Kemenade FJ, Rozendaal L, Heideman DA, Hesselink AT, Bekkers RL, Steenbergen RD, Massuger LF, Melchers WJ, Bulten J, Overbeek LI, Berkhof J, Snijders PJ, Meijer CJ.

Lancet Oncol. 2014 Mar;15(3):315-22. doi: 10.1016/S1470-2045(14)70019-1. Epub 2014 Feb 13.


The current position and the future perspectives of cervical cancer screening.

Bosgraaf RP, Siebers AG, De Hullu JA, Massuger LF, Bulten J, Bekkers RL, Melchers WJ.

Expert Rev Anticancer Ther. 2014 Jan;14(1):75-92. doi: 10.1586/14737140.2014.856273. Epub 2013 Nov 28. Review.


In reply.

Bosgraaf RP, Mast PP, Struik-van der Zanden PH, Bulten J, Massuger LF, Bekkers RL.

Obstet Gynecol. 2013 Dec;122(6):1304-5. doi: 10.1097/AOG.0000000000000031. No abstract available.


Qualitative insights into the psychological stress before and during colposcopy: a focus group study.

Bosgraaf RP, de Jager WC, Servaes P, Prins JB, Massuger LF, Bekkers RL.

J Psychosom Obstet Gynaecol. 2013 Dec;34(4):150-6. doi: 10.3109/0167482X.2013.849688.


Overtreatment in a see-and-treat approach to cervical intraepithelial lesions.

Bosgraaf RP, Mast PP, Struik-van der Zanden PH, Bulten J, Massuger LF, Bekkers RL.

Obstet Gynecol. 2013 Jun;121(6):1209-16. doi: 10.1097/AOG.0b013e318293ab22.


A second generation cervico-vaginal lavage device shows similar performance as its preceding version with respect to DNA yield and HPV DNA results.

Verhoef VM, Dijkstra MG, Bosgraaf RP, Hesselink AT, Melchers WJ, Bekkers RL, Berkhof J, van Kemenade FJ.

BMC Womens Health. 2013 May 2;13:21. doi: 10.1186/1472-6874-13-21.


Dry storage and transport of a cervicovaginal self-sample by use of the Evalyn Brush, providing reliable human papillomavirus detection combined with comfort for women.

van Baars R, Bosgraaf RP, ter Harmsel BW, Melchers WJ, Quint WG, Bekkers RL.

J Clin Microbiol. 2012 Dec;50(12):3937-43. doi: 10.1128/JCM.01506-12. Epub 2012 Sep 26.


Treatment of flaring of the costal arch after the minimally invasive pectus excavatum repair (Nuss procedure) in children.

Bosgraaf RP, Aronson DC.

J Pediatr Surg. 2010 Sep;45(9):1904-6. doi: 10.1016/j.jpedsurg.2010.05.037.


Lung function after the minimal invasive pectus excavatum repair (Nuss procedure).

Aronson DC, Bosgraaf RP, Merz EM, van Steenwijk RP, van Aalderen WM, van Baren R.

World J Surg. 2007 Jul;31(7):1518-22. Epub 2007 May 30.


Nuss procedure: pediatric surgical solution for adults with pectus excavatum.

Aronson DC, Bosgraaf RP, van der Horst C, Ekkelkamp S.

World J Surg. 2007 Jan;31(1):26-9; discussion 30.


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