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Items: 1 to 50 of 101

1.

Species-specific co-localization of MERS-CoV attachment and entry receptors.

Widagdo W, Okba NMA, Li W, de Jong A, de Swart RYL, Begeman L, van den Brand JMA, Bosch BJ, Haagmans BL.

J Virol. 2019 Jun 5. pii: JVI.00107-19. doi: 10.1128/JVI.00107-19. [Epub ahead of print]

PMID:
31167913
2.

Structural basis for human coronavirus attachment to sialic acid receptors.

Tortorici MA, Walls AC, Lang Y, Wang C, Li Z, Koerhuis D, Boons GJ, Bosch BJ, Rey FA, de Groot RJ, Veesler D.

Nat Struct Mol Biol. 2019 Jun;26(6):481-489. doi: 10.1038/s41594-019-0233-y. Epub 2019 Jun 3.

PMID:
31160783
3.

Towards a solution to MERS: protective human monoclonal antibodies targeting different domains and functions of the MERS-coronavirus spike glycoprotein.

Widjaja I, Wang C, van Haperen R, Gutiérrez-Álvarez J, van Dieren B, Okba NMA, Raj VS, Li W, Fernandez-Delgado R, Grosveld F, van Kuppeveld FJM, Haagmans BL, Enjuanes L, Drabek D, Bosch BJ.

Emerg Microbes Infect. 2019;8(1):516-530. doi: 10.1080/22221751.2019.1597644.

4.

Human coronaviruses OC43 and HKU1 bind to 9-O-acetylated sialic acids via a conserved receptor-binding site in spike protein domain A.

Hulswit RJG, Lang Y, Bakkers MJG, Li W, Li Z, Schouten A, Ophorst B, van Kuppeveld FJM, Boons GJ, Bosch BJ, Huizinga EG, de Groot RJ.

Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2681-2690. doi: 10.1073/pnas.1809667116. Epub 2019 Jan 24.

PMID:
30679277
5.

Evolution of Dihydropyrimidine Dehydrogenase Diagnostic Testing in a Single Center during an 8-Year Period of Time.

Coenen MJH, Paulussen ADC, Breuer M, Lindhout M, Tserpelis DCJ, Steyls A, Bierau J, van den Bosch BJC.

Curr Ther Res Clin Exp. 2018 Oct 31;90:1-7. doi: 10.1016/j.curtheres.2018.10.001. eCollection 2019.

6.

Metabolic events in HIV-infected patients using abacavir are associated with erythrocyte inosine triphosphatase activity.

Peltenburg NC, Bierau J, Schippers JA, Lowe SH, Paulussen ADC, van den Bosch BJC, Leers MPG, Andrinopoulou ER, Bakker JA, Verbon A.

J Antimicrob Chemother. 2019 Jan 1;74(1):157-164. doi: 10.1093/jac/dky383.

PMID:
30304447
7.

Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection.

Stalin Raj V, Okba NMA, Gutierrez-Alvarez J, Drabek D, van Dieren B, Widagdo W, Lamers MM, Widjaja I, Fernandez-Delgado R, Sola I, Bensaid A, Koopmans MP, Segalés J, Osterhaus ADME, Bosch BJ, Enjuanes L, Haagmans BL.

Sci Adv. 2018 Aug 8;4(8):eaas9667. doi: 10.1126/sciadv.aas9667. eCollection 2018 Aug.

8.

Porcine epidemic diarrhea virus (PEDV) introduction into a naive Dutch pig population in 2014.

Dortmans JCFM, Li W, van der Wolf PJ, Buter GJ, Franssen PJM, van Schaik G, Houben M, Bosch BJ.

Vet Microbiol. 2018 Jul;221:13-18. doi: 10.1016/j.vetmic.2018.05.014. Epub 2018 May 24.

PMID:
29981699
9.

Broad receptor engagement of an emerging global coronavirus may potentiate its diverse cross-species transmissibility.

Li W, Hulswit RJG, Kenney SP, Widjaja I, Jung K, Alhamo MA, van Dieren B, van Kuppeveld FJM, Saif LJ, Bosch BJ.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5135-E5143. doi: 10.1073/pnas.1802879115. Epub 2018 May 14.

10.

Genetic defects in mtDNA-encoded protein translation cause pediatric, mitochondrial cardiomyopathy with early-onset brain disease.

Kamps R, Szklarczyk R, Theunissen TE, Hellebrekers DMEI, Sallevelt SCEH, Boesten IB, de Koning B, van den Bosch BJ, Salomons GS, Simas-Mendes M, Verdijk R, Schoonderwoerd K, de Coo IFM, Vanoevelen JM, Smeets HJM.

Eur J Hum Genet. 2018 Apr;26(4):537-551. doi: 10.1038/s41431-017-0058-2. Epub 2018 Feb 13.

11.

Erythrocyte Inosine triphosphatase activity: A potential biomarker for adverse events during combination antiretroviral therapy for HIV.

Peltenburg NC, Bierau J, Bakker JA, Schippers JA, Lowe SH, Paulussen ADC, van den Bosch BJC, Leers MPG, Hansen BE, Verbon A.

PLoS One. 2018 Jan 12;13(1):e0191069. doi: 10.1371/journal.pone.0191069. eCollection 2018.

12.

A glycerophospholipid-specific pocket in the RVFV class II fusion protein drives target membrane insertion.

Guardado-Calvo P, Atkovska K, Jeffers SA, Grau N, Backovic M, Pérez-Vargas J, de Boer SM, Tortorici MA, Pehau-Arnaudet G, Lepault J, England P, Rottier PJ, Bosch BJ, Hub JS, Rey FA.

Science. 2017 Nov 3;358(6363):663-667. doi: 10.1126/science.aal2712.

PMID:
29097548
13.

Glycan Shield and Fusion Activation of a Deltacoronavirus Spike Glycoprotein Fine-Tuned for Enteric Infections.

Xiong X, Tortorici MA, Snijder J, Yoshioka C, Walls AC, Li W, McGuire AT, Rey FA, Bosch BJ, Veesler D.

J Virol. 2018 Jan 30;92(4). pii: e01628-17. doi: 10.1128/JVI.01628-17. Print 2018 Feb 15.

14.

Tectonic conformational changes of a coronavirus spike glycoprotein promote membrane fusion.

Walls AC, Tortorici MA, Snijder J, Xiong X, Bosch BJ, Rey FA, Veesler D.

Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11157-11162. doi: 10.1073/pnas.1708727114. Epub 2017 Oct 3.

15.

Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein.

Li W, Hulswit RJG, Widjaja I, Raj VS, McBride R, Peng W, Widagdo W, Tortorici MA, van Dieren B, Lang Y, van Lent JWM, Paulson JC, de Haan CAM, de Groot RJ, van Kuppeveld FJM, Haagmans BL, Bosch BJ.

Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):E8508-E8517. doi: 10.1073/pnas.1712592114. Epub 2017 Sep 18.

16.

Cell Attachment Domains of the Porcine Epidemic Diarrhea Virus Spike Protein Are Key Targets of Neutralizing Antibodies.

Li C, Li W, Lucio de Esesarte E, Guo H, van den Elzen P, Aarts E, van den Born E, Rottier PJM, Bosch BJ.

J Virol. 2017 May 26;91(12). pii: e00273-17. doi: 10.1128/JVI.00273-17. Print 2017 Jun 15.

17.

Aminopeptidase N is not required for porcine epidemic diarrhea virus cell entry.

Li W, Luo R, He Q, van Kuppeveld FJM, Rottier PJM, Bosch BJ.

Virus Res. 2017 May 2;235:6-13. doi: 10.1016/j.virusres.2017.03.018. Epub 2017 Mar 28.

PMID:
28363778
18.

Next-Generation Sequencing in Oncology: Genetic Diagnosis, Risk Prediction and Cancer Classification.

Kamps R, Brandão RD, Bosch BJ, Paulussen AD, Xanthoulea S, Blok MJ, Romano A.

Int J Mol Sci. 2017 Jan 31;18(2). pii: E308. doi: 10.3390/ijms18020308. Review.

19.

Rapid Resolution of Blended or Composite Multigenic Disease in Infants by Whole-Exome Sequencing.

Theunissen TEJ, Sallevelt SCEH, Hellebrekers DMEI, de Koning B, Hendrickx ATM, van den Bosch BJC, Kamps R, Schoonderwoerd K, Szklarczyk R, Mulder-Den Hartog ENM, de Coo IFM, Smeets HJM.

J Pediatr. 2017 Mar;182:371-374.e2. doi: 10.1016/j.jpeds.2016.12.032. Epub 2017 Jan 9.

PMID:
28081892
20.

Inosine Triphosphate Pyrophosphohydrolase Expression: Decreased in Leukocytes of HIV-Infected Patients Using Combination Antiretroviral Therapy.

Peltenburg NC, Leers MP, Bakker JA, Lowe SH, Vroemen WH, Paulussen AD, van den Bosch BJ, Bierau J, Verbon A.

J Acquir Immune Defic Syndr. 2016 Dec 1;73(4):390-395.

PMID:
27792682
21.

Crucial steps in the structure determination of a coronavirus spike glycoprotein using cryo-electron microscopy.

Walls A, Tortorici MA, Bosch BJ, Frenz B, Rottier PJ, DiMaio F, Rey FA, Veesler D.

Protein Sci. 2017 Jan;26(1):113-121. doi: 10.1002/pro.3048. Epub 2016 Oct 18.

22.

Coronavirus Spike Protein and Tropism Changes.

Hulswit RJ, de Haan CA, Bosch BJ.

Adv Virus Res. 2016;96:29-57. doi: 10.1016/bs.aivir.2016.08.004. Epub 2016 Sep 13. Review.

PMID:
27712627
23.

Glycan shield and epitope masking of a coronavirus spike protein observed by cryo-electron microscopy.

Walls AC, Tortorici MA, Frenz B, Snijder J, Li W, Rey FA, DiMaio F, Bosch BJ, Veesler D.

Nat Struct Mol Biol. 2016 Oct;23(10):899-905. doi: 10.1038/nsmb.3293. Epub 2016 Sep 12.

24.

Differences in Strength and Timing of the mtDNA Bottleneck between Zebrafish Germline and Non-germline Cells.

Otten AB, Theunissen TE, Derhaag JG, Lambrichs EH, Boesten IB, Winandy M, van Montfoort AP, Tarbashevich K, Raz E, Gerards M, Vanoevelen JM, van den Bosch BJ, Muller M, Smeets HJ.

Cell Rep. 2016 Jul 19;16(3):622-30. doi: 10.1016/j.celrep.2016.06.023. Epub 2016 Jun 30.

25.

Cellular entry of the porcine epidemic diarrhea virus.

Li W, van Kuppeveld FJM, He Q, Rottier PJM, Bosch BJ.

Virus Res. 2016 Dec 2;226:117-127. doi: 10.1016/j.virusres.2016.05.031. Epub 2016 Jun 15. Review.

26.

MERS-CoV Infection of Alpaca in a Region Where MERS-CoV is Endemic.

Reusken CB, Schilp C, Raj VS, De Bruin E, Kohl RH, Farag EA, Haagmans BL, Al-Romaihi H, Le Grange F, Bosch BJ, Koopmans MP.

Emerg Infect Dis. 2016 Jun;22(6):1129-31. doi: 10.3201/eid2206.152113. Epub 2016 Jun 15. No abstract available.

27.

Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels.

Widagdo W, Raj VS, Schipper D, Kolijn K, van Leenders GJLH, Bosch BJ, Bensaid A, Segalés J, Baumgärtner W, Osterhaus ADME, Koopmans MP, van den Brand JMA, Haagmans BL.

J Virol. 2016 Apr 14;90(9):4838-4842. doi: 10.1128/JVI.02994-15. Print 2016 May.

28.

Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer.

Walls AC, Tortorici MA, Bosch BJ, Frenz B, Rottier PJM, DiMaio F, Rey FA, Veesler D.

Nature. 2016 Mar 3;531(7592):114-117. doi: 10.1038/nature16988. Epub 2016 Feb 8.

29.

Budded baculovirus particle structure revisited.

Wang Q, Bosch BJ, Vlak JM, van Oers MM, Rottier PJ, van Lent JWM.

J Invertebr Pathol. 2016 Feb;134:15-22. doi: 10.1016/j.jip.2015.12.001. Epub 2015 Dec 29.

PMID:
26743500
30.

Crimean-Congo Hemorrhagic Fever Virus Subunit Vaccines Induce High Levels of Neutralizing Antibodies But No Protection in STAT1 Knockout Mice.

Kortekaas J, Vloet RP, McAuley AJ, Shen X, Bosch BJ, de Vries L, Moormann RJ, Bente DA.

Vector Borne Zoonotic Dis. 2015 Dec;15(12):759-64. doi: 10.1089/vbz.2015.1855.

PMID:
26684523
31.

Occupational Exposure to Dromedaries and Risk for MERS-CoV Infection, Qatar, 2013-2014.

Reusken CB, Farag EA, Haagmans BL, Mohran KA, Godeke GJ 5th, Raj S, Alhajri F, Al-Marri SA, Al-Romaihi HE, Al-Thani M, Bosch BJ, van der Eijk AA, El-Sayed AM, Ibrahim AK, Al-Molawi N, Müller MA, Pasha SK, Drosten C, AlHajri MM, Koopmans MP.

Emerg Infect Dis. 2015 Aug;21(8):1422-5. doi: 10.3201/eid2108.150481.

32.

Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study.

Müller MA, Meyer B, Corman VM, Al-Masri M, Turkestani A, Ritz D, Sieberg A, Aldabbagh S, Bosch BJ, Lattwein E, Alhakeem RF, Assiri AM, Albarrak AM, Al-Shangiti AM, Al-Tawfiq JA, Wikramaratna P, Alrabeeah AA, Drosten C, Memish ZA.

Lancet Infect Dis. 2015 Jun;15(6):629. doi: 10.1016/S1473-3099(15)00029-8. Epub 2015 May 17. No abstract available.

PMID:
26008827
33.

A Single Point Mutation Creating a Furin Cleavage Site in the Spike Protein Renders Porcine Epidemic Diarrhea Coronavirus Trypsin Independent for Cell Entry and Fusion.

Li W, Wicht O, van Kuppeveld FJ, He Q, Rottier PJ, Bosch BJ.

J Virol. 2015 Aug;89(15):8077-81. doi: 10.1128/JVI.00356-15. Epub 2015 May 13.

34.

Presence of Middle East respiratory syndrome coronavirus antibodies in Saudi Arabia: a nationwide, cross-sectional, serological study.

Müller MA, Meyer B, Corman VM, Al-Masri M, Turkestani A, Ritz D, Sieberg A, Aldabbagh S, Bosch BJ, Lattwein E, Alhakeem RF, Assiri AM, Albarrak AM, Al-Shangiti AM, Al-Tawfiq JA, Wikramaratna P, Alrabeeah AA, Drosten C, Memish ZA.

Lancet Infect Dis. 2015 May;15(5):559-64. doi: 10.1016/S1473-3099(15)70090-3. Epub 2015 Apr 8. Erratum in: Lancet Infect Dis. 2015 Jun;15(6):629.

PMID:
25863564
35.

Two Novel Mutations in the SLC25A4 Gene in a Patient with Mitochondrial Myopathy.

Körver-Keularts IM, de Visser M, Bakker HD, Wanders RJ, Vansenne F, Scholte HR, Dorland L, Nicolaes GA, Spaapen LM, Smeets HJ, Hendrickx AT, van den Bosch BJ.

JIMD Rep. 2015;22:39-45. doi: 10.1007/8904_2015_409. Epub 2015 Mar 3.

36.

Identification of protein receptors for coronaviruses by mass spectrometry.

Raj VS, Lamers MM, Smits SL, Demmers JA, Mou H, Bosch BJ, Haagmans BL.

Methods Mol Biol. 2015;1282:165-82. doi: 10.1007/978-1-4939-2438-7_15.

PMID:
25720480
37.

ATP1A1-mediated Src signaling inhibits coronavirus entry into host cells.

Burkard C, Verheije MH, Haagmans BL, van Kuppeveld FJ, Rottier PJ, Bosch BJ, de Haan CA.

J Virol. 2015 Apr;89(8):4434-48. doi: 10.1128/JVI.03274-14. Epub 2015 Feb 4.

38.

MERS coronavirus neutralizing antibodies in camels, Eastern Africa, 1983-1997.

Müller MA, Corman VM, Jores J, Meyer B, Younan M, Liljander A, Bosch BJ, Lattwein E, Hilali M, Musa BE, Bornstein S, Drosten C.

Emerg Infect Dis. 2014 Dec;20(12):2093-5. doi: 10.3201/eid2012.141026.

39.

Coronavirus cell entry occurs through the endo-/lysosomal pathway in a proteolysis-dependent manner.

Burkard C, Verheije MH, Wicht O, van Kasteren SI, van Kuppeveld FJ, Haagmans BL, Pelkmans L, Rottier PJ, Bosch BJ, de Haan CA.

PLoS Pathog. 2014 Nov 6;10(11):e1004502. doi: 10.1371/journal.ppat.1004502. eCollection 2014 Nov. Erratum in: PLoS Pathog. 2015 Feb;11(2):e1004709.

40.

Transmission of MERS-coronavirus in household contacts.

Drosten C, Meyer B, Müller MA, Corman VM, Al-Masri M, Hossain R, Madani H, Sieberg A, Bosch BJ, Lattwein E, Alhakeem RF, Assiri AM, Hajomar W, Albarrak AM, Al-Tawfiq JA, Zumla AI, Memish ZA.

N Engl J Med. 2014 Aug 28;371(9):828-35. doi: 10.1056/NEJMoa1405858.

41.

Antibodies against MERS coronavirus in dromedary camels, Kenya, 1992-2013.

Corman VM, Jores J, Meyer B, Younan M, Liljander A, Said MY, Gluecks I, Lattwein E, Bosch BJ, Drexler JF, Bornstein S, Drosten C, Müller MA.

Emerg Infect Dis. 2014 Aug;20(8):1319-22. doi: 10.3201/eid2008.140596.

42.

Geographic distribution of MERS coronavirus among dromedary camels, Africa.

Reusken CB, Messadi L, Feyisa A, Ularamu H, Godeke GJ, Danmarwa A, Dawo F, Jemli M, Melaku S, Shamaki D, Woma Y, Wungak Y, Gebremedhin EZ, Zutt I, Bosch BJ, Haagmans BL, Koopmans MP.

Emerg Infect Dis. 2014 Aug;20(8):1370-4. doi: 10.3201/eid2008.140590.

43.

Comparative efficacy of two next-generation Rift Valley fever vaccines.

Kortekaas J, Oreshkova N, van Keulen L, Kant J, Bosch BJ, Bouloy M, Moulin V, Goovaerts D, Moormann RJ.

Vaccine. 2014 Sep 3;32(39):4901-8. doi: 10.1016/j.vaccine.2014.07.037. Epub 2014 Jul 19.

PMID:
25050973
44.

Dissecting virus entry: replication-independent analysis of virus binding, internalization, and penetration using minimal complementation of β-galactosidase.

Burkard C, Bloyet LM, Wicht O, van Kuppeveld FJ, Rottier PJ, de Haan CA, Bosch BJ.

PLoS One. 2014 Jul 15;9(7):e101762. doi: 10.1371/journal.pone.0101762. eCollection 2014.

45.

A recombinant rabies vaccine expressing the trimeric form of the glycoprotein confers enhanced immunogenicity and protection in outbred mice.

Koraka P, Bosch BJ, Cox M, Chubet R, Amerongen Gv, Lövgren-Bengtsson K, Martina BE, Roose J, Rottier PJ, Osterhaus AD.

Vaccine. 2014 Aug 6;32(36):4644-50. doi: 10.1016/j.vaccine.2014.06.058. Epub 2014 Jun 21.

PMID:
24962755
46.

Middle East respiratory syndrome coronavirus (MERS-CoV) RNA and neutralising antibodies in milk collected according to local customs from dromedary camels, Qatar, April 2014.

Reusken CB, Farag EA, Jonges M, Godeke GJ, El-Sayed AM, Pas SD, Raj VS, Mohran KA, Moussa HA, Ghobashy H, Alhajri F, Ibrahim AK, Bosch BJ, Pasha SK, Al-Romaihi HE, Al-Thani M, Al-Marri SA, AlHajri MM, Haagmans BL, Koopmans MP.

Euro Surveill. 2014 Jun 12;19(23). pii: 20829.

47.

Human infection with MERS coronavirus after exposure to infected camels, Saudi Arabia, 2013.

Memish ZA, Cotten M, Meyer B, Watson SJ, Alsahafi AJ, Al Rabeeah AA, Corman VM, Sieberg A, Makhdoom HQ, Assiri A, Al Masri M, Aldabbagh S, Bosch BJ, Beer M, Müller MA, Kellam P, Drosten C.

Emerg Infect Dis. 2014 Jun;20(6):1012-5. doi: 10.3201/eid2006.140402.

48.

Proteolytic activation of the porcine epidemic diarrhea coronavirus spike fusion protein by trypsin in cell culture.

Wicht O, Li W, Willems L, Meuleman TJ, Wubbolts RW, van Kuppeveld FJ, Rottier PJ, Bosch BJ.

J Virol. 2014 Jul;88(14):7952-61. doi: 10.1128/JVI.00297-14. Epub 2014 May 7.

49.

Membrane ectopeptidases targeted by human coronaviruses.

Bosch BJ, Smits SL, Haagmans BL.

Curr Opin Virol. 2014 Jun;6:55-60. doi: 10.1016/j.coviro.2014.03.011. Epub 2014 Apr 22. Review.

50.

Antibodies against MERS coronavirus in dromedary camels, United Arab Emirates, 2003 and 2013.

Meyer B, Müller MA, Corman VM, Reusken CB, Ritz D, Godeke GJ, Lattwein E, Kallies S, Siemens A, van Beek J, Drexler JF, Muth D, Bosch BJ, Wernery U, Koopmans MP, Wernery R, Drosten C.

Emerg Infect Dis. 2014 Apr;20(4):552-9. doi: 10.3201/eid2004.131746.

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