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Items: 1 to 50 of 243

1.

Self-defense of macrophages against oxidative injury: Fighting for their own survival.

Virág L, Jaén RI, Regdon Z, Boscá L, Prieto P.

Redox Biol. 2019 Jun 28;26:101261. doi: 10.1016/j.redox.2019.101261. [Epub ahead of print] Review.

2.

Amyloid Peptide Induced Neuroinflammation Increases the P2X7 Receptor Expression in Microglial Cells, Impacting on Its Functionality.

Martínez-Frailes C, Di Lauro C, Bianchi C, de Diego-García L, Sebastián-Serrano Á, Boscá L, Díaz-Hernández M.

Front Cell Neurosci. 2019 Apr 12;13:143. doi: 10.3389/fncel.2019.00143. eCollection 2019.

3.

LXR Signaling Regulates Macrophage Survival and Inflammation in Response to Ionizing Radiation.

Tabraue C, Lara PC, De Mirecki-Garrido M, De La Rosa JV, López-Blanco F, Fernández-Pérez L, Boscá L, Castrillo A.

Int J Radiat Oncol Biol Phys. 2019 Jul 15;104(4):913-923. doi: 10.1016/j.ijrobp.2019.03.028. Epub 2019 Mar 25.

PMID:
30922944
4.

Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort.

Prieto P, Jaén RI, Calle D, Gómez-Serrano M, Núñez E, Fernández-Velasco M, Martín-Sanz P, Alonso S, Vázquez J, Cerdán S, Peinado MÁ, Boscá L.

World J Gastroenterol. 2019 Jan 28;25(4):433-446. doi: 10.3748/wjg.v25.i4.433.

5.

Post-translational modifications of prostaglandin-endoperoxide synthase 2 in colorectal cancer: An update.

Jaén RI, Prieto P, Casado M, Martín-Sanz P, Boscá L.

World J Gastroenterol. 2018 Dec 28;24(48):5454-5461. doi: 10.3748/wjg.v24.i48.5454. Review.

6.

Common and Differential Transcriptional Actions of Nuclear Receptors Liver X Receptors α and β in Macrophages.

Ramón-Vázquez A, de la Rosa JV, Tabraue C, Lopez F, Díaz-Chico BN, Bosca L, Tontonoz P, Alemany S, Castrillo A.

Mol Cell Biol. 2019 Feb 15;39(5). pii: e00376-18. doi: 10.1128/MCB.00376-18. Print 2019 Mar 1.

PMID:
30602495
7.

Endothelial NOD1 directs myeloid cell recruitment in atherosclerosis through VCAM-1.

González-Ramos S, Paz-García M, Rius C, Del Monte-Monge A, Rodríguez C, Fernández-García V, Andrés V, Martínez-González J, Lasunción MA, Martín-Sanz P, Soehnlein O, Boscá L.

FASEB J. 2019 Mar;33(3):3912-3921. doi: 10.1096/fj.201801231RR. Epub 2018 Nov 29.

PMID:
30496704
8.

Benzylamine and Thenylamine Derived Drugs Induce Apoptosis and Reduce Proliferation, Migration and Metastasis Formation in Melanoma Cells.

Mojena M, Povo-Retana A, González-Ramos S, Fernández-García V, Regadera J, Zazpe A, Artaiz I, Martín-Sanz P, Ledo F, Boscá L.

Front Oncol. 2018 Aug 23;8:328. doi: 10.3389/fonc.2018.00328. eCollection 2018.

9.

Protective Role of Hepatocyte Cyclooxygenase-2 Expression Against Liver Ischemia-Reperfusion Injury in Mice.

Motiño O, Francés DE, Casanova N, Fuertes-Agudo M, Cucarella C, Flores JM, Vallejo-Cremades MT, Olmedilla L, Pérez Peña J, Bañares R, Boscá L, Casado M, Martín-Sanz P.

Hepatology. 2018 Aug 29. doi: 10.1002/hep.30241. [Epub ahead of print]

PMID:
30155948
10.

The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras.

Oliva JL, Zarich N, Martínez N, Jorge R, Castrillo A, Azañedo M, García-Vargas S, Gutiérrez-Eisman S, Juarranz A, Boscá L, Gutkind JS, Rojas JM.

J Biol Chem. 2018 Jul 20;293(29):11651. doi: 10.1074/jbc.W118.004644. No abstract available.

11.

Deficiency of NOD1 Improves the β-Adrenergic Modulation of Ca2+ Handling in a Mouse Model of Heart Failure.

Val-Blasco A, Navarro-García JA, Tamayo M, Piedras MJ, Prieto P, Delgado C, Ruiz-Hurtado G, Rozas-Romero L, Gil-Fernández M, Zaragoza C, Boscá L, Fernández-Velasco M.

Front Physiol. 2018 Jun 14;9:702. doi: 10.3389/fphys.2018.00702. eCollection 2018.

12.

Correction: Induction of nitric oxide synthase-2 proceeds with the concomitant downregulation of the endogenous caveolin levels (doi:10.1242/jcs.01002).

Navarro-Lérida I, Teresa Portolés M, Álvarez Barrientos A, Gavilanes F, Boscá L, Rodríguez-Crespo I.

J Cell Sci. 2018 Jun 4;131(10). pii: jcs219667. doi: 10.1242/jcs.219667. No abstract available.

13.

Protection against gamma-radiation injury by protein tyrosine phosphatase 1B.

Mojena M, Pimentel-Santillana M, Povo-Retana A, Fernández-García V, González-Ramos S, Rada P, Tejedor A, Rico D, Martín-Sanz P, Valverde AM, Boscá L.

Redox Biol. 2018 Jul;17:213-223. doi: 10.1016/j.redox.2018.04.018. Epub 2018 Apr 21.

14.

GQ-11: A new PPAR agonist improves obesity-induced metabolic alterations in LDLr-/- mice.

Silva JC, de Oliveira EM, Turato WM, Trossini GHG, Maltarollo VG, Pitta MGR, Pitta IR, de Las Heras B, Boscá L, Rudnicki M, Abdalla DSP.

Int J Obes (Lond). 2018 Jun;42(5):1062-1072. doi: 10.1038/s41366-018-0011-7. Epub 2018 Jan 30.

PMID:
29453462
15.

Prostaglandin E2 Impairs P2Y2/P2Y4 Receptor Signaling in Cerebellar Astrocytes via EP3 Receptors.

Paniagua-Herranz L, Gil-Redondo JC, Queipo MJ, González-Ramos S, Boscá L, Pérez-Sen R, Miras-Portugal MT, Delicado EG.

Front Pharmacol. 2017 Dec 22;8:937. doi: 10.3389/fphar.2017.00937. eCollection 2017.

16.

PGE2 induces apoptosis of hepatic stellate cells and attenuates liver fibrosis in mice by downregulating miR-23a-5p and miR-28a-5p.

Brea R, Motiño O, Francés D, García-Monzón C, Vargas J, Fernández-Velasco M, Boscá L, Casado M, Martín-Sanz P, Agra N.

Biochim Biophys Acta Mol Basis Dis. 2018 Feb;1864(2):325-337. doi: 10.1016/j.bbadis.2017.11.001. Epub 2017 Nov 3.

17.

Expression of Concern: Induction of nitric oxide synthase-2 proceeds with the concomitant downregulation of the endogenous caveolin levels. J. Cell Sci. doi: 10.1242/jcs.01002.

Navarro-Lérida I, Portolés MT, Barrientos AÁ, Gavilanes F, Boscá L, Rodríguez-Crespo I.

J Cell Sci. 2017 Oct 1;130(19):3415. doi: 10.1242/jcs.209981. Epub 2017 Aug 30. No abstract available. Erratum in: J Cell Sci. 2018 Jun 4;131(10):.

18.

Cyclooxygenase 2 in liver dysfunction and carcinogenesis: Facts and perspectives.

Martín-Sanz P, Casado M, Boscá L.

World J Gastroenterol. 2017 May 28;23(20):3572-3580. doi: 10.3748/wjg.v23.i20.3572.

19.

Mild and Short-Term Caloric Restriction Prevents Obesity-Induced Cardiomyopathy in Young Zucker Rats without Changing in Metabolites and Fatty Acids Cardiac Profile.

Ruiz-Hurtado G, García-Prieto CF, Pulido-Olmo H, Velasco-Martín JP, Villa-Valverde P, Fernández-Valle ME, Boscá L, Fernández-Velasco M, Regadera J, Somoza B, Fernández-Alfonso MS.

Front Physiol. 2017 Feb 1;8:42. doi: 10.3389/fphys.2017.00042. eCollection 2017.

20.

Role of NOD1 in Heart Failure Progression via Regulation of Ca2+ Handling.

Val-Blasco A, Piedras MJGM, Ruiz-Hurtado G, Suarez N, Prieto P, Gonzalez-Ramos S, Gómez-Hurtado N, Delgado C, Pereira L, Benito G, Zaragoza C, Domenech N, Crespo-Leiro MG, Vasquez-Echeverri D, Nuñez G, Lopez-Collazo E, Boscá L, Fernández-Velasco M.

J Am Coll Cardiol. 2017 Jan 31;69(4):423-433. doi: 10.1016/j.jacc.2016.10.073.

21.

Cell Expansion-Dependent Inflammatory and Metabolic Profile of Human Bone Marrow Mesenchymal Stem Cells.

Prieto P, Fernández-Velasco M, Fernández-Santos ME, Sánchez PL, Terrón V, Martín-Sanz P, Fernández-Avilés F, Boscá L.

Front Physiol. 2016 Nov 16;7:548. eCollection 2016.

22.

NOD1 activation in cardiac fibroblasts induces myocardial fibrosis in a murine model of type 2 diabetes.

Val-Blasco A, Prieto P, Gonzalez-Ramos S, Benito G, Vallejo-Cremades MT, Pacheco I, González-Peramato P, Agra N, Terrón V, Delgado C, Martín-Sanz P, Boscá L, Fernández-Velasco M.

Biochem J. 2017 Feb 1;474(3):399-410. doi: 10.1042/BCJ20160556. Epub 2016 Nov 1.

PMID:
27803247
23.

Cyclooxygenase-2 expression in hepatocytes attenuates non-alcoholic steatohepatitis and liver fibrosis in mice.

Motiño O, Agra N, Brea Contreras R, Domínguez-Moreno M, García-Monzón C, Vargas-Castrillón J, Carnovale CE, Boscá L, Casado M, Mayoral R, Valdecantos MP, Valverde ÁM, Francés DE, Martín-Sanz P.

Biochim Biophys Acta. 2016 Sep;1862(9):1710-23. doi: 10.1016/j.bbadis.2016.06.009. Epub 2016 Jun 15.

24.

New thiazolidinediones affect endothelial cell activation and angiogenesis.

Rudnicki M, Tripodi GL, Ferrer R, Boscá L, Pitta MG, Pitta IR, Abdalla DS.

Eur J Pharmacol. 2016 Jul 5;782:98-106. doi: 10.1016/j.ejphar.2016.04.038. Epub 2016 Apr 21.

PMID:
27108791
25.

GM-CSF Enhances Macrophage Glycolytic Activity In Vitro and Improves Detection of Inflammation In Vivo.

Singh P, González-Ramos S, Mojena M, Rosales-Mendoza CE, Emami H, Swanson J, Morss A, Fayad ZA, Rudd JH, Gelfand J, Paz-García M, Martín-Sanz P, Boscá L, Tawakol A.

J Nucl Med. 2016 Sep;57(9):1428-35. doi: 10.2967/jnumed.115.167387. Epub 2016 Apr 14.

26.

New PPARγ partial agonist improves obesity-induced metabolic alterations and atherosclerosis in LDLr(-/-) mice.

Silva JC, César FA, de Oliveira EM, Turato WM, Tripodi GL, Castilho G, Machado-Lima A, de Las Heras B, Boscá L, Rabello MM, Hernandes MZ, Pitta MG, Pitta IR, Passarelli M, Rudnicki M, Abdalla DS.

Pharmacol Res. 2016 Feb;104:49-60. doi: 10.1016/j.phrs.2015.12.010. Epub 2015 Dec 17.

PMID:
26706782
27.

Metabolic signatures linked to macrophage polarization: from glucose metabolism to oxidative phosphorylation.

Boscá L, González-Ramos S, Prieto P, Fernández-Velasco M, Mojena M, Martín-Sanz P, Alemany S.

Biochem Soc Trans. 2015 Aug;43(4):740-4. doi: 10.1042/BST20150107. Epub 2015 Aug 3.

PMID:
26551722
28.

Activation of autophagy in macrophages by pro-resolving lipid mediators.

Prieto P, Rosales-Mendoza CE, Terrón V, Toledano V, Cuadrado A, López-Collazo E, Bannenberg G, Martín-Sanz P, Fernández-Velasco M, Boscá L.

Autophagy. 2015;11(10):1729-44. doi: 10.1080/15548627.2015.1078958.

29.

Epigenetics override pro-inflammatory PTGS transcriptomic signature towards selective hyperactivation of PGE2 in colorectal cancer.

Cebola I, Custodio J, Muñoz M, Díez-Villanueva A, Paré L, Prieto P, Aussó S, Coll-Mulet L, Boscá L, Moreno V, Peinado MA.

Clin Epigenetics. 2015 Jul 24;7:74. doi: 10.1186/s13148-015-0110-4. eCollection 2015.

30.

Regulation of MicroRNA 183 by Cyclooxygenase 2 in Liver Is DEAD-Box Helicase p68 (DDX5) Dependent: Role in Insulin Signaling.

Motiño O, Francés DE, Mayoral R, Castro-Sánchez L, Fernández-Velasco M, Boscá L, García-Monzón C, Brea R, Casado M, Agra N, Martín-Sanz P.

Mol Cell Biol. 2015 Jul;35(14):2554-67. doi: 10.1128/MCB.00198-15. Epub 2015 May 11.

31.

HIF-1α and PFKFB3 Mediate a Tight Relationship Between Proinflammatory Activation and Anerobic Metabolism in Atherosclerotic Macrophages.

Tawakol A, Singh P, Mojena M, Pimentel-Santillana M, Emami H, MacNabb M, Rudd JH, Narula J, Enriquez JA, Través PG, Fernández-Velasco M, Bartrons R, Martín-Sanz P, Fayad ZA, Tejedor A, Boscá L.

Arterioscler Thromb Vasc Biol. 2015 Jun;35(6):1463-71. doi: 10.1161/ATVBAHA.115.305551. Epub 2015 Apr 16.

32.

New indole-thiazolidine attenuates atherosclerosis in LDLr(-/-) mice.

César FA, Rudnicki M, de Las Heras B, Boscá L, Lima MC, Pitta IR, Abdalla DS.

Vascul Pharmacol. 2015 Aug;71:174-80. doi: 10.1016/j.vph.2015.03.009. Epub 2015 Apr 11.

PMID:
25869519
33.

NOD1, a new player in cardiac function and calcium handling.

Delgado C, Ruiz-Hurtado G, Gómez-Hurtado N, González-Ramos S, Rueda A, Benito G, Prieto P, Zaragoza C, Delicado EG, Pérez-Sen R, Miras-Portugal MT, Núñez G, Boscá L, Fernández-Velasco M.

Cardiovasc Res. 2015 Jun 1;106(3):375-86. doi: 10.1093/cvr/cvv118. Epub 2015 Mar 30.

PMID:
25824149
34.

A labdane diterpene exerts ex vivo and in vivo cardioprotection against post-ischemic injury: involvement of AKT-dependent mechanisms.

Cuadrado-Berrocal I, Gómez-Gaviro MV, Benito Y, Barrio A, Bermejo J, Fernández-Santos ME, Sánchez PL, Desco M, Fernández-Avilés F, Fernández-Velasco M, Boscá L, de Las Heras B.

Biochem Pharmacol. 2015 Feb 15;93(4):428-39. doi: 10.1016/j.bcp.2014.12.011. Epub 2014 Dec 31.

PMID:
25557296
35.

Hepatic cyclooxygenase-2 expression protects against diet-induced steatosis, obesity, and insulin resistance.

Francés DE, Motiño O, Agrá N, González-Rodríguez Á, Fernández-Álvarez A, Cucarella C, Mayoral R, Castro-Sánchez L, García-Casarrubios E, Boscá L, Carnovale CE, Casado M, Valverde ÁM, Martín-Sanz P.

Diabetes. 2015 May;64(5):1522-31. doi: 10.2337/db14-0979. Epub 2014 Nov 24.

36.

NFκB2/p100 is a key factor for endotoxin tolerance in human monocytes: a demonstration using primary human monocytes from patients with sepsis.

Cubillos-Zapata C, Hernández-Jiménez E, Toledano V, Esteban-Burgos L, Fernández-Ruíz I, Gómez-Piña V, Del Fresno C, Siliceo M, Prieto-Chinchiña P, Pérez de Diego R, Boscá L, Fresno M, Arnalich F, López-Collazo E.

J Immunol. 2014 Oct 15;193(8):4195-202. doi: 10.4049/jimmunol.1400721. Epub 2014 Sep 15.

37.

Sustained release of prostaglandin E₂ in fibroblasts expressing ectopically cyclooxygenase 2 impairs P2Y-dependent Ca²⁺-mobilization.

Pimentel-Santillana M, Través PG, Pérez-Sen R, Delicado EG, Martín-Sanz P, Miras-Portugal MT, Boscá L.

Mediators Inflamm. 2014;2014:832103. doi: 10.1155/2014/832103. Epub 2014 Aug 18.

38.

Anti-inflammatory actions of acanthoic acid-related diterpenes involve activation of the PI3K p110γ/δ subunits and inhibition of NF-κB.

Través PG, Pimentel-Santillana M, Rico D, Rodriguez N, Miethke T, Castrillo A, Theodorakis EA, Martín-Sanz P, Palladino MA, Boscá L.

Chem Biol. 2014 Aug 14;21(8):955-66. doi: 10.1016/j.chembiol.2014.06.005. Epub 2014 Jul 24.

39.

NOD1 receptor is up-regulated in diabetic human and murine myocardium.

Prieto P, Vallejo-Cremades MT, Benito G, González-Peramato P, Francés D, Agra N, Terrón V, Gónzalez-Ramos S, Delgado C, Ruiz-Gayo M, Pacheco I, Velasco-Martín JP, Regadera J, Martín-Sanz P, López-Collazo E, Boscá L, Fernández-Velasco M.

Clin Sci (Lond). 2014 Dec;127(12):665-77. doi: 10.1042/CS20140180.

PMID:
24934088
40.

Mitochondrial DAMPs induce endotoxin tolerance in human monocytes: an observation in patients with myocardial infarction.

Fernández-Ruiz I, Arnalich F, Cubillos-Zapata C, Hernández-Jiménez E, Moreno-González R, Toledano V, Fernández-Velasco M, Vallejo-Cremades MT, Esteban-Burgos L, de Diego RP, Llamas-Matias MA, García-Arumi E, Martí R, Boscá L, Andreu AL, López-Sendón JL, López-Collazo E.

PLoS One. 2014 May 5;9(5):e95073. doi: 10.1371/journal.pone.0095073. eCollection 2014.

41.

Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD.

González-Rodríguez A, Mayoral R, Agra N, Valdecantos MP, Pardo V, Miquilena-Colina ME, Vargas-Castrillón J, Lo Iacono O, Corazzari M, Fimia GM, Piacentini M, Muntané J, Boscá L, García-Monzón C, Martín-Sanz P, Valverde ÁM.

Cell Death Dis. 2014 Apr 17;5:e1179. doi: 10.1038/cddis.2014.162.

42.

Pivotal role of protein tyrosine phosphatase 1B (PTP1B) in the macrophage response to pro-inflammatory and anti-inflammatory challenge.

Través PG, Pardo V, Pimentel-Santillana M, González-Rodríguez Á, Mojena M, Rico D, Montenegro Y, Calés C, Martín-Sanz P, Valverde AM, Boscá L.

Cell Death Dis. 2014 Mar 13;5:e1125. doi: 10.1038/cddis.2014.90.

43.

Involvement of monocytes/macrophages as key factors in the development and progression of cardiovascular diseases.

Fernández-Velasco M, González-Ramos S, Boscá L.

Biochem J. 2014 Mar 1;458(2):187-93. doi: 10.1042/BJ20131501. Review.

PMID:
24524191
44.

2-deoxy-2-[18F]fluoro-D-mannose positron emission tomography imaging in atherosclerosis.

Tahara N, Mukherjee J, de Haas HJ, Petrov AD, Tawakol A, Haider N, Tahara A, Constantinescu CC, Zhou J, Boersma HH, Imaizumi T, Nakano M, Finn A, Fayad Z, Virmani R, Fuster V, Bosca L, Narula J.

Nat Med. 2014 Feb;20(2):215-9. doi: 10.1038/nm.3437. Epub 2014 Jan 12.

PMID:
24412923
45.

Modulation of voltage-dependent and inward rectifier potassium channels by 15-epi-lipoxin-A4 in activated murine macrophages: implications in innate immunity.

Moreno C, Prieto P, Macías Á, Pimentel-Santillana M, de la Cruz A, Través PG, Boscá L, Valenzuela C.

J Immunol. 2013 Dec 15;191(12):6136-46. doi: 10.4049/jimmunol.1300235. Epub 2013 Nov 18.

46.

Prolonged leptin treatment increases transient outward K⁺ current via upregulation of Kv4.2 and Kv4.3 channel subunits in adult rat ventricular myocytes.

Gómez-Hurtado N, Fernández-Velasco M, Fernández-Alfonso MS, Boscá L, Delgado C.

Pflugers Arch. 2014 May;466(5):903-14. doi: 10.1007/s00424-013-1348-3. Epub 2013 Sep 18.

PMID:
24046152
47.

Regulation of 15-hydroxyprostaglandin dehydrogenase expression in hepatocellular carcinoma.

Castro-Sánchez L, Agra N, Llorente Izquierdo C, Motiño O, Casado M, Boscá L, Martín-Sanz P.

Int J Biochem Cell Biol. 2013 Nov;45(11):2501-11. doi: 10.1016/j.biocel.2013.08.005. Epub 2013 Aug 15.

48.

Progression of liver oncogenesis in the double transgenic mice c-myc/TGF α is not enhanced by cyclooxygenase-2 expression.

Llorente-Izquierdo C, Mayoral R, Cucarella C, Grau C, Alvarez MS, Flores JM, García-Palencia P, Agra N, Castro-Sánchez L, Boscá L, Martín-Sanz P, Casado M.

Prostaglandins Other Lipid Mediat. 2013 Oct;106:106-15. doi: 10.1016/j.prostaglandins.2013.03.006. Epub 2013 Apr 8.

PMID:
23579063
49.

Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses.

Través PG, Pimentel-Santillana M, Carrasquero LM, Pérez-Sen R, Delicado EG, Luque A, Izquierdo M, Martín-Sanz P, Miras-Portugal MT, Boscá L.

J Immunol. 2013 Apr 15;190(8):4226-35. doi: 10.4049/jimmunol.1203029. Epub 2013 Mar 11.

50.

Identification of a novel Pfkfb1 mRNA variant in rat fetal liver.

Cosin-Roger J, Vernia S, Alvarez MS, Cucarella C, Boscá L, Martin-Sanz P, Fernández-Alvarez AJ, Casado M.

Biochem Biophys Res Commun. 2013 Feb 1;431(1):36-40. doi: 10.1016/j.bbrc.2012.12.109. Epub 2013 Jan 3.

PMID:
23291237

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