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Manipulation of the microbiome in critical illness-probiotics as a preventive measure against ventilator-associated pneumonia.

van Ruissen MCE, Bos LD, Dickson RP, Dondorp AM, Schultsz C, Schultz MJ.

Intensive Care Med Exp. 2019 Jul 25;7(Suppl 1):37. doi: 10.1186/s40635-019-0238-1. Review.


The role of hypercapnia in acute respiratory failure.

Morales-Quinteros L, Camprubí-Rimblas M, Bringué J, Bos LD, Schultz MJ, Artigas A.

Intensive Care Med Exp. 2019 Jul 25;7(Suppl 1):39. doi: 10.1186/s40635-019-0239-0. Review.


Why translational research matters: proceedings of the third international symposium on acute lung injury translational research (INSPIRES III).

Juffermans NP, Schultz M, Bos LD, Penuelas O, Laffey J, Lorente JA.

Intensive Care Med Exp. 2019 Jul 25;7(Suppl 1):40. doi: 10.1186/s40635-019-0230-9.


Changes in lung microbiome do not explain the development of ventilator-associated pneumonia.

Bos LDJ, Kalil AC.

Intensive Care Med. 2019 Aug;45(8):1133-1135. doi: 10.1007/s00134-019-05691-1. Epub 2019 Jul 17. No abstract available.


How to chair a poster discussion session.

Bos LDJ.

Breathe (Sheff). 2019 Jun;15(2):131-134. doi: 10.1183/20734735.0017-2019.


Natural moisturizing factor as a clinical marker in atopic dermatitis.

Nouwen AEM, Karadavut D, Pasmans SGMA, Elbert NJ, Bos LDN, Nijsten TEC, Arends NJT, Pijnenburg MWH, Koljenović S, Puppels GJ, Caspers PJ.

Allergy. 2019 Jun 10. doi: 10.1111/all.13942. [Epub ahead of print] No abstract available.


Age-dependent differences in pulmonary host responses in ARDS: a prospective observational cohort study.

Schouten LR, van Kaam AH, Kohse F, Veltkamp F, Bos LD, de Beer FM, van Hooijdonk RT, Horn J, Straat M, Witteveen E, Glas GJ, Wieske L, van Vught LA, Wiewel MA, Ingelse SA, Cortjens B, van Woensel JB, Bos AP, Walther T, Schultz MJ, Wösten-van Asperen RM; MARS consortium.

Ann Intensive Care. 2019 May 14;9(1):55. doi: 10.1186/s13613-019-0529-4.


Epidemiology and outcomes of source control procedures in critically ill patients with intra-abdominal infection.

van de Groep K, Verhoeff TL, Verboom DM, Bos LD, Schultz MJ, Bonten MJM, Cremer OL; MARS consortium.

J Crit Care. 2019 Aug;52:258-264. doi: 10.1016/j.jcrc.2019.02.029. Epub 2019 May 1.


Targeted treatment of acute respiratory distress syndrome with statins-a commentary on two phenotype stratified re-analysis of randomized controlled trials.

Heijnen NFL, Bergmans DCJJ, Schnabel RM, Bos LDJ.

J Thorac Dis. 2019 Mar;11(Suppl 3):S296-S299. doi: 10.21037/jtd.2019.01.23. No abstract available.


Volatile organic compound profiles in outlet air from extracorporeal life-support devices differ from breath profiles in critically ill patients.

Leopold JH, Philipp A, Bein T, Redel A, Gruber M, Schultz MJ, Abu-Hanna A, Brinkman P, Janssen HG, Bos LDJ.

ERJ Open Res. 2019 Apr 1;5(2). pii: 00134-2018. doi: 10.1183/23120541.00134-2018. eCollection 2019 Apr.


Soluble urokinase plasminogen activator receptor for the prediction of ventilator-associated pneumonia.

van Oort PM, Bos LD, Póvoa P, Ramirez P, Torres A, Artigas A, Schultz MJ, Martin-Loeches I.

ERJ Open Res. 2019 Mar 25;5(1). pii: 00212-2018. doi: 10.1183/23120541.00212-2018. eCollection 2019 Feb.


European Respiratory Society International Congress 2018: highlights from Assembly 2 on respiratory intensive care.

Fisser C, Spoletini G, Soe AK, Livesey A, Schreiber A, Swingwood E, Bos LD, Dreher M, Schultz MJ, Heunks L, Scala R.

ERJ Open Res. 2019 Mar 4;5(1). pii: 00198-2018. doi: 10.1183/23120541.00198-2018. eCollection 2019 Feb. Review.


Exhaled breath metabolomics reveals a pathogen-specific response in a rat pneumonia model for two human pathogenic bacteria: a proof-of-concept study.

van Oort PM, Brinkman P, Slingers G, Koppen G, Maas A, Roelofs JJ, Schnabel R, Bergmans DC, Raes M, Goodacre R, Fowler SJ, Schultz MJ, Bos LD.

Am J Physiol Lung Cell Mol Physiol. 2019 May 1;316(5):L751-L756. doi: 10.1152/ajplung.00449.2018. Epub 2019 Feb 13.


Understanding Heterogeneity in Biologic Phenotypes of Acute Respiratory Distress Syndrome by Leukocyte Expression Profiles.

Bos LDJ, Scicluna BP, Ong DSY, Cremer O, van der Poll T, Schultz MJ.

Am J Respir Crit Care Med. 2019 Jul 1;200(1):42-50. doi: 10.1164/rccm.201809-1808OC.


Future of the ICU: finding treatable needles in the data haystack.

Bos LDJ, Azoulay E, Martin-Loeches I.

Intensive Care Med. 2019 Feb;45(2):240-242. doi: 10.1007/s00134-018-5454-8. Epub 2018 Nov 12. No abstract available.


Preface from European Respiratory Society President 2018 Mina Gaga and European Respiratory Society Early-Career Member Committee Chair Lieuwe D. J. Bos.

Gaga M, Bos LDJ.

J Thorac Dis. 2018 Sep;10(Suppl 25):S2975-S2976. doi: 10.21037/jtd.2018.08.119. No abstract available.


Mechanical power of ventilation is associated with mortality in critically ill patients: an analysis of patients in two observational cohorts.

Serpa Neto A, Deliberato RO, Johnson AEW, Bos LD, Amorim P, Pereira SM, Cazati DC, Cordioli RL, Correa TD, Pollard TJ, Schettino GPP, Timenetsky KT, Celi LA, Pelosi P, Gama de Abreu M, Schultz MJ; PROVE Network Investigators.

Intensive Care Med. 2018 Nov;44(11):1914-1922. doi: 10.1007/s00134-018-5375-6. Epub 2018 Oct 5.


Noninvasive ventilation in hypercapnic respiratory failure: from rocking beds to fancy masks.

Schreiber A, Fusar Poli B, Bos LD, Nenna R.

Breathe (Sheff). 2018 Sep;14(3):235-237. doi: 10.1183/20734735.018918.


New Surviving Sepsis Campaign guidelines: back to the art of medicine.

Scala R, Schultz M, Bos LDJ, Artigas A.

Eur Respir J. 2018 Jul 11;52(1). pii: 1701818. doi: 10.1183/13993003.01818-2017. Print 2018 Jul. No abstract available.


Association between pre-operative biological phenotypes and postoperative pulmonary complications: An unbiased cluster analysis.

Serpa Neto A, Bos LD, Campos PPZA, Hemmes SNT, Bluth T, Calfee CS, Ferner M, Güldner A, Hollmann MW, India I, Kiss T, Laufenberg-Feldmann R, Sprung J, Sulemanji D, Unzueta C, Vidal Melo MF, Weingarten TN, Tuip-de Boer AM, Pelosi P, Gama de Abreu M, Schultz MJ; PROVHILO* and the PROVE** investigators.

Eur J Anaesthesiol. 2018 Sep;35(9):702-709. doi: 10.1097/EJA.0000000000000846.


Volatile organic compound signature from co-culture of lung epithelial cell line with Pseudomonas aeruginosa.

Lawal O, Knobel H, Weda H, Bos LD, Nijsen TME, Goodacre R, Fowler SJ.

Analyst. 2018 Jul 7;143(13):3148-3155. doi: 10.1039/c8an00759d. Epub 2018 Jun 7.


The fragility of statistically significant findings in randomised controlled anaesthesiology trials: systematic review of the medical literature.

Mazzinari G, Ball L, Serpa Neto A, Errando CL, Dondorp AM, Bos LD, Gama de Abreu M, Pelosi P, Schultz MJ.

Br J Anaesth. 2018 May;120(5):935-941. doi: 10.1016/j.bja.2018.01.012. Epub 2018 Feb 13.


Resolved versus confirmed ARDS after 24 h: insights from the LUNG SAFE study.

Madotto F, Pham T, Bellani G, Bos LD, Simonis FD, Fan E, Artigas A, Brochard L, Schultz MJ, Laffey JG; LUNG SAFE Investigators and the ESICM Trials Group.

Intensive Care Med. 2018 May;44(5):564-577. doi: 10.1007/s00134-018-5152-6. Epub 2018 Apr 9.


Contrary to popular belief, ventilator-associated lower respiratory tract infections are less common in immunocompromised patients.

Bos LD.

Eur Respir J. 2018 Mar 8;51(3). pii: 1800228. doi: 10.1183/13993003.00228-2018. Print 2018 Mar. No abstract available.


New kids on the block in the ECMC and opportunities 
for early career members in 2018.

Kahn NC, Bartel S, Amaral AFS, Bos LD, De Brandt J.

Breathe (Sheff). 2018 Mar;14(1):55-57. doi: 10.1183/20734735.019517.


How to improve quality of research in intensive care medicine.

Schultz MJ, Bos LD, Dondorp AM.

Ann Transl Med. 2018 Jan;6(2):35. doi: 10.21037/atm.2018.01.18. Review.


Diagnosis of acute respiratory distress syndrome by exhaled breath analysis.

Bos LDJ.

Ann Transl Med. 2018 Jan;6(2):33. doi: 10.21037/atm.2018.01.17. Review.


Macrolide therapy is associated with reduced mortality in acute respiratory distress syndrome (ARDS) patients.

Simonis FD, de Iudicibus G, Cremer OL, Ong DSY, van der Poll T, Bos LD, Schultz MJ; MARS consortium.

Ann Transl Med. 2018 Jan;6(2):24. doi: 10.21037/atm.2017.12.25.


ARDS: challenges in patient care and frontiers in research.

Bos LD, Martin-Loeches I, Schultz MJ.

Eur Respir Rev. 2018 Jan 24;27(147). pii: 170107. doi: 10.1183/16000617.0107-2017. Print 2018 Mar 31. Review.


The potential role of exhaled breath analysis in the diagnostic process of pneumonia-a systematic review.

van Oort PM, Povoa P, Schnabel R, Dark P, Artigas A, Bergmans DCJJ, Felton T, Coelho L, Schultz MJ, Fowler SJ, Bos LD.

J Breath Res. 2018 Feb 6;12(2):024001. doi: 10.1088/1752-7163/aaa499.


Integrative research agenda for diagnosis in sepsis.

Nolan K, O'Leary R, Bos LDJ, Martin-Loeches I.

Ann Transl Med. 2017 Nov;5(22):454. doi: 10.21037/atm.2017.06.57. No abstract available.


Airway microbiome research: a modern perspective on surveillance cultures?

Roux D, van Oort PM, Ricard JD, Bos LDJ.

Ann Transl Med. 2017 Nov;5(22):445. doi: 10.21037/atm.2017.08.05. Review.


Abstracts from the European Respiratory Society Annual Conference 2017 on respiratory critical care.

Shyamsundar M, Bos LDJ, Scala R.

J Thorac Dis. 2017 Nov;9(Suppl 16):S1537-S1540. doi: 10.21037/jtd.2017.11.46. No abstract available.


Preface from ERS President 2018 Mina Gaga and ERS Early-Career Member Committee Chair Lieuwe Bos.

Gaga M, Bos LDJ.

J Thorac Dis. 2017 Nov;9(Suppl 16):S1524-S1525. doi: 10.21037/jtd.2017.11.38. No abstract available.


Intensive care unit patients with lower respiratory tract nosocomial infections: the ENIRRIs project.

De Pascale G, Ranzani OT, Nseir S, Chastre J, Welte T, Antonelli M, Navalesi P, Garofalo E, Bruni A, Coelho LM, Skoczynski S, Longhini F, Taccone FS, Grimaldi D, Salzer HJF, Lange C, Froes F, Artigas A, Díaz E, Vallés J, Rodríguez A, Panigada M, Comellini V, Fasano L, Soave PM, Spinazzola G, Luyt CE, Alvarez-Lerma F, Marin J, Masclans JR, Chiumello D, Pezzi A, Schultz M, Mohamed H, Van Der Eerden M, Hoek RAS, Gommers DAMPJ, Pasquale MD, Civljak R, Kutleša M, Bassetti M, Dimopoulos G, Nava S, Rios F, Zampieri FG, Povoa P, Bos LD, Aliberti S, Torres A, Martín-Loeches I.

ERJ Open Res. 2017 Nov 17;3(4). pii: 00092-2017. doi: 10.1183/23120541.00092-2017. eCollection 2017 Oct.


Breathomics from exhaled volatile organic compounds in pediatric asthma.

Neerincx AH, Vijverberg SJH, Bos LDJ, Brinkman P, van der Schee MP, de Vries R, Sterk PJ, Maitland-van der Zee AH.

Pediatr Pulmonol. 2017 Dec;52(12):1616-1627. doi: 10.1002/ppul.23785. Epub 2017 Oct 30. Review.


Risk stratification using SpO2/FiO2 and PEEP at initial ARDS diagnosis and after 24 h in patients with moderate or severe ARDS.

Pisani L, Roozeman JP, Simonis FD, Giangregorio A, van der Hoeven SM, Schouten LR, Horn J, Neto AS, Festic E, Dondorp AM, Grasso S, Bos LD, Schultz MJ; MARS consortium.

Ann Intensive Care. 2017 Oct 25;7(1):108. doi: 10.1186/s13613-017-0327-9.


Respiratory Viruses in Invasively Ventilated Critically Ill Patients-A Prospective Multicenter Observational Study.

van Someren Gréve F, Juffermans NP, Bos LDJ, Binnekade JM, Braber A, Cremer OL, de Jonge E, Molenkamp R, Ong DSY, Rebers SPH, Spoelstra-de Man AME, van der Sluijs KF, Spronk PE, Verheul KD, de Waard MC, de Wilde RBP, Winters T, de Jong MD, Schultz MJ.

Crit Care Med. 2018 Jan;46(1):29-36. doi: 10.1097/CCM.0000000000002752.


Respiratory research networks in Europe and beyond: aims, achievements and aspirations for the 21st century.

Martin-Loeches I, Zampieri F, Povoa P, Ranzani O, Bos LD, Aliberti S, Torres A.

Breathe (Sheff). 2017 Sep;13(3):209-215. doi: 10.1183/20734735.009217.


Exhaled breath profiles in the monitoring of loss of control and clinical recovery in asthma.

Brinkman P, van de Pol MA, Gerritsen MG, Bos LD, Dekker T, Smids BS, Sinha A, Majoor CJ, Sneeboer MM, Knobel HH, Vink TJ, de Jongh FH, Lutter R, Sterk PJ, Fens N.

Clin Exp Allergy. 2017 Sep;47(9):1159-1169. doi: 10.1111/cea.12965. Epub 2017 Jul 10.


Opportunities for early career members.

Bos LD, Bartel S, Mathioudakis AG, Flood E.

Breathe (Sheff). 2017 Jun;13(2):127-128. doi: 10.1183/20734735.004617.


Profiling of volatile organic compounds produced by clinical Aspergillus isolates using gas chromatography-mass spectrometry.

Gerritsen MG, Brinkman P, Escobar N, Bos LD, de Heer K, Meijer M, Janssen HG, de Cock H, Wösten HAB, Visser CE, van Oers MHJ, Sterk PJ.

Med Mycol. 2018 Feb 1;56(2):253-256. doi: 10.1093/mmy/myx035.


Biomarkers kinetics in the assessment of ventilator-associated pneumonia response to antibiotics - results from the BioVAP study.

Póvoa P, Martin-Loeches I, Ramirez P, Bos LD, Esperatti M, Silvestre J, Gili G, Goma G, Berlanga E, Espasa M, Gonçalves E, Torres A, Artigas A.

J Crit Care. 2017 Oct;41:91-97. doi: 10.1016/j.jcrc.2017.05.007. Epub 2017 May 8.


Selective decontamination of the digestive tract halves the prevalence of ventilator-associated pneumonia compared to selective oral decontamination.

Bos LD, Stips C, Schouten LR, van Vught LA, Wiewel MA, Wieske L, van Hooijdonk RT, Straat M, de Beer FM, Glas GJ, Visser CE, de Jonge E, Juffermans NP, Horn J, Schultz MJ.

Intensive Care Med. 2017 Oct;43(10):1535-1537. doi: 10.1007/s00134-017-4838-5. Epub 2017 May 11. No abstract available.


Identification and validation of distinct biological phenotypes in patients with acute respiratory distress syndrome by cluster analysis.

Bos LD, Schouten LR, van Vught LA, Wiewel MA, Ong DSY, Cremer O, Artigas A, Martin-Loeches I, Hoogendijk AJ, van der Poll T, Horn J, Juffermans N, Calfee CS, Schultz MJ; MARS consortium.

Thorax. 2017 Oct;72(10):876-883. doi: 10.1136/thoraxjnl-2016-209719. Epub 2017 Apr 27.


A European Respiratory Society technical standard: exhaled biomarkers in lung disease.

Horváth I, Barnes PJ, Loukides S, Sterk PJ, Högman M, Olin AC, Amann A, Antus B, Baraldi E, Bikov A, Boots AW, Bos LD, Brinkman P, Bucca C, Carpagnano GE, Corradi M, Cristescu S, de Jongste JC, Dinh-Xuan AT, Dompeling E, Fens N, Fowler S, Hohlfeld JM, Holz O, Jöbsis Q, Van De Kant K, Knobel HH, Kostikas K, Lehtimäki L, Lundberg J, Montuschi P, Van Muylem A, Pennazza G, Reinhold P, Ricciardolo FLM, Rosias P, Santonico M, van der Schee MP, van Schooten FJ, Spanevello A, Tonia T, Vink TJ.

Eur Respir J. 2017 Apr 26;49(4). pii: 1600965. doi: 10.1183/13993003.00965-2016. Print 2017 Apr.


Volatile organic compounds in exhaled breath are independent of systemic inflammatory syndrome caused by intravenous lipopolysaccharide infusion in humans: results from an experiment in healthy volunteers.

Peters AL, Gerritsen MG, Brinkman P, Zwinderman KAH, Vlaar APJ, Bos LD.

J Breath Res. 2017 Apr 11;11(2):026003. doi: 10.1088/1752-7163/aa6545.


New ECMC members: Early Career Forum.

Bos LD, Langer D, Flood E.

Breathe (Sheff). 2017 Mar;13(1):51-52. doi: 10.1183/20734735.019816.


A new prediction score for critically ill patients-do we need an Apgar score for acute respiratory distress syndrome?

Bos LD, Artigas-Raventos A, Schultz MJ.

J Thorac Dis. 2017 Feb;9(2):E142-E145. doi: 10.21037/jtd.2017.02.01. No abstract available.


Non-invasive breath monitoring with eNose does not improve glucose diagnostics in critically ill patients in comparison to continuous glucose monitoring in blood.

Leopold JH, Bos LDJ, Colombo C, Sterk PJ, Schultz MJ, Abu-Hanna A.

J Breath Res. 2017 Apr 7;11(2):026002. doi: 10.1088/1752-7163/aa6488.


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