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Items: 1 to 50 of 252

1.

An organoid platform for ovarian cancer captures intra- and interpatient heterogeneity.

Kopper O, de Witte CJ, Lõhmussaar K, Valle-Inclan JE, Hami N, Kester L, Balgobind AV, Korving J, Proost N, Begthel H, van Wijk LM, Revilla SA, Theeuwsen R, van de Ven M, van Roosmalen MJ, Ponsioen B, Ho VWH, Neel BG, Bosse T, Gaarenstroom KN, Vrieling H, Vreeswijk MPG, van Diest PJ, Witteveen PO, Jonges T, Bos JL, van Oudenaarden A, Zweemer RP, Snippert HJG, Kloosterman WP, Clevers H.

Nat Med. 2019 May;25(5):838-849. doi: 10.1038/s41591-019-0422-6. Epub 2019 Apr 22.

PMID:
31011202
2.

CRISPR-induced RASGAP deficiencies in colorectal cancer organoids reveal that only loss of NF1 promotes resistance to EGFR inhibition.

Post JB, Hami N, Mertens AEE, Elfrink S, Bos JL, Snippert HJG.

Oncotarget. 2019 Feb 15;10(14):1440-1457. doi: 10.18632/oncotarget.26677. eCollection 2019 Feb 15.

3.

A Tuba/Cdc42/Par6A complex is required to ensure singularity in apical domain formation during enterocyte polarization.

Bruurs LJM, van der Net MC, Zwakenberg S, Zwartkruis FJT, Bos JL.

PLoS One. 2018 Nov 8;13(11):e0207159. doi: 10.1371/journal.pone.0207159. eCollection 2018.

4.

The Phosphatase PTPL1 Is Required for PTEN-Mediated Regulation of Apical Membrane Size.

Bruurs LJM, van der Net MC, Zwakenberg S, Rosendahl Huber AKM, Post A, Zwartkruis FJ, Bos JL.

Mol Cell Biol. 2018 May 29;38(12). pii: e00102-18. doi: 10.1128/MCB.00102-18. Print 2018 Jun 15.

5.

Multiple Rap1 effectors control Epac1-mediated tightening of endothelial junctions.

Pannekoek WJ, Vliem MJ, Bos JL.

Small GTPases. 2018 Feb 17:1-8. doi: 10.1080/21541248.2018.1431512. [Epub ahead of print]

PMID:
29388865
6.

From Ras to Rap and Back, a Journey of 35 Years.

Bos JL.

Cold Spring Harb Perspect Med. 2018 Feb 1;8(2). pii: a031468. doi: 10.1101/cshperspect.a031468. Review.

PMID:
28778969
7.

A Two-Tiered Mechanism Enables Localized Cdc42 Signaling during Enterocyte Polarization.

Bruurs LJM, Zwakenberg S, van der Net MC, Zwartkruis FJ, Bos JL.

Mol Cell Biol. 2017 Mar 17;37(7). pii: e00547-16. doi: 10.1128/MCB.00547-16. Print 2017 Apr 1.

8.

Ras Association-Domain Dimers Bring Proteins Together.

Rehmann H, Bos JL.

Structure. 2016 Dec 6;24(12):2039-2040. doi: 10.1016/j.str.2016.11.010.

9.

Targeting mutant RAS in patient-derived colorectal cancer organoids by combinatorial drug screening.

Verissimo CS, Overmeer RM, Ponsioen B, Drost J, Mertens S, Verlaan-Klink I, Gerwen BV, van der Ven M, Wetering MV, Egan DA, Bernards R, Clevers H, Bos JL, Snippert HJ.

Elife. 2016 Nov 15;5. pii: e18489. doi: 10.7554/eLife.18489.

10.

ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization.

Bruurs LJ, Donker L, Zwakenberg S, Zwartkruis FJ, Begthel H, Knisely AS, Posthuma G, van de Graaf SF, Paulusma CC, Bos JL.

J Cell Biol. 2015 Sep 28;210(7):1055-63. doi: 10.1083/jcb.201505118.

11.

Rap1 Spatially Controls ArhGAP29 To Inhibit Rho Signaling during Endothelial Barrier Regulation.

Post A, Pannekoek WJ, Ponsioen B, Vliem MJ, Bos JL.

Mol Cell Biol. 2015 Jul;35(14):2495-502. doi: 10.1128/MCB.01453-14. Epub 2015 May 11.

12.

Structure-guided design of selective Epac1 and Epac2 agonists.

Schwede F, Bertinetti D, Langerijs CN, Hadders MA, Wienk H, Ellenbroek JH, de Koning EJ, Bos JL, Herberg FW, Genieser HG, Janssen RA, Rehmann H.

PLoS Biol. 2015 Jan 20;13(1):e1002038. doi: 10.1371/journal.pbio.1002038. eCollection 2015 Jan.

13.

Mechanisms of isoform specific Rap2 signaling during enterocytic brush border formation.

Bruurs LJ, Bos JL.

PLoS One. 2014 Sep 9;9(9):e106687. doi: 10.1371/journal.pone.0106687. eCollection 2014.

14.

The PDZ domain of the guanine nucleotide exchange factor PDZGEF directs binding to phosphatidic acid during brush border formation.

Consonni SV, Brouwer PM, van Slobbe ES, Bos JL.

PLoS One. 2014 May 23;9(5):e98253. doi: 10.1371/journal.pone.0098253. eCollection 2014.

15.

DEP domains: structurally similar but functionally different.

Consonni SV, Maurice MM, Bos JL.

Nat Rev Mol Cell Biol. 2014 May;15(5):357-62. doi: 10.1038/nrm3791. Epub 2014 Apr 16. Review.

PMID:
24739740
16.

Control of epithelial cell migration and invasion by the IKKβ- and CK1α-mediated degradation of RAPGEF2.

Magliozzi R, Low TY, Weijts BG, Cheng T, Spanjaard E, Mohammed S, van Veen A, Ovaa H, de Rooij J, Zwartkruis FJ, Bos JL, de Bruin A, Heck AJ, Guardavaccaro D.

Dev Cell. 2013 Dec 9;27(5):574-85. doi: 10.1016/j.devcel.2013.10.023. Epub 2013 Nov 27.

17.

Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop β-cell dysfunction and metabolic syndrome.

Kai AK, Lam AK, Chen Y, Tai AC, Zhang X, Lai AK, Yeung PK, Tam S, Wang J, Lam KS, Vanhoutte PM, Bos JL, Chung SS, Xu A, Chung SK.

FASEB J. 2013 Oct;27(10):4122-35. doi: 10.1096/fj.13-230433. Epub 2013 Jun 27.

PMID:
23825225
18.

Rasip1 mediates Rap1 regulation of Rho in endothelial barrier function through ArhGAP29.

Post A, Pannekoek WJ, Ross SH, Verlaan I, Brouwer PM, Bos JL.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11427-32. doi: 10.1073/pnas.1306595110. Epub 2013 Jun 24.

19.

Rap1 and Rap2 antagonistically control endothelial barrier resistance.

Pannekoek WJ, Linnemann JR, Brouwer PM, Bos JL, Rehmann H.

PLoS One. 2013;8(2):e57903. doi: 10.1371/journal.pone.0057903. Epub 2013 Feb 28.

20.

Quantitative global phosphoproteomics of human umbilical vein endothelial cells after activation of the Rap signaling pathway.

Meijer LA, Zhou H, Chan OY, Altelaar AF, Hennrich ML, Mohammed S, Bos JL, Heck AJ.

Mol Biosyst. 2013 Apr 5;9(4):732-49. doi: 10.1039/c3mb25524g.

PMID:
23403867
21.

Rap1 signaling in endothelial barrier control.

Pannekoek WJ, Post A, Bos JL.

Cell Adh Migr. 2014;8(2):100-7.

22.

Rap1 can bypass the FAK-Src-Paxillin cascade to induce cell spreading and focal adhesion formation.

Ross SH, Spanjaard E, Post A, Vliem MJ, Kristyanto H, Bos JL, de Rooij J.

PLoS One. 2012;7(11):e50072. doi: 10.1371/journal.pone.0050072. Epub 2012 Nov 27.

23.

Rap2A links intestinal cell polarity to brush border formation.

Gloerich M, ten Klooster JP, Vliem MJ, Koorman T, Zwartkruis FJ, Clevers H, Bos JL.

Nat Cell Biol. 2012 Aug;14(8):793-801. doi: 10.1038/ncb2537. Epub 2012 Jul 15.

PMID:
22797597
24.

Semaphorin signaling meets rap.

Bos JL, Pannekoek WJ.

Sci Signal. 2012 Feb 21;5(212):pe6. doi: 10.1126/scisignal.2002913.

PMID:
22355186
25.

cAMP regulates DEP domain-mediated binding of the guanine nucleotide exchange factor Epac1 to phosphatidic acid at the plasma membrane.

Consonni SV, Gloerich M, Spanjaard E, Bos JL.

Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3814-9. doi: 10.1073/pnas.1117599109. Epub 2012 Feb 16.

26.

Evolution of the TOR pathway.

van Dam TJ, Zwartkruis FJ, Bos JL, Snel B.

J Mol Evol. 2011 Oct;73(3-4):209-20. doi: 10.1007/s00239-011-9469-9. Epub 2011 Nov 5.

27.

Epac1 and PDZ-GEF cooperate in Rap1 mediated endothelial junction control.

Pannekoek WJ, van Dijk JJ, Chan OY, Huveneers S, Linnemann JR, Spanjaard E, Brouwer PM, van der Meer AJ, Zwartkruis FJ, Rehmann H, de Rooij J, Bos JL.

Cell Signal. 2011 Dec;23(12):2056-64. doi: 10.1016/j.cellsig.2011.07.022. Epub 2011 Aug 4.

PMID:
21840392
28.

Regulating Rap small G-proteins in time and space.

Gloerich M, Bos JL.

Trends Cell Biol. 2011 Oct;21(10):615-23. doi: 10.1016/j.tcb.2011.07.001. Epub 2011 Aug 4. Review.

PMID:
21820312
29.

Evolution of the Ras-like small GTPases and their regulators.

van Dam TJ, Bos JL, Snel B.

Small GTPases. 2011 Jan;2(1):4-16.

30.

The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.

Gloerich M, Vliem MJ, Prummel E, Meijer LA, Rensen MG, Rehmann H, Bos JL.

J Cell Biol. 2011 Jun 13;193(6):1009-20. doi: 10.1083/jcb.201011126.

31.

Ezrin is required for efficient Rap1-induced cell spreading.

Ross SH, Post A, Raaijmakers JH, Verlaan I, Gloerich M, Bos JL.

J Cell Sci. 2011 Jun 1;124(Pt 11):1808-18. doi: 10.1242/jcs.079830. Epub 2011 May 3.

32.

Epac-Rap signaling reduces cellular stress and ischemia-induced kidney failure.

Stokman G, Qin Y, Genieser HG, Schwede F, de Heer E, Bos JL, Bajema IM, van de Water B, Price LS.

J Am Soc Nephrol. 2011 May;22(5):859-72. doi: 10.1681/ASN.2010040423. Epub 2011 Apr 14.

33.

TSPYL5 suppresses p53 levels and function by physical interaction with USP7.

Epping MT, Meijer LA, Krijgsman O, Bos JL, Pandolfi PP, Bernards R.

Nat Cell Biol. 2011 Jan;13(1):102-8. doi: 10.1038/ncb2142. Epub 2010 Dec 19.

PMID:
21170034
34.

Spatial regulation of cyclic AMP-Epac1 signaling in cell adhesion by ERM proteins.

Gloerich M, Ponsioen B, Vliem MJ, Zhang Z, Zhao J, Kooistra MR, Price LS, Ritsma L, Zwartkruis FJ, Rehmann H, Jalink K, Bos JL.

Mol Cell Biol. 2010 Nov;30(22):5421-31. doi: 10.1128/MCB.00463-10. Epub 2010 Sep 20.

35.

Epac: defining a new mechanism for cAMP action.

Gloerich M, Bos JL.

Annu Rev Pharmacol Toxicol. 2010;50:355-75. doi: 10.1146/annurev.pharmtox.010909.105714. Review.

PMID:
20055708
36.

UNC45A confers resistance to histone deacetylase inhibitors and retinoic acid.

Epping MT, Meijer LA, Bos JL, Bernards R.

Mol Cancer Res. 2009 Nov;7(11):1861-70. doi: 10.1158/1541-7786.MCR-09-0187. Epub 2009 Oct 20.

37.

Phylogeny of the CDC25 homology domain reveals rapid differentiation of Ras pathways between early animals and fungi.

van Dam TJ, Rehmann H, Bos JL, Snel B.

Cell Signal. 2009 Nov;21(11):1579-85. doi: 10.1016/j.cellsig.2009.06.004. Epub 2009 Jun 28.

PMID:
19567266
38.

Involvement of Rap-1 activation and early termination of immune synapse in CTLA-4-mediated negative signal.

Hara S, Nakaseko C, Yamasaki S, Hattori M, Bos JL, Saito Y, Minato N, Saito T.

Hematology. 2009 Jun;14(3):150-8. doi: 10.1179/102453309X402241.

PMID:
19490760
39.

Direct spatial control of Epac1 by cyclic AMP.

Ponsioen B, Gloerich M, Ritsma L, Rehmann H, Bos JL, Jalink K.

Mol Cell Biol. 2009 May;29(10):2521-31. doi: 10.1128/MCB.01630-08. Epub 2009 Mar 9.

40.

Cell-cell junction formation: the role of Rap1 and Rap1 guanine nucleotide exchange factors.

Pannekoek WJ, Kooistra MR, Zwartkruis FJ, Bos JL.

Biochim Biophys Acta. 2009 Apr;1788(4):790-6. doi: 10.1016/j.bbamem.2008.12.010. Epub 2008 Dec 29. Review.

41.

Specificity in Ras and Rap signaling.

Raaijmakers JH, Bos JL.

J Biol Chem. 2009 Apr 24;284(17):10995-9. doi: 10.1074/jbc.R800061200. Epub 2008 Dec 17. Review.

42.

Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B.

Rehmann H, Arias-Palomo E, Hadders MA, Schwede F, Llorca O, Bos JL.

Nature. 2008 Sep 4;455(7209):124-7. doi: 10.1038/nature07187. Epub 2008 Jul 27.

PMID:
18660803
43.

PKA and Epac1 regulate endothelial integrity and migration through parallel and independent pathways.

Lorenowicz MJ, Fernandez-Borja M, Kooistra MR, Bos JL, Hordijk PL.

Eur J Cell Biol. 2008 Oct;87(10):779-92. doi: 10.1016/j.ejcb.2008.05.004. Epub 2008 Jul 16.

PMID:
18635287
44.

8-pCPT-2'-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue.

Vliem MJ, Ponsioen B, Schwede F, Pannekoek WJ, Riedl J, Kooistra MR, Jalink K, Genieser HG, Bos JL, Rehmann H.

Chembiochem. 2008 Sep 1;9(13):2052-4. doi: 10.1002/cbic.200800216. No abstract available.

PMID:
18633951
45.

The RapGEF PDZ-GEF2 is required for maturation of cell-cell junctions.

Dubé N, Kooistra MR, Pannekoek WJ, Vliem MJ, Oorschot V, Klumperman J, Rehmann H, Bos JL.

Cell Signal. 2008 Sep;20(9):1608-15. doi: 10.1016/j.cellsig.2008.05.006. Epub 2008 May 23.

PMID:
18585005
46.

Cyclic nucleotide analogs as probes of signaling pathways.

Poppe H, Rybalkin SD, Rehmann H, Hinds TR, Tang XB, Christensen AE, Schwede F, Genieser HG, Bos JL, Doskeland SO, Beavo JA, Butt E.

Nat Methods. 2008 Apr;5(4):277-8. doi: 10.1038/nmeth0408-277. No abstract available.

PMID:
18376388
47.

cAMP-induced Epac-Rap activation inhibits epithelial cell migration by modulating focal adhesion and leading edge dynamics.

Lyle KS, Raaijmakers JH, Bruinsma W, Bos JL, de Rooij J.

Cell Signal. 2008 Jun;20(6):1104-16. doi: 10.1016/j.cellsig.2008.01.018. Epub 2008 Jan 31.

PMID:
18346875
48.

Structural dynamics in the activation of Epac.

Harper SM, Wienk H, Wechselberger RW, Bos JL, Boelens R, Rehmann H.

J Biol Chem. 2008 Mar 7;283(10):6501-8. doi: 10.1074/jbc.M707849200. Epub 2007 Dec 31.

49.

RAP-1 and the RAL-1/exocyst pathway coordinate hypodermal cell organization in Caenorhabditis elegans.

Frische EW, Pellis-van Berkel W, van Haaften G, Cuppen E, Plasterk RH, Tijsterman M, Bos JL, Zwartkruis FJ.

EMBO J. 2007 Dec 12;26(24):5083-92. Epub 2007 Nov 8.

50.

GEFs and GAPs: critical elements in the control of small G proteins.

Bos JL, Rehmann H, Wittinghofer A.

Cell. 2007 Jun 1;129(5):865-77. Review. Erratum in: Cell. 2007 Jul 27;130(2):385.

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