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The 1980s: D-AP5, LTP and a Decade of NMDA Receptor Discoveries.

Lodge D, Watkins JC, Bortolotto ZA, Jane DE, Volianskis A.

Neurochem Res. 2018 Oct 4. doi: 10.1007/s11064-018-2640-6. [Epub ahead of print]


Some distorted thoughts about ketamine as a psychedelic and a novel hypothesis based on NMDA receptor-mediated synaptic plasticity.

Ingram R, Kang H, Lightman S, Jane DE, Bortolotto ZA, Collingridge GL, Lodge D, Volianskis A.

Neuropharmacology. 2018 Jun 6. pii: S0028-3908(18)30284-3. doi: 10.1016/j.neuropharm.2018.06.008. [Epub ahead of print] Review.


Amygdala levels of the GluA1 subunit of glutamate receptors and its phosphorylation state at serine 845 in the anterior hippocampus are biomarkers of ictal fear but not anxiety.

Leal RB, Lopes MW, Formolo DA, de Carvalho CR, Hoeller AA, Latini A, Sousa DS, Wolf P, Prediger RD, Bortolotto ZA, Linhares MN, Lin K, Walz R.

Mol Psychiatry. 2018 Jun 7. doi: 10.1038/s41380-018-0084-7. [Epub ahead of print]


Evaluation of β-Aminocarboxylic Acid Derivatives in Hippocampal Excitatory Synaptic Transmission.

Oliveira DR, Luchez CV, Bortolotto ZA, Fernandes JPS.

Arch Pharm (Weinheim). 2017 Nov;350(11). doi: 10.1002/ardp.201700179. Epub 2017 Sep 5.


Synaptoimmunology - roles in health and disease.

Nisticò R, Salter E, Nicolas C, Feligioni M, Mango D, Bortolotto ZA, Gressens P, Collingridge GL, Peineau S.

Mol Brain. 2017 Jun 20;10(1):26. doi: 10.1186/s13041-017-0308-9. Review.


A single high dose of dexamethasone affects the phosphorylation state of glutamate AMPA receptors in the human limbic system.

Lopes MW, Leal RB, Guarnieri R, Schwarzbold ML, Hoeller A, Diaz AP, Boos GL, Lin K, Linhares MN, Nunes JC, Quevedo J, Bortolotto ZA, Markowitsch HJ, Lightman SL, Walz R.

Transl Psychiatry. 2016 Dec 13;6(12):e986. doi: 10.1038/tp.2016.251.


Antidepressant Actions of Ketamine Versus Hydroxynorketamine.

Collingridge GL, Lee Y, Bortolotto ZA, Kang H, Lodge D.

Biol Psychiatry. 2017 Apr 15;81(8):e65-e67. doi: 10.1016/j.biopsych.2016.06.029. Epub 2016 Sep 28. No abstract available.


Multiple roles of GluN2B-containing NMDA receptors in synaptic plasticity in juvenile hippocampus.

France G, Fernández-Fernández D, Burnell ES, Irvine MW, Monaghan DT, Jane DE, Bortolotto ZA, Collingridge GL, Volianskis A.

Neuropharmacology. 2017 Jan;112(Pt A):76-83. doi: 10.1016/j.neuropharm.2016.08.010. Epub 2016 Aug 12.


Ephenidine: A new psychoactive agent with ketamine-like NMDA receptor antagonist properties.

Kang H, Park P, Bortolotto ZA, Brandt SD, Colestock T, Wallach J, Collingridge GL, Lodge D.

Neuropharmacology. 2017 Jan;112(Pt A):144-149. doi: 10.1016/j.neuropharm.2016.08.004. Epub 2016 Aug 9.


Pharmacological Investigations of the Dissociative 'Legal Highs' Diphenidine, Methoxphenidine and Analogues.

Wallach J, Kang H, Colestock T, Morris H, Bortolotto ZA, Collingridge GL, Lodge D, Halberstadt AL, Brandt SD, Adejare A.

PLoS One. 2016 Jun 17;11(6):e0157021. doi: 10.1371/journal.pone.0157021. eCollection 2016.


The Role of Hippocampal NMDA Receptors in Long-Term Emotional Responses following Muscarinic Receptor Activation.

Hoeller AA, Costa AP, Bicca MA, Matheus FC, Lach G, Spiga F, Lightman SL, Walz R, Collingridge GL, Bortolotto ZA, de Lima TC.

PLoS One. 2016 Jan 21;11(1):e0147293. doi: 10.1371/journal.pone.0147293. eCollection 2016.


Calcium-Permeable AMPA Receptors Mediate the Induction of the Protein Kinase A-Dependent Component of Long-Term Potentiation in the Hippocampus.

Park P, Sanderson TM, Amici M, Choi SL, Bortolotto ZA, Zhuo M, Kaang BK, Collingridge GL.

J Neurosci. 2016 Jan 13;36(2):622-31. doi: 10.1523/JNEUROSCI.3625-15.2016.


An interchangeable role for kainate and metabotropic glutamate receptors in the induction of rat hippocampal mossy fiber long-term potentiation in vivo.

Wallis JL, Irvine MW, Jane DE, Lodge D, Collingridge GL, Bortolotto ZA.

Hippocampus. 2015 Nov;25(11):1407-17. doi: 10.1002/hipo.22460. Epub 2015 Apr 25.


Long-term potentiation and the role of N-methyl-D-aspartate receptors.

Volianskis A, France G, Jensen MS, Bortolotto ZA, Jane DE, Collingridge GL.

Brain Res. 2015 Sep 24;1621:5-16. doi: 10.1016/j.brainres.2015.01.016. Epub 2015 Jan 22. Review.


NMDA receptor-dependent long-term potentiation comprises a family of temporally overlapping forms of synaptic plasticity that are induced by different patterns of stimulation.

Park P, Volianskis A, Sanderson TM, Bortolotto ZA, Jane DE, Zhuo M, Kaang BK, Collingridge GL.

Philos Trans R Soc Lond B Biol Sci. 2013 Dec 2;369(1633):20130131. doi: 10.1098/rstb.2013.0131. Print 2014 Jan 5. Review.


The role of JAK-STAT signaling within the CNS.

Nicolas CS, Amici M, Bortolotto ZA, Doherty A, Csaba Z, Fafouri A, Dournaud P, Gressens P, Collingridge GL, Peineau S.

JAKSTAT. 2013 Jan 1;2(1):e22925. doi: 10.4161/jkst.22925. Review.


Antagonists reversibly reverse chemical LTD induced by group I, group II and group III metabotropic glutamate receptors.

Lodge D, Tidball P, Mercier MS, Lucas SJ, Hanna L, Ceolin L, Kritikos M, Fitzjohn SM, Sherwood JL, Bannister N, Volianskis A, Jane DE, Bortolotto ZA, Collingridge GL.

Neuropharmacology. 2013 Nov;74:135-46. doi: 10.1016/j.neuropharm.2013.03.011. Epub 2013 Mar 26.


Characterisation of an mGlu8 receptor-selective agonist and antagonist in the lateral and medial perforant path inputs to the dentate gyrus.

Mercier MS, Lodge D, Fang G, Nicolas CS, Collett VJ, Jane DE, Collingridge GL, Bortolotto ZA.

Neuropharmacology. 2013 Apr;67:294-303. doi: 10.1016/j.neuropharm.2012.11.020. Epub 2012 Dec 5.


The NMDA receptor as a target for cognitive enhancement.

Collingridge GL, Volianskis A, Bannister N, France G, Hanna L, Mercier M, Tidball P, Fang G, Irvine MW, Costa BM, Monaghan DT, Bortolotto ZA, Molnár E, Lodge D, Jane DE.

Neuropharmacology. 2013 Jan;64:13-26. doi: 10.1016/j.neuropharm.2012.06.051. Epub 2012 Jul 11. Review.


Inactivation of the constitutively active ghrelin receptor attenuates limbic seizure activity in rodents.

Portelli J, Thielemans L, Ver Donck L, Loyens E, Coppens J, Aourz N, Aerssens J, Vermoesen K, Clinckers R, Schallier A, Michotte Y, Moechars D, Collingridge GL, Bortolotto ZA, Smolders I.

Neurotherapeutics. 2012 Jul;9(3):658-72. doi: 10.1007/s13311-012-0125-x.


Differences in kainate receptor involvement in hippocampal mossy fibre long-term potentiation depending on slice orientation.

Sherwood JL, Amici M, Dargan SL, Culley GR, Fitzjohn SM, Jane DE, Collingridge GL, Lodge D, Bortolotto ZA.

Neurochem Int. 2012 Sep;61(4):482-9. doi: 10.1016/j.neuint.2012.04.021. Epub 2012 Apr 27.


Selective activation of either mGlu2 or mGlu3 receptors can induce LTD in the amygdala.

Lucas SJ, Bortolotto ZA, Collingridge GL, Lodge D.

Neuropharmacology. 2013 Mar;66:196-201. doi: 10.1016/j.neuropharm.2012.04.006. Epub 2012 Apr 17.


A novel anti-epileptic agent, perampanel, selectively inhibits AMPA receptor-mediated synaptic transmission in the hippocampus.

Ceolin L, Bortolotto ZA, Bannister N, Collingridge GL, Lodge D, Volianskis A.

Neurochem Int. 2012 Sep;61(4):517-22. doi: 10.1016/j.neuint.2012.02.035. Epub 2012 Mar 10.


A pivotal role of GSK-3 in synaptic plasticity.

Bradley CA, Peineau S, Taghibiglou C, Nicolas CS, Whitcomb DJ, Bortolotto ZA, Kaang BK, Cho K, Wang YT, Collingridge GL.

Front Mol Neurosci. 2012 Feb 15;5:13. doi: 10.3389/fnmol.2012.00013. eCollection 2012.


Synergistic interactions between kainate and mGlu receptors regulate bouton Ca signalling and mossy fibre LTP.

Nisticò R, Dargan SL, Amici M, Collingridge GL, Bortolotto ZA.

Sci Rep. 2011;1:103. doi: 10.1038/srep00103. Epub 2011 Sep 27.


The Jak/STAT pathway is involved in synaptic plasticity.

Nicolas CS, Peineau S, Amici M, Csaba Z, Fafouri A, Javalet C, Collett VJ, Hildebrandt L, Seaton G, Choi SL, Sim SE, Bradley C, Lee K, Zhuo M, Kaang BK, Gressens P, Dournaud P, Fitzjohn SM, Bortolotto ZA, Cho K, Collingridge GL.

Neuron. 2012 Jan 26;73(2):374-90. doi: 10.1016/j.neuron.2011.11.024.


Piperazine-2,3-dicarboxylic acid derivatives as dual antagonists of NMDA and GluK1-containing kainate receptors.

Irvine MW, Costa BM, Dlaboga D, Culley GR, Hulse R, Scholefield CL, Atlason P, Fang G, Eaves R, Morley R, Mayo-Martin MB, Amici M, Bortolotto ZA, Donaldson L, Collingridge GL, Molnár E, Monaghan DT, Jane DE.

J Med Chem. 2012 Jan 12;55(1):327-41. doi: 10.1021/jm201230z. Epub 2011 Dec 14.


Study of novel selective mGlu2 agonist in the temporo-ammonic input to CA1 neurons reveals reduced mGlu2 receptor expression in a Wistar substrain with an anxiety-like phenotype.

Ceolin L, Kantamneni S, Barker GR, Hanna L, Murray L, Warburton EC, Robinson ES, Monn JA, Fitzjohn SM, Collingridge GL, Bortolotto ZA, Lodge D.

J Neurosci. 2011 May 4;31(18):6721-31. doi: 10.1523/JNEUROSCI.0418-11.2011.


Synaptic plasticity in the hippocampal slice preparation.

Bortolotto ZA, Amici M, Anderson WW, Isaac JT, Collingridge GL.

Curr Protoc Neurosci. 2011 Jan;Chapter 6:Unit 6.13. doi: 10.1002/0471142301.ns0613s54.


GLUK1 receptor antagonists and hippocampal mossy fiber function.

Nisticò R, Dargan S, Fitzjohn SM, Lodge D, Jane DE, Collingridge GL, Bortolotto ZA.

Int Rev Neurobiol. 2009;85:13-27. doi: 10.1016/S0074-7742(09)85002-2. Review.


A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases.

Peineau S, Nicolas CS, Bortolotto ZA, Bhat RV, Ryves WJ, Harwood AJ, Dournaud P, Fitzjohn SM, Collingridge GL.

Mol Brain. 2009 Jul 7;2:22. doi: 10.1186/1756-6606-2-22.


ACET is a highly potent and specific kainate receptor antagonist: characterisation and effects on hippocampal mossy fibre function.

Dargan SL, Clarke VR, Alushin GM, Sherwood JL, Nisticò R, Bortolotto ZA, Ogden AM, Bleakman D, Doherty AJ, Lodge D, Mayer ML, Fitzjohn SM, Jane DE, Collingridge GL.

Neuropharmacology. 2009 Jan;56(1):121-30. doi: 10.1016/j.neuropharm.2008.08.016. Epub 2008 Aug 22.


The induction of long-term plasticity of non-synaptic, synchronized activity by the activation of group I mGluRs.

Piccinin S, Thuault SJ, Doherty AJ, Brown JT, Randall AD, Davies CH, Bortolotto ZA, Collingridge GL.

Neuropharmacology. 2008 Sep;55(4):459-63. doi: 10.1016/j.neuropharm.2008.05.017. Epub 2008 May 28.


An analysis of the stimulus requirements for setting the molecular switch reveals a lower threshold for metaplasticity than synaptic plasticity.

Bortolotto ZA, Collett VJ, Conquet F, Jia Z, Collingridge GL.

Neuropharmacology. 2008 Sep;55(4):454-8. doi: 10.1016/j.neuropharm.2008.06.020. Epub 2008 Jun 19.


Synaptic plasticity in the hippocampal slice preparation.

Bortolotto ZA, Anderson WW, Isaac JT, Collingridge GL.

Curr Protoc Neurosci. 2001 Nov;Chapter 6:Unit 6.13. doi: 10.1002/0471142301.ns0613s16.


The role of GSK-3 in synaptic plasticity.

Peineau S, Bradley C, Taghibiglou C, Doherty A, Bortolotto ZA, Wang YT, Collingridge GL.

Br J Pharmacol. 2008 Mar;153 Suppl 1:S428-37. doi: 10.1038/bjp.2008.2. Review.


LTP inhibits LTD in the hippocampus via regulation of GSK3beta.

Peineau S, Taghibiglou C, Bradley C, Wong TP, Liu L, Lu J, Lo E, Wu D, Saule E, Bouschet T, Matthews P, Isaac JT, Bortolotto ZA, Wang YT, Collingridge GL.

Neuron. 2007 Mar 1;53(5):703-17.


Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus.

Bartlett TE, Bannister NJ, Collett VJ, Dargan SL, Massey PV, Bortolotto ZA, Fitzjohn SM, Bashir ZI, Collingridge GL, Lodge D.

Neuropharmacology. 2007 Jan;52(1):60-70. Epub 2006 Aug 10.


Transient incorporation of native GluR2-lacking AMPA receptors during hippocampal long-term potentiation.

Plant K, Pelkey KA, Bortolotto ZA, Morita D, Terashima A, McBain CJ, Collingridge GL, Isaac JT.

Nat Neurosci. 2006 May;9(5):602-4. Epub 2006 Apr 2.


Rapid responses to thyroxine in the testis: active protein synthesis-independent pathway.

Menegaz D, Zamoner A, Royer C, Leite LD, Bortolotto ZA, Silva FR.

Mol Cell Endocrinol. 2006 Feb 26;246(1-2):128-34. Epub 2006 Jan 18.


Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors.

Dolman NP, Troop HM, More JC, Alt A, Knauss JL, Nistico R, Jack S, Morley RM, Bortolotto ZA, Roberts PJ, Bleakman D, Collingridge GL, Jane DE.

J Med Chem. 2005 Dec 1;48(24):7867-81.


The regulation of hippocampal LTP by the molecular switch, a form of metaplasticity, requires mGlu5 receptors.

Bortolotto ZA, Collett VJ, Conquet F, Jia Z, van der Putten H, Collingridge GL.

Neuropharmacology. 2005;49 Suppl 1:13-25.


Kainate receptors and mossy fiber LTP.

Bortolotto ZA, Nistico R, More JC, Jane DE, Collingridge GL.

Neurotoxicology. 2005 Oct;26(5):769-77. Epub 2005 Jun 6. Review.


Characterisation of UBP296: a novel, potent and selective kainate receptor antagonist.

More JC, Nistico R, Dolman NP, Clarke VR, Alt AJ, Ogden AM, Buelens FP, Troop HM, Kelland EE, Pilato F, Bleakman D, Bortolotto ZA, Collingridge GL, Jane DE.

Neuropharmacology. 2004 Jul;47(1):46-64.


Parallel kinase cascades are involved in the induction of LTP at hippocampal CA1 synapses.

Wikström MA, Matthews P, Roberts D, Collingridge GL, Bortolotto ZA.

Neuropharmacology. 2003 Nov;45(6):828-36.


A role for Ca2+ stores in kainate receptor-dependent synaptic facilitation and LTP at mossy fiber synapses in the hippocampus.

Lauri SE, Bortolotto ZA, Nistico R, Bleakman D, Ornstein PL, Lodge D, Isaac JT, Collingridge GL.

Neuron. 2003 Jul 17;39(2):327-41.


Kainate receptors and the induction of mossy fibre long-term potentiation.

Bortolotto ZA, Lauri S, Isaac JT, Collingridge GL.

Philos Trans R Soc Lond B Biol Sci. 2003 Apr 29;358(1432):657-66. Review.


Phosphatidylinositol 3 kinase regulates synapse specificity of hippocampal long-term depression.

Daw MI, Bortolotto ZA, Saulle E, Zaman S, Collingridge GL, Isaac JT.

Nat Neurosci. 2002 Sep;5(9):835-6.


Antagonists of GLU(K5)-containing kainate receptors prevent pilocarpine-induced limbic seizures.

Smolders I, Bortolotto ZA, Clarke VR, Warre R, Khan GM, O'Neill MJ, Ornstein PL, Bleakman D, Ogden A, Weiss B, Stables JP, Ho KH, Ebinger G, Collingridge GL, Lodge D, Michotte Y.

Nat Neurosci. 2002 Aug;5(8):796-804.


Inhibitory role of the zona incerta in the pilocarpine model of epilepsy.

Hamani C, Sakabe S, Bortolotto ZA, Cavalheiro EA, Mello LE.

Epilepsy Res. 2002 Mar;49(1):73-80.


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