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Items: 1 to 50 of 74

1.

Identification of novel HIV-1-derived HLA-E-binding peptides.

Hannoun Z, Lin Z, Brackenridge S, Kuse N, Akahoshi T, Borthwick N, McMichael A, Murakoshi H, Takiguchi M, Hanke T.

Immunol Lett. 2018 Oct;202:65-72. doi: 10.1016/j.imlet.2018.08.005. Epub 2018 Aug 30.

2.

Randomized phase I trial HIV-CORE 003: Depletion of serum amyloid P component and immunogenicity of DNA vaccination against HIV-1.

Borthwick NJ, Lane T, Moyo N, Crook A, Shim JM, Baines I, Wee EG, Hawkins PN, Gillmore JD, Hanke T, Pepys MB.

PLoS One. 2018 May 17;13(5):e0197299. doi: 10.1371/journal.pone.0197299. eCollection 2018.

3.

HIV-1-neutralizing antibody induced by simian adenovirus- and poxvirus MVA-vectored BG505 native-like envelope trimers.

Capucci S, Wee EG, Schiffner T, LaBranche CC, Borthwick N, Cupo A, Dodd J, Dean H, Sattentau Q, Montefiori D, Klasse PJ, Sanders RW, Moore JP, Hanke T.

PLoS One. 2017 Aug 9;12(8):e0181886. doi: 10.1371/journal.pone.0181886. eCollection 2017.

4.

Long-term follow up of human T-cell responses to conserved HIV-1 regions elicited by DNA/simian adenovirus/MVA vaccine regimens.

Moyo N, Borthwick NJ, Wee EG, Capucci S, Crook A, Dorrell L, Hanke T.

PLoS One. 2017 Jul 18;12(7):e0181382. doi: 10.1371/journal.pone.0181382. eCollection 2017.

5.

Novel, in-natural-infection subdominant HIV-1 CD8+ T-cell epitopes revealed in human recipients of conserved-region T-cell vaccines.

Borthwick N, Lin Z, Akahoshi T, Llano A, Silva-Arrieta S, Ahmed T, Dorrell L, Brander C, Murakoshi H, Takiguchi M, Hanke T.

PLoS One. 2017 Apr 27;12(4):e0176418. doi: 10.1371/journal.pone.0176418. eCollection 2017.

6.

Broad HIV-1 inhibition in vitro by vaccine-elicited CD8(+) T cells in African adults.

Mutua G, Farah B, Langat R, Indangasi J, Ogola S, Onsembe B, Kopycinski JT, Hayes P, Borthwick NJ, Ashraf A, Dally L, Barin B, Tillander A, Gilmour J, De Bont J, Crook A, Hannaman D, Cox JH, Anzala O, Fast PE, Reilly M, Chinyenze K, Jaoko W, Hanke T, Hiv-Core 004 Study Group T.

Mol Ther Methods Clin Dev. 2016 Aug 31;3:16061. doi: 10.1038/mtm.2016.61. eCollection 2016.

7.

A statistical approach to determining responses to individual peptides from pooled-peptide ELISpot data.

Ström P, Støer N, Borthwick N, Dong T, Hanke T, Reilly M.

J Immunol Methods. 2016 Aug;435:43-9. doi: 10.1016/j.jim.2016.05.006. Epub 2016 May 16.

PMID:
27196788
8.

Control of HIV-1 replication in vitro by vaccine-induced human CD8(+) T cells through conserved subdominant Pol epitopes.

Ahmed T, Borthwick NJ, Gilmour J, Hayes P, Dorrell L, Hanke T.

Vaccine. 2016 Feb 24;34(9):1215-24. doi: 10.1016/j.vaccine.2015.12.021. Epub 2016 Jan 16.

9.

Humoral responses to HIVconsv induced by heterologous vaccine modalities in rhesus macaques.

Borthwick NJ, Rosario M, Schiffner T, Bowles E, Ahmed T, Liljeström P, Stewart-Jones GE, Drijfhout JW, Melief CJ, Hanke T.

Immun Inflamm Dis. 2015 Jun;3(2):82-93. doi: 10.1002/iid3.52. Epub 2015 Mar 11.

10.

Early Kinetics of the HLA Class I-Associated Peptidome of MVA.HIVconsv-Infected Cells.

Ternette N, Block PD, Sánchez-Bernabéu Á, Borthwick N, Pappalardo E, Abdul-Jawad S, Ondondo B, Charles PD, Dorrell L, Kessler BM, Hanke T.

J Virol. 2015 Jun;89(11):5760-71. doi: 10.1128/JVI.03627-14. Epub 2015 Mar 25.

11.

PedVacc 002: a phase I/II randomized clinical trial of MVA.HIVA vaccine administered to infants born to human immunodeficiency virus type 1-positive mothers in Nairobi.

Njuguna IN, Ambler G, Reilly M, Ondondo B, Kanyugo M, Lohman-Payne B, Gichuhi C, Borthwick N, Black A, Mehedi SR, Sun J, Maleche-Obimbo E, Chohan B, John-Stewart GC, Jaoko W, Hanke T.

Vaccine. 2014 Oct 7;32(44):5801-8. doi: 10.1016/j.vaccine.2014.08.034. Epub 2014 Aug 27.

12.

A phase I randomized clinical trial of candidate human immunodeficiency virus type 1 vaccine MVA.HIVA administered to Gambian infants.

Afolabi MO, Ndure J, Drammeh A, Darboe F, Mehedi SR, Rowland-Jones SL, Borthwick N, Black A, Ambler G, John-Stewart GC, Reilly M, Hanke T, Flanagan KL.

PLoS One. 2013 Oct 24;8(10):e78289. doi: 10.1371/journal.pone.0078289. eCollection 2013.

13.

Vaccine-elicited human T cells recognizing conserved protein regions inhibit HIV-1.

Borthwick N, Ahmed T, Ondondo B, Hayes P, Rose A, Ebrahimsa U, Hayton EJ, Black A, Bridgeman A, Rosario M, Hill AV, Berrie E, Moyle S, Frahm N, Cox J, Colloca S, Nicosia A, Gilmour J, McMichael AJ, Dorrell L, Hanke T.

Mol Ther. 2014 Feb;22(2):464-475. doi: 10.1038/mt.2013.248. Epub 2013 Oct 31.

14.

Prime-boost regimens with adjuvanted synthetic long peptides elicit T cells and antibodies to conserved regions of HIV-1 in macaques.

Rosario M, Borthwick N, Stewart-Jones GB, Mbewe-Mvula A, Bridgeman A, Colloca S, Montefiori D, McMichael AJ, Nicosia A, Quakkelaar ED, Drijfhout JW, Melief CJ, Hanke T.

AIDS. 2012 Jan 28;26(3):275-84. doi: 10.1097/QAD.0b013e32834ed9b2.

PMID:
22095198
15.

The biology of micrometastases from uveal melanoma.

Borthwick NJ, Thombs J, Polak M, Gabriel FG, Hungerford JL, Damato B, Rennie IG, Jager MJ, Cree IA.

J Clin Pathol. 2011 Aug;64(8):666-71. doi: 10.1136/jcp.2010.087999. Epub 2011 May 18.

PMID:
21593344
16.

Safety and immunogenicity of novel recombinant BCG and modified vaccinia virus Ankara vaccines in neonate rhesus macaques.

Rosario M, Fulkerson J, Soneji S, Parker J, Im EJ, Borthwick N, Bridgeman A, Bourne C, Joseph J, Sadoff JC, Hanke T.

J Virol. 2010 Aug;84(15):7815-21. doi: 10.1128/JVI.00726-10. Epub 2010 May 19.

17.

Long peptides induce polyfunctional T cells against conserved regions of HIV-1 with superior breadth to single-gene vaccines in macaques.

Rosario M, Bridgeman A, Quakkelaar ED, Quigley MF, Hill BJ, Knudsen ML, Ammendola V, Ljungberg K, Borthwick N, Im EJ, McMichael AJ, Drijfhout JW, Greenaway HY, Venturi V, Douek DC, Colloca S, Liljeström P, Nicosia A, Price DA, Melief CJ, Hanke T.

Eur J Immunol. 2010 Jul;40(7):1973-84. doi: 10.1002/eji.201040344.

18.

Novel recombinant Mycobacterium bovis BCG, ovine atadenovirus, and modified vaccinia virus Ankara vaccines combine to induce robust human immunodeficiency virus-specific CD4 and CD8 T-cell responses in rhesus macaques.

Rosario M, Hopkins R, Fulkerson J, Borthwick N, Quigley MF, Joseph J, Douek DC, Greenaway HY, Venturi V, Gostick E, Price DA, Both GW, Sadoff JC, Hanke T.

J Virol. 2010 Jun;84(12):5898-908. doi: 10.1128/JVI.02607-09. Epub 2010 Apr 7.

19.

Melanoma vaccines: The problems of local immunosuppression.

Polak ME, Borthwick NJ, Jager MJ, Cree IA.

Hum Immunol. 2009 May;70(5):331-9.

PMID:
19405172
20.

Activation of tonsil dendritic cells with immuno-adjuvants.

Polak ME, Borthwick NJ, Gabriel FG, Jager MJ, Cree IA.

BMC Immunol. 2008 Mar 18;9:10. doi: 10.1186/1471-2172-9-10.

21.

Mechanisms of local immunosuppression in cutaneous melanoma.

Polak ME, Borthwick NJ, Gabriel FG, Johnson P, Higgins B, Hurren J, McCormick D, Jager MJ, Cree IA.

Br J Cancer. 2007 Jun 18;96(12):1879-87. Epub 2007 Jun 12.

22.

Presence and phenotype of dendritic cells in uveal melanoma.

Polak ME, Borthwick NJ, Johnson P, Hungerford JL, Higgins B, Di Palma S, Jager MJ, Cree IA.

Br J Ophthalmol. 2007 Jul;91(7):971-6. Epub 2007 Mar 8.

23.

Post-menopausal bleeding: a rare presentation of metastatic uveal melanoma.

Coutts MA, Borthwick NJ, Hungerford JL, Cree IA.

Pathol Oncol Res. 2006;12(3):184-7. Epub 2006 Sep 23.

24.

Presence and maturity of dendritic cells in melanoma lymph node metastases.

Polak ME, Johnson P, Di Palma S, Higgins B, Hurren J, Borthwick NJ, Jager MJ, Mccormick D, Cree IA.

J Pathol. 2005 Sep;207(1):83-90.

PMID:
15983979
25.

Recruiting donors for autopsy based cancer research.

Thombs J, Borthwick NJ, Hungerford JL, Cree IA.

J Med Ethics. 2005 Jun;31(6):360-1.

26.

Transendothelial migration confers a survival advantage to activated T lymphocytes: role of LFA-1/ICAM-1 interactions.

Borthwick NJ, Akbar AA, Buckley C, Pilling D, Salmon M, Jewell AP, Yong KL.

Clin Exp Immunol. 2003 Nov;134(2):246-52.

27.
29.

CD38 in health and disease.

Bofill M, Borthwick NJ.

Chem Immunol. 2000;75:218-34. Review. No abstract available.

PMID:
10851787
30.

Novel mechanism for the impairment of cell proliferation in HIV-1 infection.

Bofill M, Borthwick NJ, Simmonds HA.

Immunol Today. 1999 Jun;20(6):258-61. Review.

PMID:
10354550
31.

Interferon-beta mediates stromal cell rescue of T cells from apoptosis.

Pilling D, Akbar AN, Girdlestone J, Orteu CH, Borthwick NJ, Amft N, Scheel-Toellner D, Buckley CD, Salmon M.

Eur J Immunol. 1999 Mar;29(3):1041-50.

32.

Activation-associated necrosis in human immunodeficiency virus infection.

Borthwick NJ, Wickremasinghe RG, Lewin J, Fairbanks LD, Bofill M.

J Infect Dis. 1999 Feb;179(2):352-60.

PMID:
9878018
33.

IL-7-dependent extrathymic expansion of CD45RA+ T cells enables preservation of a naive repertoire.

Soares MV, Borthwick NJ, Maini MK, Janossy G, Salmon M, Akbar AN.

J Immunol. 1998 Dec 1;161(11):5909-17.

34.

Herbimycin A accelerates the induction of apoptosis following etoposide treatment or gamma-irradiation of bcr/abl-positive leukaemia cells.

Riordan FA, Bravery CA, Mengubas K, Ray N, Borthwick NJ, Akbar AN, Hart SM, Hoffbrand AV, Mehta AB, Wickremasinghe RG.

Oncogene. 1998 Mar 26;16(12):1533-42.

35.

Selective migration of highly differentiated primed T cells across human umbilical vein endothelial cells.

Borthwick NJ, Akbar AN, MacCormac LP, Salmon M, Yong KL.

Biochem Soc Trans. 1997 May;25(2):258S. No abstract available.

PMID:
9191302
36.

Dissociation of T cell anergy from apoptosis by blockade of Fas/Apo-1 (CD95) signaling.

Hargreaves RG, Borthwick NJ, Gilardini Montani MS, Piccolella E, Carmichael P, Lechler RI, Akbar AN, Lombardi G.

J Immunol. 1997 Apr 1;158(7):3099-107.

PMID:
9120262
37.
38.

Selective migration of highly differentiated primed T cells, defined by low expression of CD45RB, across human umbilical vein endothelial cells: effects of viral infection on transmigration.

Borthwick NJ, Akbar AN, MacCormac LP, Lowdell M, Craigen JL, Hassan I, Grundy JE, Salmon M, Yong KL.

Immunology. 1997 Feb;90(2):272-80.

39.

Induction of apoptosis following antigen presentation by T cells: anergy and apoptosis are two separate phenomena.

Hargreaves RG, Borthwick NJ, Gilardini Montani MS, Piccolella E, Carmichael P, Lechler RI, Akbar AN, Lombardi G.

Transplant Proc. 1997 Feb-Mar;29(1-2):1102-4. No abstract available. Erratum in: Transplant Proc. 2006 Jun;38(5):1641. Montani, MS [corrected to Gilardini Montani, MS].

PMID:
9123219
40.

CD8+,CD38+ lymphocyte percent: a useful immunological marker for monitoring HIV-1-infected patients.

Mocroft A, Bofill M, Lipman M, Medina E, Borthwick N, Timms A, Batista L, Winter M, Sabin CA, Johnson M, Lee CA, Phillips A, Janossy G.

J Acquir Immune Defic Syndr Hum Retrovirol. 1997 Feb 1;14(2):158-62.

PMID:
9052725
41.

Fibroblasts prevent apoptosis of IL-2-deprived T cells without inducing proliferation: a selective effect on Bcl-XL expression.

Gombert W, Borthwick NJ, Wallace DL, Hyde H, Bofill M, Pilling D, Beverley PC, Janossy G, Salmon M, Akbar AN.

Immunology. 1996 Nov;89(3):397-404.

43.

Increased numbers of primed activated CD8+CD38+CD45RO+ T cells predict the decline of CD4+ T cells in HIV-1-infected patients.

Bofill M, Mocroft A, Lipman M, Medina E, Borthwick NJ, Sabin CA, Timms A, Winter M, Baptista L, Johnson MA, Lee CA, Phillips AN, Janossy G.

AIDS. 1996 Jul;10(8):827-34.

PMID:
8828739
44.
45.

Presence of CD3+CD8+Bcl-2(low) lymphocytes undergoing apoptosis and activated macrophages in lymph nodes of HIV-1+ patients.

Bofill M, Gombert W, Borthwick NJ, Akbar AN, McLaughlin JE, Lee CA, Johnson MA, Pinching AJ, Janossy G.

Am J Pathol. 1995 Jun;146(6):1542-55.

46.

The specific recognition by macrophages of CD8+,CD45RO+ T cells undergoing apoptosis: a mechanism for T cell clearance during resolution of viral infections.

Akbar AN, Savill J, Gombert W, Bofill M, Borthwick NJ, Whitelaw F, Grundy J, Janossy G, Salmon M.

J Exp Med. 1994 Nov 1;180(5):1943-7.

47.
48.

The progressive differentiation of primed T cells is associated with an increasing susceptibility to apoptosis.

Salmon M, Pilling D, Borthwick NJ, Viner N, Janossy G, Bacon PA, Akbar AN.

Eur J Immunol. 1994 Apr;24(4):892-9.

PMID:
8149960
49.

Lymphocyte activation in HIV-1 infection. II. Functional defects of CD28- T cells.

Borthwick NJ, Bofill M, Gombert WM, Akbar AN, Medina E, Sagawa K, Lipman MC, Johnson MA, Janossy G.

AIDS. 1994 Apr;8(4):431-41.

PMID:
8011246
50.

Co-stimulation with anti-CD28 (Kolt-2) enhances DNA synthesis by defective T cells in common variable immunodeficiency.

North ME, Akbar AN, Borthwick N, Sagawa K, Funauchi M, Webster AD, Farrant J.

Clin Exp Immunol. 1994 Feb;95(2):204-8.

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