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Items: 1 to 50 of 148

1.

Potential Therapeutic Value of a Novel FAAH Inhibitor for the Treatment of Anxiety.

Marco EM, Rapino C, Caprioli A, Borsini F, Laviola G, Maccarrone M.

PLoS One. 2015 Sep 11;10(9):e0137034. doi: 10.1371/journal.pone.0137034. eCollection 2015.

2.

Potent, Metabolically Stable 2-Alkyl-8-(2H-1,2,3-triazol-2-yl)-9H-adenines as Adenosine A2A Receptor Ligands.

Pace S, Brogin G, Stasi MA, Riccioni T, Borsini F, Capocasa F, Manera F, Tallarico C, Grossi P, Vacondio F, Bassi M, Bartoccini F, Lucarini S, Piersanti G, Tarzia G, Cabri W, Minetti P.

ChemMedChem. 2015 Jul;10(7):1149-52. doi: 10.1002/cmdc.201500113. Epub 2015 May 7.

PMID:
25951302
3.

Animal models of Parkinson׳s disease: Effects of two adenosine A2A receptor antagonists ST4206 and ST3932, metabolites of 2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine (ST1535).

Stasi MA, Minetti P, Lombardo K, Riccioni T, Caprioli A, Vertechy M, Di Serio S, Pace S, Borsini F.

Eur J Pharmacol. 2015 Aug 15;761:353-61. doi: 10.1016/j.ejphar.2015.03.070. Epub 2015 Apr 30.

PMID:
25936513
4.

Effects of ST1936, a selective serotonin-6 agonist, on electrical activity of putative mesencephalic dopaminergic neurons in the rat brain.

Borsini F, Bordi F, Poggi A, Di Matteo V.

J Psychopharmacol. 2015 Jul;29(7):802-11. doi: 10.1177/0269881115573804. Epub 2015 Mar 3.

PMID:
25735994
5.

Towards the development of 5-HT₇ ligands combining serotonin-like and arylpiperazine moieties.

Spadoni G, Bedini A, Bartolucci S, Pala D, Mor M, Riccioni T, Borsini F, Cabri W, Celona D, Marzi M, Tarzia G, Rivara S, Minetti P.

Eur J Med Chem. 2014 Jun 10;80:8-35. doi: 10.1016/j.ejmech.2014.04.034. Epub 2014 Apr 13.

PMID:
24763360
6.

Propionyl-L-Carnitine is Efficacious in Ulcerative Colitis Through its Action on the Immune Function and Microvasculature.

Scioli MG, Stasi MA, Passeri D, Doldo E, Costanza G, Camerini R, Fociani P, Arcuri G, Lombardo K, Pace S, Borsini F, Orlandi A.

Clin Transl Gastroenterol. 2014 Mar 20;5:e55. doi: 10.1038/ctg.2014.4.

7.

Synthesis and biological evaluation of metabolites of 2-n-butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine (ST1535), a potent antagonist of the A2A adenosine receptor for the treatment of Parkinson's disease.

Piersanti G, Bartoccini F, Lucarini S, Cabri W, Stasi MA, Riccioni T, Borsini F, Tarzia G, Minetti P.

J Med Chem. 2013 Jul 11;56(13):5456-63. doi: 10.1021/jm400491x. Epub 2013 Jun 24.

PMID:
23789814
8.

Synthesis of (E)-8-(3-chlorostyryl)caffeine analogues leading to 9-deazaxanthine derivatives as dual A(2A) antagonists/MAO-B inhibitors.

Rivara S, Piersanti G, Bartoccini F, Diamantini G, Pala D, Riccioni T, Stasi MA, Cabri W, Borsini F, Mor M, Tarzia G, Minetti P.

J Med Chem. 2013 Feb 14;56(3):1247-61. doi: 10.1021/jm301686s. Epub 2013 Jan 16.

PMID:
23281824
9.

Identification of a novel arylpiperazine scaffold for fatty acid amide hydrolase inhibition with improved drug disposition properties.

Butini S, Gemma S, Brindisi M, Maramai S, Minetti P, Celona D, Napolitano R, Borsini F, Cabri W, Fezza F, Merlini L, Dallavalle S, Campiani G, Maccarrone M.

Bioorg Med Chem Lett. 2013 Jan 15;23(2):492-5. doi: 10.1016/j.bmcl.2012.11.035. Epub 2012 Nov 22.

10.

Serotonin receptor of type 6 (5-HT6) in human prefrontal cortex and hippocampus post-mortem: an immunohistochemical and immunofluorescence study.

Marazziti D, Baroni S, Pirone A, Giannaccini G, Betti L, Testa G, Schmid L, Palego L, Borsini F, Bordi F, Piano I, Gargini C, Castagna M, Catena-Dell'osso M, Lucacchini A.

Neurochem Int. 2013 Jan;62(2):182-8. doi: 10.1016/j.neuint.2012.11.013. Epub 2012 Dec 3.

PMID:
23219521
11.

Serotonin receptors of type 6 (5-HT6): from neuroscience to clinical pharmacology.

Marazziti D, Baroni S, Borsini F, Picchetti M, Vatteroni E, Falaschi V, Catena-Dell'Osso M.

Curr Med Chem. 2013;20(3):371-7. Review.

PMID:
23157629
12.

Evidence for a role of a dopamine/5-HT6 receptor interaction in cocaine reinforcement.

Valentini V, Piras G, De Luca MA, Perra V, Bordi F, Borsini F, Frau R, Di Chiara G.

Neuropharmacology. 2013 Feb;65:58-64. doi: 10.1016/j.neuropharm.2012.08.025. Epub 2012 Sep 7. Erratum in: Neuropharmacology. 2013 Oct;73:397.

PMID:
22982249
13.

Discovery of potent inhibitors of human and mouse fatty acid amide hydrolases.

Butini S, Brindisi M, Gemma S, Minetti P, Cabri W, Gallo G, Vincenti S, Talamonti E, Borsini F, Caprioli A, Stasi MA, Di Serio S, Ros S, Borrelli G, Maramai S, Fezza F, Campiani G, Maccarrone M.

J Med Chem. 2012 Aug 9;55(15):6898-915. doi: 10.1021/jm300689c. Epub 2012 Jul 26.

PMID:
22779702
14.

A2A adenosine receptor antagonism enhances synaptic and motor effects of cocaine via CB1 cannabinoid receptor activation.

Tozzi A, de Iure A, Marsili V, Romano R, Tantucci M, Di Filippo M, Costa C, Napolitano F, Mercuri NB, Borsini F, Giampà C, Fusco FR, Picconi B, Usiello A, Calabresi P.

PLoS One. 2012;7(6):e38312. doi: 10.1371/journal.pone.0038312. Epub 2012 Jun 8.

15.

The novel reversible fatty acid amide hydrolase inhibitor ST4070 increases endocannabinoid brain levels and counteracts neuropathic pain in different animal models.

Caprioli A, Coccurello R, Rapino C, Di Serio S, Di Tommaso M, Vertechy M, Vacca V, Battista N, Pavone F, Maccarrone M, Borsini F.

J Pharmacol Exp Ther. 2012 Jul;342(1):188-95. doi: 10.1124/jpet.111.191403. Epub 2012 Apr 18.

PMID:
22514334
16.

An inhibitor of neuronal exocytosis (DD04107) displays long-lasting in vivo activity against chronic inflammatory and neuropathic pain.

Ponsati B, Carreño C, Curto-Reyes V, Valenzuela B, Duart MJ, Van den Nest W, Cauli O, Beltran B, Fernandez J, Borsini F, Caprioli A, Di Serio S, Veretchy M, Baamonde A, Menendez L, Barros F, de la Pena P, Borges R, Felipo V, Planells-Cases R, Ferrer-Montiel A.

J Pharmacol Exp Ther. 2012 Jun;341(3):634-45. doi: 10.1124/jpet.111.190678. Epub 2012 Mar 5.

PMID:
22393248
17.

In vitro cardiovascular effects of dihydroartemisin-piperaquine combination compared with other antimalarials.

Borsini F, Crumb W, Pace S, Ubben D, Wible B, Yan GX, Funck-Brentano C.

Antimicrob Agents Chemother. 2012 Jun;56(6):3261-70. doi: 10.1128/AAC.05688-11. Epub 2012 Mar 5.

18.

Distribution of serotonin receptor of type 6 (5-HT₆) in human brain post-mortem. A pharmacology, autoradiography and immunohistochemistry study.

Marazziti D, Baroni S, Pirone A, Giannaccini G, Betti L, Schmid L, Vatteroni E, Palego L, Borsini F, Bordi F, Piano I, Gargini C, Castagna M, Catena-Dell'osso M, Lucacchini A.

Neurochem Res. 2012 May;37(5):920-7. doi: 10.1007/s11064-011-0684-y. Epub 2012 Jan 26.

PMID:
22278721
19.

Serotonin receptors of type 6 (5-HT6): what can we expect from them?

Marazziti D, Baroni S, Catena Dell'Osso M, Bordi F, Borsini F.

Curr Med Chem. 2011;18(18):2783-90. Review.

PMID:
21649582
20.

Effects of the 5-HT(6) receptor agonist ST 1936 on depression- and anhedonia-like experimental models.

Scheggi S, Marchese G, Borsini F, Bordi F, De Montis MG.

Behav Brain Res. 2011 Oct 10;224(1):35-43. doi: 10.1016/j.bbr.2011.05.019. Epub 2011 May 27.

PMID:
21645553
21.

Activation of 5-HT6 receptors inhibits corticostriatal glutamatergic transmission.

Tassone A, Madeo G, Schirinzi T, Vita D, Puglisi F, Ponterio G, Borsini F, Pisani A, Bonsi P.

Neuropharmacology. 2011 Sep;61(4):632-7. doi: 10.1016/j.neuropharm.2011.05.004. Epub 2011 May 19.

PMID:
21619890
22.

ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned human 5-HT6 receptors.

Riccioni T, Bordi F, Minetti P, Spadoni G, Yun HM, Im BH, Tarzia G, Rhim H, Borsini F.

Eur J Pharmacol. 2011 Jul 1;661(1-3):8-14. doi: 10.1016/j.ejphar.2011.04.028. Epub 2011 Apr 28.

PMID:
21549693
23.

Adrenergic effects on force-frequency relationship: a pivotal role for the cardiac intrinsic systems.

Mattera GG, Vanoli E, Martinez V, Luciani M, Falco T, Borsini F.

Acta Physiol (Oxf). 2011 Jun;202(2):141-9. doi: 10.1111/j.1748-1716.2011.02266.x. Epub 2011 Apr 6.

PMID:
21338472
24.

Other 5-HT6 receptor-mediated effects.

Borsini F.

Int Rev Neurobiol. 2011;96:189-91. doi: 10.1016/B978-0-12-385902-0.00008-5. Review. No abstract available.

PMID:
21329789
25.

Social encounter with a novel partner in adolescent rats: activation of the central endocannabinoid system.

Marco EM, Rapino C, Caprioli A, Borsini F, Maccarrone M, Laviola G.

Behav Brain Res. 2011 Jun 20;220(1):140-5. doi: 10.1016/j.bbr.2011.01.044. Epub 2011 Feb 2.

PMID:
21295077
26.

The distinct role of medium spiny neurons and cholinergic interneurons in the D₂/A₂A receptor interaction in the striatum: implications for Parkinson's disease.

Tozzi A, de Iure A, Di Filippo M, Tantucci M, Costa C, Borsini F, Ghiglieri V, Giampà C, Fusco FR, Picconi B, Calabresi P.

J Neurosci. 2011 Feb 2;31(5):1850-62. doi: 10.1523/JNEUROSCI.4082-10.2011.

27.

Chronic istaroxime improves cardiac function and heart rate variability in cardiomyopathic hamsters.

Lo Giudice P, Mattera GG, Gagnol JP, Borsini F.

Cardiovasc Drugs Ther. 2011 Apr;25(2):133-8. doi: 10.1007/s10557-011-6283-y.

PMID:
21287411
28.

5-HT6 pharmacology inconsistencies.

Borsini F, Bordi F, Riccioni T.

Pharmacol Biochem Behav. 2011 Apr;98(2):169-72. doi: 10.1016/j.pbb.2010.12.021. Epub 2010 Dec 28. Review.

PMID:
21192969
29.

A microdialysis study of ST1936, a novel 5-HT6 receptor agonist.

Valentini V, Frau R, Bordi F, Borsini F, Di Chiara G.

Neuropharmacology. 2011 Mar;60(4):602-8. doi: 10.1016/j.neuropharm.2010.12.006. Epub 2010 Dec 23.

PMID:
21185318
30.

Pharmacology of 5-HT6 receptors--Part 1. Preface.

Borsini F.

Int Rev Neurobiol. 2010;94:xi-xii. doi: 10.1016/B978-0-12-384976-2.00013-7. No abstract available.

PMID:
21081199
31.

Neuroprotective and anti-inflammatory effects of the adenosine A(2A) receptor antagonist ST1535 in a MPTP mouse model of Parkinson's disease.

Frau L, Borsini F, Wardas J, Khairnar AS, Schintu N, Morelli M.

Synapse. 2011 Mar;65(3):181-8. doi: 10.1002/syn.20833.

PMID:
20665698
32.

Efficacy of PTX3 in a rat model of invasive aspergillosis.

Lo Giudice P, Campo S, Verdoliva A, Rivieccio V, Borsini F, De Santis R, Salvatori G.

Antimicrob Agents Chemother. 2010 Oct;54(10):4513-5. doi: 10.1128/AAC.00674-10. Epub 2010 Jul 12.

33.

The effects of clozapine on quinpirole-induced non-regulatory drinking and prepulse inhibition disruption in rats.

De Carolis L, Stasi MA, Serlupi-Crescenzi O, Borsini F, Nencini P.

Psychopharmacology (Berl). 2010 Sep;212(1):105-15. doi: 10.1007/s00213-010-1937-1. Epub 2010 Jul 10.

PMID:
20623106
34.

A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase.

Gattinoni S, Simone CD, Dallavalle S, Fezza F, Nannei R, Battista N, Minetti P, Quattrociocchi G, Caprioli A, Borsini F, Cabri W, Penco S, Merlini L, Maccarrone M.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4406-11. doi: 10.1016/j.bmcl.2010.06.050. Epub 2010 Jun 15.

PMID:
20591666
35.

Effects of the increase in neuronal fatty acids availability on food intake and satiety in mice.

Coccurello R, Caprioli A, Bellantuono S, D'Amato FR, Conti R, Giannessi F, Borsini F, Moles A.

Psychopharmacology (Berl). 2010 May;210(1):85-95. doi: 10.1007/s00213-010-1820-0. Epub 2010 Mar 16.

PMID:
20232053
36.

Enol carbamates as inhibitors of fatty acid amide hydrolase (FAAH) endowed with high selectivity for FAAH over the other targets of the endocannabinoid system.

Gattinoni S, De Simone C, Dallavalle S, Fezza F, Nannei R, Amadio D, Minetti P, Quattrociocchi G, Caprioli A, Borsini F, Cabri W, Penco S, Merlini L, Maccarrone M.

ChemMedChem. 2010 Mar 1;5(3):357-60. doi: 10.1002/cmdc.200900472. No abstract available.

PMID:
20112328
37.

Propionyl-L-carnitine improves postischemic blood flow recovery and arteriogenetic revascularization and reduces endothelial NADPH-oxidase 4-mediated superoxide production.

Stasi MA, Scioli MG, Arcuri G, Mattera GG, Lombardo K, Marcellini M, Riccioni T, De Falco S, Pisano C, Spagnoli LG, Borsini F, Orlandi A.

Arterioscler Thromb Vasc Biol. 2010 Mar;30(3):426-35. doi: 10.1161/ATVBAHA.109.201533. Epub 2010 Jan 7.

PMID:
20056909
38.

Adenosine A(2A) Receptor Binding Profile of Two Antagonists, ST1535 and KW6002: Consideration on the Presence of Atypical Adenosine A(2A) Binding Sites.

Riccioni T, Leonardi F, Borsini F.

Front Psychiatry. 2010 Aug 6;1:22. doi: 10.3389/fpsyt.2010.00022. eCollection 2010.

39.

Effects of ST2472, a novel antipsychotic, on prepulse inhibition.

Lombardo K, Stasi MA, Borsini F.

Eur J Pharmacol. 2009 Oct 25;621(1-3):53-60. doi: 10.1016/j.ejphar.2009.08.035. Epub 2009 Sep 6.

PMID:
19737551
40.

Immunogenic, antigenic, fibrillogenic and inflammatory properties of new simplified beta-amyloid peptides.

Rossi M, Piovesan P, Ghirardi O, Mastroianni D, Bombardi V, Battistini L, Cencioni MT, Capobianco D, Borsini F, Colombo M, Verdoliva A.

Mol Immunol. 2009 Aug;46(13):2524-32. doi: 10.1016/j.molimm.2009.05.017. Epub 2009 Jun 16.

PMID:
19535144
41.

A2A adenosine receptor antagonists protect the striatum against rotenone-induced neurotoxicity.

Belcastro V, Tozzi A, Tantucci M, Costa C, Di Filippo M, Autuori A, Picconi B, Siliquini S, Luchetti E, Borsini F, Calabresi P.

Exp Neurol. 2009 May;217(1):231-4. doi: 10.1016/j.expneurol.2009.01.010. Epub 2009 Jan 29.

PMID:
19416678
42.

Sympathomimetic inefficiency in restoring contractility in the acute or chronic beta-blocker-treated ischaemic heart: comparison with a new agent.

Mattera GG, Vanoli E, Gagnol JP, Loi FM, Borsini F, Carminati P.

Eur J Heart Fail. 2008 Oct;10(10):990-6. doi: 10.1016/j.ejheart.2008.07.007. Epub 2008 Aug 6.

43.

Haloperidol both prevents and reverses quinpirole-induced nonregulatory water intake, a putative animal model of psychogenic polydipsia.

Amato D, Stasi MA, Borsini F, Nencini P.

Psychopharmacology (Berl). 2008 Oct;200(2):157-65. doi: 10.1007/s00213-008-1229-1. Epub 2008 Jul 3.

PMID:
18597076
44.
45.

Behavioural and neurochemical characterization of the adenosine A2A receptor antagonist ST1535.

Galluzzo M, Pintor A, Pèzzola A, Grieco R, Borsini F, Popoli P.

Eur J Pharmacol. 2008 Jan 28;579(1-3):149-52. Epub 2007 Oct 30.

PMID:
18036583
46.

ST2472: a new potential antipsychotic with very low liability to induce side-effects.

Stasi MA, Di Serio S, Vertechy M, Schiavone A, Ghirardi O, Minetti P, Campiani G, Borsini F, Carminati P.

Int J Neuropsychopharmacol. 2008 May;11(3):309-19. Epub 2007 Oct 10.

PMID:
17925059
47.

Interaction of A2A adenosine and D2 dopamine receptors modulates corticostriatal glutamatergic transmission.

Tozzi A, Tscherter A, Belcastro V, Tantucci M, Costa C, Picconi B, Centonze D, Calabresi P, Borsini F.

Neuropharmacology. 2007 Nov;53(6):783-9. Epub 2007 Aug 16.

PMID:
17889039
49.

Characterization of the antiparkinsonian effects of the new adenosine A2A receptor antagonist ST1535: acute and subchronic studies in rats.

Tronci E, Simola N, Borsini F, Schintu N, Frau L, Carminati P, Morelli M.

Eur J Pharmacol. 2007 Jul 2;566(1-3):94-102. Epub 2007 Mar 24.

PMID:
17445798
50.

Istaroxime: a new luso-inotropic agent for heart failure.

Mattera GG, Lo Giudice P, Loi FM, Vanoli E, Gagnol JP, Borsini F, Carminati P.

Am J Cardiol. 2007 Jan 22;99(2A):33A-40A. Epub 2006 Sep 18.

PMID:
17239702

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