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Items: 1 to 50 of 82

1.

Sulfated fucans and a sulfated galactan from sea urchins as potent inhibitors of selectin-dependent hematogenous metastasis.

Teixeira FCOB, Kozlowski EO, Micheli KVA, Vilela-Silva ACES, Borsig L, Pavão MSG.

Glycobiology. 2018 Jun 1;28(6):427-434. doi: 10.1093/glycob/cwy020.

PMID:
29522135
2.

Single cell polarity in liquid phase facilitates tumour metastasis.

Lorentzen A, Becker PF, Kosla J, Saini M, Weidele K, Ronchi P, Klein C, Wolf MJ, Geist F, Seubert B, Ringelhan M, Mihic-Probst D, Esser K, Roblek M, Kuehne F, Bianco G, O'Connor T, Müller Q, Schuck K, Lange S, Hartmann D, Spaich S, Groß O, Utikal J, Haferkamp S, Sprick MR, Damle-Vartak A, Hapfelmeier A, Hüser N, Protzer U, Trumpp A, Saur D, Vartak N, Klein CA, Polzer B, Borsig L, Heikenwalder M.

Nat Commun. 2018 Feb 28;9(1):887. doi: 10.1038/s41467-018-03139-6.

3.

Gut microbiota modulate T cell trafficking into human colorectal cancer.

Cremonesi E, Governa V, Garzon JFG, Mele V, Amicarella F, Muraro MG, Trella E, Galati-Fournier V, Oertli D, Däster SR, Droeser RA, Weixler B, Bolli M, Rosso R, Nitsche U, Khanna N, Egli A, Keck S, Slotta-Huspenina J, Terracciano LM, Zajac P, Spagnoli GC, Eppenberger-Castori S, Janssen KP, Borsig L, Iezzi G.

Gut. 2018 Nov;67(11):1984-1994. doi: 10.1136/gutjnl-2016-313498. Epub 2018 Feb 6.

PMID:
29437871
4.

Selectins in cancer immunity.

Borsig L.

Glycobiology. 2018 Sep 1;28(9):648-655. doi: 10.1093/glycob/cwx105.

PMID:
29272415
5.

Transcription factor c-Myb inhibits breast cancer lung metastasis by suppression of tumor cell seeding.

Knopfová L, Biglieri E, Volodko N, Masařík M, Hermanová M, Glaus Garzón JF, Dúcka M, Kučírková T, Souček K, Šmarda J, Beneš P, Borsig L.

Oncogene. 2018 Feb 22;37(8):1020-1030. doi: 10.1038/onc.2017.392. Epub 2017 Oct 30.

6.

Custom Glycosylation of Cells and Proteins Using Cyclic Carbamate-Derivatized Oligosaccharides.

Whitehead MWJ, Khanzhin N, Borsig L, Hennet T.

Cell Chem Biol. 2017 Nov 16;24(11):1336-1346.e3. doi: 10.1016/j.chembiol.2017.08.012. Epub 2017 Sep 21.

PMID:
28943358
7.

A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.

Boege Y, Malehmir M, Healy ME, Bettermann K, Lorentzen A, Vucur M, Ahuja AK, Böhm F, Mertens JC, Shimizu Y, Frick L, Remouchamps C, Mutreja K, Kähne T, Sundaravinayagam D, Wolf MJ, Rehrauer H, Koppe C, Speicher T, Padrissa-Altés S, Maire R, Schattenberg JM, Jeong JS, Liu L, Zwirner S, Boger R, Hüser N, Davis RJ, Müllhaupt B, Moch H, Schulze-Bergkamen H, Clavien PA, Werner S, Borsig L, Luther SA, Jost PJ, Weinlich R, Unger K, Behrens A, Hillert L, Dillon C, Di Virgilio M, Wallach D, Dejardin E, Zender L, Naumann M, Walczak H, Green DR, Lopes M, Lavrik I, Luedde T, Heikenwalder M, Weber A.

Cancer Cell. 2017 Sep 11;32(3):342-359.e10. doi: 10.1016/j.ccell.2017.08.010.

8.

Stromal Expression of Activated Leukocyte Cell Adhesion Molecule Promotes Lung Tumor Growth and Metastasis.

Willrodt AH, Beffinger M, Vranova M, Protsyuk D, Schuler K, Jadhav M, Heikenwalder M, van den Broek M, Borsig L, Halin C.

Am J Pathol. 2017 Nov;187(11):2558-2569. doi: 10.1016/j.ajpath.2017.07.008. Epub 2017 Aug 17.

PMID:
28822802
9.

Monocyte Induction of E-Selectin-Mediated Endothelial Activation Releases VE-Cadherin Junctions to Promote Tumor Cell Extravasation in the Metastasis Cascade.

Häuselmann I, Roblek M, Protsyuk D, Huck V, Knopfova L, Grässle S, Bauer AT, Schneider SW, Borsig L.

Cancer Res. 2016 Sep 15;76(18):5302-12. doi: 10.1158/0008-5472.CAN-16-0784. Epub 2016 Aug 3.

10.

Antimetastatic Properties of Low Molecular Weight Heparin.

Läubli H, Varki A, Borsig L.

J Clin Oncol. 2016 Jul 20;34(21):2560-1. doi: 10.1200/JCO.2016.66.4607. Epub 2016 May 16. No abstract available.

PMID:
27185851
11.

Breastfed at Tiffany's.

Hennet T, Borsig L.

Trends Biochem Sci. 2016 Jun;41(6):508-518. doi: 10.1016/j.tibs.2016.02.008. Epub 2016 Apr 16. Review.

PMID:
27093946
12.

Transcriptional signature induced by a metastasis-promoting c-Src mutant in a human breast cell line.

Broecker F, Hardt C, Herwig R, Timmermann B, Kerick M, Wunderlich A, Schweiger MR, Borsig L, Heikenwalder M, Lehrach H, Moelling K.

FEBS J. 2016 May;283(9):1669-88. doi: 10.1111/febs.13694. Epub 2016 Mar 25.

13.

Targeting of CCL2-CCR2-Glycosaminoglycan Axis Using a CCL2 Decoy Protein Attenuates Metastasis through Inhibition of Tumor Cell Seeding.

Roblek M, Strutzmann E, Zankl C, Adage T, Heikenwalder M, Atlic A, Weis R, Kungl A, Borsig L.

Neoplasia. 2016 Jan;18(1):49-59. doi: 10.1016/j.neo.2015.11.013.

14.

IL17A-Mediated Endothelial Breach Promotes Metastasis Formation.

Kulig P, Burkhard S, Mikita-Geoffroy J, Croxford AL, Hövelmeyer N, Gyülvészi G, Gorzelanny C, Waisman A, Borsig L, Becher B.

Cancer Immunol Res. 2016 Jan;4(1):26-32. doi: 10.1158/2326-6066.CIR-15-0154. Epub 2015 Nov 19.

15.

Targeted delivery of CCR2 antagonist to activated pulmonary endothelium prevents metastasis.

Roblek M, Calin M, Schlesinger M, Stan D, Zeisig R, Simionescu M, Bendas G, Borsig L.

J Control Release. 2015 Dec 28;220(Pt A):341-347. doi: 10.1016/j.jconrel.2015.10.055. Epub 2015 Oct 30.

16.

A novel pVHL-independent but NEMO-driven pathway in renal cancer promotes HIF stabilization.

Nowicka AM, Häuselmann I, Borsig L, Bolduan S, Schindler M, Schraml P, Heikenwalder M, Moch H.

Oncogene. 2016 Jun 16;35(24):3125-38. doi: 10.1038/onc.2015.400. Epub 2015 Oct 26.

PMID:
26500060
17.

Inhibition of chemokine receptor CCR2 reduces sarcoma cell transendothelial migration and metastasis to the lungs.

Schlesinger M, Zeisig R, Ortmann K, Calin M, Gerber U, Roblek M, Borsig L, Bendas G.

Int J Clin Pharmacol Ther. 2015 Dec;53(12):1046-8. doi: 10.5414/CPXCES14EA04. No abstract available.

PMID:
26249764
18.

Hypoxia attenuates the proinflammatory response in colon cancer cells by regulating IκB.

Müller-Edenborn K, Léger K, Glaus Garzon JF, Oertli C, Mirsaidi A, Richards PJ, Rehrauer H, Spielmann P, Hoogewijs D, Borsig L, Hottiger MO, Wenger RH.

Oncotarget. 2015 Aug 21;6(24):20288-301.

19.

VWF fibers induce thrombosis during cancer.

Borsig L.

Blood. 2015 May 14;125(20):3042-3. doi: 10.1182/blood-2015-03-632141. No abstract available.

20.

CCL2-CCR2 Signaling in Disease Pathogenesis.

O'Connor T, Borsig L, Heikenwalder M.

Endocr Metab Immune Disord Drug Targets. 2015;15(2):105-18. Review.

21.

Nuclear heparanase-1 activity suppresses melanoma progression via its DNA-binding affinity.

Yang Y, Gorzelanny C, Bauer AT, Halter N, Komljenovic D, Bäuerle T, Borsig L, Roblek M, Schneider SW.

Oncogene. 2015 Nov 19;34(47):5832-42. doi: 10.1038/onc.2015.40. Epub 2015 Mar 9.

22.

VCAM-1 directed target-sensitive liposomes carrying CCR2 antagonists bind to activated endothelium and reduce adhesion and transmigration of monocytes.

Calin M, Stan D, Schlesinger M, Simion V, Deleanu M, Constantinescu CA, Gan AM, Pirvulescu MM, Butoi E, Manduteanu I, Bota M, Enachescu M, Borsig L, Bendas G, Simionescu M.

Eur J Pharm Biopharm. 2015 Jan;89:18-29. doi: 10.1016/j.ejpb.2014.11.016. Epub 2014 Nov 28.

23.

Antitumor properties of a new non-anticoagulant heparin analog from the mollusk Nodipecten nodosus: Effect on P-selectin, heparanase, metastasis and cellular recruitment.

Gomes AM, Kozlowski EO, Borsig L, Teixeira FC, Vlodavsky I, Pavão MS.

Glycobiology. 2015 Apr;25(4):386-93. doi: 10.1093/glycob/cwu119. Epub 2014 Nov 3.

24.

The role of VLA-4 binding for experimental melanoma metastasis and its inhibition by heparin.

Schlesinger M, Roblek M, Ortmann K, Naggi A, Torri G, Borsig L, Bendas G.

Thromb Res. 2014 May;133(5):855-62. doi: 10.1016/j.thromres.2014.02.020. Epub 2014 Feb 26.

PMID:
24636486
25.

Altered tumor-cell glycosylation promotes metastasis.

Häuselmann I, Borsig L.

Front Oncol. 2014 Feb 13;4:28. doi: 10.3389/fonc.2014.00028. eCollection 2014. Review.

26.

Decoding breast milk oligosaccharides.

Hennet T, Weiss A, Borsig L.

Swiss Med Wkly. 2014 Feb 19;144:w13927. doi: 10.4414/smw.2014.13927. Review.

27.

Metastatic growth progression caused by PSGL-1-mediated recruitment of monocytes to metastatic sites.

Hoos A, Protsyuk D, Borsig L.

Cancer Res. 2014 Feb 1;74(3):695-704. doi: 10.1158/0008-5472.CAN-13-0946. Epub 2013 Dec 9.

28.

Increasing the antitumor effect of an EpCAM-targeting fusion toxin by facile click PEGylation.

Simon M, Stefan N, Borsig L, Plückthun A, Zangemeister-Wittke U.

Mol Cancer Ther. 2014 Feb;13(2):375-85. doi: 10.1158/1535-7163.MCT-13-0523. Epub 2013 Nov 1.

29.

Milk oligosaccharide sialyl(α2,3)lactose activates intestinal CD11c+ cells through TLR4.

Kurakevich E, Hennet T, Hausmann M, Rogler G, Borsig L.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17444-9. doi: 10.1073/pnas.1306322110. Epub 2013 Oct 7.

30.

Inflammatory chemokines and metastasis--tracing the accessory.

Borsig L, Wolf MJ, Roblek M, Lorentzen A, Heikenwalder M.

Oncogene. 2014 Jun 19;33(25):3217-24. doi: 10.1038/onc.2013.272. Epub 2013 Jul 15. Review.

31.

Ontogenetic regulation of leukocyte recruitment in mouse yolk sac vessels.

Sperandio M, Quackenbush EJ, Sushkova N, Altstätter J, Nussbaum C, Schmid S, Pruenster M, Kurz A, Margraf A, Steppner A, Schweiger N, Borsig L, Boros I, Krajewski N, Genzel-Boroviczeny O, Jeschke U, Frommhold D, von Andrian UH.

Blood. 2013 May 23;121(21):e118-28. doi: 10.1182/blood-2012-07-447144. Epub 2013 Mar 22.

32.

Pathways of metastasizing intestinal cancer cells revealed: how will fighting metastases at the site of cancer cell arrest affect drug development?

Heikenwalder M, Borsig L.

Future Oncol. 2013 Jan;9(1):1-4. doi: 10.2217/fon.12.163. No abstract available.

33.

Endothelial chemokine receptors as facilitators of tumor cell extravasation?

Hoos A, Wolf MJ, Bauer J, Borsig L, Heikenwalder M.

Oncotarget. 2012 Sep;3(9):919-20.

34.

Endothelial CCR2 signaling induced by colon carcinoma cells enables extravasation via the JAK2-Stat5 and p38MAPK pathway.

Wolf MJ, Hoos A, Bauer J, Boettcher S, Knust M, Weber A, Simonavicius N, Schneider C, Lang M, Stürzl M, Croner RS, Konrad A, Manz MG, Moch H, Aguzzi A, van Loo G, Pasparakis M, Prinz M, Borsig L, Heikenwalder M.

Cancer Cell. 2012 Jul 10;22(1):91-105. doi: 10.1016/j.ccr.2012.05.023.

35.

Volatile anesthetics reduce invasion of colorectal cancer cells through down-regulation of matrix metalloproteinase-9.

Müller-Edenborn B, Roth-Zʼgraggen B, Bartnicka K, Borgeat A, Hoos A, Borsig L, Beck-Schimmer B.

Anesthesiology. 2012 Aug;117(2):293-301. doi: 10.1097/ALN.0b013e3182605df1.

36.

Complete absence of the αGal xenoantigen and isoglobotrihexosylceramide in α1,3galactosyltransferase knock-out pigs.

Puga Yung GL, Li Y, Borsig L, Millard AL, Karpova MB, Zhou D, Seebach JD.

Xenotransplantation. 2012 May-Jun;19(3):196-206. doi: 10.1111/j.1399-3089.2012.00705.x.

37.

Cancer cell adhesion and metastasis: selectins, integrins, and the inhibitory potential of heparins.

Bendas G, Borsig L.

Int J Cell Biol. 2012;2012:676731. doi: 10.1155/2012/676731. Epub 2012 Feb 12.

38.

Inhibitory effect of non-anticoagulant heparin (S-NACH) on pancreatic cancer cell adhesion and metastasis in human umbilical cord vessel segment and in mouse model.

Sudha T, Phillips P, Kanaan C, Linhardt RJ, Borsig L, Mousa SA.

Clin Exp Metastasis. 2012 Jun;29(5):431-9. doi: 10.1007/s10585-012-9461-9. Epub 2012 Mar 14.

PMID:
22415710
39.

Deletion of L-selectin increases atherosclerosis development in ApoE-/- mice.

Rozenberg I, Sluka SH, Mocharla P, Hallenberg A, Rotzius P, Borén J, Kränkel N, Landmesser U, Borsig L, Lüscher TF, Eriksson EE, Tanner FC.

PLoS One. 2011;6(7):e21675. doi: 10.1371/journal.pone.0021675. Epub 2011 Jul 8.

40.

Ascidian dermatan sulfates attenuate metastasis, inflammation and thrombosis by inhibition of P-selectin.

Kozlowski EO, Pavao MS, Borsig L.

J Thromb Haemost. 2011 Sep;9(9):1807-15. doi: 10.1111/j.1538-7836.2011.04401.x.

41.

Sulfated hexasaccharides attenuate metastasis by inhibition of P-selectin and heparanase.

Borsig L, Vlodavsky I, Ishai-Michaeli R, Torri G, Vismara E.

Neoplasia. 2011 May;13(5):445-52.

42.

Metal complex mediated conjugation of peptides to nucleus targeting acridine orange: a modular concept for dual-modality imaging agents.

Zelenka K, Borsig L, Alberto R.

Bioconjug Chem. 2011 May 18;22(5):958-67. doi: 10.1021/bc2000269. Epub 2011 May 2.

PMID:
21480670
43.

Selectins as mediators of lung metastasis.

Läubli H, Borsig L.

Cancer Microenviron. 2010 Feb 27;3(1):97-105. doi: 10.1007/s12307-010-0043-6.

44.

Trifunctional 99mTc based radiopharmaceuticals: metal-mediated conjugation of a peptide with a nucleus targeting intercalator.

Zelenka K, Borsig L, Alberto R.

Org Biomol Chem. 2011 Feb 21;9(4):1071-8. doi: 10.1039/c0ob00504e. Epub 2010 Dec 24.

PMID:
21186394
45.

Milk sialyllactose influences colitis in mice through selective intestinal bacterial colonization.

Fuhrer A, Sprenger N, Kurakevich E, Borsig L, Chassard C, Hennet T.

J Exp Med. 2010 Dec 20;207(13):2843-54. doi: 10.1084/jem.20101098. Epub 2010 Nov 22.

46.

Prolyl-4-hydroxylase PHD2- and hypoxia-inducible factor 2-dependent regulation of amphiregulin contributes to breast tumorigenesis.

Bordoli MR, Stiehl DP, Borsig L, Kristiansen G, Hausladen S, Schraml P, Wenger RH, Camenisch G.

Oncogene. 2011 Feb 3;30(5):548-60. doi: 10.1038/onc.2010.433. Epub 2010 Sep 20.

PMID:
20856199
47.

Heparin as an inhibitor of cancer progression.

Borsig L.

Prog Mol Biol Transl Sci. 2010;93:335-49. doi: 10.1016/S1877-1173(10)93014-7. Review.

48.

Antimetastatic activities of heparins and modified heparins. Experimental evidence.

Borsig L.

Thromb Res. 2010 Apr;125 Suppl 2:S66-71. doi: 10.1016/S0049-3848(10)70017-7. Review.

49.

Selectins promote tumor metastasis.

Läubli H, Borsig L.

Semin Cancer Biol. 2010 Jun;20(3):169-77. doi: 10.1016/j.semcancer.2010.04.005. Epub 2010 May 7. Review.

50.

Analysis of SM4 sulfatide as a P-selectin ligand using model membranes.

Simonis D, Schlesinger M, Seelandt C, Borsig L, Bendas G.

Biophys Chem. 2010 Aug;150(1-3):98-104. doi: 10.1016/j.bpc.2010.01.007. Epub 2010 Feb 1.

PMID:
20163908

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