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Items: 1 to 50 of 70

1.

JNK signaling activation in the Ube3a maternal deficient mouse model: Its specific inhibition prevents post-synaptic protein-enriched fraction alterations and cognitive deficits in Angelman Syndrome model.

Musi CA, Agrò G, Buccarello L, Camuso S, Borsello T.

Neurobiol Dis. 2020 Feb 19:104812. doi: 10.1016/j.nbd.2020.104812. [Epub ahead of print]

2.

Deregulated Local Protein Synthesis in the Brain Synaptosomes of a Mouse Model for Alzheimer's Disease.

Cefaliello C, Penna E, Barbato C, Di Ruberto G, Mollica MP, Trinchese G, Cigliano L, Borsello T, Chun JT, Giuditta A, Perrone-Capano C, Miniaci MC, Crispino M.

Mol Neurobiol. 2020 Mar;57(3):1529-1541. doi: 10.1007/s12035-019-01835-y. Epub 2019 Nov 30.

PMID:
31784883
3.

The Stress c-Jun N-terminal Kinase Signaling Pathway Activation Correlates with Synaptic Pathology and Presents A Sex Bias in P301L Mouse Model of Tauopathy.

Buccarello L, Musi CA, Turati A, Borsello T.

Neuroscience. 2018 Nov 21;393:196-205. doi: 10.1016/j.neuroscience.2018.09.049. Epub 2018 Oct 11.

PMID:
30315879
4.

Pharmacological c-Jun NH2-Terminal Kinase (JNK) Pathway Inhibition Reduces Severity of Spinal Muscular Atrophy Disease in Mice.

Schellino R, Boido M, Borsello T, Vercelli A.

Front Mol Neurosci. 2018 Sep 4;11:308. doi: 10.3389/fnmol.2018.00308. eCollection 2018.

5.

The Parkinson's Disease-Linked Protein DJ-1 Associates with Cytoplasmic mRNP Granules During Stress and Neurodegeneration.

Repici M, Hassanjani M, Maddison DC, Garção P, Cimini S, Patel B, Szegö ÉM, Straatman KR, Lilley KS, Borsello T, Outeiro TF, Panman L, Giorgini F.

Mol Neurobiol. 2019 Jan;56(1):61-77. doi: 10.1007/s12035-018-1084-y. Epub 2018 Apr 19.

6.

Motor coordination and synaptic plasticity deficits are associated with increased cerebellar activity of NADPH oxidase, CAMKII, and PKC at preplaque stage in the TgCRND8 mouse model of Alzheimer's disease.

Russo R, Cattaneo F, Lippiello P, Cristiano C, Zurlo F, Castaldo M, Irace C, Borsello T, Santamaria R, Ammendola R, Calignano A, Miniaci MC.

Neurobiol Aging. 2018 Aug;68:123-133. doi: 10.1016/j.neurobiolaging.2018.02.025. Epub 2018 Mar 5.

PMID:
29602494
7.

Axonal transport in a peripheral diabetic neuropathy model: sex-dimorphic features.

Pesaresi M, Giatti S, Spezzano R, Romano S, Diviccaro S, Borsello T, Mitro N, Caruso D, Garcia-Segura LM, Melcangi RC.

Biol Sex Differ. 2018 Jan 19;9(1):6. doi: 10.1186/s13293-018-0164-z.

8.

The c-jun N-terminal kinase plays a key role in ocular degenerative changes in a mouse model of Alzheimer disease suggesting a correlation between ocular and brain pathologies.

Buccarello L, Sclip A, Sacchi M, Castaldo AM, Bertani I, ReCecconi A, Maestroni S, Zerbini G, Nucci P, Borsello T.

Oncotarget. 2017 Aug 3;8(47):83038-83051. doi: 10.18632/oncotarget.19886. eCollection 2017 Oct 10.

9.

Molecular and Cellular Mechanisms of Synaptopathies.

Ardiles AO, Grabrucker AM, Scholl FG, Rudenko G, Borsello T.

Neural Plast. 2017;2017:2643943. doi: 10.1155/2017/2643943. Epub 2017 Apr 30. No abstract available.

10.

Neuroprotective effects of low fat-protein diet in the P301L mouse model of tauopathy.

Buccarello L, Grignaschi G, Di Giancamillo A, Domeneghini C, Melcangi RC, Borsello T.

Neuroscience. 2017 Jun 23;354:208-220. doi: 10.1016/j.neuroscience.2017.04.027. Epub 2017 Apr 27.

PMID:
28456717
11.

Evidence of Presynaptic Localization and Function of the c-Jun N-Terminal Kinase.

Biggi S, Buccarello L, Sclip A, Lippiello P, Tonna N, Rumio C, Di Marino D, Miniaci MC, Borsello T.

Neural Plast. 2017;2017:6468356. doi: 10.1155/2017/6468356. Epub 2017 Mar 7.

12.

Sex Impact on Tau-Aggregation and Postsynaptic Protein Levels in the P301L Mouse Model of Tauopathy.

Buccarello L, Grignaschi G, Castaldo AM, Di Giancamillo A, Domeneghini C, Melcangi RC, Borsello T.

J Alzheimers Dis. 2017;56(4):1279-1292. doi: 10.3233/JAD-161087.

PMID:
28157099
13.

The Tat-Aβ1-6A2V(D) peptide against AD synaptopathy.

Buccarello L, Borsello T.

Oncotarget. 2017 Feb 14;8(7):10773-10774. doi: 10.18632/oncotarget.14604. No abstract available.

14.

Epidermal RAF prevents allergic skin disease.

Raguz J, Jeric I, Niault T, Nowacka JD, Kuzet SE, Rupp C, Fischer I, Biggi S, Borsello T, Baccarini M.

Elife. 2016 Jul 19;5. pii: e14012. doi: 10.7554/eLife.14012.

15.

A cationic tetrapyrrole inhibits toxic activities of the cellular prion protein.

Massignan T, Cimini S, Stincardini C, Cerovic M, Vanni I, Elezgarai SR, Moreno J, Stravalaci M, Negro A, Sangiovanni V, Restelli E, Riccardi G, Gobbi M, Castilla J, Borsello T, Nonno R, Biasini E.

Sci Rep. 2016 Mar 15;6:23180. doi: 10.1038/srep23180.

16.

The cell-permeable Aβ1-6A2VTAT(D) peptide reverts synaptopathy induced by Aβ1-42wt.

Cimini S, Sclip A, Mancini S, Colombo L, Messa M, Cagnotto A, Di Fede G, Tagliavini F, Salmona M, Borsello T.

Neurobiol Dis. 2016 May;89:101-11. doi: 10.1016/j.nbd.2015.12.013. Epub 2015 Dec 22.

PMID:
26721320
17.

Differential Relevance of NF-κB and JNK in the Pathophysiology of Hemorrhage/Resususcitation-Induced Liver Injury after Chronic Ethanol Feeding.

Relja B, Weber R, Maraslioglu M, Wagner N, Borsello T, Jobin C, Marzi I, Lehnert M.

PLoS One. 2015 Sep 14;10(9):e0137875. doi: 10.1371/journal.pone.0137875. eCollection 2015.

18.

Exploring the role of MKK7 in excitotoxicity and cerebral ischemia: a novel pharmacological strategy against brain injury.

Vercelli A, Biggi S, Sclip A, Repetto IE, Cimini S, Falleroni F, Tomasi S, Monti R, Tonna N, Morelli F, Grande V, Stravalaci M, Biasini E, Marin O, Bianco F, di Marino D, Borsello T.

Cell Death Dis. 2015 Aug 13;6:e1854. doi: 10.1038/cddis.2015.226.

19.

Abnormal cortical lysosomal β-hexosaminidase and β-galactosidase activity at post-synaptic sites during Alzheimer's disease progression.

Magini A, Polchi A, Tozzi A, Tancini B, Tantucci M, Urbanelli L, Borsello T, Calabresi P, Emiliani C.

Int J Biochem Cell Biol. 2015 Jan;58:62-70. doi: 10.1016/j.biocel.2014.11.001. Epub 2014 Nov 12.

PMID:
25462158
20.

Region- and age-dependent reductions of hippocampal long-term potentiation and NMDA to AMPA ratio in a genetic model of Alzheimer's disease.

Tozzi A, Sclip A, Tantucci M, de Iure A, Ghiglieri V, Costa C, Di Filippo M, Borsello T, Calabresi P.

Neurobiol Aging. 2015 Jan;36(1):123-33. doi: 10.1016/j.neurobiolaging.2014.07.002. Epub 2014 Jul 10.

PMID:
25104560
21.

Determination of tissue levels of a neuroprotectant drug: the cell permeable JNK inhibitor peptide.

Davoli E, Sclip A, Cecchi M, Cimini S, Carrà A, Salmona M, Borsello T.

J Pharmacol Toxicol Methods. 2014 Jul-Aug;70(1):55-61. doi: 10.1016/j.vascn.2014.04.001. Epub 2014 May 9.

PMID:
24814549
22.

c-Jun N-terminal kinase has a key role in Alzheimer disease synaptic dysfunction in vivo.

Sclip A, Tozzi A, Abaza A, Cardinetti D, Colombo I, Calabresi P, Salmona M, Welker E, Borsello T.

Cell Death Dis. 2014 Jan 23;5:e1019. doi: 10.1038/cddis.2013.559.

23.

Soluble Aβ oligomer-induced synaptopathy: c-Jun N-terminal kinase's role.

Sclip A, Arnaboldi A, Colombo I, Veglianese P, Colombo L, Messa M, Mancini S, Cimini S, Morelli F, Antoniou X, Welker E, Salmona M, Borsello T.

J Mol Cell Biol. 2013 Aug;5(4):277-9. doi: 10.1093/jmcb/mjt015. Epub 2013 Apr 18. No abstract available.

PMID:
23606726
24.

An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo.

Fluharty BR, Biasini E, Stravalaci M, Sclip A, Diomede L, Balducci C, La Vitola P, Messa M, Colombo L, Forloni G, Borsello T, Gobbi M, Harris DA.

J Biol Chem. 2013 Mar 15;288(11):7857-66. doi: 10.1074/jbc.M112.423954. Epub 2013 Jan 28.

25.

The neurodegeneration in Alzheimer disease and the prion protein.

Forloni G, Sclip A, Borsello T, Balducci C.

Prion. 2013 Jan-Feb;7(1):60-5. doi: 10.4161/pri.23286. Epub 2013 Jan 1. Review.

26.

Contribution of serine racemase/d-serine pathway to neuronal apoptosis.

Esposito S, Pristerà A, Maresca G, Cavallaro S, Felsani A, Florenzano F, Manni L, Ciotti MT, Pollegioni L, Borsello T, Canu N.

Aging Cell. 2012 Aug;11(4):588-98. doi: 10.1111/j.1474-9726.2012.00822.x. Epub 2012 Jun 5.

27.

Specific inhibition of the JNK pathway promotes locomotor recovery and neuroprotection after mouse spinal cord injury.

Repici M, Chen X, Morel MP, Doulazmi M, Sclip A, Cannaya V, Veglianese P, Kraftsik R, Mariani J, Borsello T, Dusart I.

Neurobiol Dis. 2012 Jun;46(3):710-21. doi: 10.1016/j.nbd.2012.03.014. Epub 2012 Mar 9.

PMID:
22426389
28.

The JNK signalling transduction pathway in the brain.

Antoniou X, Borsello T.

Front Biosci (Elite Ed). 2012 Jan 1;4:2110-20. Review.

PMID:
22202023
29.

Crosstalk between JNK and SUMO signaling pathways: deSUMOylation is protective against H2O2-induced cell injury.

Feligioni M, Brambilla E, Camassa A, Sclip A, Arnaboldi A, Morelli F, Antoniou X, Borsello T.

PLoS One. 2011;6(12):e28185. doi: 10.1371/journal.pone.0028185. Epub 2011 Dec 2.

30.

c-Jun N-terminal kinase regulates soluble Aβ oligomers and cognitive impairment in AD mouse model.

Sclip A, Antoniou X, Colombo A, Camici GG, Pozzi L, Cardinetti D, Feligioni M, Veglianese P, Bahlmann FH, Cervo L, Balducci C, Costa C, Tozzi A, Calabresi P, Forloni G, Borsello T.

J Biol Chem. 2011 Dec 23;286(51):43871-80. doi: 10.1074/jbc.M111.297515. Epub 2011 Oct 27.

31.

JNK plays a key role in tau hyperphosphorylation in Alzheimer's disease models.

Ploia C, Antoniou X, Sclip A, Grande V, Cardinetti D, Colombo A, Canu N, Benussi L, Ghidoni R, Forloni G, Borsello T.

J Alzheimers Dis. 2011;26(2):315-29. doi: 10.3233/JAD-2011-110320.

PMID:
21628793
32.

JNK3 as a therapeutic target for neurodegenerative diseases.

Antoniou X, Falconi M, Di Marino D, Borsello T.

J Alzheimers Dis. 2011;24(4):633-42. doi: 10.3233/JAD-2011-091567. Review.

PMID:
21321401
33.

c-Jun N-terminal kinase (JNK) and p38 play different roles in age-related Purkinje cell death in murine organotypic culture.

Repici M, Wehrlé R, Antoniou X, Borsello T, Dusart I.

Cerebellum. 2011 Jun;10(2):281-90. doi: 10.1007/s12311-010-0244-z.

PMID:
21191679
34.

A new fluorogenic peptide determines proteasome activity in single cells.

Urru SA, Veglianese P, De Luigi A, Fumagalli E, Erba E, Gonella Diaza R, Carrà A, Davoli E, Borsello T, Forloni G, Pengo N, Monzani E, Cascio P, Cenci S, Sitia R, Salmona M.

J Med Chem. 2010 Oct 28;53(20):7452-60. doi: 10.1021/jm100362x.

PMID:
20883027
35.

Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease.

Epis R, Marcello E, Gardoni F, Vastagh C, Malinverno M, Balducci C, Colombo A, Borroni B, Vara H, Dell'Agli M, Cattabeni F, Giustetto M, Borsello T, Forloni G, Padovani A, Di Luca M.

Brain. 2010 Nov;133(11):3323-35. doi: 10.1093/brain/awq217. Epub 2010 Aug 30.

PMID:
20805102
36.

Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein.

Balducci C, Beeg M, Stravalaci M, Bastone A, Sclip A, Biasini E, Tapella L, Colombo L, Manzoni C, Borsello T, Chiesa R, Gobbi M, Salmona M, Forloni G.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2295-300. doi: 10.1073/pnas.0911829107. Epub 2010 Jan 19.

37.

Cell Permeable Peptides: A Promising Tool to Deliver Neuroprotective Agents in the Brain.

Antoniou X, Borsello T.

Pharmaceuticals (Basel). 2010 Feb 3;3(2):379-392. Review.

38.

JNK contributes to Hif-1alpha regulation in hypoxic neurons.

Antoniou X, Sclip A, Ploia C, Colombo A, Moroy G, Borsello T.

Molecules. 2009 Dec 30;15(1):114-27. doi: 10.3390/molecules15010114.

39.

Role of Glycogen Synthase Kinase-3β in APP Hyperphosphorylation Induced by NMDA Stimulation in Cortical Neurons.

Ploia C, Sclip A, Colombo A, Repici M, Gardoni F, Di Luca M, Forloni G, Antoniou X, Borsello T.

Pharmaceuticals (Basel). 2010 Jan 7;3(1):42-58.

40.

c-Jun N-terminal kinase pathway activation in human and experimental cerebral contusion.

Ortolano F, Colombo A, Zanier ER, Sclip A, Longhi L, Perego C, Stocchetti N, Borsello T, De Simoni MG.

J Neuropathol Exp Neurol. 2009 Sep;68(9):964-71. doi: 10.1097/NEN.0b013e3181b20670.

PMID:
19680147
41.

Inhibition of c-Jun N-terminal kinase after hemorrhage but before resuscitation mitigates hepatic damage and inflammatory response in male rats.

Relja B, Schwestka B, Lee VS, Henrich D, Czerny C, Borsello T, Marzi I, Lehnert M.

Shock. 2009 Nov;32(5):509-16. doi: 10.1097/SHK.0b013e3181a2530d.

PMID:
19295484
42.

JNK regulates APP cleavage and degradation in a model of Alzheimer's disease.

Colombo A, Bastone A, Ploia C, Sclip A, Salmona M, Forloni G, Borsello T.

Neurobiol Dis. 2009 Mar;33(3):518-25. doi: 10.1016/j.nbd.2008.12.014. Epub 2009 Jan 8.

PMID:
19166938
43.

c-Jun N-terminal kinase binding domain-dependent phosphorylation of mitogen-activated protein kinase kinase 4 and mitogen-activated protein kinase kinase 7 and balancing cross-talk between c-Jun N-terminal kinase and extracellular signal-regulated kinase pathways in cortical neurons.

Repici M, Mare L, Colombo A, Ploia C, Sclip A, Bonny C, Nicod P, Salmona M, Borsello T.

Neuroscience. 2009 Mar 3;159(1):94-103. doi: 10.1016/j.neuroscience.2008.11.049. Epub 2008 Dec 14.

PMID:
19135136
44.

Specific JNK inhibition by D-JNKI1 protects Purkinje cells from cell death in Lurcher mutant mouse.

Repici M, Zanjani HS, Gautheron V, Borsello T, Dusart I, Mariani J.

Cerebellum. 2008;7(4):534-8. doi: 10.1007/s12311-008-0070-8.

PMID:
18949529
45.

A peptide inhibitor of C-jun N-terminal kinase modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation.

Lehnert M, Relja B, Sun-Young Lee V, Schwestka B, Henrich D, Czerny C, Froh M, Borsello T, Marzi I.

Shock. 2008 Aug;30(2):159-65. doi: 10.1097/SHK.0b013e31815dd623.

PMID:
18628689
46.

Neuronal death and neuroprotection: a review.

Repici M, Mariani J, Borsello T.

Methods Mol Biol. 2007;399:1-14. doi: 10.1007/978-1-59745-504-6_1. Review.

PMID:
18309921
47.

Recombinant human TNF-binding protein-1 (rhTBP-1) treatment delays both symptoms progression and motor neuron loss in the wobbler mouse.

Bigini P, Repici M, Cantarella G, Fumagalli E, Barbera S, Cagnotto A, De Luigi A, Tonelli R, Bernardini R, Borsello T, Mennini T.

Neurobiol Dis. 2008 Mar;29(3):465-76. doi: 10.1016/j.nbd.2007.11.005. Epub 2007 Nov 12.

PMID:
18201889
48.

Time-course of c-Jun N-terminal kinase activation after cerebral ischemia and effect of D-JNKI1 on c-Jun and caspase-3 activation.

Repici M, Centeno C, Tomasi S, Forloni G, Bonny C, Vercelli A, Borsello T.

Neuroscience. 2007 Nov 30;150(1):40-9. Epub 2007 Aug 28.

PMID:
17900813
49.

Phosphorylation-dependent dimerization and subcellular localization of islet-brain 1/c-Jun N-terminal kinase-interacting protein 1.

Borsello T, Centeno C, Riederer IM, Haefliger JA, Riederer BM.

J Neurosci Res. 2007 Dec;85(16):3632-41.

PMID:
17663463
50.

The TAT-JNK inhibitor peptide interferes with beta amyloid protein stability.

Colombo A, Repici M, Pesaresi M, Santambrogio S, Forloni G, Borsello T.

Cell Death Differ. 2007 Oct;14(10):1845-8. Epub 2007 Jul 20. No abstract available.

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