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Items: 11

1.

Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.

Yin Y, Wu M, Hsu AL, Borschel WF, Borgnia MJ, Lander GC, Lee SY.

Nat Commun. 2019 Aug 20;10(1):3740. doi: 10.1038/s41467-019-11733-5.

2.

Regulatory switch at the cytoplasmic interface controls TRPV channel gating.

Zubcevic L, Borschel WF, Hsu AL, Borgnia MJ, Lee SY.

Elife. 2019 May 9;8. pii: e47746. doi: 10.7554/eLife.47746.

3.

Conformational ensemble of the human TRPV3 ion channel.

Zubcevic L, Herzik MA Jr, Wu M, Borschel WF, Hirschi M, Song AS, Lander GC, Lee SY.

Nat Commun. 2018 Nov 14;9(1):4773. doi: 10.1038/s41467-018-07117-w.

4.

Structure of the cold- and menthol-sensing ion channel TRPM8.

Yin Y, Wu M, Zubcevic L, Borschel WF, Lander GC, Lee SY.

Science. 2018 Jan 12;359(6372):237-241. doi: 10.1126/science.aan4325. Epub 2017 Dec 7.

5.

Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3.

Hirschi M, Herzik MA Jr, Wie J, Suo Y, Borschel WF, Ren D, Lander GC, Lee SY.

Nature. 2017 Oct 19;550(7676):411-414. doi: 10.1038/nature24055. Epub 2017 Oct 11.

6.

Conformational changes at cytoplasmic intersubunit interactions control Kir channel gating.

Wang S, Borschel WF, Heyman S, Hsu P, Nichols CG.

J Biol Chem. 2017 Jun 16;292(24):10087-10096. doi: 10.1074/jbc.M117.785154. Epub 2017 Apr 26.

7.

Control of Kir channel gating by cytoplasmic domain interface interactions.

Borschel WF, Wang S, Lee S, Nichols CG.

J Gen Physiol. 2017 May 1;149(5):561-576. doi: 10.1085/jgp.201611719. Epub 2017 Apr 7.

8.

Structural dynamics of potassium-channel gating revealed by single-molecule FRET.

Wang S, Vafabakhsh R, Borschel WF, Ha T, Nichols CG.

Nat Struct Mol Biol. 2016 Jan;23(1):31-36. doi: 10.1038/nsmb.3138. Epub 2015 Dec 7.

9.

Kinetic contributions to gating by interactions unique to N-methyl-D-aspartate (NMDA) receptors.

Borschel WF, Cummings KA, Tindell LK, Popescu GK.

J Biol Chem. 2015 Oct 30;290(44):26846-55. doi: 10.1074/jbc.M115.678656. Epub 2015 Sep 14.

10.

Gating reaction mechanism of neuronal NMDA receptors.

Borschel WF, Myers JM, Kasperek EM, Smith TP, Graziane NM, Nowak LM, Popescu GK.

J Neurophysiol. 2012 Dec;108(11):3105-15. doi: 10.1152/jn.00551.2012. Epub 2012 Sep 19.

11.

NMDA receptor activation requires remodelling of intersubunit contacts within ligand-binding heterodimers.

Borschel WF, Murthy SE, Kasperek EM, Popescu GK.

Nat Commun. 2011 Oct 11;2:498. doi: 10.1038/ncomms1512.

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