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Items: 25


Dynamic reorganisation of intermediate filaments coordinates early B-cell activation.

Tsui C, Maldonado P, Montaner B, Borroto A, Alarcon B, Bruckbauer A, Martinez-Martin N, Batista FD.

Life Sci Alliance. 2018 Aug 20;1(5):e201800060. doi: 10.26508/lsa.201800060. eCollection 2018 Oct.


A non-conserved amino acid variant regulates differential signalling between human and mouse CD28.

Porciello N, Grazioli P, Campese AF, Kunkl M, Caristi S, Mastrogiovanni M, Muscolini M, Spadaro F, Favre C, Nunès JA, Borroto A, Alarcon B, Screpanti I, Tuosto L.

Nat Commun. 2018 Mar 14;9(1):1080. doi: 10.1038/s41467-018-03385-8.


Author Correction: Conventional CD4+ T cells present bacterial antigens to induce cytotoxic and memory CD8+ T cell responses.

Cruz-Adalia A, Ramirez-Santiago G, Osuna-Pérez J, Torres-Torresano M, Zorita V, Martínez-Riaño A, Boccasavia V, Borroto A, Martínez Del Hoyo G, González-Granado JM, Alarcón B, Sánchez-Madrid F, Veiga E.

Nat Commun. 2018 Jan 31;9(1):495. doi: 10.1038/s41467-018-03074-6.


Conventional CD4+ T cells present bacterial antigens to induce cytotoxic and memory CD8+ T cell responses.

Cruz-Adalia A, Ramirez-Santiago G, Osuna-Pérez J, Torres-Torresano M, Zorita V, Martínez-Riaño A, Boccasavia V, Borroto A, Martínez Del Hoyo G, González-Granado JM, Alarcón B, Sánchez-Madrid F, Veiga E.

Nat Commun. 2017 Nov 17;8(1):1591. doi: 10.1038/s41467-017-01661-7. Erratum in: Nat Commun. 2018 Jan 31;9(1):495.


First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases.

Borroto A, Reyes-Garau D, Jiménez MA, Carrasco E, Moreno B, Martínez-Pasamar S, Cortés JR, Perona A, Abia D, Blanco S, Fuentes M, Arellano I, Lobo J, Heidarieh H, Rueda J, Esteve P, Cibrián D, Martinez-Riaño A, Mendoza P, Prieto C, Calleja E, Oeste CL, Orfao A, Fresno M, Sánchez-Madrid F, Alcamí A, Bovolenta P, Martín P, Villoslada P, Morreale A, Messeguer A, Alarcon B.

Sci Transl Med. 2016 Dec 21;8(370):370ra184. doi: 10.1126/scitranslmed.aaf2140.


A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation.

Swamy M, Beck-Garcia K, Beck-Garcia E, Hartl FA, Morath A, Yousefi OS, Dopfer EP, Molnár E, Schulze AK, Blanco R, Borroto A, Martín-Blanco N, Alarcon B, Höfer T, Minguet S, Schamel WW.

Immunity. 2016 May 17;44(5):1091-101. doi: 10.1016/j.immuni.2016.04.011.


Aurora A drives early signalling and vesicle dynamics during T-cell activation.

Blas-Rus N, Bustos-Morán E, Pérez de Castro I, de Cárcer G, Borroto A, Camafeita E, Jorge I, Vázquez J, Alarcón B, Malumbres M, Martín-Cófreces NB, Sánchez-Madrid F.

Nat Commun. 2016 Apr 19;7:11389. doi: 10.1038/ncomms11389.


CD3ε recruits Numb to promote TCR degradation.

Martin-Blanco N, Jiménez Teja D, Bretones G, Borroto A, Caraballo M, Screpanti I, León J, Alarcón B, Canelles M.

Int Immunol. 2016 Mar;28(3):127-37. doi: 10.1093/intimm/dxv060. Epub 2015 Oct 27.


Conformational changes in the T cell receptor differentially determine T cell subset development in mice.

Blanco R, Borroto A, Schamel W, Pereira P, Alarcon B.

Sci Signal. 2014 Dec 2;7(354):ra115. doi: 10.1126/scisignal.2005650.


Crammed signaling motifs in the T-cell receptor.

Borroto A, Abia D, Alarcón B.

Immunol Lett. 2014 Sep;161(1):113-7. doi: 10.1016/j.imlet.2014.05.007. Epub 2014 May 27. Review.


Relevance of Nck-CD3 epsilon interaction for T cell activation in vivo.

Borroto A, Arellano I, Blanco R, Fuentes M, Orfao A, Dopfer EP, Prouza M, Suchànek M, Schamel WW, Alarcón B.

J Immunol. 2014 Mar 1;192(5):2042-53. doi: 10.4049/jimmunol.1203414. Epub 2014 Jan 27.


Nck recruitment to the TCR required for ZAP70 activation during thymic development.

Borroto A, Arellano I, Dopfer EP, Prouza M, Suchànek M, Fuentes M, Orfao A, Schamel WW, Alarcón B.

J Immunol. 2013 Feb 1;190(3):1103-12. doi: 10.4049/jimmunol.1202055. Epub 2012 Dec 24.


Interaction between the N-terminal SH3 domain of Nck-alpha and CD3-epsilon-derived peptides: non-canonical and canonical recognition motifs.

Santiveri CM, Borroto A, Simón L, Rico M, Alarcón B, Jiménez MA.

Biochim Biophys Acta. 2009 Jan;1794(1):110-7. doi: 10.1016/j.bbapap.2008.09.016. Epub 2008 Oct 10.


Occurrence of enterovirus RNA in serum of children with newly diagnosed type 1 diabetes and islet cell autoantibody-positive subjects in a population with a low incidence of type 1 diabetes.

Sarmiento L, Cabrera-Rode E, Lekuleni L, Cuba I, Molina G, Fonseca M, Heng-Hung L, Borroto AD, Gonzalez P, Mas-Lago P, Diaz-Horta O.

Autoimmunity. 2007 Nov;40(7):540-5.


Recycling of cell surface pro-transforming growth factor-{alpha} regulates epidermal growth factor receptor activation.

Martínez-Arca S, Bech-Serra JJ, Hurtado-Küttner M, Borroto A, Arribas J.

J Biol Chem. 2005 Nov 4;280(44):36970-7. Epub 2005 Aug 29.


Impaired trafficking and activation of tumor necrosis factor-alpha-converting enzyme in cell mutants defective in protein ectodomain shedding.

Borroto A, Ruiz-Paz S, de la Torre TV, Borrell-Pages M, Merlos-Suarez A, Pandiella A, Blobel CP, Baselga J, Arribas J.

J Biol Chem. 2003 Jul 11;278(28):25933-9. Epub 2003 Apr 24. Erratum in: J Biol Chem. 2004 Jan 23;279(4):3119.


Protein ectodomain shedding.

Arribas J, Borroto A.

Chem Rev. 2002 Dec;102(12):4627-38. Review. No abstract available.


The carboxy-terminal cysteine of the tetraspanin L6 antigen is required for its interaction with SITAC, a novel PDZ protein.

Borrell-Pagès M, Fernández-Larrea J, Borroto A, Rojo F, Baselga J, Arribas J.

Mol Biol Cell. 2000 Dec;11(12):4217-25.


Rho regulates T cell receptor ITAM-induced lymphocyte spreading in an integrin-independent manner.

Borroto A, Gil D, Delgado P, Vicente-Manzanares M, Alcover A, Sánchez-Madrid F, Alarcón B.

Eur J Immunol. 2000 Dec;30(12):3403-10.


Triggering the TCR complex causes the downregulation of nonengaged receptors by a signal transduction-dependent mechanism.

San José E, Borroto A, Niedergang F, Alcover A, Alarcón B.

Immunity. 2000 Feb;12(2):161-70.


The CD3 epsilon subunit of the TCR contains endocytosis signals.

Borroto A, Lama J, Niedergang F, Dautry-Varsat A, Alarcón B, Alcover A.

J Immunol. 1999 Jul 1;163(1):25-31.


Characterization of the region involved in CD3 pairwise interactions within the T cell receptor complex.

Borroto A, Mallabiabarrena A, Albar JP, Martínez-A C, Alarcón B.

J Biol Chem. 1998 May 22;273(21):12807-16.


Transferrin receptor induces tyrosine phosphorylation in T cells and is physically associated with the TCR zeta-chain.

Salmerón A, Borroto A, Fresno M, Crumpton MJ, Ley SC, Alarcón B.

J Immunol. 1995 Feb 15;154(4):1675-83.


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