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Items: 1 to 50 of 287

1.

Lipocalin-2 Functions as Inhibitor of Innate Resistance to Mycobacterium tuberculosis.

Dahl SL, Woodworth JS, Lerche CJ, Cramer EP, Nielsen PR, Moser C, Thomsen AR, Borregaard N, Cowland JB.

Front Immunol. 2018 Nov 26;9:2717. doi: 10.3389/fimmu.2018.02717. eCollection 2018.

2.

Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin.

Reckzeh K, Kizilkaya H, Helbo AS, Alrich ME, Deslauriers AG, Grover A, Rapin N, Asmar F, Grønbæk K, Porse B, Borregaard N, Vestweber D, Nerlov C, Theilgaard-Mönch K.

Blood Adv. 2018 Jul 10;2(13):1628-1632. doi: 10.1182/bloodadvances.2018015743. No abstract available.

3.

Applying label-free dynamic mass redistribution assay for studying endogenous FPR1 receptor signalling in human neutrophils.

Christensen HB, Gloriam DE, Pedersen DS, Cowland JB, Borregaard N, Bräuner-Osborne H.

J Pharmacol Toxicol Methods. 2017 Nov;88(Pt 1):72-78. doi: 10.1016/j.vascn.2017.07.003. Epub 2017 Jul 15.

PMID:
28716665
4.

Lipocalin-2 from both myeloid cells and the epithelium combats Klebsiella pneumoniae lung infection in mice.

Cramer EP, Dahl SL, Rozell B, Knudsen KJ, Thomsen K, Moser C, Cowland JB, Borregaard N.

Blood. 2017 May 18;129(20):2813-2817. doi: 10.1182/blood-2016-11-753434. Epub 2017 Apr 10. No abstract available.

PMID:
28396494
5.

Interleukin (IL)-17A and IL-22-producing neutrophils in psoriatic skin.

Dyring-Andersen B, Honoré TV, Madelung A, Bzorek M, Simonsen S, Clemmensen SN, Clark RA, Borregaard N, Skov L.

Br J Dermatol. 2017 Dec;177(6):e321-e322. doi: 10.1111/bjd.15533. Epub 2017 Oct 8. No abstract available.

6.

Prolonged pharmacological inhibition of cathepsin C results in elimination of neutrophil serine proteases.

Guarino C, Hamon Y, Croix C, Lamort AS, Dallet-Choisy S, Marchand-Adam S, Lesner A, Baranek T, Viaud-Massuard MC, Lauritzen C, Pedersen J, Heuzé-Vourc'h N, Si-Tahar M, Fıratlı E, Jenne DE, Gauthier F, Horwitz MS, Borregaard N, Korkmaz B.

Biochem Pharmacol. 2017 May 1;131:52-67. doi: 10.1016/j.bcp.2017.02.009. Epub 2017 Feb 11.

PMID:
28193451
7.

MicroRNA-941 Expression in Polymorphonuclear Granulocytes Is Not Related to Granulomatosis with Polyangiitis.

Svendsen JB, Baslund B, Cramer EP, Rapin N, Borregaard N, Cowland JB.

PLoS One. 2016 Oct 18;11(10):e0164985. doi: 10.1371/journal.pone.0164985. eCollection 2016.

8.

Granulopoiesis and granules of human neutrophils.

Cowland JB, Borregaard N.

Immunol Rev. 2016 Sep;273(1):11-28. doi: 10.1111/imr.12440. Review.

PMID:
27558325
9.

Changes in Gene Expression during G-CSF-Induced Emergency Granulopoiesis in Humans.

Pedersen CC, Borup R, Fischer-Nielsen A, Mora-Jensen H, Fossum A, Cowland JB, Borregaard N.

J Immunol. 2016 Sep 1;197(5):1989-99. doi: 10.4049/jimmunol.1502690. Epub 2016 Aug 1.

10.

Extracellular superoxide dismutase is present in secretory vesicles of human neutrophils and released upon stimulation.

Iversen MB, Gottfredsen RH, Larsen UG, Enghild JJ, Praetorius J, Borregaard N, Petersen SV.

Free Radic Biol Med. 2016 Aug;97:478-488. doi: 10.1016/j.freeradbiomed.2016.07.004. Epub 2016 Jul 6.

PMID:
27394172
11.

Neutrophil extracellular traps - the dark side of neutrophils.

Sørensen OE, Borregaard N.

J Clin Invest. 2016 May 2;126(5):1612-20. doi: 10.1172/JCI84538. Epub 2016 May 2. Review.

12.

To stimulate the phagocytes.

Borregaard N.

Blood. 2015 Dec 17;126(25):2659-61. doi: 10.1182/blood-2015-10-675447. No abstract available.

PMID:
26679543
13.

Impact of microRNA-130a on the neutrophil proteome.

Pedersen CC, Refsgaard JC, Østergaard O, Jensen LJ, Heegaard NH, Borregaard N, Cowland JB.

BMC Immunol. 2015 Nov 25;16:70. doi: 10.1186/s12865-015-0134-8.

14.

Plasma levels of OLFM4 in normals and patients with gastrointestinal cancer.

Clemmensen SN, Glenthøj AJ, Heebøll S, Nielsen HJ, Koch C, Borregaard N.

J Cell Mol Med. 2015 Dec;19(12):2865-73. doi: 10.1111/jcmm.12679. Epub 2015 Sep 28.

15.

Research update for articles published in EJCI in 2013.

Abbate R, Al-Daghri NM, Andreozzi P, Borregaard N, Can G, Caridi G, Carstensen-Kirberg M, Cioni G, Conte E, Cuomo R, Denis MA, Fakhfouri G, Fakhfouri G, Fiasse R, Glenthøj A, Goliasc G, Gremmel T, Herder C, Iemmolo M, Jing ZC, Krause R, Marrone O, Miazgowski B, Miazgowski T, Minchiotti L, Mousavizadeh K, Ndrepepa G, Niessner A, Ogayar Luque C, Onat A, Papassotiriou I, Ruiz Ortiz M, Sabico S, Schooling CM, Sakka SD, Sołtysiak P, Visseren FL, Wagner J, Wang XJ, Westerink J.

Eur J Clin Invest. 2015 Oct;45(10):1005-16. doi: 10.1111/eci.12512. No abstract available. Erratum in: Eur J Clin Invest. 2016 Apr;46(4):375.

PMID:
26394055
16.

A novel mechanism for NETosis provides antimicrobial defense at the oral mucosa.

Mohanty T, Sjögren J, Kahn F, Abu-Humaidan AH, Fisker N, Assing K, Mörgelin M, Bengtsson AA, Borregaard N, Sørensen OE.

Blood. 2015 Oct 29;126(18):2128-37. doi: 10.1182/blood-2015-04-641142. Epub 2015 Aug 4.

PMID:
26243777
17.

The antimicrobial propeptide hCAP-18 plasma levels in neutropenia of various aetiologies: a prospective study.

Ye Y, Carlsson G, Karlsson-Sjöberg JM, Borregaard N, Modéer TU, Andersson ML, Pütsep KL.

Sci Rep. 2015 Jun 29;5:11685. doi: 10.1038/srep11685.

18.

Inflammation on the move.

Borregaard N.

J Exp Med. 2015 Jun 1;212(6):829-30. doi: 10.1084/jem.2126insight3. No abstract available.

19.

Interplay between enterobactin, myeloperoxidase and lipocalin 2 regulates E. coli survival in the inflamed gut.

Singh V, Yeoh BS, Xiao X, Kumar M, Bachman M, Borregaard N, Joe B, Vijay-Kumar M.

Nat Commun. 2015 May 12;6:7113. doi: 10.1038/ncomms8113.

20.

Processing of Neutrophil α-Defensins Does Not Rely on Serine Proteases In Vivo.

Glenthøj A, Nickles K, Cowland J, Borregaard N.

PLoS One. 2015 May 6;10(5):e0125483. doi: 10.1371/journal.pone.0125483. eCollection 2015.

21.

Cellular origin of prognostic chromosomal aberrations in AML patients.

Mora-Jensen H, Jendholm J, Rapin N, Andersen MK, Roug AS, Bagger FO, Bullinger L, Winther O, Borregaard N, Porse BT, Theilgaard-Mönch K.

Leukemia. 2015 Aug;29(8):1785-9. doi: 10.1038/leu.2015.30. Epub 2015 Feb 11. No abstract available.

PMID:
25670329
22.

Secondary necrotic neutrophils release interleukin-16C and macrophage migration inhibitory factor from stores in the cytosol.

Roth S, Agthe M, Eickhoff S, Möller S, Karsten CM, Borregaard N, Solbach W, Laskay T.

Cell Death Discov. 2015 Nov 30;1:15056. doi: 10.1038/cddiscovery.2015.56. eCollection 2015.

23.

Papillon-Lefèvre syndrome patient reveals species-dependent requirements for neutrophil defenses.

Sørensen OE, Clemmensen SN, Dahl SL, Østergaard O, Heegaard NH, Glenthøj A, Nielsen FC, Borregaard N.

J Clin Invest. 2014 Oct;124(10):4539-48. doi: 10.1172/JCI76009. Epub 2014 Sep 17.

24.

Liver is the major source of elevated serum lipocalin-2 levels after bacterial infection or partial hepatectomy: a critical role for IL-6/STAT3.

Xu MJ, Feng D, Wu H, Wang H, Chan Y, Kolls J, Borregaard N, Porse B, Berger T, Mak TW, Cowland JB, Kong X, Gao B.

Hepatology. 2015 Feb;61(2):692-702. doi: 10.1002/hep.27447.

25.

ADAM9 is a novel product of polymorphonuclear neutrophils: regulation of expression and contributions to extracellular matrix protein degradation during acute lung injury.

Roychaudhuri R, Hergrueter AH, Polverino F, Laucho-Contreras ME, Gupta K, Borregaard N, Owen CA.

J Immunol. 2014 Sep 1;193(5):2469-82. doi: 10.4049/jimmunol.1303370. Epub 2014 Jul 25.

26.

Neutrophils at work.

Nauseef WM, Borregaard N.

Nat Immunol. 2014 Jul;15(7):602-11. doi: 10.1038/ni.2921. Review.

PMID:
24940954
27.

ProHNPs are specific markers of normal myelopoiesis.

Emmertsen F, Glenthøj A, Sønderskov J, Kampmann P, Sengeløv H, Borregaard N.

Blood Cancer J. 2014 Mar 21;4:e193. doi: 10.1038/bcj.2014.11.

28.

Human α-defensin expression is not dependent on CCAAT/enhancer binding protein-ε in a murine model.

Glenthøj A, Dahl S, Larsen MT, Cowland JB, Borregaard N.

PLoS One. 2014 Mar 21;9(3):e92471. doi: 10.1371/journal.pone.0092471. eCollection 2014.

29.

Regulation of the human cathelicidin antimicrobial peptide gene by 1α,25-dihydroxyvitamin D3 in primary immune cells.

Lowry MB, Guo C, Borregaard N, Gombart AF.

J Steroid Biochem Mol Biol. 2014 Sep;143:183-91. doi: 10.1016/j.jsbmb.2014.02.004. Epub 2014 Feb 22.

30.

Subcellular fractionation of human neutrophils and analysis of subcellular markers.

Clemmensen SN, Udby L, Borregaard N.

Methods Mol Biol. 2014;1124:53-76. doi: 10.1007/978-1-62703-845-4_5.

PMID:
24504946
31.

Severe congenital neutropenia: new lane for ELANE.

Borregaard N.

Blood. 2014 Jan 23;123(4):462-3. doi: 10.1182/blood-2013-11-537068.

PMID:
24458273
32.

What doesn't kill you makes you stronger: the anti-inflammatory effect of neutrophil respiratory burst.

Borregaard N.

Immunity. 2014 Jan 16;40(1):1-2. doi: 10.1016/j.immuni.2013.12.003.

33.

Localization and functionality of the inflammasome in neutrophils.

Bakele M, Joos M, Burdi S, Allgaier N, Pöschel S, Fehrenbacher B, Schaller M, Marcos V, Kümmerle-Deschner J, Rieber N, Borregaard N, Yazdi A, Hector A, Hartl D.

J Biol Chem. 2014 Feb 21;289(8):5320-9. doi: 10.1074/jbc.M113.505636. Epub 2014 Jan 7.

34.

miRNA-130a regulates C/EBP-ε expression during granulopoiesis.

Larsen MT, Häger M, Glenthøj A, Asmar F, Clemmensen SN, Mora-Jensen H, Borregaard N, Cowland JB.

Blood. 2014 Feb 13;123(7):1079-89. doi: 10.1182/blood-2013-08-523233. Epub 2014 Jan 7.

PMID:
24398327
35.

Comparing cancer vs normal gene expression profiles identifies new disease entities and common transcriptional programs in AML patients.

Rapin N, Bagger FO, Jendholm J, Mora-Jensen H, Krogh A, Kohlmann A, Thiede C, Borregaard N, Bullinger L, Winther O, Theilgaard-Mönch K, Porse BT.

Blood. 2014 Feb 6;123(6):894-904. doi: 10.1182/blood-2013-02-485771. Epub 2013 Dec 20.

PMID:
24363398
36.

NSP4 is stored in azurophil granules and released by activated neutrophils as active endoprotease with restricted specificity.

Perera NC, Wiesmüller KH, Larsen MT, Schacher B, Eickholz P, Borregaard N, Jenne DE.

J Immunol. 2013 Sep 1;191(5):2700-7. doi: 10.4049/jimmunol.1301293. Epub 2013 Jul 31.

37.

Novel Gemini vitamin D3 analogs: large structure/function analysis and ability to induce antimicrobial peptide.

Okamoto R, Gery S, Kuwayama Y, Borregaard N, Ho Q, Alvarez R, Akagi T, Liu GY, Uskokovic MR, Koeffler HP.

Int J Cancer. 2014 Jan 1;134(1):207-17. doi: 10.1002/ijc.28328. Epub 2013 Jul 16.

38.

ProHNPs are the principal α-defensins of human plasma.

Glenthøj A, Glenthøj AJ, Borregaard N.

Eur J Clin Invest. 2013 Aug;43(8):836-43. doi: 10.1111/eci.12114. Epub 2013 May 30.

PMID:
23718714
39.

Proteome profiling of human neutrophil granule subsets, secretory vesicles, and cell membrane: correlation with transcriptome profiling of neutrophil precursors.

Rørvig S, Østergaard O, Heegaard NH, Borregaard N.

J Leukoc Biol. 2013 Oct;94(4):711-21. doi: 10.1189/jlb.1212619. Epub 2013 May 6.

PMID:
23650620
40.

Candida albicans escapes from mouse neutrophils.

Ermert D, Niemiec MJ, Röhm M, Glenthøj A, Borregaard N, Urban CF.

J Leukoc Biol. 2013 Aug;94(2):223-36. doi: 10.1189/jlb.0213063. Epub 2013 May 6.

PMID:
23650619
41.

MicroRNA profiling in human neutrophils during bone marrow granulopoiesis and in vivo exudation.

Larsen MT, Hother C, Häger M, Pedersen CC, Theilgaard-Mönch K, Borregaard N, Cowland JB.

PLoS One. 2013;8(3):e58454. doi: 10.1371/journal.pone.0058454. Epub 2013 Mar 12.

42.

Investigation of human cationic antimicrobial protein-18 (hCAP-18), lactoferrin and CD163 as potential biomarkers for ovarian cancer.

Lim R, Lappas M, Riley C, Borregaard N, Moller HJ, Ahmed N, Rice GE.

J Ovarian Res. 2013 Jan 22;6(1):5. doi: 10.1186/1757-2215-6-5.

43.

Azurophil granule proteins constitute the major mycobactericidal proteins in human neutrophils and enhance the killing of mycobacteria in macrophages.

Jena P, Mohanty S, Mohanty T, Kallert S, Morgelin M, Lindstrøm T, Borregaard N, Stenger S, Sonawane A, Sørensen OE.

PLoS One. 2012;7(12):e50345. doi: 10.1371/journal.pone.0050345. Epub 2012 Dec 14.

44.

Positive correlation between circulating cathelicidin antimicrobial peptide (hCAP18/LL-37) and 25-hydroxyvitamin D levels in healthy adults.

Dixon BM, Barker T, McKinnon T, Cuomo J, Frei B, Borregaard N, Gombart AF.

BMC Res Notes. 2012 Oct 24;5:575. doi: 10.1186/1756-0500-5-575.

45.

Serum cathelicidin level is associated with viral etiology and severity of bronchiolitis.

Mansbach JM, Piedra PA, Borregaard N, Martineau AR, Neuman MI, Espinola JA, Camargo CA Jr.

J Allergy Clin Immunol. 2012 Oct;130(4):1007-8.e1. doi: 10.1016/j.jaci.2012.07.044. Epub 2012 Sep 1. No abstract available.

46.

Curcumin induces human cathelicidin antimicrobial peptide gene expression through a vitamin D receptor-independent pathway.

Guo C, Rosoha E, Lowry MB, Borregaard N, Gombart AF.

J Nutr Biochem. 2013 May;24(5):754-9. doi: 10.1016/j.jnutbio.2012.04.002. Epub 2012 Jul 25.

47.

Lipocalin 2 deficiency dysregulates iron homeostasis and exacerbates endotoxin-induced sepsis.

Srinivasan G, Aitken JD, Zhang B, Carvalho FA, Chassaing B, Shashidharamurthy R, Borregaard N, Jones DP, Gewirtz AT, Vijay-Kumar M.

J Immunol. 2012 Aug 15;189(4):1911-9. doi: 10.4049/jimmunol.1200892. Epub 2012 Jul 11.

48.

No effect of NGAL/lipocalin-2 on aggressiveness of cancer in the MMTV-PyMT/FVB/N mouse model for breast cancer.

Cramer EP, Glenthøj A, Häger M, Juncker-Jensen A, Engelholm LH, Santoni-Rugiu E, Lund LR, Laerum OD, Cowland JB, Borregaard N.

PLoS One. 2012;7(6):e39646. doi: 10.1371/journal.pone.0039646. Epub 2012 Jun 21.

49.

Variation in FCN1 affects biosynthesis of ficolin-1 and is associated with outcome of systemic inflammation.

Munthe-Fog L, Hummelshoj T, Honoré C, Moller ME, Skjoedt MO, Palsgaard I, Borregaard N, Madsen HO, Garred P.

Genes Immun. 2012 Oct;13(7):515-22. doi: 10.1038/gene.2012.27. Epub 2012 Jun 7.

PMID:
22673311
50.

Olfactomedin 4 defines a subset of human neutrophils.

Clemmensen SN, Bohr CT, Rørvig S, Glenthøj A, Mora-Jensen H, Cramer EP, Jacobsen LC, Larsen MT, Cowland JB, Tanassi JT, Heegaard NH, Wren JD, Silahtaroglu AN, Borregaard N.

J Leukoc Biol. 2012 Mar;91(3):495-500. doi: 10.1189/jlb.0811417. Epub 2011 Dec 20.

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