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Items: 1 to 50 of 113

1.

Nitrite-mediated antagonism of cyanide inhibition of cytochrome c oxidase in dopamine neurons.

Leavesley HB, Li L, Mukhopadhyay S, Borowitz JL, Isom GE.

Toxicol Sci. 2010 Jun;115(2):569-76. doi: 10.1093/toxsci/kfq084. Epub 2010 Mar 24.

2.

Cyanide-induced apoptosis of dopaminergic cells is promoted by BNIP3 and Bax modulation of endoplasmic reticulum-mitochondrial Ca2+ levels.

Zhang L, Li L, Leavesley HW, Zhang X, Borowitz JL, Isom GE.

J Pharmacol Exp Ther. 2010 Jan;332(1):97-105. doi: 10.1124/jpet.109.159103. Epub 2009 Oct 19.

3.

BNIP3 mediates cell death by different pathways following localization to endoplasmic reticulum and mitochondrion.

Zhang L, Li L, Liu H, Borowitz JL, Isom GE.

FASEB J. 2009 Oct;23(10):3405-14. doi: 10.1096/fj.08-124354. Epub 2009 Jun 17.

4.

Cyanide-induced death of dopaminergic cells is mediated by uncoupling protein-2 up-regulation and reduced Bcl-2 expression.

Zhang X, Li L, Zhang L, Borowitz JL, Isom GE.

Toxicol Appl Pharmacol. 2009 Jul 1;238(1):11-9. doi: 10.1016/j.taap.2009.03.020. Epub 2009 Apr 8.

5.

Nicotine and type 2 diabetes.

Borowitz JL, Isom GE.

Toxicol Sci. 2008 Jun;103(2):225-7. doi: 10.1093/toxsci/kfn050. Epub 2008 Mar 18. No abstract available.

PMID:
18353801
6.

1Alpha,25-dihydroxyvitamin D3 attenuates cyanide-induced neurotoxicity by inhibiting uncoupling protein-2 up-regulation.

Li L, Prabhakaran K, Zhang X, Zhang L, Liu H, Borowitz JL, Isom GE.

J Neurosci Res. 2008 May 1;86(6):1397-408. doi: 10.1002/jnr.21596.

PMID:
18183618
7.

Upregulation of BNIP3 and translocation to mitochondria mediates cyanide-induced apoptosis in cortical cells.

Prabhakaran K, Li L, Zhang L, Borowitz JL, Isom GE.

Neuroscience. 2007 Nov 30;150(1):159-67. Epub 2007 Jul 29.

8.

Interaction of cyanide and nitric oxide with cytochrome c oxidase: implications for acute cyanide toxicity.

Leavesley HB, Li L, Prabhakaran K, Borowitz JL, Isom GE.

Toxicol Sci. 2008 Jan;101(1):101-11. Epub 2007 Sep 28.

PMID:
17906319
9.

Uncoupling protein-2 up-regulation and enhanced cyanide toxicity are mediated by PPARalpha activation and oxidative stress.

Zhang X, Li L, Prabhakaran K, Zhang L, Leavesley HB, Borowitz JL, Isom GE.

Toxicol Appl Pharmacol. 2007 Aug 15;223(1):10-9. Epub 2007 May 18.

10.

HIF-1alpha activation by a redox-sensitive pathway mediates cyanide-induced BNIP3 upregulation and mitochondrial-dependent cell death.

Zhang L, Li L, Liu H, Prabhakaran K, Zhang X, Borowitz JL, Isom GE.

Free Radic Biol Med. 2007 Jul 1;43(1):117-27. Epub 2007 Apr 10.

11.
12.

Trimethyltin-induced apoptosis is associated with upregulation of inducible nitric oxide synthase and Bax in a hippocampal cell line.

Zhang L, Li L, Prabhakaran K, Borowitz JL, Isom GE.

Toxicol Appl Pharmacol. 2006 Oct 1;216(1):34-43. Epub 2006 May 19.

PMID:
16797631
13.

PPARalpha-mediated upregulation of uncoupling protein-2 switches cyanide-induced apoptosis to necrosis in primary cortical cells.

Li L, Prabhakaran K, Zhang X, Borowitz JL, Isom GE.

Toxicol Sci. 2006 Sep;93(1):136-45. Epub 2006 Jun 16.

PMID:
16782780
14.

Up-regulation of uncoupling protein 2 by cyanide is linked with cytotoxicity in mesencephalic cells.

Prabhakaran K, Li L, Mills EM, Borowitz JL, Isom GE.

J Pharmacol Exp Ther. 2005 Sep;314(3):1338-45. Epub 2005 Jun 3.

PMID:
15937145
15.

Enhancement of cyanide-induced mitochondrial dysfunction and cortical cell necrosis by uncoupling protein-2.

Li L, Prabhakaran K, Mills EM, Borowitz JL, Isom GE.

Toxicol Sci. 2005 Jul;86(1):116-24. Epub 2005 Mar 30.

PMID:
15800031
16.

Receptor mechanisms mediating cyanide generation in PC12 cells and rat brain.

Gunasekar PG, Prabhakaran K, Li L, Zhang L, Isom GE, Borowitz JL.

Neurosci Res. 2004 May;49(1):13-8.

PMID:
15099699
17.

Caspase inhibition switches the mode of cell death induced by cyanide by enhancing reactive oxygen species generation and PARP-1 activation.

Prabhakaran K, Li L, Borowitz JL, Isom GE.

Toxicol Appl Pharmacol. 2004 Mar 1;195(2):194-202.

PMID:
14998685
18.

Calcineurin-mediated Bad translocation regulates cyanide-induced neuronal apoptosis.

Shou Y, Li L, Prabhakaran K, Borowitz JL, Isom GE.

Biochem J. 2004 May 1;379(Pt 3):805-13.

19.

p38 Mitogen-activated protein kinase regulates Bax translocation in cyanide-induced apoptosis.

Shou Y, Li L, Prabhakaran K, Borowitz JL, Isom GE.

Toxicol Sci. 2003 Sep;75(1):99-107. Epub 2003 Jun 12.

PMID:
12805646
20.

Cyanide enhancement of dopamine-induced apoptosis in mesencephalic cells involves mitochondrial dysfunction and oxidative stress.

Jones DC, Prabhakaran K, Li L, Gunasekar PG, Shou Y, Borowitz JL, Isom GE.

Neurotoxicology. 2003 Jun;24(3):333-42.

PMID:
12782099
21.

Oxidative stress and cyclooxygenase-2 induction mediate cyanide-induced apoptosis of cortical cells.

Li L, Prabhakaran K, Shou Y, Borowitz JL, Isom GE.

Toxicol Appl Pharmacol. 2002 Nov 15;185(1):55-63.

PMID:
12460737
22.

Cyanide induces different modes of death in cortical and mesencephalon cells.

Prabhakaran K, Li L, Borowitz JL, Isom GE.

J Pharmacol Exp Ther. 2002 Nov;303(2):510-9.

PMID:
12388630
23.
24.

Role of astrocytes in trimethyltin neurotoxicity.

Gunasekar PG, Mickova V, Kotyzova D, Li L, Borowitz JL, Eybl V, Isom GE.

J Biochem Mol Toxicol. 2001;15(5):256-62.

PMID:
11835622
25.

Reactive oxygen species mediate pyridostigmine-induced neuronal apoptosis: involvement of muscarinic and NMDA receptors.

Li L, Shou Y, Borowitz JL, Isom GE.

Toxicol Appl Pharmacol. 2001 Nov 15;177(1):17-25.

PMID:
11708896
26.

Mechanisms of the apoptotic and necrotic actions of trimethyltin in cerebellar granule cells.

Gunasekar P, Li L, Prabhakaran K, Eybl V, Borowitz JL, Isom GE.

Toxicol Sci. 2001 Nov;64(1):83-9.

PMID:
11606804
27.

Muscarinic receptor-mediated pyridostigmine-induced neuronal apoptosis.

Li L, Gunasekar PG, Borowitz JL, Isom GE.

Neurotoxicology. 2000 Aug;21(4):541-52.

PMID:
11022862
28.

Endogenous generation of cyanide in neuronal tissue: involvement of a peroxidase system.

Gunasekar PG, Borowitz JL, Turek JJ, Van Horn DA, Isom GE.

J Neurosci Res. 2000 Sep 1;61(5):570-5.

PMID:
10956427
29.

Dopamine-induced apoptosis is mediated by oxidative stress and Is enhanced by cyanide in differentiated PC12 cells.

Jones DC, Gunasekar PG, Borowitz JL, Isom GE.

J Neurochem. 2000 Jun;74(6):2296-304.

30.

Cyanide-induced apoptosis involves oxidative-stress-activated NF-kappaB in cortical neurons.

Shou Y, Gunasekar PG, Borowitz JL, Isom GE.

Toxicol Appl Pharmacol. 2000 Apr 15;164(2):196-205.

PMID:
10764633
31.

Cyanide interaction with redox modulatory sites enhances NMDA receptor responses.

Sun P, Rane SG, Gunasekar PG, Borowitz JL, Isom GE.

J Biochem Mol Toxicol. 1999;13(5):253-9.

PMID:
10402559
32.

Differential susceptibility of brain areas to cyanide involves different modes of cell death.

Mills EM, Gunasekar PG, Li L, Borowitz JL, Isom GE.

Toxicol Appl Pharmacol. 1999 Apr 1;156(1):6-16.

PMID:
10101094
33.

Cyanide-induced generation of oxidative species: involvement of nitric oxide synthase and cyclooxygenase-2.

Gunasekar PG, Borowitz JL, Isom GE.

J Pharmacol Exp Ther. 1998 Apr;285(1):236-41.

PMID:
9536016
34.

Reactive oxygen species generated by cyanide mediate toxicity in rat pheochromocytoma cells.

Kanthasamy AG, Ardelt B, Malave A, Mills EM, Powley TL, Borowitz JL, Isom GE.

Toxicol Lett. 1997 Sep 19;93(1):47-54.

PMID:
9381482
35.

Hydrogen cyanide generation by mu-opiate receptor activation: possible neuromodulatory role of endogenous cyanide.

Borowitz JL, Gunasekar PG, Isom GE.

Brain Res. 1997 Sep 12;768(1-2):294-300.

PMID:
9369328
36.

Modulation of the NMDA receptor by cyanide: enhancement of receptor-mediated responses.

Sun P, Rane SG, Gunasekar PG, Borowitz JL, Isom GE.

J Pharmacol Exp Ther. 1997 Mar;280(3):1341-8.

PMID:
9067322
37.

Cyanide-induced neurotoxicity involves nitric oxide and reactive oxygen species generation after N-methyl-D-aspartate receptor activation.

Gunasekar PG, Sun PW, Kanthasamy AG, Borowitz JL, Isom GE.

J Pharmacol Exp Ther. 1996 Apr;277(1):150-5.

PMID:
8613912
38.

Cyanide-stimulated inositol 1,4,5-trisphosphate formation: an intracellular neurotoxic signaling cascade.

Yang CW, Borowitz JL, Gunasekar PG, Isom GE.

J Biochem Toxicol. 1996;11(5):251-6.

PMID:
9110247
39.

Antagonism of cyanide toxicity by isosorbide dinitrate: possible role of nitric oxide.

Sun P, Borowitz JL, Kanthasamy AG, Kane MD, Gunasekar PG, Isom GE.

Toxicology. 1995 Dec 15;104(1-3):105-11.

PMID:
8560488
40.

Modification of cyanide toxicodynamics: mechanistic based antidote development.

Isom GE, Borowitz JL.

Toxicol Lett. 1995 Dec;82-83:795-9. Review.

PMID:
8597144
41.

Role of intracellular Cd2+ in catecholamine release and lethality in PC12 cells.

Kanthasamy AG, Isom GE, Borowitz JL.

Toxicol Lett. 1995 Nov 15;81(2-3):151-7.

PMID:
8553369
42.

NMDA receptor activation produces concurrent generation of nitric oxide and reactive oxygen species: implication for cell death.

Gunasekar PG, Kanthasamy AG, Borowitz JL, Isom GE.

J Neurochem. 1995 Nov;65(5):2016-21.

PMID:
7595485
43.

Monitoring intracellular nitric oxide formation by dichlorofluorescin in neuronal cells.

Gunasekar PG, Kanthasamy AG, Borowitz JL, Isom GE.

J Neurosci Methods. 1995 Sep-Oct;61(1-2):15-21.

PMID:
8618413
44.

Accumulation of labeled cyanide in neuronal tissue.

Borowitz JL, Rathinavelu A, Kanthasamy A, Wilsbacher J, Isom GE.

Toxicol Appl Pharmacol. 1994 Nov;129(1):80-5.

PMID:
7974498
45.

Cyanide induces protein kinase C translocation: blockade by NMDA antagonists.

Rathinavelu A, Sun P, Pavlakovic G, Borowitz JL, Isom GE.

J Biochem Toxicol. 1994 Oct;9(5):235-40.

PMID:
7853358
46.

Dopaminergic neurotoxicity of cyanide: neurochemical, histological, and behavioral characterization.

Kanthasamy AG, Borowitz JL, Pavlakovic G, Isom GE.

Toxicol Appl Pharmacol. 1994 May;126(1):156-63.

PMID:
7910421
47.

Cyanide-induced lipid peroxidation in different organs: subcellular distribution and hydroperoxide generation in neuronal cells.

Ardelt BK, Borowitz JL, Maduh EU, Swain SL, Isom GE.

Toxicology. 1994 Apr 18;89(2):127-37.

PMID:
8197590
48.

Activation of a calcium- and pH-dependent phospholipase A2 by cyanide in PC12 cells.

Yang CW, Rathinavelu A, Borowitz JL, Isom GE.

Toxicol Appl Pharmacol. 1994 Feb;124(2):262-7.

PMID:
8122272
49.

Plasma membrane hyperpolarization by cyanide in chromaffin cells: role of potassium channels.

Latha MV, Borowitz JL, Yim GK, Kanthasamy A, Isom GE.

Arch Toxicol. 1994;68(6):370-4.

PMID:
8092929
50.

Interaction of cyanide with a dopamine metabolite: formation of a cyanohydrin adduct and its implications for cyanide-induced neurotoxicity.

Kanthasamy AG, Rathinavelu A, Borowitz JL, Isom GE.

Neurotoxicology. 1994 Winter;15(4):887-95.

PMID:
7715859

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