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Items: 1 to 50 of 148

1.

Grp78 Loss in Epithelial Progenitors Reveals an Age-linked Role for Endoplasmic Reticulum Stress in Pulmonary Fibrosis.

Borok Z, Horie M, Flodby P, Wang H, Liu Y, Ganesh S, Firth AL, Minoo P, Li C, Beers MF, Lee AS, Zhou B.

Am J Respir Crit Care Med. 2020 Jan 15;201(2):198-211. doi: 10.1164/rccm.201902-0451OC.

PMID:
31738079
2.

Transcriptional control of lung alveolar type 1 cell development and maintenance by NK homeobox 2-1.

Little DR, Gerner-Mauro KN, Flodby P, Crandall ED, Borok Z, Akiyama H, Kimura S, Ostrin EJ, Chen J.

Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20545-20555. doi: 10.1073/pnas.1906663116. Epub 2019 Sep 23.

PMID:
31548395
3.

Perspectives on Burnout from Pulmonary, Critical Care, and Sleep Medicine Division Directors.

Rinne ST, Swamy L, Anderson E, Shah T, Dixon AE, Kaminski N, Borok Z, Thomson CC.

Am J Respir Crit Care Med. 2020 Jan 1;201(1):111-114. doi: 10.1164/rccm.201906-1262LE. No abstract available.

PMID:
31469580
4.

Dichotomous roles of claudins as tumor promoters or suppressors: lessons from knockout mice.

Kage H, Flodby P, Zhou B, Borok Z.

Cell Mol Life Sci. 2019 Dec;76(23):4663-4672. doi: 10.1007/s00018-019-03238-7. Epub 2019 Jul 23. Review.

PMID:
31332482
5.

Secondary crest myofibroblast PDGFRα controls the elastogenesis pathway via a secondary tier of signaling networks during alveologenesis.

Li C, Lee MK, Gao F, Webster S, Di H, Duan J, Yang CY, Bhopal N, Peinado N, Pryhuber G, Smith SM, Borok Z, Bellusci S, Minoo P.

Development. 2019 Aug 9;146(15). pii: dev176354. doi: 10.1242/dev.176354.

PMID:
31331942
6.

Circulating angiotensin peptides levels in Acute Respiratory Distress Syndrome correlate with clinical outcomes: A pilot study.

Reddy R, Asante I, Liu S, Parikh P, Liebler J, Borok Z, Rodgers K, Baydur A, Louie SG.

PLoS One. 2019 Mar 7;14(3):e0213096. doi: 10.1371/journal.pone.0213096. eCollection 2019.

7.

LINC00261 Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response.

Shahabi S, Kumaran V, Castillo J, Cong Z, Nandagopal G, Mullen DJ, Alvarado A, Correa MR, Saizan A, Goel R, Bhat A, Lynch SK, Zhou B, Borok Z, Marconett CN.

Cancer Res. 2019 Jun 15;79(12):3050-3062. doi: 10.1158/0008-5472.CAN-18-2034. Epub 2019 Feb 22.

8.

CLDN18.1 attenuates malignancy and related signaling pathways of lung adenocarcinoma in vivo and in vitro.

Luo J, Chimge NO, Zhou B, Flodby P, Castaldi A, Firth AL, Liu Y, Wang H, Yang C, Marconett CN, Crandall ED, Offringa IA, Frenkel B, Borok Z.

Int J Cancer. 2018 Dec 15;143(12):3169-3180. doi: 10.1002/ijc.31734. Epub 2018 Oct 16.

9.

Positional integration of lung adenocarcinoma susceptibility loci with primary human alveolar epithelial cell epigenomes.

Yang C, Stueve TR, Yan C, Rhie SK, Mullen DJ, Luo J, Zhou B, Borok Z, Marconett CN, Offringa IA.

Epigenomics. 2018 Sep;10(9):1167-1187. doi: 10.2217/epi-2018-0003. Epub 2018 Sep 13.

10.

CISH is a negative regulator of IL-13-induced CCL26 production in lung fibroblasts.

Takeshima H, Horie M, Mikami Y, Makita K, Miyashita N, Matsuzaki H, Noguchi S, Urushiyama H, Hiraishi Y, Mitani A, Borok Z, Nagase T, Yamauchi Y.

Allergol Int. 2019 Jan;68(1):101-109. doi: 10.1016/j.alit.2018.08.005. Epub 2018 Sep 6.

11.

Addressing Gender Inequality in Our Disciplines: Report from the Association of Pulmonary, Critical Care, and Sleep Division Chiefs.

Thomson CC, Riekert KA, Bates CK, Jena AB, Borok Z, McCallister JW, Schnapp LM, Lama VN, Kraft M, Davis SD, Finn P, Carson SS, Beck JM, Powell CA, Tanoue LT, Kaminski N, Dixon AE.

Ann Am Thorac Soc. 2018 Dec;15(12):1382-1390. doi: 10.1513/AnnalsATS.201804-252AR.

PMID:
30153425
12.

Isolation of Rat and Mouse Alveolar Type II Epithelial Cells.

Jansing NL, McClendon J, Kage H, Sunohara M, Alvarez JR, Borok Z, Zemans RL.

Methods Mol Biol. 2018;1809:69-82. doi: 10.1007/978-1-4939-8570-8_6.

PMID:
29987783
13.

Alveolar epithelial cell processing of nanoparticles activates autophagy and lysosomal exocytosis.

Sipos A, Kim KJ, Chow RH, Flodby P, Borok Z, Crandall ED.

Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L286-L300. doi: 10.1152/ajplung.00108.2018. Epub 2018 May 3.

14.

Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis.

Zhou B, Flodby P, Luo J, Castillo DR, Liu Y, Yu FX, McConnell A, Varghese B, Li G, Chimge NO, Sunohara M, Koss MN, Elatre W, Conti P, Liebler JM, Yang C, Marconett CN, Laird-Offringa IA, Minoo P, Guan K, Stripp BR, Crandall ED, Borok Z.

J Clin Invest. 2018 Mar 1;128(3):970-984. doi: 10.1172/JCI90429. Epub 2018 Feb 5.

15.

Epigenome-wide analysis of DNA methylation in lung tissue shows concordance with blood studies and identifies tobacco smoke-inducible enhancers.

Stueve TR, Li WQ, Shi J, Marconett CN, Zhang T, Yang C, Mullen D, Yan C, Wheeler W, Hua X, Zhou B, Borok Z, Caporaso NE, Pesatori AC, Duan J, Laird-Offringa IA, Landi MT.

Hum Mol Genet. 2017 Aug 1;26(15):3014-3027. doi: 10.1093/hmg/ddx188.

16.

Platelet CLEC-2 protects against lung injury via effects of its ligand podoplanin on inflammatory alveolar macrophages in the mouse.

Lax S, Rayes J, Wichaiyo S, Haining EJ, Lowe K, Grygielska B, Laloo R, Flodby P, Borok Z, Crandall ED, Thickett DR, Watson SP.

Am J Physiol Lung Cell Mol Physiol. 2017 Dec 1;313(6):L1016-L1029. doi: 10.1152/ajplung.00023.2017. Epub 2017 Aug 24.

17.

Oligopeptide Transport in Rat Lung Alveolar Epithelial Cells is Mediated by Pept2.

Gukasyan HJ, Uchiyama T, Kim KJ, Ehrhardt C, Wu SK, Borok Z, Crandall ED, Lee VHL.

Pharm Res. 2017 Dec;34(12):2488-2497. doi: 10.1007/s11095-017-2234-z. Epub 2017 Aug 22.

PMID:
28831683
18.

Astrocytic tight junctions control inflammatory CNS lesion pathogenesis.

Horng S, Therattil A, Moyon S, Gordon A, Kim K, Argaw AT, Hara Y, Mariani JN, Sawai S, Flodby P, Crandall ED, Borok Z, Sofroniew MV, Chapouly C, John GR.

J Clin Invest. 2017 Aug 1;127(8):3136-3151. doi: 10.1172/JCI91301. Epub 2017 Jul 24.

19.

Wnt/β-catenin activation and macrophage induction during liver cancer development following steatosis.

Debebe A, Medina V, Chen CY, Mahajan IM, Jia C, Fu D, He L, Zeng N, Stiles BW, Chen CL, Wang M, Aggarwal KR, Peng Z, Huang J, Chen J, Li M, Dong T, Atkins S, Borok Z, Yuan W, Machida K, Ju C, Kahn M, Johnson D, Stiles BL.

Oncogene. 2017 Oct 26;36(43):6020-6029. doi: 10.1038/onc.2017.207. Epub 2017 Jul 3.

20.

Cell-specific expression of aquaporin-5 (Aqp5) in alveolar epithelium is directed by GATA6/Sp1 via histone acetylation.

Flodby P, Li C, Liu Y, Wang H, Rieger ME, Minoo P, Crandall ED, Ann DK, Borok Z, Zhou B.

Sci Rep. 2017 Jun 14;7(1):3473. doi: 10.1038/s41598-017-03152-7.

21.

Region-specific role for Pten in maintenance of epithelial phenotype and integrity.

Flodby P, Liebler JM, Sunohara M, Castillo DR, McConnell AM, Krishnaveni MS, Banfalvi A, Li M, Stripp B, Zhou B, Crandall ED, Minoo P, Borok Z.

Am J Physiol Lung Cell Mol Physiol. 2017 Jan 1;312(1):L131-L142. doi: 10.1152/ajplung.00005.2015. Epub 2016 Nov 18.

22.

IL-1R1-MyD88 axis elicits papain-induced lung inflammation.

Agoro R, Piotet-Morin J, Palomo J, Michaudel C, Vigne S, Maillet I, Chenuet P, Guillou N, Le Bérichel J, Kisielow M, Flodby P, Borok Z, Crandall ED, Le Bert M, Quesniaux V, Muller M, Di Padova F, Ryffel B, Gabay C, Couturier-Maillard A.

Eur J Immunol. 2016 Nov;46(11):2531-2541. doi: 10.1002/eji.201646366. Epub 2016 Sep 22.

23.

Cross-Species Transcriptome Profiling Identifies New Alveolar Epithelial Type I Cell-Specific Genes.

Marconett CN, Zhou B, Sunohara M, Pouldar TM, Wang H, Liu Y, Rieger ME, Tran E, Flodby P, Siegmund KD, Crandall ED, Laird-Offringa IA, Borok Z.

Am J Respir Cell Mol Biol. 2017 Mar;56(3):310-321. doi: 10.1165/rcmb.2016-0071OC.

24.

Pleiotropic Analysis of Lung Cancer and Blood Triglycerides.

Zuber V, Marconett CN, Shi J, Hua X, Wheeler W, Yang C, Song L, Dale AM, Laplana M, Risch A, Witoelar A, Thompson WK, Schork AJ, Bettella F, Wang Y, Djurovic S, Zhou B, Borok Z, van der Heijden HF, de Graaf J, Swinkels D, Aben KK, McKay J, Hung RJ, Bikeböller H, Stevens VL, Albanes D, Caporaso NE, Han Y, Wei Y, Panadero MA, Mayordomo JI, Christiani DC, Kiemeney L, Andreassen OA, Houlston R, Amos CI, Chatterjee N, Laird-Offringa IA, Mills IG, Landi MT.

J Natl Cancer Inst. 2016 Aug 26;108(12). pii: djw167. doi: 10.1093/jnci/djw167. Print 2016 Dec.

25.

The importance of detailed epigenomic profiling of different cell types within organs.

Stueve TR, Marconett CN, Zhou B, Borok Z, Laird-Offringa IA.

Epigenomics. 2016 Jun;8(6):817-29. doi: 10.2217/epi-2016-0005. Epub 2016 Jun 15. Review.

26.

Knockout Mice Reveal a Major Role for Alveolar Epithelial Type I Cells in Alveolar Fluid Clearance.

Flodby P, Kim YH, Beard LL, Gao D, Ji Y, Kage H, Liebler JM, Minoo P, Kim KJ, Borok Z, Crandall ED.

Am J Respir Cell Mol Biol. 2016 Sep;55(3):395-406. doi: 10.1165/rcmb.2016-0005OC.

27.

An American Thoracic Society Official Research Statement: Future Directions in Lung Fibrosis Research.

White ES, Borok Z, Brown KK, Eickelberg O, Guenther A, Jenkins RG, Kolb M, Martinez FJ, Roman J, Sime P; American Thoracic Society Respiratory Cell and Molecular Biology Assembly Working Group on Pulmonary Fibrosis.

Am J Respir Crit Care Med. 2016 Apr 1;193(7):792-800. doi: 10.1164/rccm.201602-0254ST.

28.

Mesodermal ALK5 controls lung myofibroblast versus lipofibroblast cell fate.

Li A, Ma S, Smith SM, Lee MK, Fischer A, Borok Z, Bellusci S, Li C, Minoo P.

BMC Biol. 2016 Mar 16;14:19. doi: 10.1186/s12915-016-0242-9.

29.

p300/β-Catenin Interactions Regulate Adult Progenitor Cell Differentiation Downstream of WNT5a/Protein Kinase C (PKC).

Rieger ME, Zhou B, Solomon N, Sunohara M, Li C, Nguyen C, Liu Y, Pan JH, Minoo P, Crandall ED, Brody SL, Kahn M, Borok Z.

J Biol Chem. 2016 Mar 18;291(12):6569-82. doi: 10.1074/jbc.M115.706416. Epub 2016 Feb 1.

30.

Transforming Growth Factor-β1 Induced Epithelial Mesenchymal Transition is blocked by a chemical antagonist of translation factor eIF4E.

Smith KA, Zhou B, Avdulov S, Benyumov A, Peterson M, Liu Y, Okon A, Hergert P, Braziunas J, Wagner CR, Borok Z, Bitterman PB.

Sci Rep. 2015 Dec 18;5:18233. doi: 10.1038/srep18233.

31.

Non-canonical WNT signalling in the lung.

Li C, Bellusci S, Borok Z, Minoo P.

J Biochem. 2015 Nov;158(5):355-65. doi: 10.1093/jb/mvv081. Epub 2015 Aug 10. Review.

32.

A fluid secretion pathway unmasked by acinar-specific Tmem16A gene ablation in the adult mouse salivary gland.

Catalán MA, Kondo Y, Peña-Munzenmayer G, Jaramillo Y, Liu F, Choi S, Crandall E, Borok Z, Flodby P, Shull GE, Melvin JE.

Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2263-8. doi: 10.1073/pnas.1415739112. Epub 2015 Feb 2.

33.

Progenitors of secondary crest myofibroblasts are developmentally committed in early lung mesoderm.

Li C, Li M, Li S, Xing Y, Yang CY, Li A, Borok Z, De Langhe S, Minoo P.

Stem Cells. 2015 Mar;33(3):999-1012. doi: 10.1002/stem.1911.

34.

Transcriptomic Profiling of Primary Alveolar Epithelial Cell Differentiation in Human and Rat.

Marconett CN, Zhou B, Siegmund KD, Borok Z, Laird-Offringa IA.

Genom Data. 2014 Dec 1;2:105-109.

35.

Dynamic involvement of ATG5 in cellular stress responses.

Lin HH, Lin SM, Chung Y, Vonderfecht S, Camden JM, Flodby P, Borok Z, Limesand KH, Mizushima N, Ann DK.

Cell Death Dis. 2014 Oct 23;5:e1478. doi: 10.1038/cddis.2014.428.

36.

Claudin 4 knockout mice: normal physiological phenotype with increased susceptibility to lung injury.

Kage H, Flodby P, Gao D, Kim YH, Marconett CN, DeMaio L, Kim KJ, Crandall ED, Borok Z.

Am J Physiol Lung Cell Mol Physiol. 2014 Oct 1;307(7):L524-36. doi: 10.1152/ajplung.00077.2014. Epub 2014 Aug 8.

37.

Alveolar epithelium: beyond the barrier.

Borok Z.

Am J Respir Cell Mol Biol. 2014 May;50(5):853-6. doi: 10.1165/rcmb.2014-0089PS.

38.

Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis.

Li G, Flodby P, Luo J, Kage H, Sipos A, Gao D, Ji Y, Beard LL, Marconett CN, DeMaio L, Kim YH, Kim KJ, Laird-Offringa IA, Minoo P, Liebler JM, Zhou B, Crandall ED, Borok Z.

Am J Respir Cell Mol Biol. 2014 Aug;51(2):210-22. doi: 10.1165/rcmb.2013-0353OC.

39.

Characterizing the genetic basis of methylome diversity in histologically normal human lung tissue.

Shi J, Marconett CN, Duan J, Hyland PL, Li P, Wang Z, Wheeler W, Zhou B, Campan M, Lee DS, Huang J, Zhou W, Triche T, Amundadottir L, Warner A, Hutchinson A, Chen PH, Chung BS, Pesatori AC, Consonni D, Bertazzi PA, Bergen AW, Freedman M, Siegmund KD, Berman BP, Borok Z, Chatterjee N, Tucker MA, Caporaso NE, Chanock SJ, Laird-Offringa IA, Landi MT.

Nat Commun. 2014 Feb 27;5:3365. doi: 10.1038/ncomms4365.

40.

Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report.

Blackwell TS, Tager AM, Borok Z, Moore BB, Schwartz DA, Anstrom KJ, Bar-Joseph Z, Bitterman P, Blackburn MR, Bradford W, Brown KK, Chapman HA, Collard HR, Cosgrove GP, Deterding R, Doyle R, Flaherty KR, Garcia CK, Hagood JS, Henke CA, Herzog E, Hogaboam CM, Horowitz JC, King TE Jr, Loyd JE, Lawson WE, Marsh CB, Noble PW, Noth I, Sheppard D, Olsson J, Ortiz LA, O'Riordan TG, Oury TD, Raghu G, Roman J, Sime PJ, Sisson TH, Tschumperlin D, Violette SM, Weaver TE, Wells RG, White ES, Kaminski N, Martinez FJ, Wynn TA, Thannickal VJ, Eu JP.

Am J Respir Crit Care Med. 2014 Jan 15;189(2):214-22. doi: 10.1164/rccm.201306-1141WS.

41.

Deletion of ATG5 shows a role of autophagy in salivary homeostatic control.

Morgan-Bathke M, Lin HH, Chibly AM, Zhang W, Sun X, Chen CH, Flodby P, Borok Z, Wu R, Arnett D, Klein RR, Ann DK, Limesand KH.

J Dent Res. 2013 Oct;92(10):911-7. doi: 10.1177/0022034513499350. Epub 2013 Jul 24.

42.

Integrated transcriptomic and epigenomic analysis of primary human lung epithelial cell differentiation.

Marconett CN, Zhou B, Rieger ME, Selamat SA, Dubourd M, Fang X, Lynch SK, Stueve TR, Siegmund KD, Berman BP, Borok Z, Laird-Offringa IA.

PLoS Genet. 2013 Jun;9(6):e1003513. doi: 10.1371/journal.pgen.1003513. Epub 2013 Jun 20.

43.

Tissue-dependent consequences of Apc inactivation on proliferation and differentiation of ciliated cell progenitors via Wnt and notch signaling.

Li A, Chan B, Felix JC, Xing Y, Li M, Brody SL, Borok Z, Li C, Minoo P.

PLoS One. 2013 Apr 30;8(4):e62215. doi: 10.1371/journal.pone.0062215. Print 2013.

44.

Apc deficiency alters pulmonary epithelial cell fate and inhibits Nkx2.1 via triggering TGF-beta signaling.

Li C, Li A, Xing Y, Li M, Chan B, Ouyang R, Taketo MM, Kucherlapati R, Borok Z, Minoo P.

Dev Biol. 2013 Jun 1;378(1):13-24. doi: 10.1016/j.ydbio.2013.03.018. Epub 2013 Apr 3.

45.

Nanoparticle translocation across mouse alveolar epithelial cell monolayers: species-specific mechanisms.

Fazlollahi F, Kim YH, Sipos A, Hamm-Alvarez SF, Borok Z, Kim KJ, Crandall ED.

Nanomedicine. 2013 Aug;9(6):786-94. doi: 10.1016/j.nano.2013.01.007. Epub 2013 Feb 20.

46.

Aqp5 is a new transcriptional target of Dot1a and a regulator of Aqp2.

Wu H, Chen L, Zhang X, Zhou Q, Li JM, Berger S, Borok Z, Zhou B, Xiao Z, Yin H, Liu M, Wang Y, Jin J, Blackburn MR, Xia Y, Zhang W.

PLoS One. 2013;8(1):e53342. doi: 10.1371/journal.pone.0053342. Epub 2013 Jan 10.

47.

Mesodermal Pten inactivation leads to alveolar capillary dysplasia- like phenotype.

Tiozzo C, Carraro G, Al Alam D, Baptista S, Danopoulos S, Li A, Lavarreda-Pearce M, Li C, De Langhe S, Chan B, Borok Z, Bellusci S, Minoo P.

J Clin Invest. 2012 Nov;122(11):3862-72.

48.

EMT and interstitial lung disease: a mysterious relationship.

Kage H, Borok Z.

Curr Opin Pulm Med. 2012 Sep;18(5):517-23. doi: 10.1097/MCP.0b013e3283566721. Review.

49.

Troglitazone attenuates TGF-β1-induced EMT in alveolar epithelial cells via a PPARγ-independent mechanism.

Zhou B, Buckley ST, Patel V, Liu Y, Luo J, Krishnaveni MS, Ivan M, DeMaio L, Kim KJ, Ehrhardt C, Crandall ED, Borok Z.

PLoS One. 2012;7(6):e38827. doi: 10.1371/journal.pone.0038827. Epub 2012 Jun 20.

50.

Cigarette smoke extract stimulates epithelial-mesenchymal transition through Src activation.

Zhang H, Liu H, Borok Z, Davies KJ, Ursini F, Forman HJ.

Free Radic Biol Med. 2012 Apr 15;52(8):1437-42. doi: 10.1016/j.freeradbiomed.2012.01.024. Epub 2012 Feb 4.

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