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Items: 1 to 50 of 220

1.

A marine bacterial enzymatic cascade degrades the algal polysaccharide ulvan.

Reisky L, Préchoux A, Zühlke MK, Bäumgen M, Robb CS, Gerlach N, Roret T, Stanetty C, Larocque R, Michel G, Song T, Markert S, Unfried F, Mihovilovic MD, Trautwein-Schult A, Becher D, Schweder T, Bornscheuer UT, Hehemann JH.

Nat Chem Biol. 2019 Aug;15(8):803-812. doi: 10.1038/s41589-019-0311-9. Epub 2019 Jul 8.

PMID:
31285597
2.

Structure of the plastic-degrading Ideonella sakaiensis MHETase bound to a substrate.

Palm GJ, Reisky L, Böttcher D, Müller H, Michels EAP, Walczak MC, Berndt L, Weiss MS, Bornscheuer UT, Weber G.

Nat Commun. 2019 Apr 12;10(1):1717. doi: 10.1038/s41467-019-09326-3.

3.

A Retro-biosynthesis-Based Route to Generate Pinene-Derived Polyesters.

Stamm A, Biundo A, Schmidt B, Brücher J, Lundmark S, Olsén P, Fogelström L, Malmström E, Bornscheuer UT, Syrén PO.

Chembiochem. 2019 Feb 22. doi: 10.1002/cbic.201900046. [Epub ahead of print]

PMID:
30793830
4.

(Chemo-) enzymatic cascade reactions.

Bornscheuer UT.

Z Naturforsch C. 2019 Feb 25;74(3-4):61-62. doi: 10.1515/znc-2019-0016. No abstract available.

PMID:
30739100
5.

A multi-enzyme cascade reaction for the production of 6-hydroxyhexanoic acid.

Srinivasamurthy VST, Böttcher D, Bornscheuer UT.

Z Naturforsch C. 2019 Feb 25;74(3-4):71-76. doi: 10.1515/znc-2018-0216.

PMID:
30685749
6.

One-Pot Bioconversion of l-Arabinose to l-Ribulose in an Enzymatic Cascade.

Chuaboon L, Wongnate T, Punthong P, Kiattisewee C, Lawan N, Hsu CY, Lin CH, Bornscheuer UT, Chaiyen P.

Angew Chem Int Ed Engl. 2019 Feb 18;58(8):2428-2432. doi: 10.1002/anie.201814219. Epub 2019 Jan 29.

PMID:
30605256
7.

Alteration of Chain Length Selectivity of Candida antarctica Lipase A by Semi-Rational Design for the Enrichment of Erucic and Gondoic Fatty Acids.

Zorn K, Oroz-Guinea I, Brundiek H, Dörr M, Bornscheuer UT.

Adv Synth Catal. 2018 Nov 5;360(21):4115-4131. doi: 10.1002/adsc.201800889. Epub 2018 Sep 26.

8.

Directed Evolution Empowered Redesign of Natural Proteins for the Sustainable Production of Chemicals and Pharmaceuticals.

Bornscheuer UT, Hauer B, Jaeger KE, Schwaneberg U.

Angew Chem Int Ed Engl. 2019 Jan 2;58(1):36-40. doi: 10.1002/anie.201812717. Epub 2018 Dec 6. Review.

PMID:
30520553
9.

Specificity and mechanism of carbohydrate demethylation by cytochrome P450 monooxygenases.

Robb CS, Reisky L, Bornscheuer UT, Hehemann JH.

Biochem J. 2018 Dec 12;475(23):3875-3886. doi: 10.1042/BCJ20180762.

10.

Biocompatible metal-assisted C-C cross-coupling combined with biocatalytic chiral reductions in a concurrent tandem cascade.

Schaaf P, Bayer T, Koley M, Schnürch M, Bornscheuer UT, Rudroff F, Mihovilovic MD.

Chem Commun (Camb). 2018 Nov 15;54(92):12978-12981. doi: 10.1039/c8cc05304a.

PMID:
30383064
11.

Combination of the Suzuki-Miyaura Cross-Coupling Reaction with Engineered Transaminases.

Dawood AWH, Bassut J, de Souza ROMA, Bornscheuer UT.

Chemistry. 2018 Oct 26;24(60):16009-16013. doi: 10.1002/chem.201804366. Epub 2018 Oct 4.

PMID:
30156347
12.

Protein Engineering of the Progesterone Hydroxylating P450-Monooxygenase CYP17A1 Alters Its Regioselectivity.

Morlock LK, Grobe S, Balke K, Mauersberger S, Böttcher D, Bornscheuer UT.

Chembiochem. 2018 Sep 17;19(18):1954-1958. doi: 10.1002/cbic.201800371. Epub 2018 Aug 7.

PMID:
29981252
13.

Biochemical characterization of an ulvan lyase from the marine flavobacterium Formosa agariphila KMM 3901T.

Reisky L, Stanetty C, Mihovilovic MD, Schweder T, Hehemann JH, Bornscheuer UT.

Appl Microbiol Biotechnol. 2018 Aug;102(16):6987-6996. doi: 10.1007/s00253-018-9142-y. Epub 2018 Jun 12.

PMID:
29948117
14.

The oxygenating constituent of 3,6-diketocamphane monooxygenase from the CAM plasmid of Pseudomonas putida: the first crystal structure of a type II Baeyer-Villiger monooxygenase. Corrigendum.

Isupov MN, Schröder E, Gibson RP, Beecher J, Donadio G, Saneei V, Dcunha SA, McGhie EJ, Sayer C, Davenport CF, Lau PCK, Hasegawa Y, Iwaki H, Kadow M, Balke K, Bornscheuer UT, Bourenkov G, Littlechild JA.

Acta Crystallogr D Struct Biol. 2018 Apr 1;74(Pt 4):379. doi: 10.1107/S205979831800150X. Epub 2018 Apr 6.

PMID:
29652264
15.

Publisher Correction: Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases.

Reisky L, Büchsenschütz HC, Engel J, Song T, Schweder T, Hehemann JH, Bornscheuer UT.

Nat Chem Biol. 2018 Sep;14(9):902. doi: 10.1038/s41589-018-0020-9.

PMID:
29520043
16.

Oxidative demethylation of algal carbohydrates by cytochrome P450 monooxygenases.

Reisky L, Büchsenschütz HC, Engel J, Song T, Schweder T, Hehemann JH, Bornscheuer UT.

Nat Chem Biol. 2018 Apr;14(4):342-344. doi: 10.1038/s41589-018-0005-8. Epub 2018 Feb 19. Erratum in: Nat Chem Biol. 2018 Mar 8;:.

PMID:
29459682
17.

Getting Momentum: From Biocatalysis to Advanced Synthetic Biology.

Badenhorst CPS, Bornscheuer UT.

Trends Biochem Sci. 2018 Mar;43(3):180-198. doi: 10.1016/j.tibs.2018.01.003. Epub 2018 Feb 6. Review.

PMID:
29426712
18.

Enzymes in Lipid Modification.

Bornscheuer UT.

Annu Rev Food Sci Technol. 2018 Mar 25;9:85-103. doi: 10.1146/annurev-food-030117-012336. Epub 2018 Jan 18.

PMID:
29350562
19.

Baeyer-Villiger monooxygenases from Yarrowia lipolytica catalyze preferentially sulfoxidations.

Bordewick S, Beier A, Balke K, Bornscheuer UT.

Enzyme Microb Technol. 2018 Feb;109:31-42. doi: 10.1016/j.enzmictec.2017.09.008. Epub 2017 Sep 20.

PMID:
29224624
20.

The fourth wave of biocatalysis is approaching.

Bornscheuer UT.

Philos Trans A Math Phys Eng Sci. 2018 Jan 13;376(2110). pii: 20170063. doi: 10.1098/rsta.2017.0063. Review.

PMID:
29175831
21.

Hot spots for the protein engineering of Baeyer-Villiger monooxygenases.

Balke K, Beier A, Bornscheuer UT.

Biotechnol Adv. 2018 Jan - Feb;36(1):247-263. doi: 10.1016/j.biotechadv.2017.11.007. Epub 2017 Nov 22. Review.

PMID:
29174001
22.

Simultaneous detection of NADPH consumption and H2O2 production using the Ampliflu™ Red assay for screening of P450 activities and uncoupling.

Morlock LK, Böttcher D, Bornscheuer UT.

Appl Microbiol Biotechnol. 2018 Jan;102(2):985-994. doi: 10.1007/s00253-017-8636-3. Epub 2017 Nov 17.

PMID:
29150709
23.

Co-expression of an alcohol dehydrogenase and a cyclohexanone monooxygenase for cascade reactions facilitates the regeneration of the NADPH cofactor.

Kohl A, Srinivasamurthy V, Böttcher D, Kabisch J, Bornscheuer UT.

Enzyme Microb Technol. 2018 Jan;108:53-58. doi: 10.1016/j.enzmictec.2017.09.003. Epub 2017 Sep 11.

PMID:
29108627
24.

Solid-Phase Agar Plate Assay for Screening Amine Transaminases.

Weiß MS, Bornscheuer UT, Höhne M.

Methods Mol Biol. 2018;1685:283-296. doi: 10.1007/978-1-4939-7366-8_17.

PMID:
29086316
25.

Program-Guided Design of High-Throughput Enzyme Screening Experiments and Automated Data Analysis/Evaluation.

Dörr M, Bornscheuer UT.

Methods Mol Biol. 2018;1685:269-282. doi: 10.1007/978-1-4939-7366-8_16.

PMID:
29086315
26.

Normalized Screening of Protein Engineering Libraries by Split-GFP Crude Cell Extract Quantification.

Santos-Aberturas J, Dörr M, Bornscheuer UT.

Methods Mol Biol. 2018;1685:157-170. doi: 10.1007/978-1-4939-7366-8_9.

PMID:
29086308
27.

Library Growth and Protein Expression: Optimal and Reproducible Microtiter Plate Expression of Recombinant Enzymes in E. coli Using MTP Shakers.

Schmidt S, Dörr M, Bornscheuer UT.

Methods Mol Biol. 2018;1685:145-156. doi: 10.1007/978-1-4939-7366-8_8.

PMID:
29086307
28.

Alkene hydrogenation activity of enoate reductases for an environmentally benign biosynthesis of adipic acid.

Joo JC, Khusnutdinova AN, Flick R, Kim T, Bornscheuer UT, Yakunin AF, Mahadevan R.

Chem Sci. 2017 Feb 1;8(2):1406-1413. doi: 10.1039/c6sc02842j. Epub 2016 Oct 11.

29.

CorNet: Assigning function to networks of co-evolving residues by automated literature mining.

van den Bergh T, Tamo G, Nobili A, Tao Y, Tan T, Bornscheuer UT, Kuipers RKP, Vroling B, de Jong RM, Subramanian K, Schaap PJ, Desmet T, Nidetzky B, Vriend G, Joosten HJ.

PLoS One. 2017 May 18;12(5):e0176427. doi: 10.1371/journal.pone.0176427. eCollection 2017.

30.

Multiple States of Nitrile Hydratase from Rhodococcus equi TG328-2: Structural and Mechanistic Insights from Electron Paramagnetic Resonance and Density Functional Theory Studies.

Stein N, Gumataotao N, Hajnas N, Wu R, Lankathilaka KPW, Bornscheuer UT, Liu D, Fiedler AT, Holz RC, Bennett B.

Biochemistry. 2017 Jun 20;56(24):3068-3077. doi: 10.1021/acs.biochem.6b00876. Epub 2017 Jun 2.

31.

A Retrosynthesis Approach for Biocatalysis in Organic Synthesis.

de Souza ROMA, Miranda LSM, Bornscheuer UT.

Chemistry. 2017 Sep 7;23(50):12040-12063. doi: 10.1002/chem.201702235. Epub 2017 Jun 22. Review.

PMID:
28514518
32.

Controlling the Regioselectivity of Baeyer-Villiger Monooxygenases by Mutation of Active-Site Residues.

Balke K, Bäumgen M, Bornscheuer UT.

Chembiochem. 2017 Aug 17;18(16):1627-1638. doi: 10.1002/cbic.201700223. Epub 2017 Jun 26.

PMID:
28504873
33.

Amine Transaminase Engineering for Spatially Bulky Substrate Acceptance.

Weiß MS, Pavlidis IV, Spurr P, Hanlon SP, Wirz B, Iding H, Bornscheuer UT.

Chembiochem. 2017 Jun 1;18(11):1022-1026. doi: 10.1002/cbic.201700033. Epub 2017 Apr 27.

PMID:
28334484
34.

First chemo-enzymatic synthesis of the (R)-Taniguchi lactone and substrate profiles of CAMO and OTEMO, two new Baeyer-Villiger monooxygenases.

Rudroff F, Fink MJ, Pydi R, Bornscheuer UT, Mihovilovic MD.

Monatsh Chem. 2017;148(1):157-165. doi: 10.1007/s00706-016-1873-9. Epub 2016 Dec 21.

35.

Kinetic insights into ϵ-caprolactone synthesis: Improvement of an enzymatic cascade reaction.

Scherkus C, Schmidt S, Bornscheuer UT, Gröger H, Kara S, Liese A.

Biotechnol Bioeng. 2017 Jun;114(6):1215-1221. doi: 10.1002/bit.26258. Epub 2017 Mar 14.

PMID:
28112389
36.

Biotransformation and reduction of estrogenicity of bisphenol A by the biphenyl-degrading Cupriavidus basilensis.

Zühlke MK, Schlüter R, Mikolasch A, Zühlke D, Giersberg M, Schindler H, Henning AK, Frenzel H, Hammer E, Lalk M, Bornscheuer UT, Riedel K, Kunze G, Schauer F.

Appl Microbiol Biotechnol. 2017 May;101(9):3743-3758. doi: 10.1007/s00253-016-8061-z. Epub 2017 Jan 3.

PMID:
28050635
37.

Chemical biology: A radical change in enzyme catalysis.

Bornscheuer UT.

Nature. 2016 Dec 14;540(7633):345-346. doi: 10.1038/540345a. No abstract available.

PMID:
27974776
38.

A Microtiter Plate-Based Assay to Screen for Active and Stereoselective Hydrolytic Enzymes in Enzyme Libraries.

Böttcher D, Zägel P, Schmidt M, Bornscheuer UT.

Methods Mol Biol. 2017;1539:197-204.

PMID:
27900690
39.

Protein-engineering of an amine transaminase for the stereoselective synthesis of a pharmaceutically relevant bicyclic amine.

Weiß MS, Pavlidis IV, Spurr P, Hanlon SP, Wirz B, Iding H, Bornscheuer UT.

Org Biomol Chem. 2016 Nov 2;14(43):10249-10254.

PMID:
27739550
40.

Structural Basis for Phospholyase Activity of a Class III Transaminase Homologue.

Cuetos A, Steffen-Munsberg F, Mangas Sanchez J, Frese A, Bornscheuer UT, Höhne M, Grogan G.

Chembiochem. 2016 Dec 14;17(24):2308-2311. doi: 10.1002/cbic.201600482. Epub 2016 Oct 31.

PMID:
27709756
41.

Bioinformatic analysis of fold-type III PLP-dependent enzymes discovers multimeric racemases.

Knight AM, Nobili A, van den Bergh T, Genz M, Joosten HJ, Albrecht D, Riedel K, Pavlidis IV, Bornscheuer UT.

Appl Microbiol Biotechnol. 2017 Feb;101(4):1499-1507. doi: 10.1007/s00253-016-7940-7. Epub 2016 Oct 27.

PMID:
27787586
42.

Identification of (S)-selective transaminases for the asymmetric synthesis of bulky chiral amines.

Pavlidis IV, Weiß MS, Genz M, Spurr P, Hanlon SP, Wirz B, Iding H, Bornscheuer UT.

Nat Chem. 2016 Nov;8(11):1076-1082. doi: 10.1038/nchem.2578. Epub 2016 Jul 18.

PMID:
27768108
43.

Switch in Cofactor Specificity of a Baeyer-Villiger Monooxygenase.

Beier A, Bordewick S, Genz M, Schmidt S, van den Bergh T, Peters C, Joosten HJ, Bornscheuer UT.

Chembiochem. 2016 Dec 14;17(24):2312-2315. doi: 10.1002/cbic.201600484. Epub 2016 Nov 9.

PMID:
27735116
44.

3'-UTR engineering to improve soluble expression and fine-tuning of activity of cascade enzymes in Escherichia coli.

Song JW, Woo JM, Jung GY, Bornscheuer UT, Park JB.

Sci Rep. 2016 Jul 11;6:29406. doi: 10.1038/srep29406.

45.

Engineering and application of enzymes for lipid modification, an update.

Zorn K, Oroz-Guinea I, Brundiek H, Bornscheuer UT.

Prog Lipid Res. 2016 Jul;63:153-64. doi: 10.1016/j.plipres.2016.06.001. Epub 2016 Jun 11. Review.

PMID:
27301784
46.

Fast, Continuous, and High-Throughput (Bio)Chemical Activity Assay for N-Acyl-l-Homoserine Lactone Quorum-Quenching Enzymes.

Last D, Krüger GH, Dörr M, Bornscheuer UT.

Appl Environ Microbiol. 2016 Jun 30;82(14):4145-54. doi: 10.1128/AEM.00830-16. Print 2016 Jul 15.

47.

MICROBIOLOGY. Feeding on plastic.

Bornscheuer UT.

Science. 2016 Mar 11;351(6278):1154-5. doi: 10.1126/science.aaf2853. No abstract available.

PMID:
26965614
48.

Bacillus anthracis ω-amino acid:pyruvate transaminase employs a different mechanism for dual substrate recognition than other amine transaminases.

Steffen-Munsberg F, Matzel P, Sowa MA, Berglund P, Bornscheuer UT, Höhne M.

Appl Microbiol Biotechnol. 2016 May;100(10):4511-21. doi: 10.1007/s00253-015-7275-9. Epub 2016 Jan 21.

PMID:
26795966
49.

Fully automatized high-throughput enzyme library screening using a robotic platform.

Dörr M, Fibinger MP, Last D, Schmidt S, Santos-Aberturas J, Böttcher D, Hummel A, Vickers C, Voss M, Bornscheuer UT.

Biotechnol Bioeng. 2016 Jul;113(7):1421-32. doi: 10.1002/bit.25925. Epub 2016 Feb 3.

PMID:
26724475
50.

Highly efficient and easy protease-mediated protein purification.

Last D, Müller J, Dawood AW, Moldenhauer EJ, Pavlidis IV, Bornscheuer UT.

Appl Microbiol Biotechnol. 2016 Feb;100(4):1945-53. doi: 10.1007/s00253-015-7206-9. Epub 2015 Dec 16.

PMID:
26671615

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