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Items: 1 to 50 of 226

1.

Glutathione peroxidase 4 and vitamin E control reticulocyte maturation, stress erythropoiesis and iron homeostasis.

Altamura S, Vegi NM, Hoppe PS, Schroeder T, Aichler M, Walch A, Okreglicka K, Hültner L, Schneider M, Ladinig C, Kuklik-Roos C, Mysliwietz J, Janik D, Neff F, Rathkolb B, Hrabé de Angelis M, Buske C, da Silva AR, Muedder K, Conrad M, Ganz T, Kopf M, Muckenthaler MU, Bornkamm GW.

Haematologica. 2019 Jun 27. pii: haematol.2018.212977. doi: 10.3324/haematol.2018.212977. [Epub ahead of print]

2.

The thioredoxin-1 and glutathione/glutaredoxin-1 systems redundantly fuel murine B-cell development and responses.

Muri J, Thut H, Heer S, Krueger CC, Bornkamm GW, Bachmann MF, Kopf M.

Eur J Immunol. 2019 May;49(5):709-723. doi: 10.1002/eji.201848044. Epub 2019 Mar 1.

PMID:
30802940
3.

Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors.

Canli Ö, Alankuş YB, Grootjans S, Vegi N, Hültner L, Hoppe PS, Schroeder T, Vandenabeele P, Bornkamm GW, Greten FR.

Blood. 2016 Jan 7;127(1):139-48. doi: 10.1182/blood-2015-06-654194. Epub 2015 Oct 13.

4.

T cell lipid peroxidation induces ferroptosis and prevents immunity to infection.

Matsushita M, Freigang S, Schneider C, Conrad M, Bornkamm GW, Kopf M.

J Exp Med. 2015 Apr 6;212(4):555-68. doi: 10.1084/jem.20140857. Epub 2015 Mar 30.

5.

Elevation of c-MYC disrupts HLA class II-mediated immune recognition of human B cell tumors.

God JM, Cameron C, Figueroa J, Amria S, Hossain A, Kempkes B, Bornkamm GW, Stuart RK, Blum JS, Haque A.

J Immunol. 2015 Feb 15;194(4):1434-45. doi: 10.4049/jimmunol.1402382. Epub 2015 Jan 16.

6.

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice.

Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A, Eggenhofer E, Basavarajappa D, Rådmark O, Kobayashi S, Seibt T, Beck H, Neff F, Esposito I, Wanke R, Förster H, Yefremova O, Heinrichmeyer M, Bornkamm GW, Geissler EK, Thomas SB, Stockwell BR, O'Donnell VB, Kagan VE, Schick JA, Conrad M.

Nat Cell Biol. 2014 Dec;16(12):1180-91. doi: 10.1038/ncb3064. Epub 2014 Nov 17.

7.

Virus and autoantigen-specific CD4+ T cells are key effectors in a SCID mouse model of EBV-associated post-transplant lymphoproliferative disorders.

Linnerbauer S, Behrends U, Adhikary D, Witter K, Bornkamm GW, Mautner J.

PLoS Pathog. 2014 May 22;10(5):e1004068. doi: 10.1371/journal.ppat.1004068. eCollection 2014 May.

8.

Targeting high-grade B cell lymphoma with CD19-specific T cells.

Lehmann FM, Maurberger A, Feicht S, Helm F, Ladinig C, Kieback E, Uckert W, Kammertöns T, Kremmer E, Mautner J, Gerbitz A, Bornkamm GW.

Int J Cancer. 2014 Sep 1;135(5):1153-64. doi: 10.1002/ijc.28760. Epub 2014 Feb 20.

9.

Targeting c-MYC with T-cells.

Helm F, Kammertoens T, Lehmann FM, Wilke A, Bruns H, Mautner J, Bornkamm GW, Gerbitz A.

PLoS One. 2013 Oct 10;8(10):e77375. doi: 10.1371/journal.pone.0077375. eCollection 2013.

10.

Combined deficiency in glutathione peroxidase 4 and vitamin E causes multiorgan thrombus formation and early death in mice.

Wortmann M, Schneider M, Pircher J, Hellfritsch J, Aichler M, Vegi N, Kölle P, Kuhlencordt P, Walch A, Pohl U, Bornkamm GW, Conrad M, Beck H.

Circ Res. 2013 Aug 2;113(4):408-17. doi: 10.1161/CIRCRESAHA.113.279984. Epub 2013 Jun 14.

PMID:
23770613
11.

AP4 is a mediator of epithelial-mesenchymal transition and metastasis in colorectal cancer.

Jackstadt R, Röh S, Neumann J, Jung P, Hoffmann R, Horst D, Berens C, Bornkamm GW, Kirchner T, Menssen A, Hermeking H.

J Exp Med. 2013 Jul 1;210(7):1331-50. doi: 10.1084/jem.20120812. Epub 2013 Jun 10.

12.

Humanized c-Myc mouse.

Lehmann FM, Feicht S, Helm F, Maurberger A, Ladinig C, Zimber-Strobl U, Kühn R, Mautner J, Gerbitz A, Bornkamm GW.

PLoS One. 2012;7(7):e42021. doi: 10.1371/journal.pone.0042021. Epub 2012 Jul 31.

13.

Burkitt lymphoma: the role of Epstein-Barr virus revisited.

Grömminger S, Mautner J, Bornkamm GW.

Br J Haematol. 2012 Mar;156(6):719-29. Review. No abstract available.

PMID:
22482131
14.

Stromal interferon-γ signaling and cross-presentation are required to eliminate antigen-loss variants of B cell lymphomas in mice.

Gerbitz A, Sukumar M, Helm F, Wilke A, Friese C, Fahrenwaldt C, Lehmann FM, Loddenkemper C, Kammertoens T, Mautner J, Schmitt CA, Blankenstein T, Bornkamm GW.

PLoS One. 2012;7(3):e34552. doi: 10.1371/journal.pone.0034552. Epub 2012 Mar 30.

15.

Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesis.

Nilsson LM, Forshell TZ, Rimpi S, Kreutzer C, Pretsch W, Bornkamm GW, Nilsson JA.

PLoS Genet. 2012;8(3):e1002573. doi: 10.1371/journal.pgen.1002573. Epub 2012 Mar 15.

16.

B-cell-specific elements enhance sustained gene expression mediated by self-replicating extrachromosomal vectors.

Zehnpfennig D, Deissler H, Polack A, Herr D, Bornkamm GW, Kurzeder C.

Mol Med Rep. 2010 Jul-Aug;3(4):689-92. doi: 10.3892/mmr_00000318.

PMID:
21472300
17.

The role of virus-specific CD4+ T cells in the control of Epstein-Barr virus infection.

Mautner J, Bornkamm GW.

Eur J Cell Biol. 2012 Jan;91(1):31-5. doi: 10.1016/j.ejcb.2011.01.007. Epub 2011 Apr 1. Review.

PMID:
21458882
18.

Mutations in the mitochondrial thioredoxin reductase gene TXNRD2 cause dilated cardiomyopathy.

Sibbing D, Pfeufer A, Perisic T, Mannes AM, Fritz-Wolf K, Unwin S, Sinner MF, Gieger C, Gloeckner CJ, Wichmann HE, Kremmer E, Schäfer Z, Walch A, Hinterseer M, Näbauer M, Kääb S, Kastrati A, Schömig A, Meitinger T, Bornkamm GW, Conrad M, von Beckerath N.

Eur Heart J. 2011 May;32(9):1121-33. doi: 10.1093/eurheartj/ehq507. Epub 2011 Jan 18.

PMID:
21247928
19.

Loss of thioredoxin reductase 1 renders tumors highly susceptible to pharmacologic glutathione deprivation.

Mandal PK, Schneider M, Kölle P, Kuhlencordt P, Förster H, Beck H, Bornkamm GW, Conrad M.

Cancer Res. 2010 Nov 15;70(22):9505-14. doi: 10.1158/0008-5472.CAN-10-1509. Epub 2010 Nov 2.

20.

Identification of MHC II-restricted minor histocompatibility antigens after HLA-identical stem-cell transplantation.

Milosevic S, Bachnick B, Karim K, Bornkamm GW, Witter K, Gerbitz A, Mautner J, Behrends U.

Transplantation. 2010 Nov 15;90(9):1030-5. doi: 10.1097/TP.0b013e3181f5470c.

PMID:
20802400
21.

12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases.

Conrad M, Sandin A, Förster H, Seiler A, Frijhoff J, Dagnell M, Bornkamm GW, Rådmark O, Hooft van Huijsduijnen R, Aspenström P, Böhmer F, Ostman A.

Proc Natl Acad Sci U S A. 2010 Sep 7;107(36):15774-9. doi: 10.1073/pnas.1007909107. Epub 2010 Aug 23.

22.

System x(c)- and thioredoxin reductase 1 cooperatively rescue glutathione deficiency.

Mandal PK, Seiler A, Perisic T, Kölle P, Banjac Canak A, Förster H, Weiss N, Kremmer E, Lieberman MW, Bannai S, Kuhlencordt P, Sato H, Bornkamm GW, Conrad M.

J Biol Chem. 2010 Jul 16;285(29):22244-53. doi: 10.1074/jbc.M110.121327. Epub 2010 May 12.

23.

STAT1-dependent IgG cell-surface expression in a human B cell line derived from a STAT1-deficient patient.

Najjar I, Deglesne PA, Schischmanoff PO, Fabre EE, Boisson-Dupuis S, Nimmerjahn F, Bornkamm GW, Dusanter-Fourt I, Fagard R.

J Leukoc Biol. 2010 Jun;87(6):1145-52. doi: 10.1189/jlb.1109714. Epub 2010 Mar 3.

PMID:
20200400
24.

Requirements for control of B-cell lymphoma by NK cells.

Brenner CD, King S, Przewoznik M, Wolters I, Adam C, Bornkamm GW, Busch DH, Röcken M, Mocikat R.

Eur J Immunol. 2010 Feb;40(2):494-504. doi: 10.1002/eji.200939937.

25.

Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration.

Wirth EK, Conrad M, Winterer J, Wozny C, Carlson BA, Roth S, Schmitz D, Bornkamm GW, Coppola V, Tessarollo L, Schomburg L, Köhrle J, Hatfield DL, Schweizer U.

FASEB J. 2010 Mar;24(3):844-52. doi: 10.1096/fj.09-143974. Epub 2009 Nov 4.

26.

Epstein-Barr virus and its role in the pathogenesis of Burkitt's lymphoma: an unresolved issue.

Bornkamm GW.

Semin Cancer Biol. 2009 Dec;19(6):351-65. doi: 10.1016/j.semcancer.2009.07.002. Epub 2009 Jul 18. Review.

PMID:
19619654
27.

An Epstein-Barr virus anti-apoptotic protein constitutively expressed in transformed cells and implicated in burkitt lymphomagenesis: the Wp/BHRF1 link.

Kelly GL, Long HM, Stylianou J, Thomas WA, Leese A, Bell AI, Bornkamm GW, Mautner J, Rickinson AB, Rowe M.

PLoS Pathog. 2009 Mar;5(3):e1000341. doi: 10.1371/journal.ppat.1000341. Epub 2009 Mar 13.

28.

c-Myc and Rel/NF-kappaB are the two master transcriptional systems activated in the latency III program of Epstein-Barr virus-immortalized B cells.

Faumont N, Durand-Panteix S, Schlee M, Grömminger S, Schuhmacher M, Hölzel M, Laux G, Mailhammer R, Rosenwald A, Staudt LM, Bornkamm GW, Feuillard J.

J Virol. 2009 May;83(10):5014-27. doi: 10.1128/JVI.02264-08. Epub 2009 Mar 4.

29.

Epstein-Barr virus and the pathogenesis of Burkitt's lymphoma: more questions than answers.

Bornkamm GW.

Int J Cancer. 2009 Apr 15;124(8):1745-55. doi: 10.1002/ijc.24223. Review.

30.

Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death.

Seiler A, Schneider M, Förster H, Roth S, Wirth EK, Culmsee C, Plesnila N, Kremmer E, Rådmark O, Wurst W, Bornkamm GW, Schweizer U, Conrad M.

Cell Metab. 2008 Sep;8(3):237-48. doi: 10.1016/j.cmet.2008.07.005.

31.

Novel function of STAT1beta in B cells: induction of cell death by a mechanism different from that of STAT1alpha.

Najjar I, Schischmanoff PO, Baran-Marszak F, Deglesne PA, Youlyouz-Marfak I, Pampin M, Feuillard J, Bornkamm GW, Chelbi-Alix MK, Fagard R.

J Leukoc Biol. 2008 Dec;84(6):1604-12. doi: 10.1189/jlb.0508287. Epub 2008 Sep 11.

PMID:
18753311
32.

Endogenous presentation of a nuclear antigen on MHC class II by autophagy in the absence of CRM1-mediated nuclear export.

Riedel A, Nimmerjahn F, Burdach S, Behrends U, Bornkamm GW, Mautner J.

Eur J Immunol. 2008 Aug;38(8):2090-5. doi: 10.1002/eji.200737900.

33.

Identification of a novel p53-dependent activation pathway of STAT1 by antitumour genotoxic agents.

Youlyouz-Marfak I, Gachard N, Le Clorennec C, Najjar I, Baran-Marszak F, Reminieras L, May E, Bornkamm GW, Fagard R, Feuillard J.

Cell Death Differ. 2008 Feb;15(2):376-85. Epub 2007 Nov 9.

34.

Physiological role of phospholipid hydroperoxide glutathione peroxidase in mammals.

Conrad M, Schneider M, Seiler A, Bornkamm GW.

Biol Chem. 2007 Oct;388(10):1019-25. Review.

PMID:
17937615
35.

Gadd45 beta is a pro-survival factor associated with stress-resistant tumors.

Engelmann A, Speidel D, Bornkamm GW, Deppert W, Stocking C.

Oncogene. 2008 Feb 28;27(10):1429-38. Epub 2007 Sep 24.

PMID:
17891184
36.

The cystine/cysteine cycle: a redox cycle regulating susceptibility versus resistance to cell death.

Banjac A, Perisic T, Sato H, Seiler A, Bannai S, Weiss N, Kölle P, Tschoep K, Issels RD, Daniel PT, Conrad M, Bornkamm GW.

Oncogene. 2008 Mar 6;27(11):1618-28. Epub 2007 Sep 10.

PMID:
17828297
37.

Immunodominance of lytic cycle antigens in Epstein-Barr virus-specific CD4+ T cell preparations for therapy.

Adhikary D, Behrends U, Boerschmann H, Pfünder A, Burdach S, Moosmann A, Witter K, Bornkamm GW, Mautner J.

PLoS One. 2007 Jul 4;2(7):e583. Review.

38.

c-MYC impairs immunogenicity of human B cells.

Schlee M, Schuhmacher M, Hölzel M, Laux G, Bornkamm GW.

Adv Cancer Res. 2007;97:167-88. Review.

PMID:
17419945
39.

C-myc activation impairs the NF-kappaB and the interferon response: implications for the pathogenesis of Burkitt's lymphoma.

Schlee M, Hölzel M, Bernard S, Mailhammer R, Schuhmacher M, Reschke J, Eick D, Marinkovic D, Wirth T, Rosenwald A, Staudt LM, Eilers M, Baran-Marszak F, Fagard R, Feuillard J, Laux G, Bornkamm GW.

Int J Cancer. 2007 Apr 1;120(7):1387-95.

40.

Autoactivation of the Epstein-Barr virus oncogenic protein LMP1 during type II latency through opposite roles of the NF-kappaB and JNK signaling pathways.

Goormachtigh G, Ouk TS, Mougel A, Tranchand-Bunel D, Masy E, Le Clorennec C, Feuillard J, Bornkamm GW, Auriault C, Manet E, Fafeur V, Adriaenssens E, Coll J.

J Virol. 2006 Aug;80(15):7382-93.

41.

Activated Notch1 alters differentiation of embryonic stem cells into mesodermal cell lineages at multiple stages of development.

Schroeder T, Meier-Stiegen F, Schwanbeck R, Eilken H, Nishikawa S, Häsler R, Schreiber S, Bornkamm GW, Nishikawa S, Just U.

Mech Dev. 2006 Jul;123(7):570-9. Epub 2006 May 25.

42.

The infectious kiss: newly infected B cells deliver Epstein-Barr virus to epithelial cells.

Bornkamm GW, Behrends U, Mautner J.

Proc Natl Acad Sci U S A. 2006 May 9;103(19):7201-2. Epub 2006 May 1. No abstract available.

43.

Control of Epstein-Barr virus infection in vitro by T helper cells specific for virion glycoproteins.

Adhikary D, Behrends U, Moosmann A, Witter K, Bornkamm GW, Mautner J.

J Exp Med. 2006 Apr 17;203(4):995-1006. Epub 2006 Mar 20.

44.

Embryonic expression profile of phospholipid hydroperoxide glutathione peroxidase.

Schneider M, Vogt Weisenhorn DM, Seiler A, Bornkamm GW, Brielmeier M, Conrad M.

Gene Expr Patterns. 2006 Jun;6(5):489-94. Epub 2006 Feb 2.

PMID:
16458079
45.

EBV latency III immortalization program sensitizes B cells to induction of CD95-mediated apoptosis via LMP1: role of NF-kappaB, STAT1, and p53.

Le Clorennec C, Youlyouz-Marfak I, Adriaenssens E, Coll J, Bornkamm GW, Feuillard J.

Blood. 2006 Mar 1;107(5):2070-8. Epub 2005 Nov 29.

46.

Stringent doxycycline-dependent control of gene activities using an episomal one-vector system.

Bornkamm GW, Berens C, Kuklik-Roos C, Bechet JM, Laux G, Bachl J, Korndoerfer M, Schlee M, Hölzel M, Malamoussi A, Chapman RD, Nimmerjahn F, Mautner J, Hillen W, Bujard H, Feuillard J.

Nucleic Acids Res. 2005 Sep 7;33(16):e137.

47.

The nuclear form of phospholipid hydroperoxide glutathione peroxidase is a protein thiol peroxidase contributing to sperm chromatin stability.

Conrad M, Moreno SG, Sinowatz F, Ursini F, Kölle S, Roveri A, Brielmeier M, Wurst W, Maiorino M, Bornkamm GW.

Mol Cell Biol. 2005 Sep;25(17):7637-44.

48.

Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation.

Hölzel M, Rohrmoser M, Schlee M, Grimm T, Harasim T, Malamoussi A, Gruber-Eber A, Kremmer E, Hiddemann W, Bornkamm GW, Eick D.

J Cell Biol. 2005 Aug 1;170(3):367-78. Epub 2005 Jul 25.

49.

Alternative splicing generates putative soluble CD83 proteins that inhibit T cell proliferation.

Dudziak D, Nimmerjahn F, Bornkamm GW, Laux G.

J Immunol. 2005 Jun 1;174(11):6672-6.

50.

Latent membrane protein 1 regulates STAT1 through NF-kappaB-dependent interferon secretion in Epstein-Barr virus-immortalized B cells.

Najjar I, Baran-Marszak F, Le Clorennec C, Laguillier C, Schischmanoff O, Youlyouz-Marfak I, Schlee M, Bornkamm GW, Raphaël M, Feuillard J, Fagard R.

J Virol. 2005 Apr;79(8):4936-43.

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