Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 26

1.

A Hyperstabilizing Mutation in the Base of the Ebola Virus Glycoprotein Acts at Multiple Steps To Abrogate Viral Entry.

Fels JM, Spence JS, Bortz RH 3rd, Bornholdt ZA, Chandran K.

MBio. 2019 Jul 9;10(4). pii: e01408-19. doi: 10.1128/mBio.01408-19.

2.

A Two-Antibody Pan-Ebolavirus Cocktail Confers Broad Therapeutic Protection in Ferrets and Nonhuman Primates.

Bornholdt ZA, Herbert AS, Mire CE, He S, Cross RW, Wec AZ, Abelson DM, Geisbert JB, James RM, Rahim MN, Zhu W, Borisevich V, Banadyga L, Gunn BM, Agans KN, Wirchnianski AS, Goodwin E, Tierney K, Shestowsky WS, Bohorov O, Bohorova N, Velasco J, Ailor E, Kim D, Pauly MH, Whaley KJ, Alter G, Walker LM, Chandran K, Zeitlin L, Qiu X, Geisbert TW, Dye JM.

Cell Host Microbe. 2019 Jan 9;25(1):49-58.e5. doi: 10.1016/j.chom.2018.12.005.

PMID:
30629918
3.

Development of a Human Antibody Cocktail that Deploys Multiple Functions to Confer Pan-Ebolavirus Protection.

Wec AZ, Bornholdt ZA, He S, Herbert AS, Goodwin E, Wirchnianski AS, Gunn BM, Zhang Z, Zhu W, Liu G, Abelson DM, Moyer CL, Jangra RK, James RM, Bakken RR, Bohorova N, Bohorov O, Kim DH, Pauly MH, Velasco J, Bortz RH 3rd, Whaley KJ, Goldstein T, Anthony SJ, Alter G, Walker LM, Dye JM, Zeitlin L, Qiu X, Chandran K.

Cell Host Microbe. 2019 Jan 9;25(1):39-48.e5. doi: 10.1016/j.chom.2018.12.004.

PMID:
30629917
4.

Structural Basis of Pan-Ebolavirus Neutralization by an Antibody Targeting the Glycoprotein Fusion Loop.

Murin CD, Bruhn JF, Bornholdt ZA, Copps J, Stanfield R, Ward AB.

Cell Rep. 2018 Sep 4;24(10):2723-2732.e4. doi: 10.1016/j.celrep.2018.08.009.

5.

Ebola virus vaccination and the longevity of total versus neutralising antibody response-is it enough?

Bornholdt ZA, Bradfute SB.

Lancet Infect Dis. 2018 Jul;18(7):699-700. doi: 10.1016/S1473-3099(18)30175-0. Epub 2018 Apr 5. No abstract available.

PMID:
29627146
6.

Antibodies from a Human Survivor Define Sites of Vulnerability for Broad Protection against Ebolaviruses.

Wec AZ, Herbert AS, Murin CD, Nyakatura EK, Abelson DM, Fels JM, He S, James RM, de La Vega MA, Zhu W, Bakken RR, Goodwin E, Turner HL, Jangra RK, Zeitlin L, Qiu X, Lai JR, Walker LM, Ward AB, Dye JM, Chandran K, Bornholdt ZA.

Cell. 2017 May 18;169(5):878-890.e15. doi: 10.1016/j.cell.2017.04.037.

7.

A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses.

Wec AZ, Nyakatura EK, Herbert AS, Howell KA, Holtsberg FW, Bakken RR, Mittler E, Christin JR, Shulenin S, Jangra RK, Bharrhan S, Kuehne AI, Bornholdt ZA, Flyak AI, Saphire EO, Crowe JE Jr, Aman MJ, Dye JM, Lai JR, Chandran K.

Science. 2016 Oct 21;354(6310):350-354. Epub 2016 Sep 8.

8.

Analytical Validation of the ReEBOV Antigen Rapid Test for Point-of-Care Diagnosis of Ebola Virus Infection.

Cross RW, Boisen ML, Millett MM, Nelson DS, Oottamasathien D, Hartnett JN, Jones AB, Goba A, Momoh M, Fullah M, Bornholdt ZA, Fusco ML, Abelson DM, Oda S, Brown BL, Pham H, Rowland MM, Agans KN, Geisbert JB, Heinrich ML, Kulakosky PC, Shaffer JG, Schieffelin JS, Kargbo B, Gbetuwa M, Gevao SM, Wilson RB, Saphire EO, Pitts KR, Khan SH, Grant DS, Geisbert TW, Branco LM, Garry RF.

J Infect Dis. 2016 Oct 15;214(suppl 3):S210-S217. Epub 2016 Aug 31.

9.

Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak.

Bornholdt ZA, Turner HL, Murin CD, Li W, Sok D, Souders CA, Piper AE, Goff A, Shamblin JD, Wollen SE, Sprague TR, Fusco ML, Pommert KB, Cavacini LA, Smith HL, Klempner M, Reimann KA, Krauland E, Gerngross TU, Wittrup KD, Saphire EO, Burton DR, Glass PJ, Ward AB, Walker LM.

Science. 2016 Mar 4;351(6277):1078-83. doi: 10.1126/science.aad5788. Epub 2016 Feb 18.

10.

Host-Primed Ebola Virus GP Exposes a Hydrophobic NPC1 Receptor-Binding Pocket, Revealing a Target for Broadly Neutralizing Antibodies.

Bornholdt ZA, Ndungo E, Fusco ML, Bale S, Flyak AI, Crowe JE Jr, Chandran K, Saphire EO.

MBio. 2016 Feb 23;7(1):e02154-15. doi: 10.1128/mBio.02154-15.

11.

Crystal Structure of Marburg Virus VP40 Reveals a Broad, Basic Patch for Matrix Assembly and a Requirement of the N-Terminal Domain for Immunosuppression.

Oda S, Noda T, Wijesinghe KJ, Halfmann P, Bornholdt ZA, Abelson DM, Armbrust T, Stahelin RV, Kawaoka Y, Saphire EO.

J Virol. 2015 Dec 9;90(4):1839-48. doi: 10.1128/JVI.01597-15. Print 2016 Feb 15.

12.

Development of Prototype Filovirus Recombinant Antigen Immunoassays.

Boisen ML, Oottamasathien D, Jones AB, Millett MM, Nelson DS, Bornholdt ZA, Fusco ML, Abelson DM, Oda S, Hartnett JN, Rowland MM, Heinrich ML, Akdag M, Goba A, Momoh M, Fullah M, Baimba F, Gbakie M, Safa S, Fonnie R, Kanneh L, Cross RW, Geisbert JB, Geisbert TW, Kulakosky PC, Grant DS, Shaffer JG, Schieffelin JS, Wilson RB, Saphire EO, Branco LM, Garry RF, Khan SH, Pitts KR; Viral Hemorrhagic Fever Consortium.

J Infect Dis. 2015 Oct 1;212 Suppl 2:S359-67. doi: 10.1093/infdis/jiv353. Epub 2015 Jul 30.

13.

Structural basis for Marburg virus neutralization by a cross-reactive human antibody.

Hashiguchi T, Fusco ML, Bornholdt ZA, Lee JE, Flyak AI, Matsuoka R, Kohda D, Yanagi Y, Hammel M, Crowe JE Jr, Saphire EO.

Cell. 2015 Feb 26;160(5):904-912. doi: 10.1016/j.cell.2015.01.041.

14.

Mechanism of human antibody-mediated neutralization of Marburg virus.

Flyak AI, Ilinykh PA, Murin CD, Garron T, Shen X, Fusco ML, Hashiguchi T, Bornholdt ZA, Slaughter JC, Sapparapu G, Klages C, Ksiazek TG, Ward AB, Saphire EO, Bukreyev A, Crowe JE Jr.

Cell. 2015 Feb 26;160(5):893-903. doi: 10.1016/j.cell.2015.01.031.

15.

Structures of protective antibodies reveal sites of vulnerability on Ebola virus.

Murin CD, Fusco ML, Bornholdt ZA, Qiu X, Olinger GG, Zeitlin L, Kobinger GP, Ward AB, Saphire EO.

Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17182-7. doi: 10.1073/pnas.1414164111. Epub 2014 Nov 17.

16.

Crystal structure of Marburg virus VP24.

Zhang AP, Bornholdt ZA, Abelson DM, Saphire EO.

J Virol. 2014 May;88(10):5859-63. doi: 10.1128/JVI.03565-13. Epub 2014 Feb 26.

17.

The influenza A virus protein NS1 displays structural polymorphism.

Carrillo B, Choi JM, Bornholdt ZA, Sankaran B, Rice AP, Prasad BV.

J Virol. 2014 Apr;88(8):4113-22. doi: 10.1128/JVI.03692-13. Epub 2014 Jan 29.

18.

Crystal structure of the nipah virus phosphoprotein tetramerization domain.

Bruhn JF, Barnett KC, Bibby J, Thomas JM, Keegan RM, Rigden DJ, Bornholdt ZA, Saphire EO.

J Virol. 2014 Jan;88(1):758-62. doi: 10.1128/JVI.02294-13. Epub 2013 Oct 23.

19.

Structural rearrangement of ebola virus VP40 begets multiple functions in the virus life cycle.

Bornholdt ZA, Noda T, Abelson DM, Halfmann P, Wood MR, Kawaoka Y, Saphire EO.

Cell. 2013 Aug 15;154(4):763-74. doi: 10.1016/j.cell.2013.07.015.

20.

Ebolavirus VP35 coats the backbone of double-stranded RNA for interferon antagonism.

Bale S, Julien JP, Bornholdt ZA, Krois AS, Wilson IA, Saphire EO.

J Virol. 2013 Sep;87(18):10385-8. doi: 10.1128/JVI.01452-13. Epub 2013 Jul 3.

21.

The ebolavirus VP24 interferon antagonist: know your enemy.

Zhang AP, Abelson DM, Bornholdt ZA, Liu T, Woods VL Jr, Saphire EO.

Virulence. 2012 Aug 15;3(5):440-5. doi: 10.4161/viru.21302. Epub 2012 Aug 15.

22.

Marburg virus VP35 can both fully coat the backbone and cap the ends of dsRNA for interferon antagonism.

Bale S, Julien JP, Bornholdt ZA, Kimberlin CR, Halfmann P, Zandonatti MA, Kunert J, Kroon GJ, Kawaoka Y, MacRae IJ, Wilson IA, Saphire EO.

PLoS Pathog. 2012 Sep;8(9):e1002916. doi: 10.1371/journal.ppat.1002916. Epub 2012 Sep 13.

23.

The ebola virus interferon antagonist VP24 directly binds STAT1 and has a novel, pyramidal fold.

Zhang AP, Bornholdt ZA, Liu T, Abelson DM, Lee DE, Li S, Woods VL Jr, Saphire EO.

PLoS Pathog. 2012 Feb;8(2):e1002550. doi: 10.1371/journal.ppat.1002550. Epub 2012 Feb 23. Erratum in: PLoS Pathog. 2013 Dec;9(12). doi:10.1371/annotation/360ddc68-0313-4eae-af24-043cc040c52d.

24.

Ebolavirus VP35 uses a bimodal strategy to bind dsRNA for innate immune suppression.

Kimberlin CR, Bornholdt ZA, Li S, Woods VL Jr, MacRae IJ, Saphire EO.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):314-9. doi: 10.1073/pnas.0910547107. Epub 2009 Dec 14.

25.

X-ray structure of NS1 from a highly pathogenic H5N1 influenza virus.

Bornholdt ZA, Prasad BV.

Nature. 2008 Dec 18;456(7224):985-8. doi: 10.1038/nature07444. Epub 2008 Nov 5.

26.

X-ray structure of influenza virus NS1 effector domain.

Bornholdt ZA, Prasad BV.

Nat Struct Mol Biol. 2006 Jun;13(6):559-60. Epub 2006 May 21.

PMID:
16715094

Supplemental Content

Loading ...
Support Center