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Gamma-glutamyl transpeptidase null mice fail to develop tolerance to coumarin-induced Clara cell toxicity.
Vassallo JD, Kaetzel RS, Born SL, Lewis CL, Lehman-McKeeman LD, Reed DJ.
Food Chem Toxicol. 2010 Jun;48(6):1612-8. doi: 10.1016/j.fct.2010.03.034. Epub 2010 Mar 27.
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Roles for epoxidation and detoxification of coumarin in determining species differences in clara cell toxicity.
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Comparative metabolism and kinetics of coumarin in mice and rats.
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Identification of the cytochromes P450 that catalyze coumarin 3,4-epoxidation and 3-hydroxylation.
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In vitro kinetics of coumarin 3,4-epoxidation: application to species differences in toxicity and carcinogenicity.
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o-hydroxyphenylacetaldehyde is a hepatotoxic metabolite of coumarin.
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Development of tolerance to Clara cell necrosis with repeat administration of coumarin.
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Selective Clara cell injury in mouse lung following acute administration of coumarin.
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Synthesis and reactivity of coumarin 3,4-epoxide.
Born SL, Rodriguez PA, Eddy CL, Lehman-McKeeman LD.
Drug Metab Dispos. 1997 Nov;25(11):1318-24.
Escherichia coli expression and substrate specificities of canine cytochrome P450 3A12 and rabbit cytochrome P450 3A6.
Born SL, Fraser DJ, Harlow GR, Halpert JR.
J Pharmacol Exp Ther. 1996 Aug;278(2):957-63.
Suppression of rat hepatic microsomal cytochromes P450 by cyclophosphamide is correlated with plasma thyroid hormone levels and displays differential strain sensitivity.
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Characterization of the progesterone 21-hydroxylase activity of canine cytochrome P450 PBD-2/P450 2B11 through reconstitution, heterologous expression, and site-directed mutagenesis.
Born SL, John GH, Harlow GR, Halpert JR.
Drug Metab Dispos. 1995 Jul;23(7):702-7.
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