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Items: 43

1.

SIGNAL TRANSDUCTION. Structural basis for nucleotide exchange in heterotrimeric G proteins.

Dror RO, Mildorf TJ, Hilger D, Manglik A, Borhani DW, Arlow DH, Philippsen A, Villanueva N, Yang Z, Lerch MT, Hubbell WL, Kobilka BK, Sunahara RK, Shaw DE.

Science. 2015 Jun 19;348(6241):1361-5. doi: 10.1126/science.aaa5264.

2.

Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs.

Dror RO, Green HF, Valant C, Borhani DW, Valcourt JR, Pan AC, Arlow DH, Canals M, Lane JR, Rahmani R, Baell JB, Sexton PM, Christopoulos A, Shaw DE.

Nature. 2013 Nov 14;503(7475):295-9. doi: 10.1038/nature12595. Epub 2013 Oct 13.

PMID:
24121438
3.

Molecular determinants of drug-receptor binding kinetics.

Pan AC, Borhani DW, Dror RO, Shaw DE.

Drug Discov Today. 2013 Jul;18(13-14):667-73. doi: 10.1016/j.drudis.2013.02.007. Epub 2013 Feb 27. Review.

PMID:
23454741
4.

Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor.

Argiriadi MA, Goedken ER, Banach D, Borhani DW, Burchat A, Dixon RW, Marcotte D, Overmeyer G, Pivorunas V, Sadhukhan R, Sousa S, Moore NS, Tomlinson M, Voss J, Wang L, Wishart N, Woller K, Talanian RV.

BMC Struct Biol. 2012 Sep 20;12:22. doi: 10.1186/1472-6807-12-22.

5.

Mechanism of voltage gating in potassium channels.

Jensen MØ, Jogini V, Borhani DW, Leffler AE, Dror RO, Shaw DE.

Science. 2012 Apr 13;336(6078):229-33. doi: 10.1126/science.1216533.

6.

The future of molecular dynamics simulations in drug discovery.

Borhani DW, Shaw DE.

J Comput Aided Mol Des. 2012 Jan;26(1):15-26. doi: 10.1007/s10822-011-9517-y. Epub 2011 Dec 20.

7.

Rethinking clinical trials: biology's mysteries.

Borhani DW, Butts JA.

Science. 2011 Dec 9;334(6061):1346-7. doi: 10.1126/science.334.6061.1346-c. No abstract available.

PMID:
22158802
8.

Activation mechanism of the β2-adrenergic receptor.

Dror RO, Arlow DH, Maragakis P, Mildorf TJ, Pan AC, Xu H, Borhani DW, Shaw DE.

Proc Natl Acad Sci U S A. 2011 Nov 15;108(46):18684-9. doi: 10.1073/pnas.1110499108. Epub 2011 Oct 26.

9.

Pathway and mechanism of drug binding to G-protein-coupled receptors.

Dror RO, Pan AC, Arlow DH, Borhani DW, Maragakis P, Shan Y, Xu H, Shaw DE.

Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13118-23. doi: 10.1073/pnas.1104614108. Epub 2011 Jul 21.

10.

Comment on "A bacterium that can grow by using arsenic instead of phosphorus".

Borhani DW.

Science. 2011 Jun 3;332(6034):1149; author reply 1149. doi: 10.1126/science.1201255. Epub 2011 May 27.

11.

Include Israel when comparing metrics.

Borhani DW.

Nature. 2011 Mar 3;471(7336):37. doi: 10.1038/471037b. No abstract available.

PMID:
21368812
12.

Discovery and characterization of non-ATP site inhibitors of the mitogen activated protein (MAP) kinases.

Comess KM, Sun C, Abad-Zapatero C, Goedken ER, Gum RJ, Borhani DW, Argiriadi M, Groebe DR, Jia Y, Clampit JE, Haasch DL, Smith HT, Wang S, Song D, Coen ML, Cloutier TE, Tang H, Cheng X, Quinn C, Liu B, Xin Z, Liu G, Fry EH, Stoll V, Ng TI, Banach D, Marcotte D, Burns DJ, Calderwood DJ, Hajduk PJ.

ACS Chem Biol. 2011 Mar 18;6(3):234-44. doi: 10.1021/cb1002619. Epub 2011 Jan 20.

PMID:
21090814
13.

Exploring atomic resolution physiology on a femtosecond to millisecond timescale using molecular dynamics simulations.

Dror RO, Jensen MØ, Borhani DW, Shaw DE.

J Gen Physiol. 2010 Jun;135(6):555-62. doi: 10.1085/jgp.200910373. No abstract available.

14.

Principles of conduction and hydrophobic gating in K+ channels.

Jensen MØ, Borhani DW, Lindorff-Larsen K, Maragakis P, Jogini V, Eastwood MP, Dror RO, Shaw DE.

Proc Natl Acad Sci U S A. 2010 Mar 30;107(13):5833-8. doi: 10.1073/pnas.0911691107. Epub 2010 Mar 15.

15.

2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization.

Harris CM, Ericsson AM, Argiriadi MA, Barberis C, Borhani DW, Burchat A, Calderwood DJ, Cunha GA, Dixon RW, Frank KE, Johnson EF, Kamens J, Kwak S, Li B, Mullen KD, Perron DC, Wang L, Wishart N, Wu X, Zhang X, Zmetra TR, Talanian RV.

Bioorg Med Chem Lett. 2010 Jan 1;20(1):334-7. doi: 10.1016/j.bmcl.2009.10.103. Epub 2009 Oct 29.

PMID:
19926477
16.

2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode.

Argiriadi MA, Ericsson AM, Harris CM, Banach DL, Borhani DW, Calderwood DJ, Demers MD, Dimauro J, Dixon RW, Hardman J, Kwak S, Li B, Mankovich JA, Marcotte D, Mullen KD, Ni B, Pietras M, Sadhukhan R, Sousa S, Tomlinson MJ, Wang L, Xiang T, Talanian RV.

Bioorg Med Chem Lett. 2010 Jan 1;20(1):330-3. doi: 10.1016/j.bmcl.2009.10.102. Epub 2009 Oct 29.

PMID:
19919896
17.

Unusual water-mediated antigenic recognition of the proinflammatory cytokine interleukin-18.

Argiriadi MA, Xiang T, Wu C, Ghayur T, Borhani DW.

J Biol Chem. 2009 Sep 4;284(36):24478-89. doi: 10.1074/jbc.M109.023887. Epub 2009 Jun 24.

18.

Rational mutagenesis to support structure-based drug design: MAPKAP kinase 2 as a case study.

Argiriadi MA, Sousa S, Banach D, Marcotte D, Xiang T, Tomlinson MJ, Demers M, Harris C, Kwak S, Hardman J, Pietras M, Quinn L, DiMauro J, Ni B, Mankovich J, Borhani DW, Talanian RV, Sadhukhan R.

BMC Struct Biol. 2009 Mar 18;9:16. doi: 10.1186/1472-6807-9-16.

19.

Identification of two distinct inactive conformations of the beta2-adrenergic receptor reconciles structural and biochemical observations.

Dror RO, Arlow DH, Borhani DW, Jensen MØ, Piana S, Shaw DE.

Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4689-94. doi: 10.1073/pnas.0811065106. Epub 2009 Mar 3.

20.

Covalent JNK inhibitors?

Borhani DW.

Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):E18; author reply E19. doi: 10.1073/pnas.0812246106. Epub 2009 Feb 9. No abstract available.

21.

Dynamic control of slow water transport by aquaporin 0: implications for hydration and junction stability in the eye lens.

Jensen MØ, Dror RO, Xu H, Borhani DW, Arkin IT, Eastwood MP, Shaw DE.

Proc Natl Acad Sci U S A. 2008 Sep 23;105(38):14430-5. doi: 10.1073/pnas.0802401105. Epub 2008 Sep 11.

22.

Novel boron-containing, nonclassical antifolates: synthesis and preliminary biological and structural evaluation.

Reynolds RC, Campbell SR, Fairchild RG, Kisliuk RL, Micca PL, Queener SF, Riordan JM, Sedwick WD, Waud WR, Leung AK, Dixon RW, Suling WJ, Borhani DW.

J Med Chem. 2007 Jul 12;50(14):3283-9. Epub 2007 Jun 15.

PMID:
17569517
23.

Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection.

Burchat A, Borhani DW, Calderwood DJ, Hirst GC, Li B, Stachlewitz RF.

Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22. Epub 2005 Oct 10.

PMID:
16216497
24.

Polymerization of C-terminally truncated Mycobacterium tuberculosis FtsZ is unlikely to be physiologically relevant.

Borhani DW, White EL.

Microbiology. 2004 Dec;150(Pt 12):3903-6. No abstract available.

PMID:
15583142
25.

Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches.

Leung AK, Lucile White E, Ross LJ, Reynolds RC, DeVito JA, Borhani DW.

J Mol Biol. 2004 Sep 17;342(3):953-70.

PMID:
15342249
26.

A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection.

Borhani DW, Calderwood DJ, Friedman MM, Hirst GC, Li B, Leung AK, McRae B, Ratnofsky S, Ritter K, Waegell W.

Bioorg Med Chem Lett. 2004 May 17;14(10):2613-6.

PMID:
15109663
27.

Atomic structures of human dihydrofolate reductase complexed with NADPH and two lipophilic antifolates at 1.09 a and 1.05 a resolution.

Klon AE, Héroux A, Ross LJ, Pathak V, Johnson CA, Piper JR, Borhani DW.

J Mol Biol. 2002 Jul 12;320(3):677-93.

PMID:
12096917
28.

Structural models of human apolipoprotein A-I: a critical analysis and review.

Brouillette CG, Anantharamaiah GM, Engler JA, Borhani DW.

Biochim Biophys Acta. 2001 Mar 30;1531(1-2):4-46. Review.

PMID:
11278170
29.

Substrate deformation in a hypoxanthine-guanine phosphoribosyltransferase ternary complex: the structural basis for catalysis.

Héroux A, White EL, Ross LJ, Kuzin AP, Borhani DW.

Structure. 2000 Dec 15;8(12):1309-18.

30.

Crystallization of the Mycobacterium tuberculosis cell-division protein FtsZ.

Leung AK, White EL, Ross LJ, Borhani DW.

Acta Crystallogr D Biol Crystallogr. 2000 Dec;56(Pt 12):1634-7.

PMID:
11092931
31.

Slow polymerization of Mycobacterium tuberculosis FtsZ.

White EL, Ross LJ, Reynolds RC, Seitz LE, Moore GD, Borhani DW.

J Bacteriol. 2000 Jul;182(14):4028-34.

32.

The two toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase isozymes form heterotetramers.

White EL, Ross LJ, Davis RL, Zywno-Van Ginkel S, Vasanthakumar G, Borhani DW.

J Biol Chem. 2000 Jun 23;275(25):19218-23.

33.

Human apolipoprotein A-I: structure determination and analysis of unusual diffraction characteristics.

Borhani DW, Engler JA, Brouillette CG.

Acta Crystallogr D Biol Crystallogr. 1999 Dec;55(Pt 12):2013-21.

PMID:
10666577
34.
36.

Crystal structure of the ectodomain of human transferrin receptor.

Lawrence CM, Ray S, Babyonyshev M, Galluser R, Borhani DW, Harrison SC.

Science. 1999 Oct 22;286(5440):779-82.

37.

Crystallization of truncated human apolipoprotein A-I in a novel conformation.

Borhani DW, Engler JA, Brouillette CG.

Acta Crystallogr D Biol Crystallogr. 1999 Sep;55(Pt 9):1578-83.

PMID:
10489452
38.

Michellamine alkaloids inhibit protein kinase C.

White EL, Chao WR, Ross LJ, Borhani DW, Hobbs PD, Upender V, Dawson MI.

Arch Biochem Biophys. 1999 May 1;365(1):25-30.

PMID:
10222035
39.

Crystal structure of truncated human apolipoprotein A-I suggests a lipid-bound conformation.

Borhani DW, Rogers DP, Engler JA, Brouillette CG.

Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12291-6.

40.
41.

Probing the active site of human aldose reductase. Site-directed mutagenesis of Asp-43, Tyr-48, Lys-77, and His-110.

Tarle I, Borhani DW, Wilson DK, Quiocho FA, Petrash JM.

J Biol Chem. 1993 Dec 5;268(34):25687-93.

42.

The crystal structure of the aldose reductase.NADPH binary complex.

Borhani DW, Harter TM, Petrash JM.

J Biol Chem. 1992 Dec 5;267(34):24841-7.

43.

Crystallization and X-ray diffraction studies of a soluble form of the human transferrin receptor.

Borhani DW, Harrison SC.

J Mol Biol. 1991 Apr 20;218(4):685-9.

PMID:
2023243

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