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Items: 40


Cryo-EM reveals active site coordination within a multienzyme pre-rRNA processing complex.

Pillon MC, Hsu AL, Krahn JM, Williams JG, Goslen KH, Sobhany M, Borgnia MJ, Stanley RE.

Nat Struct Mol Biol. 2019 Sep;26(9):830-839. doi: 10.1038/s41594-019-0289-8. Epub 2019 Sep 5.


Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.

Yin Y, Wu M, Hsu AL, Borschel WF, Borgnia MJ, Lander GC, Lee SY.

Nat Commun. 2019 Aug 20;10(1):3740. doi: 10.1038/s41467-019-11733-5.


Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes.

Zubcevic L, Hsu AL, Borgnia MJ, Lee SY.

Elife. 2019 May 15;8. pii: e45779. doi: 10.7554/eLife.45779.


Regulatory switch at the cytoplasmic interface controls TRPV channel gating.

Zubcevic L, Borschel WF, Hsu AL, Borgnia MJ, Lee SY.

Elife. 2019 May 9;8. pii: e47746. doi: 10.7554/eLife.47746.


Structural Basis for Recognition of Ubiquitylated Nucleosome by Dot1L Methyltransferase.

Anderson CJ, Baird MR, Hsu A, Barbour EH, Koyama Y, Borgnia MJ, McGinty RK.

Cell Rep. 2019 Feb 12;26(7):1681-1690.e5. doi: 10.1016/j.celrep.2019.01.058.


Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel.

Yin Y, Le SC, Hsu AL, Borgnia MJ, Yang H, Lee SY.

Science. 2019 Mar 1;363(6430). pii: eaav9334. doi: 10.1126/science.aav9334. Epub 2019 Feb 7.


Cryo-EM structure of the essential ribosome assembly AAA-ATPase Rix7.

Lo YH, Sobhany M, Hsu AL, Ford BL, Krahn JM, Borgnia MJ, Stanley RE.

Nat Commun. 2019 Jan 31;10(1):513. doi: 10.1038/s41467-019-08373-0.


Polymer Nanodiscs: Discoidal Amphiphilic Block Copolymer Membranes as a New Platform for Membrane Proteins.

Fiori MC, Jiang Y, Zheng W, Anzaldua M, Borgnia MJ, Altenberg GA, Liang H.

Sci Rep. 2017 Nov 9;7(1):15227. doi: 10.1038/s41598-017-15151-9.


Grc3 programs the essential endoribonuclease Las1 for specific RNA cleavage.

Pillon MC, Sobhany M, Borgnia MJ, Williams JG, Stanley RE.

Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):E5530-E5538. doi: 10.1073/pnas.1703133114. Epub 2017 Jun 26.


Cryo-EM Analysis of the Conformational Landscape of Human P-glycoprotein (ABCB1) During its Catalytic Cycle.

Frank GA, Shukla S, Rao P, Borgnia MJ, Bartesaghi A, Merk A, Mobin A, Esser L, Earl LA, Gottesman MM, Xia D, Ambudkar SV, Subramaniam S.

Mol Pharmacol. 2016 Jul;90(1):35-41. doi: 10.1124/mol.116.104190. Epub 2016 May 11.


Using Cryo-EM to Map Small Ligands on Dynamic Metabolic Enzymes: Studies with Glutamate Dehydrogenase.

Borgnia MJ, Banerjee S, Merk A, Matthies D, Bartesaghi A, Rao P, Pierson J, Earl LA, Falconieri V, Subramaniam S, Milne JL.

Mol Pharmacol. 2016 Jun;89(6):645-51. doi: 10.1124/mol.116.103382. Epub 2016 Apr 1.


Cryo-EM Structures of the Magnesium Channel CorA Reveal Symmetry Break upon Gating.

Matthies D, Dalmas O, Borgnia MJ, Dominik PK, Merk A, Rao P, Reddy BG, Islam S, Bartesaghi A, Perozo E, Subramaniam S.

Cell. 2016 Feb 11;164(4):747-56. doi: 10.1016/j.cell.2015.12.055.


Prefusion structure of trimeric HIV-1 envelope glycoprotein determined by cryo-electron microscopy.

Bartesaghi A, Merk A, Borgnia MJ, Milne JL, Subramaniam S.

Nat Struct Mol Biol. 2013 Dec;20(12):1352-7. doi: 10.1038/nsmb.2711. Epub 2013 Oct 23.


Glutamate receptor desensitization is mediated by changes in quaternary structure of the ligand binding domain.

Schauder DM, Kuybeda O, Zhang J, Klymko K, Bartesaghi A, Borgnia MJ, Mayer ML, Subramaniam S.

Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):5921-6. doi: 10.1073/pnas.1217549110. Epub 2013 Mar 25.


Cryo-electron microscopy--a primer for the non-microscopist.

Milne JL, Borgnia MJ, Bartesaghi A, Tran EE, Earl LA, Schauder DM, Lengyel J, Pierson J, Patwardhan A, Subramaniam S.

FEBS J. 2013 Jan;280(1):28-45. doi: 10.1111/febs.12078. Epub 2012 Dec 17. Review.


Structural mechanism of trimeric HIV-1 envelope glycoprotein activation.

Tran EE, Borgnia MJ, Kuybeda O, Schauder DM, Bartesaghi A, Frank GA, Sapiro G, Milne JL, Subramaniam S.

PLoS Pathog. 2012;8(7):e1002797. doi: 10.1371/journal.ppat.1002797. Epub 2012 Jul 12.


Computational separation of conformational heterogeneity using cryo-electron tomography and 3D sub-volume averaging.

Frank GA, Bartesaghi A, Kuybeda O, Borgnia MJ, White TA, Sapiro G, Subramaniam S.

J Struct Biol. 2012 May;178(2):165-76. doi: 10.1016/j.jsb.2012.01.004. Epub 2012 Jan 10.


Determination of molecular structures of HIV envelope glycoproteins using cryo-electron tomography and automated sub-tomogram averaging.

Meyerson JR, White TA, Bliss D, Moran A, Bartesaghi A, Borgnia MJ, de la Cruz MJ, Schauder D, Hartnell LM, Nandwani R, Dawood M, Kim B, Kim JH, Sununu J, Yang L, Bhatia S, Subramaniam C, Hurt DE, Gaudreault L, Subramaniam S.

J Vis Exp. 2011 Dec 1;(58). pii: 2770. doi: 10.3791/2770.


Three-dimensional structures of soluble CD4-bound states of trimeric simian immunodeficiency virus envelope glycoproteins determined by using cryo-electron tomography.

White TA, Bartesaghi A, Borgnia MJ, de la Cruz MJ, Nandwani R, Hoxie JA, Bess JW, Lifson JD, Milne JL, Subramaniam S.

J Virol. 2011 Dec;85(23):12114-23. doi: 10.1128/JVI.05297-11. Epub 2011 Sep 21.


Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures.

Harris A, Borgnia MJ, Shi D, Bartesaghi A, He H, Pejchal R, Kang YK, Depetris R, Marozsan AJ, Sanders RW, Klasse PJ, Milne JL, Wilson IA, Olson WC, Moore JP, Subramaniam S.

Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11440-5. doi: 10.1073/pnas.1101414108. Epub 2011 Jun 27.


Lateral density of receptor arrays in the membrane plane influences sensitivity of the E. coli chemotaxis response.

Khursigara CM, Lan G, Neumann S, Wu X, Ravindran S, Borgnia MJ, Sourjik V, Milne J, Tu Y, Subramaniam S.

EMBO J. 2011 May 4;30(9):1719-29. doi: 10.1038/emboj.2011.77. Epub 2011 Mar 25.


Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: strain-dependent variation in quaternary structure.

White TA, Bartesaghi A, Borgnia MJ, Meyerson JR, de la Cruz MJ, Bess JW, Nandwani R, Hoxie JA, Lifson JD, Milne JL, Subramaniam S.

PLoS Pathog. 2010 Dec 23;6(12):e1001249. doi: 10.1371/journal.ppat.1001249.


Molecular architecture of native HIV-1 gp120 trimers.

Liu J, Bartesaghi A, Borgnia MJ, Sapiro G, Subramaniam S.

Nature. 2008 Sep 4;455(7209):109-13. doi: 10.1038/nature07159. Epub 2008 Jul 30.


Evaluation of denoising algorithms for biological electron tomography.

Narasimha R, Aganj I, Bennett AE, Borgnia MJ, Zabransky D, Sapiro G, McLaughlin SW, Milne JL, Subramaniam S.

J Struct Biol. 2008 Oct;164(1):7-17. doi: 10.1016/j.jsb.2008.04.006. Epub 2008 Apr 22.


Three-dimensional imaging of the highly bent architecture of Bdellovibrio bacteriovorus by using cryo-electron tomography.

Borgnia MJ, Subramaniam S, Milne JL.

J Bacteriol. 2008 Apr;190(7):2588-96. doi: 10.1128/JB.01538-07. Epub 2008 Jan 18.


Molecular structure of a 9-MDa icosahedral pyruvate dehydrogenase subcomplex containing the E2 and E3 enzymes using cryoelectron microscopy.

Milne JL, Wu X, Borgnia MJ, Lengyel JS, Brooks BR, Shi D, Perham RN, Subramaniam S.

J Biol Chem. 2006 Feb 17;281(7):4364-70. Epub 2005 Nov 23.


Automated image acquisition and processing using a new generation of 4K x 4K CCD cameras for cryo electron microscopic studies of macromolecular assemblies.

Zhang P, Borgnia MJ, Mooney P, Shi D, Pan M, O'Herron P, Mao A, Brogan D, Milne JL, Subramaniam S.

J Struct Biol. 2003 Aug;143(2):135-44.


A core-weighted fitting method for docking atomic structures into low-resolution maps: application to cryo-electron microscopy.

Wu X, Milne JL, Borgnia MJ, Rostapshov AV, Subramaniam S, Brooks BR.

J Struct Biol. 2003 Jan;141(1):63-76.


Highly selective water channel activity measured by voltage clamp: analysis of planar lipid bilayers reconstituted with purified AqpZ.

Pohl P, Saparov SM, Borgnia MJ, Agre P.

Proc Natl Acad Sci U S A. 2001 Aug 14;98(17):9624-9. Epub 2001 Aug 7.


The 3.7 A projection map of the glycerol facilitator GlpF: a variant of the aquaporin tetramer.

Braun T, Philippsen A, Wirtz S, Borgnia MJ, Agre P, K├╝hlbrandt W, Engel A, Stahlberg H.

EMBO Rep. 2000 Aug;1(2):183-9.


Reconstitution and functional comparison of purified GlpF and AqpZ, the glycerol and water channels from Escherichia coli.

Borgnia MJ, Agre P.

Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2888-93. Epub 2001 Feb 20.


The 6.9-A structure of GlpF: a basis for homology modeling of the glycerol channel from Escherichia coli.

Stahlberg H, Braun T, de Groot B, Philippsen A, Borgnia MJ, Agre P, K├╝hlbrandt W, Engel A.

J Struct Biol. 2000 Nov;132(2):133-41.


Structure of the water channel AqpZ from Escherichia coli revealed by electron crystallography.

Ringler P, Borgnia MJ, Stahlberg H, Maloney PC, Agre P, Engel A.

J Mol Biol. 1999 Sep 3;291(5):1181-90.


Functional reconstitution and characterization of AqpZ, the E. coli water channel protein.

Borgnia MJ, Kozono D, Calamita G, Maloney PC, Agre P.

J Mol Biol. 1999 Sep 3;291(5):1169-79.


The aquaporins, blueprints for cellular plumbing systems.

Agre P, Bonhivers M, Borgnia MJ.

J Biol Chem. 1998 Jun 12;273(24):14659-62. No abstract available.


Transport of polypeptide ionophores into proteoliposomes reconstituted with rat liver P-glycoprotein.

Eytan GD, Borgnia MJ, Regev R, Assaraf YG.

J Biol Chem. 1994 Oct 21;269(42):26058-65.


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