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Items: 31

1.

Stat5 Exerts Distinct, Vital Functions in the Cytoplasm and Nucleus of Bcr-Abl+ K562 and Jak2(V617F)+ HEL Leukemia Cells.

Weber A, Borghouts C, Brendel C, Moriggl R, Delis N, Brill B, Vafaizadeh V, Groner B.

Cancers (Basel). 2015 Mar 19;7(1):503-37. doi: 10.3390/cancers7010503.

2.

The inhibition of stat5 by a Peptide aptamer ligand specific for the DNA binding domain prevents target gene transactivation and the growth of breast and prostate tumor cells.

Weber A, Borghouts C, Brendel C, Moriggl R, Delis N, Brill B, Vafaizadeh V, Groner B.

Pharmaceuticals (Basel). 2013 Aug 20;6(8):960-87. doi: 10.3390/ph6080960.

3.

Inhibition of Stat3 by peptide aptamer rS3-PA enhances growth suppressive effects of irinotecan on colorectal cancer cells.

Weber A, Borghouts C, Delis N, Mack L, Brill B, Bernard AC, Coqueret O, Groner B.

Horm Mol Biol Clin Investig. 2012 Jun;10(2):273-9. doi: 10.1515/hmbci-2012-0014.

PMID:
25436684
4.

Stat3 is activated in skin lesions by the local application of imiquimod, a ligand of TLR7, and inhibited by the recombinant peptide aptamer rS3-PA.

Mack L, Brill B, Delis N, Borghouts C, Weber A, Groner B.

Horm Mol Biol Clin Investig. 2012 Jun;10(2):265-72. doi: 10.1515/hmbci-2012-0007.

PMID:
25436683
5.

Survivin inhibition by an interacting recombinant peptide, derived from the human ferritin heavy chain, impedes tumor cell growth.

Weiss A, Brill B, Borghouts C, Delis N, Mack L, Groner B.

J Cancer Res Clin Oncol. 2012 Jul;138(7):1205-20. doi: 10.1007/s00432-012-1195-1. Epub 2012 Mar 18.

PMID:
22426960
6.

A membrane penetrating peptide aptamer inhibits STAT3 function and suppresses the growth of STAT3 addicted tumor cells.

Borghouts C, Delis N, Brill B, Weiss A, Mack L, Lucks P, Groner B.

JAKSTAT. 2012 Jan 1;1(1):44-54. doi: 10.4161/jkst.18947.

7.

The integration of a Stat3 specific peptide aptamer into the thioredoxin scaffold protein strongly enhances its inhibitory potency.

Schöneberger H, Weiss A, Brill B, Delis N, Borghouts C, Groner B.

Horm Mol Biol Clin Investig. 2011 Mar 1;5(1):1-9. doi: 10.1515/HMBCI.2011.013.

PMID:
25961238
8.

The intracellular delivery of a recombinant peptide derived from the acidic domain of PIAS3 inhibits STAT3 transactivation and induces tumor cell death.

Borghouts C, Tittmann H, Delis N, Kirchenbauer M, Brill B, Groner B.

Mol Cancer Res. 2010 Apr;8(4):539-53. doi: 10.1158/1541-7786.MCR-09-0417. Epub 2010 Apr 6.

9.

Visualization of Stat3 and Stat5 transactivation activity with specific response element dependent reporter constructs integrated into lentiviral gene transfer vectors.

Gäbel K, Bednorz NL, Klemmt P, Vafaizadeh V, Borghouts C, Groner B.

Horm Mol Biol Clin Investig. 2010 Jan 1;1(3):127-37. doi: 10.1515/HMBCI.2010.017.

PMID:
25961188
10.

The function of Stat3 in tumor cells and their microenvironment.

Groner B, Lucks P, Borghouts C.

Semin Cell Dev Biol. 2008 Aug;19(4):341-50. doi: 10.1016/j.semcdb.2008.06.005. Epub 2008 Jun 24. Review.

PMID:
18621135
11.

Peptide aptamer libraries.

Borghouts C, Kunz C, Groner B.

Comb Chem High Throughput Screen. 2008 Feb;11(2):135-45. Review.

PMID:
18336207
12.

Monomeric recombinant peptide aptamers are required for efficient intracellular uptake and target inhibition.

Borghouts C, Kunz C, Delis N, Groner B.

Mol Cancer Res. 2008 Feb;6(2):267-81. doi: 10.1158/1541-7786.MCR-07-0245.

14.

The biological functions of the versatile transcription factors STAT3 and STAT5 and new strategies for their targeted inhibition.

Desrivières S, Kunz C, Barash I, Vafaizadeh V, Borghouts C, Groner B.

J Mammary Gland Biol Neoplasia. 2006 Jan;11(1):75-87. Review.

PMID:
16947086
15.

Current strategies for the development of peptide-based anti-cancer therapeutics.

Borghouts C, Kunz C, Groner B.

J Pept Sci. 2005 Nov;11(11):713-26. Review.

PMID:
16138387
16.

Peptide aptamers: recent developments for cancer therapy.

Borghouts C, Kunz C, Groner B.

Expert Opin Biol Ther. 2005 Jun;5(6):783-97. Review.

PMID:
15952909
17.

Rtg2 protein links metabolism and genome stability in yeast longevity.

Borghouts C, Benguria A, Wawryn J, Jazwinski SM.

Genetics. 2004 Feb;166(2):765-77.

18.
19.

Copper homeostasis and aging in the fungal model system Podospora anserina: differential expression of PaCtr3 encoding a copper transporter.

Borghouts C, Scheckhuber CQ, Stephan O, Osiewacz HD.

Int J Biochem Cell Biol. 2002 Nov;34(11):1355-71.

PMID:
12200031
20.

Respiration, copper availability and SOD activity in P. anserina strains with different lifespan.

Borghouts C, Scheckhuber CQ, Werner A, Osiewacz HD.

Biogerontology. 2002;3(3):143-53.

PMID:
12075133
21.

[Day-care and day-treatment in psychogeriatrics. Changes in the characteristics of users in the course of a year].

Huijvenaar ML, Borghouts CG, Lakerveld A, Hogeling JJ, ten Horn GH.

Tijdschr Gerontol Geriatr. 2001 Dec;32(6):265-70. Dutch.

PMID:
11789416
22.

Molecular control of copper homeostasis in filamentous fungi: increased expression of a metallothionein gene during aging of Podospora anserina.

Averbeck NB, Borghouts C, Hamann A, Specke V, Osiewacz HD.

Mol Gen Genet. 2001 Jan;264(5):604-12.

PMID:
11212915
23.

Copper-modulated gene expression and senescence in the filamentous fungus Podospora anserina.

Borghouts C, Werner A, Elthon T, Osiewacz HD.

Mol Cell Biol. 2001 Jan;21(2):390-9.

24.
25.

Nuclear-mitochondrial interactions involved in aging in Podospora anserina.

Borghouts C, Osiewacz HD.

Ann N Y Acad Sci. 2000 Jun;908:291-4. No abstract available.

PMID:
10911968
26.

Mitochondrial oxidative stress and aging in the filamentous fungus Podospora anserina.

Osiewacz HD, Borghouts C.

Ann N Y Acad Sci. 2000 Jun;908:31-9. Review.

PMID:
10911945
27.

Copper-dependence of mitochondrial DNA rearrangements in Podospora anserina.

Borghouts C, kerschner S, Osiewacz HD.

Curr Genet. 2000 Apr;37(4):268-75.

PMID:
10803888
28.

[Instrument for determination and planning of care].

Hogeling JJ, Borghouts CG, Lakerveld A, Huijvenaar ML, ten Horn GH.

Tijdschr Gerontol Geriatr. 1999 Oct;30(5):200-4. Dutch.

PMID:
10568244
30.

Mitochondrial DNA rearrangements of Podospora anserina are under the control of the nuclear gene grisea.

Borghouts C, Kimpel E, Osiewacz HD.

Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10768-73.

31.

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